Application | Comment | Organism |
---|---|---|
drug development | indole and benzofuran derivatives are promising reversible MAO-B inhibitors with a possible role in the treatment of neurodegenerative diseases such as Parkinsons disease | Homo sapiens |
medicine | monoamine oxidase is an important drug target for the treatment of neurological disorders | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
expression of MAO-A and MAO-B in baculovirus infected BTI insect cells | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(2E)-3-(3-chlorophenyl)-N-(2-methyl-1H-indol-5-yl)prop-2-enamide | - |
Homo sapiens | |
(2E)-N-(2-methyl-1H-indol-5-yl)-3-phenylprop-2-enamide | - |
Homo sapiens | |
(E)-3-chlorocinnamic acid 2-oxo-2,3-dihydro-benzofuran-5-yl ester | - |
Homo sapiens | |
(E)-cinnamic acid 2-oxo-2,3-dihydro-benzofuran-5-yl ester | - |
Homo sapiens | |
(R)-deprenyl | i.e. selegiline, a MAO-B inhibitor | Homo sapiens | |
1-methyl-N-(2-methyl-1H-indol-5-yl)-1lambda4-pyridine-3-carboxamide | - |
Homo sapiens | |
3,4-dichloro-N-(2-methyl-1H-indol-5-yl)benzamide | - |
Homo sapiens | |
3-chloro-N-(2-methyl-1H-indol-5-yl)benzamide | - |
Homo sapiens | |
3-chlorobenzoic acid 2-oxo-2,3-dihydro-benzofuran-5-yl ester | - |
Homo sapiens | |
3-[(2-methyl-1H-indol-5-yl)carbamoyl]benzene-1-sulfonic acid | - |
Homo sapiens | |
benzoic acid 2-oxo-2,3-dihydro-benzofuran-5-yl ester | - |
Homo sapiens | |
additional information | design and synthesis of a series of indole and benzofuran derivatives, and evaluation as reversible inhibitors of the two MAO isozymes MAO-A and MAO-B, most compounds are selective MAO-B inhibitors, ligand docking study, overview | Homo sapiens | |
N-(2-methyl-1H-indol-5-yl)benzamide | - |
Homo sapiens | |
N-(2-methyl-1H-indol-5-yl)cyclohexanecarboxamide | - |
Homo sapiens | |
rasagiline | i.e. AGN 1135 | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P27338 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
kynuramine + O2 | - |
Homo sapiens | 4-hydroxyquinoline + NH3 + H2O2 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
MAO | - |
Homo sapiens |
MAO-A | - |
Homo sapiens |
MAO-B | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
assay at | Homo sapiens |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.00003 | - |
3,4-dichloro-N-(2-methyl-1H-indol-5-yl)benzamide | pH 7.4, 37°C, MAO-B | Homo sapiens | |
0.00019 | - |
(E)-3-chlorocinnamic acid 2-oxo-2,3-dihydro-benzofuran-5-yl ester | pH 7.4, 37°C, MAO-B | Homo sapiens | |
0.00033 | - |
