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Literature summary for 1.4.3.4 extracted from

  • Sampaio, T.B.; Da Rocha, J.T.; Prigol, M.; Saraiva, R.A.; Nogara, P.F.; Stein, A.L.; da Rocha, J.B.; Zeni, G.; Nogueira, C.W.
    4-Organoseleno-isoquinolines selectively and reversibly inhibit the cerebral monoamine oxidase B activity (2016), J. Mol. Neurosci., 59, 135-145 .
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
3-phenyl-4-(phenylseleno)isoquinoline reversibly inhibits isoform MAO-B activity Rattus norvegicus
3-phenyl-4-(phenylthio)isoquinoline
-
Rattus norvegicus
4-(4-fluorophenylseleno)-3-phenylisoquinoline
-
Rattus norvegicus
additional information 3-phenyl-4-(phenyltelluro) isoquinoline does not inhibit 50% of the isoform MAO-B activity up to concentration of 0.1 mM Rattus norvegicus
rasagiline specific MAO-B inhibitor Rattus norvegicus
selegiline specific MAO-B inhibitor Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
Rattus norvegicus 5739
-

Organism

Organism UniProt Comment Textmining
Rattus norvegicus P19643
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
kynuramine + O2
-
Rattus norvegicus 4-hydroxyquinoline + NH3 + H2O2
-
?

Synonyms

Synonyms Comment Organism
MAO-B isoform Rattus norvegicus
monoamine oxidase B
-
Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
FAD
-
Rattus norvegicus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.03645
-
isoform MAO-B, at pH 7.4 and 37°C Rattus norvegicus 3-phenyl-4-(phenylseleno)isoquinoline
0.07586
-
isoform MAO-B, at pH 7.4 and 37°C Rattus norvegicus 3-phenyl-4-(phenylthio)isoquinoline
0.08241
-
isoform MAO-B, at pH 7.4 and 37°C Rattus norvegicus 4-(4-fluorophenylseleno)-3-phenylisoquinoline