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Literature summary for 1.4.3.4 extracted from
- The pH dependence of kinetic isotope effects in monoamine oxidase A indicates stabilization of the neutral amine in the enzyme-substrate complex (2008), FEBS J., 275, 3850-3858.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| MAO A, expression in Pichia pastoris strain KM17H | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| D-amphetamine | competitive inhibition | Homo sapiens |  |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| additional information | - |
additional information | determination of substrate-dependent steady-state and stopped flow kinetics, pH dependence, overview | Homo sapiens | |
| 0.028 | - |
kynuramine | pH 9.0, 20°C, MAO A | Homo sapiens | |
| 0.041 | - |
kynuramine | pH 7.5, 20°C, MAO A | Homo sapiens | |
| 0.077 | - |
benzylamine | pH 8.5, 20°C, MAO A | Homo sapiens | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| mitochondrion | - |
Homo sapiens | 5739 | - |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | P21397 | - |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| recombinant MAO A from Pichia pastoris strain KM17H by anion exchange chromatography, ultrafiltration, and dialysis in presence of 20% glycerol and inhibitor D-amphetamine | Homo sapiens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| benzylamine + H2O + O2 | MAO-A | Homo sapiens | benzaldehyde + NH3 + H2O2 | - |
? | |
| kynuramine + H2O + O2 | MAO-A | Homo sapiens | 3-(2-aminophenyl)-3-oxopropanal + NH3 + H2O2 | - |
? | |
| phenylethylamine + H2O + O2 | MAO-A | Homo sapiens | 2-phenylethanal + NH3 + H2O2 | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| MAO A | - |
Homo sapiens |
| monoamine oxidase A | - |
Homo sapiens |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 20 | - |
assay at | Homo sapiens |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| additional information | - |
pH dependence of steady-state kinetics, overview | Homo sapiens |
pH Range
| pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|
| 6.5 | 9.5 | - |
Homo sapiens |
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Release 2023.1 (January 2023)
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