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Literature summary for 1.4.3.4 extracted from
- Do monomeric vs dimeric forms of MAO-A make a difference? A direct comparison of the catalytic properties of rat and human MAO-As (2007), J. Neural Transm., 114, 721-724.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Clorgyline | addition of a 10fold molar excess of the acetylenic inhibitor clorgyline to rat MAO-A results in the formation of flavocyanine adduct | Rattus norvegicus |  |
| isatin | - |
Homo sapiens | |
| isatin | - |
Rattus norvegicus | |
| additional information | no inhibition: 1,4-diphenyl-2-butene and chlorostyrylcaffeine | Homo sapiens | |
| additional information | no inhibition: 1,4-diphenyl-2-butene and chlorostyrylcaffeine | Rattus norvegicus | |
| phentermine | - |
Homo sapiens | |
| phentermine | - |
Rattus norvegicus | |
| rasagiline | - |
Homo sapiens | |
| rasagiline | - |
Rattus norvegicus | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.09 | - |
kynuramine | - |
Homo sapiens | |
| 0.13 | - |
kynuramine | - |
Rattus norvegicus | |
| 0.21 | - |
benzylamine | - |
Homo sapiens | |
| 0.3 | - |
serotonin | - |
Homo sapiens | |
| 0.3 | - |
serotonin | - |
Rattus norvegicus | |
| 0.35 | - |
Phenylethylamine | - |
Homo sapiens | |
| 1.04 | - |
benzylamine | - |
Rattus norvegicus | |
| 1.48 | - |
Phenylethylamine | - |
Rattus norvegicus | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | P21397 | expressed in Pichia pastoris strain KM71 | - |
| Rattus norvegicus | P21396 | expressed in Pichia pastoris strain KM71 | - |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Homo sapiens |
- |
Rattus norvegicus |
Reaction
| Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|
| RCH2NHR' + H2O + O2 = RCHO + R'NH2 + H2O2 | catalysis occur via proton abstraction mechanisms | Homo sapiens | |
| RCH2NHR' + H2O + O2 = RCHO + R'NH2 + H2O2 | catalysis occur via proton abstraction mechanisms | Rattus norvegicus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| benzylamine + H2O + O2 | - |
Homo sapiens | benzaldehyde + NH3 + H2O2 | - |
? | |
| benzylamine + H2O + O2 | - |
Rattus norvegicus | benzaldehyde + NH3 + H2O2 | - |
? | |
| kynuramine + H2O + O2 | - |
Homo sapiens | 3-(2-aminophenyl)-3-oxopropanal + NH3 + H2O2 | - |
? | |
| kynuramine + H2O + O2 | - |
Rattus norvegicus | 3-(2-aminophenyl)-3-oxopropanal + NH3 + H2O2 | - |
? | |
| phenylethylamine + H2O + O2 | - |
Homo sapiens | 2-phenylethanal + NH3 + H2O2 | - |
? | |
| phenylethylamine + H2O + O2 | - |
Rattus norvegicus | 2-phenylethanal + NH3 + H2O2 | - |
? | |
| serotonin + H2O + O2 | - |
Homo sapiens | (5-hydroxy-1H-indol-3-yl)acetaldehyde + NH3 + H2O2 | - |
? | |
| serotonin + H2O + O2 | - |
Rattus norvegicus | (5-hydroxy-1H-indol-3-yl)acetaldehyde + NH3 + H2O2 | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| dimer | - |
Rattus norvegicus |
| monomer | - |
Homo sapiens |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| MAO-A | - |
Homo sapiens |
| MAO-A | - |
Rattus norvegicus |
Temperature Stability [°C]
| Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
|---|---|---|---|
- |
- |
stable for at least 120 min without losing activity | Homo sapiens |
- |
- |
stable for at least 120 min without losing activity | Rattus norvegicus |
| 25 | - |
120 min, MAO-A retains 40% of its activity | Homo sapiens |
| 25 | - |
120 min, MAO-A retains 90% of its activity | Rattus norvegicus |
| 30 | - |
120 min, MAO-A retains 20% of its activity | Homo sapiens |
| 30 | - |
120 min, MAO-A retains 80% of its activity | Rattus norvegicus |
Turnover Number [1/s]
| Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.042 | - |
benzylamine | - |
Rattus norvegicus | |
| 0.26 | - |
kynuramine | - |
Rattus norvegicus | |
| 0.325 | - |
benzylamine | - |
Homo sapiens | |
| 0.897 | - |
Phenylethylamine | - |
Rattus norvegicus | |
| 1.4 | - |
Phenylethylamine | - |
Homo sapiens | |
| 2.5 | - |
kynuramine | - |
Homo sapiens | |
| 2.9 | - |
serotonin | - |
Rattus norvegicus | |
| 6 | - |
serotonin | - |
Homo sapiens | |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| flavin | - |
Homo sapiens | |
| flavin | - |
Rattus norvegicus | |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.01 | - |
rasagiline | - |
Homo sapiens | |
| 0.0105 | - |
isatin | - |
Rattus norvegicus | |
| 0.015 | - |
isatin | - |
Homo sapiens | |
| 0.0256 | - |
rasagiline | - |
Rattus norvegicus | |
| 0.498 | - |
phentermine | - |
Homo sapiens | |
| 0.626 | - |
phentermine | - |
Rattus norvegicus | |
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