3-chloro-N-(2-methyl-1H-indol-5-yl)benzamide | pH 7.4, 37°C, MAO-B | Homo sapiens | |
0.00043 | - |
3-chlorobenzoic acid 2-oxo-2,3-dihydro-benzofuran-5-yl ester | pH 7.4, 37°C, MAO-B | Homo sapiens | |
0.00052 | - |
(E)-cinnamic acid 2-oxo-2,3-dihydro-benzofuran-5-yl ester | pH 7.4, 37°C, MAO-B | Homo sapiens | |
0.001 | - |
(E)-3-chlorocinnamic acid 2-oxo-2,3-dihydro-benzofuran-5-yl ester | pH 7.4, 37°C, MAO-A | Homo sapiens | |
0.00165 | - |
N-(2-methyl-1H-indol-5-yl)benzamide | pH 7.4, 37°C, MAO-B | Homo sapiens | |
0.002 | - |
(2E)-3-(3-chlorophenyl)-N-(2-methyl-1H-indol-5-yl)prop-2-enamide | pH 7.4, 37°C, MAO-A | Homo sapiens | |
0.002 | - |
3-chlorobenzoic acid 2-oxo-2,3-dihydro-benzofuran-5-yl ester | pH 7.4, 37°C, MAO-A | Homo sapiens | |
0.0026 | - |
3,4-dichloro-N-(2-methyl-1H-indol-5-yl)benzamide | pH 7.4, 37°C, MAO-A | Homo sapiens | |
0.003 | - |
N-(2-methyl-1H-indol-5-yl)cyclohexanecarboxamide | pH 7.4, 37°C, MAO-B | Homo sapiens | |
0.00305 | - |
benzoic acid 2-oxo-2,3-dihydro-benzofuran-5-yl ester | pH 7.4, 37°C, MAO-A | Homo sapiens | |
0.0033 | - |
(E)-cinnamic acid 2-oxo-2,3-dihydro-benzofuran-5-yl ester | pH 7.4, 37°C, MAO-A | Homo sapiens | |
0.00383 | - |
benzoic acid 2-oxo-2,3-dihydro-benzofuran-5-yl ester | pH 7.4, 37°C, MAO-B | Homo sapiens | |
0.00423 | - |
(2E)-3-(3-chlorophenyl)-N-(2-methyl-1H-indol-5-yl)prop-2-enamide | pH 7.4, 37°C, MAO-B | Homo sapiens | |
0.0055 | - |
1-methyl-N-(2-methyl-1H-indol-5-yl)-1lambda4-pyridine-3-carboxamide | pH 7.4, 37°C, MAO-A | Homo sapiens | |
0.00801 | - |
(2E)-N-(2-methyl-1H-indol-5-yl)-3-phenylprop-2-enamide | pH 7.4, 37°C, MAO-B | Homo sapiens | |
0.0082 | - |
3-chloro-N-(2-methyl-1H-indol-5-yl)benzamide | pH 7.4, 37°C, MAO-A | Homo sapiens | |
0.0183 | - |
N-(2-methyl-1H-indol-5-yl)cyclohexanecarboxamide | pH 7.4, 37°C, MAO-A | Homo sapiens | |
0.0395 | - |
N-(2-methyl-1H-indol-5-yl)benzamide | pH 7.4, 37°C, MAO-A | Homo sapiens | |
0.0399 | - |
1-methyl-N-(2-methyl-1H-indol-5-yl)-1lambda4-pyridine-3-carboxamide | pH 7.4, 37°C, MAO-B | Homo sapiens | |
0.0683 | - |
3-[(2-methyl-1H-indol-5-yl)carbamoyl]benzene-1-sulfonic acid | pH 7.4, 37°C, MAO-A | Homo sapiens | |
0.0757 | - |
3-[(2-methyl-1H-indol-5-yl)carbamoyl]benzene-1-sulfonic acid | pH 7.4, 37°C, MAO-B | Homo sapiens | |
0.175 | - |
(2E)-N-(2-methyl-1H-indol-5-yl)-3-phenylprop-2-enamide | pH 7.4, 37°C, MAO-A | Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.00006 | - |
pH 7.4, 37°C, MAO-B | Homo sapiens | 3,4-dichloro-N-(2-methyl-1H-indol-5-yl)benzamide | |
