6.1.1.15: proline-tRNA ligase

This is an abbreviated version!
For detailed information about proline-tRNA ligase, go to the full flat file.

Reaction

Synonyms

bifunctional aminoacyl-tRNA synthetase, bifunctional glutamate/proline-tRNA ligase, class II prolyl-tRNA synthetase, class II ProRS, dual-specificity prolyl-cysteinyl-tRNA synthetase, dual-specificity prolyl-tRNA synthetase, EPRS, Global RNA synthesis factor, GluProRS, glutamyl-/prolyl-tRNA synthetase, glutamyl-prolyl tRNA synthetase, glutamyl-prolyl-tRNA synthetase, More, MSMEG_2621, Pro-tRNA synthetase, ProCysRS, Proline translase, Proline--tRNA ligase, proline/cysteine-tRNA ligase, Prolyl RNA synthetase, prolyl tRNA synthetase, prolyl-cysteinyl-tRNA synthetase, Prolyl-transfer ribonucleate synthetase, Prolyl-transfer ribonucleic acid synthetase, Prolyl-transfer RNA synthetase, Prolyl-tRNA synthetase, ProRS, ProRS-Cyt, ProRS-Org, ProRSTT, proS, PRS

ECTree

     6 Ligases

         6.1 Forming carbon-oxygen bonds

             6.1.1 Ligases forming aminoacyl-tRNA and related compounds

                6.1.1.15 proline-tRNA ligase

Advanced search results

Do not include text mining results

Include results (more...)

Include results (more...)

Results	in table
2	Activating Compound
53727	AA Sequence
3	Application
1	CAS Registry Number
33	Cloned(Commentary)
67	Cofactor
14	Crystallization (Commentary)
63	Disease/ Diagnostics
7	Expression
19	General Information
28	General Stability
35	IC50 Value
171	Inhibitors
27	kcat/KM [mM/s]
4	Ki Value [mM]
131	KM Value [mM]
17	Localization
29	Metals/Ions
11	Molecular Weight [Da]
88	Natural Substrates/ Products (Substrates)
232	Organism
4	Pathway
144	PDB ID
43	pH Optimum
2	pH Range
1	pH Stability
6	Posttranslational Modification
83	Protein Variants
47	Purification (Commentary)
13	Reaction
66	Reaction Type
133	Reference
30	Source Tissue
15	Specific Activity [micromol/min/mg]
3	Storage Stability
294	Substrates and Products (Substrate)
21	Subunits
450	Synonyms
1	Systematic Name
36	Temperature Optimum [°C]
1	Temperature Range [°C]
37	Temperature Stability [°C]
83	Turnover Number [1/s]

IC50 Value

print visible entries

print all entries

Go back to the abbreviated version
of the Enzyme Summary Page.

IC50 Value on EC 6.1.1.15 - proline-tRNA ligase

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.

top print hide show all columns Go to IC50 Value Search

Please wait a moment until the data is sorted. This message will disappear when the data is sorted.

IC50 VALUE [mM]

INHIBITOR

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

0.05

2-[4-(4-fluorophenyl)-5-[[(4-fluorophenyl)carbamoyl]amino]-3-(trifluoromethyl)-1H-pyrazol-1-yl]acetamide

Plasmodium falciparum

Q8I5R7

IC50 above 0.05 mM, at pH 7.0 and 37°C

743927

0.11

3-(3,3-dimethylbutanamido)-N-[(naphthalen-1-yl)methyl]pyrazine-2-carboxamide

Homo sapiens

P07814

at pH 7.5 and 25°C

744245

0.012

3-[(cyclohexanecarbonyl)amino]-N-(2,3-dihydro-1H-inden-2-yl)pyrazine-2-carboxamide

Homo sapiens

P07814

at pH 7.5 and 25°C

744245

0.008

3-[4-(4-fluorophenyl)-5-[[(4-fluorophenyl)carbamoyl]amino]-1-methyl-1H-pyrazol-3-yl]propanamide

Plasmodium falciparum

Q8I5R7

at pH 7.0 and 37°C

743927

0.05

4-(4-fluorophenyl)-1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-amine

Plasmodium falciparum

Q8I5R7

IC50 above 0.05 mM, at pH 7.0 and 37°C

743927

0.014

4-(4-fluorophenyl)-5-[[(4-fluorophenyl)carbamoyl]amino]-1-methyl-1H-pyrazole-3-carboxamide

Plasmodium falciparum

Q8I5R7

at pH 7.0 and 37°C

743927

0.000013

6-fluoro-febrifugine

Plasmodium falciparum

Q8I5R7

at pH 7.4 and 37°C

746514

0.1

azetidine-2-carboxylic acid

Arabidopsis thaliana

-

isozyme ProRS-Org, at pH 7.2 and 30°C

746082

0.000024

febrifugine

Plasmodium falciparum

Q8I5R7

at pH 7.4 and 37°C

746514

0.000009

halofuginone

Plasmodium falciparum

Q8I5R7

at pH 7.4 and 37°C

746514

0.0025

N-(2,4-difluorophenyl)-N'-[4-(4-fluorophenyl)-1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl]urea

