Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.4.3.4 extracted from

  • Qazi, S.; Naz, A.; Hameed, A.; Osra, F.; Jalil, S.; Iqbal, J.; Shah, S.; Mirza, A.
    Semicarbazones, thiosemicarbazone, thiazole and oxazole analogues as monoamine oxidase inhibitors Synthesis, characterization, biological evaluation, molecular docking, and kinetic studies (2021), Bioorg. Chem., 115, 116165 .
    View publication on PubMed
Search for more literature for 1.4.3.4

Inhibitors

Inhibitors Comment Organism Structure
(2E)-2-[(1H-indol-3-yl)methylidene]hydrazine-1-carboxamide 0.1 mM, pH 7.4, 10% inhibition; 0.1 mM, pH 7.4, 43% inhibition Homo sapiens
(2E)-2-[(2-chloro-3-methoxyphenyl)methylidene]hydrazine-1-carboxamide 0.1 mM, pH 7.4, 17% inhibition Homo sapiens
(2E)-2-[(5-chloro-2-hydroxy-3-iodophenyl)methylidene]hydrazine-1-carbothioamide 0.1 mM, pH 7.4, 32% inhibition Homo sapiens
(2E)-2-[(5-chloro-2-hydroxy-3-iodophenyl)methylidene]hydrazine-1-carboxamide
-
 Homo sapiens
(2E)-2-[1-(2,4,5-trifluorophenyl)ethylidene]hydrazine-1-carboxamide 0.1 mM, pH 7.4, 23% inhibition Homo sapiens
(2E)-2-[1-(2,4-dihydroxy-5-nitrophenyl)ethylidene]hydrazine-1-carboxamide 0.1 mM, pH 7.4, 30% inhibition; 0.1 mM, pH 7.4, 8% inhibition Homo sapiens
(2E)-2-[1-(4-chloro-3-nitrophenyl)ethylidene]hydrazine-1-carboxamide 0.1 mM, pH 7.4, 13% inhibition; 0.3% inhibition Homo sapiens
(2E)-2-[1-(4-iodophenyl)ethylidene]hydrazine-1-carboxamide 0.1 mM, pH 7.4, 25% inhibition Homo sapiens
(2E)-2-[1-[3-(dihydroxyamino)-4-methoxyphenyl]ethylidene]hydrazine-1-carboxamide 0.1 mM, pH 7.4, 19% inhibition; 0.1 mM, pH 7.4, 37.2% inhibition Homo sapiens
2-hydrazinyl-4-(3-nitrophenyl)-1,3-thiazole 0.1 mM, pH 7.4, 10% inhibition; 0.1 mM, pH 7.4, 6% inhibition Homo sapiens
4-(2,4-dichlorophenyl)-2-hydrazinyl-1,3-thiazole 0.1 mM, pH 7.4, 25% inhibition; 0.1 mM, pH 7.4, 31% inhibition Homo sapiens
4-(2-bromophenyl)-2-hydrazinyl-1,3-thiazole 0.1 mM, pH 7.4, 24% inhibition Homo sapiens
4-(2-hydrazinyl-1,3-oxazol-4-yl)benzene-1,2-diol
-
 Homo sapiens
Clorgyline
-
 Homo sapiens
Deprenyl
-
 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion external membrane Homo sapiens 5739
-

Organism

Organism UniProt Comment Textmining
Homo sapiens P21397
-
-
Homo sapiens P27338
-
-

Synonyms

Synonyms Comment Organism
MAO-A
-
 Homo sapiens
MAO-B
-
 Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0000044
-
 pH 7.4, temperature not specified in the publication Homo sapiens Clorgyline
0.000019
-
 pH 7.4, temperature not specified in the publication Homo sapiens Deprenyl
0.000578
-
 pH 7.4, temperature not specified in the publication Homo sapiens 4-(2-hydrazinyl-1,3-oxazol-4-yl)benzene-1,2-diol
0.0035
-
 pH 7.4, temperature not specified in the publication Homo sapiens 4-(2-hydrazinyl-1,3-oxazol-4-yl)benzene-1,2-diol
0.0056
-
 pH 7.4, temperature not specified in the publication Homo sapiens (2E)-2-[(5-chloro-2-hydroxy-3-iodophenyl)methylidene]hydrazine-1-carboxamide
9.95
-
 pH 7.4, temperature not specified in the publication Homo sapiens (2E)-2-[(5-chloro-2-hydroxy-3-iodophenyl)methylidene]hydrazine-1-carbothioamide
17.7
-
 pH 7.4, temperature not specified in the publication Homo sapiens (2E)-2-[(5-chloro-2-hydroxy-3-iodophenyl)methylidene]hydrazine-1-carboxamide