0.00044 | - |
pH 7.4, 37°C, MAO-B | Homo sapiens | (E)-3-chlorocinnamic acid 2-oxo-2,3-dihydro-benzofuran-5-yl ester | |
0.00076 | - |
pH 7.4, 37°C, MAO-B | Homo sapiens | 3-chloro-N-(2-methyl-1H-indol-5-yl)benzamide | |
0.00099 | - |
pH 7.4, 37°C, MAO-B | Homo sapiens | 3-chlorobenzoic acid 2-oxo-2,3-dihydro-benzofuran-5-yl ester | |
0.0012 | - |
pH 7.4, 37°C, MAO-B | Homo sapiens | (E)-cinnamic acid 2-oxo-2,3-dihydro-benzofuran-5-yl ester | |
0.00384 | - |
pH 7.4, 37°C, MAO-B | Homo sapiens | N-(2-methyl-1H-indol-5-yl)benzamide | |
0.0039 | - |
pH 7.4, 37°C, MAO-A | Homo sapiens | (E)-3-chlorocinnamic acid 2-oxo-2,3-dihydro-benzofuran-5-yl ester | |
0.00696 | - |
pH 7.4, 37°C, MAO-B | Homo sapiens | N-(2-methyl-1H-indol-5-yl)cyclohexanecarboxamide | |
0.0077 | - |
pH 7.4, 37°C, MAO-A | Homo sapiens | (2E)-3-(3-chlorophenyl)-N-(2-methyl-1H-indol-5-yl)prop-2-enamide | |
0.0077 | - |
pH 7.4, 37°C, MAO-A | Homo sapiens | 3-chlorobenzoic acid 2-oxo-2,3-dihydro-benzofuran-5-yl ester | |
0.00889 | - |
pH 7.4, 37°C, MAO-B | Homo sapiens | benzoic acid 2-oxo-2,3-dihydro-benzofuran-5-yl ester | |
0.0098 | - |
pH 7.4, 37°C, MAO-A | Homo sapiens | 3,4-dichloro-N-(2-methyl-1H-indol-5-yl)benzamide | |
0.00983 | - |
pH 7.4, 37°C, MAO-B | Homo sapiens | (2E)-3-(3-chlorophenyl)-N-(2-methyl-1H-indol-5-yl)prop-2-enamide | |
0.0116 | - |
pH 7.4, 37°C, MAO-A | Homo sapiens | benzoic acid 2-oxo-2,3-dihydro-benzofuran-5-yl ester | |
0.0125 | - |
pH 7.4, 37°C, MAO-A | Homo sapiens | (E)-cinnamic acid 2-oxo-2,3-dihydro-benzofuran-5-yl ester | |
0.01882 | - |
pH 7.4, 37°C, MAO-B | Homo sapiens | (2E)-N-(2-methyl-1H-indol-5-yl)-3-phenylprop-2-enamide | |
0.0208 | - |
pH 7.4, 37°C, MAO-A | Homo sapiens | 1-methyl-N-(2-methyl-1H-indol-5-yl)-1lambda4-pyridine-3-carboxamide | |
0.031 | - |
pH 7.4, 37°C, MAO-A | Homo sapiens | 3-chloro-N-(2-methyl-1H-indol-5-yl)benzamide | |
0.0694 | - |
pH 7.4, 37°C, MAO-A | Homo sapiens | N-(2-methyl-1H-indol-5-yl)cyclohexanecarboxamide | |
0.0926 | - |
pH 7.4, 37°C, MAO-B | Homo sapiens | 1-methyl-N-(2-methyl-1H-indol-5-yl)-1lambda4-pyridine-3-carboxamide | |
0.15 | - |
pH 7.4, 37°C, MAO-A | Homo sapiens | N-(2-methyl-1H-indol-5-yl)benzamide | |
0.1759 | - |
pH 7.4, 37°C, MAO-B | Homo sapiens | 3-[(2-methyl-1H-indol-5-yl)carbamoyl]benzene-1-sulfonic acid | |
0.259 | - |
pH 7.4, 37°C, MAO-A | Homo sapiens | 3-[(2-methyl-1H-indol-5-yl)carbamoyl]benzene-1-sulfonic acid | |
0.663 | - |
pH 7.4, 37°C, MAO-A | Homo sapiens | (2E)-N-(2-methyl-1H-indol-5-yl)-3-phenylprop-2-enamide |