6.1.1.3: threonine-tRNA ligase

This is an abbreviated version!
For detailed information about threonine-tRNA ligase, go to the full flat file.

Word Map on EC 6.1.1.3

6.1.1.3

synthetases

aminoacyl-trna

aminoacylation

threonylation

anticodon

aarss

borrelidin

phenylalanyl-trna

isoacceptors

misactivates

noncognate

alanyl-trna

mischarged

anticodon-binding

hisrs

anticodon-like

mistranslation

post-transfer

diagnostics

drug development

Reaction

Synonyms

ApThrRS-1, ApThrRS-2, BaThrRS, EcThrRS, ectRNAThr, McThrRS, mitochondrial threonyl-tRNA synthetase, MJ1197, MmThrRS, More, Mst1, ScmtThrRS, SfThrRS-1, SfThrRS-2, Synthetase, threonyl-transfer ribonucleate, TarS, Thr-tRNA synthetase, Threonine translase, Threonine--tRNA ligase, Threonine-transfer ribonucleate synthetase, threonyl tRNA synthetase, Threonyl-ribonucleic synthetase, Threonyl-transfer ribonucleate synthetase, Threonyl-transfer ribonucleic acid synthetase, Threonyl-transfer RNA synthetase, Threonyl-tRNA synthetase, ThrRS, ThrRS1, ThrS, TRS

ECTree

6 Ligases

6.1 Forming carbon-oxygen bonds

6.1.1 Ligases forming aminoacyl-tRNA and related compounds

6.1.1.3 threonine-tRNA ligase

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Results	in table
3	Activating Compound
55679	AA Sequence
2	Application
1	CAS Registry Number
35	Cloned(Commentary)
64	Cofactor
20	Crystallization (Commentary)
73	Disease/ Diagnostics
1	Expression
41	General Information
128	Inhibitors
11	kcat/KM [mM/s]
106	Ki Value [mM]
98	KM Value [mM]
24	Localization
61	Metals/Ions
20	Molecular Weight [Da]
78	Natural Substrates/ Products (Substrates)
246	Organism
4	Pathway
136	PDB ID
29	pH Optimum
1	Posttranslational Modification
102	Protein Variants
34	Purification (Commentary)
12	Reaction
27	Reaction Type
104	Reference
1	Renatured (Commentary)
23	Source Tissue
6	Specific Activity [micromol/min/mg]
4	Storage Stability
176	Substrates and Products (Substrate)
25	Subunits
259	Synonyms
1	Systematic Name
28	Temperature Optimum [°C]
2	Temperature Stability [°C]
75	Turnover Number [1/s]

Disease

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Disease on EC 6.1.1.3 - threonine-tRNA ligase

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Arthritis

Dermatomyositis with erosive arthropathy: association with the anti-PL-7 antibody.

10606385

Brucellosis, Bovine

Exploring the Molecular Basis for Binding of Inhibitors by Threonyl-tRNA Synthetase from Brucella abortus: A Virtual Screening Study.

27447614

Dermatomyositis

Dermatomyositis with erosive arthropathy: association with the anti-PL-7 antibody.

10606385

Histidyl-tRNA synthetase and asparaginyl-tRNA synthetase, autoantigens in myositis, activate chemokine receptors on T lymphocytes and immature dendritic cells.

12235211

Polydermatomyositis with anti-PL7 antibody: clinical and laboratory follow-up over a five year period.

2591129

Glioma

miR-720 is a key regulator of glioma migration and invasion by controlling TARSL2 expression.

34024034

Infections

Discovery of novel tRNA-amino acid dual-site inhibitors against threonyl-tRNA synthetase by fragment-based target hopping.

31821989

Joint Diseases

Dermatomyositis with erosive arthropathy: association with the anti-PL-7 antibody.

10606385

Leishmaniasis, Visceral

Genetic manipulation of Leishmania donovani threonyl tRNA synthetase facilitates its exploration as a potential therapeutic target.

29897900

Mitochondrial Diseases

A Human Disease-causing Point Mutation in Mitochondrial Threonyl-tRNA Synthetase Induces Both Structural and Functional Defects.

26811336

Mitochondrial Encephalomyopathies

A Human Disease-causing Point Mutation in Mitochondrial Threonyl-tRNA Synthetase Induces Both Structural and Functional Defects.

26811336

Myositis

Antibody to threonyl-transfer RNA synthetase in myositis sera.

3128989

Myositis autoantibody reactivity and catalytic function of threonyl-tRNA synthetase.

2452112

RENAL, HEPATIC AND IMMUNE FUNCTION INDICES IN PATIENTS WITH DUCHENNE MUSCULAR DYSTROPHY.

33526732

Secreted Threonyl-tRNA synthetase stimulates endothelial cell migration and angiogenesis.

23425968

Neoplasms

Assessing the effects of threonyl-tRNA synthetase on angiogenesis-related responses.

27847344

Contribution of upregulated aminoacyl-tRNA biosynthesis to metabolic dysregulation in gastric cancer.

34159625

Discovery of novel tRNA-amino acid dual-site inhibitors against threonyl-tRNA synthetase by fragment-based target hopping.

31821989

Ovarian Neoplasms

Threonyl-tRNA synthetase overexpression correlates with angiogenic markers and progression of human ovarian cancer.

25163878

Pancreatic Neoplasms

Inhibition of MUC1 biosynthesis via threonyl-tRNA synthetase suppresses pancreatic cancer cell migration.

29328069

Polymyositis

Histidyl-tRNA synthetase and asparaginyl-tRNA synthetase, autoantigens in myositis, activate chemokine receptors on T lymphocytes and immature dendritic cells.

12235211

Myositis autoantibody reactivity and catalytic function of threonyl-tRNA synthetase.

2452112

Onset of polymyositis with autoantibodies to threonyl-tRNA synthetase during pregnancy.

7983666

Precursor Cell Lymphoblastic Leukemia-Lymphoma

Borrelidin, a small molecule nitrile-containing macrolide inhibitor of threonyl-tRNA synthetase, is a potent inducer of apoptosis in acute lymphoblastic leukemia.

21678129

Starvation

Aminoacyl-tRNA synthetase gene regulation in Bacillus subtilis: induction, repression and growth-rate regulation.

7476165

Processing of the leader mRNA plays a major role in the induction of thrS expression following threonine starvation in Bacillus subtilis.

8692931

Transfer RNA-mediated antitermination in vitro.

12136084