6.1.1.3: threonine-tRNA ligase

This is an abbreviated version!
For detailed information about threonine-tRNA ligase, go to the full flat file.

Word Map on EC 6.1.1.3

6.1.1.3

synthetases

aminoacyl-trna

aminoacylation

threonylation

anticodon

aarss

borrelidin

phenylalanyl-trna

isoacceptors

misactivates

noncognate

alanyl-trna

mischarged

anticodon-binding

hisrs

anticodon-like

mistranslation

post-transfer

diagnostics

drug development

Reaction

Synonyms

ApThrRS-1, ApThrRS-2, BaThrRS, EcThrRS, ectRNAThr, McThrRS, mitochondrial threonyl-tRNA synthetase, MJ1197, MmThrRS, More, Mst1, ScmtThrRS, SfThrRS-1, SfThrRS-2, Synthetase, threonyl-transfer ribonucleate, TarS, Thr-tRNA synthetase, Threonine translase, Threonine--tRNA ligase, Threonine-transfer ribonucleate synthetase, threonyl tRNA synthetase, Threonyl-ribonucleic synthetase, Threonyl-transfer ribonucleate synthetase, Threonyl-transfer ribonucleic acid synthetase, Threonyl-transfer RNA synthetase, Threonyl-tRNA synthetase, ThrRS, ThrRS1, ThrS, TRS

ECTree

6 Ligases

6.1 Forming carbon-oxygen bonds

6.1.1 Ligases forming aminoacyl-tRNA and related compounds

6.1.1.3 threonine-tRNA ligase

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Results	in table
3	Activating Compound
55679	AA Sequence
2	Application
1	CAS Registry Number
35	Cloned(Commentary)
64	Cofactor
20	Crystallization (Commentary)
73	Disease/ Diagnostics
1	Expression
41	General Information
128	Inhibitors
11	kcat/KM [mM/s]
106	Ki Value [mM]
98	KM Value [mM]
24	Localization
61	Metals/Ions
20	Molecular Weight [Da]
78	Natural Substrates/ Products (Substrates)
246	Organism
4	Pathway
136	PDB ID
29	pH Optimum
1	Posttranslational Modification
102	Protein Variants
34	Purification (Commentary)
12	Reaction
27	Reaction Type
104	Reference
1	Renatured (Commentary)
23	Source Tissue
6	Specific Activity [micromol/min/mg]
4	Storage Stability
176	Substrates and Products (Substrate)
25	Subunits
259	Synonyms
1	Systematic Name
28	Temperature Optimum [°C]
2	Temperature Stability [°C]
75	Turnover Number [1/s]

Natural Substrates Products

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Natural Substrates Products on EC 6.1.1.3 - threonine-tRNA ligase

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ATP + L-isoleucine + tRNAIle

AMP + diphosphate + L-isoleucyl-tRNAIle

Oryctolagus cuniculus

the reaction catalyzed by the enzyme plays an important role in the transport of aminoacylated tRNAs from the nucleus to the cytoplasm

652046

ATP + L-serine + tRNASer

Saccharomyces cerevisiae

yeast mitochondrial threonyl-tRNA synthetase MST1 lacks an editing domain and utilizes pre-transfer editing to discriminate against serine. MST1 misactivates serine and edits seryl adenylate (Ser-AMP) in the absence of the cognate tRNA. MST1 hydrolyzes 80% of misactivated Ser-AMP at a rate 4fold higher than that for the cognate threonyl adenylate (Thr-AMP) while releasing 20% of Ser-AMP into the solution.

727916

ATP + L-serine + tRNAThr

AMP + diphosphate + L-seryl-tRNAThr

3 entries

ATP + L-threonine + tRNA1Thr

AMP + diphosphate + L-threonyl-tRNA1Thr

Saccharomyces cerevisiae

728681

ATP + L-threonine + tRNA2Thr

AMP + diphosphate + L-threonyl-tRNA2Thr

Saccharomyces cerevisiae

728681

ATP + L-threonine + tRNAThr

Thermus thermophilus

catalyzes the attachment of threonine onto its cognate tRNA molecule, prior to participation of the aminoacylated tRNA in the protein synthesis

398

ATP + L-threonine + tRNAThr

AMP + diphosphate + L-threonyl-tRNAThr

43 entries

ATP + L-threonine + tRNAThr1

AMP + diphosphate + L-threonyl-tRNAThr1

2 entries

ATP + L-threonine + tRNAThr2

AMP + diphosphate + L-threonyl-tRNAThr2

2 entries

additional information

14 entries