Application | Comment | Organism |
---|---|---|
medicine | the enzyme is a target for anti-depression drug design | Rattus norvegicus |
Crystallization (Comment) | Organism |
---|---|
hanging drop vapour diffusion method, crystal structure of the enzyme complexed with the specific inhibitor, clorgyline, at 3.2 A resolution | Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Clorgyline | MAOA-specific irreversible inhibitor, used clinically as antidepressant. It foms a covalent bond with FAD | Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrion | outer membrane, the enzyme has a transmembrane helix at the C-terminal region | Rattus norvegicus | 5739 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Rattus norvegicus | the enzyme catalyzes the degradation of neurotransmitters in the central nervous system and is the target for anti-depression drug design | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | P21396 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | the enzyme catalyzes the degradation of neurotransmitters in the central nervous system and is the target for anti-depression drug design | Rattus norvegicus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
MAOA | - |
Rattus norvegicus |
monoamine oxidase A | - |
Rattus norvegicus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
FAD | cofactor burried in the inside of the molecule, cofactor acts covalently with Cys406 | Rattus norvegicus |