Plasmodium falciparum

Q8I5R7

at pH 7.0 and 37°C

743927

0.008

N-(3-fluorophenyl)-N'-[4-(4-fluorophenyl)-1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl]urea

Plasmodium falciparum

Q8I5R7

at pH 7.0 and 37°C

743927

0.05

N-(4-fluorophenyl)-N'-[1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl]urea

Plasmodium falciparum

Q8I5R7

IC50 above 0.05 mM, at pH 7.0 and 37°C

743927

0.05

N-(4-fluorophenyl)-N'-[1-methyl-3-(trifluoromethyl)-4-[3-(trifluoromethyl)phenyl]-1H-pyrazol-5-yl]urea

Plasmodium falciparum

Q8I5R7

IC50 above 0.05 mM, at pH 7.0 and 37°C

743927

0.05

N-(4-fluorophenyl)-N'-[4-(4-fluorophenyl)-1-(2-hydroxyethyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl]urea

Plasmodium falciparum

Q8I5R7

IC50 above 0.05 mM, at pH 7.0 and 37°C

743927

0.05

N-(4-fluorophenyl)-N'-[4-(4-fluorophenyl)-1-methyl-1H-pyrazol-5-yl]urea

Plasmodium falciparum

Q8I5R7

IC50 above 0.05 mM, at pH 7.0 and 37°C

743927

0.005

N-(4-fluorophenyl)-N'-[4-(4-fluorophenyl)-1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl]urea

Plasmodium falciparum

Q8I5R7

at pH 7.0 and 37°C

743927

0.003

N-(4-fluorophenyl)-N'-[4-(4-fluorophenyl)-1-methyl-3-[2-(morpholin-4-yl)ethyl]-1H-pyrazol-5-yl]urea

Plasmodium falciparum

Q8I5R7

at pH 7.0 and 37°C

743927

0.018

N-(4-fluorophenyl)-N'-[4-(4-fluorophenyl)-3-(2-hydroxyethyl)-1-methyl-1H-pyrazol-5-yl]urea

Plasmodium falciparum

Q8I5R7

at pH 7.0 and 37°C

743927

0.05

N-(4-fluorophenyl)-N'-[4-(4-fluorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl]urea

Plasmodium falciparum

Q8I5R7

IC50 above 0.05 mM, at pH 7.0 and 37°C

743927

0.05

N-(4-fluorophenyl)-N'-[4-[2-(2-hydroxyethyl)phenyl]-1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl]urea

Plasmodium falciparum

Q8I5R7

IC50 above 0.05 mM, at pH 7.0 and 37°C

743927

0.02

N-(4-fluorophenyl)-N'-[4-[2-(hydroxymethyl)phenyl]-1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl]urea

Plasmodium falciparum

Q8I5R7

at pH 7.0 and 37°C

743927

0.013

N-(4-fluorophenyl)-N'-[4-[3-(2-hydroxyethyl)phenyl]-1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl]urea

Plasmodium falciparum

Q8I5R7

at pH 7.0 and 37°C

743927

0.05

N-([3-[5-[[(4-fluorophenyl)carbamoyl]amino]-1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]phenyl]methyl)methanesulfonamide

Plasmodium falciparum

Q8I5R7

IC50 above 0.05 mM, at pH 7.0 and 37°C

743927

0.25

N-[(4-chlorophenyl)methyl]-3-[(cyclohexanecarbonyl)amino]pyrazine-2-carboxamide

Homo sapiens

P07814

at pH 7.5 and 25°C

744245

0.009

N-[3-(2-cyanoethyl)-4-(4-fluorophenyl)-1-methyl-1H-pyrazol-5-yl]-N'-(4-fluorophenyl)urea

Plasmodium falciparum

Q8I5R7

at pH 7.0 and 37°C

743927

0.006

N-[3-(cyanomethyl)-4-(4-fluorophenyl)-1-methyl-1H-pyrazol-5-yl]-N'-(4-fluorophenyl)urea

Plasmodium falciparum

Q8I5R7

at pH 7.0 and 37°C

743927

0.005

N-[3-cyano-4-(4-fluorophenyl)-1-methyl-1H-pyrazol-5-yl]-N'-(4-fluorophenyl)urea

Plasmodium falciparum

Q8I5R7

at pH 7.0 and 37°C

743927

0.004

N-[3-[2-(dimethylamino)ethyl]-4-(4-fluorophenyl)-1-methyl-1H-pyrazol-5-yl]-N'-(4-fluorophenyl)urea

Plasmodium falciparum

Q8I5R7

at pH 7.0 and 37°C

743927

0.05

N-[4-(3,4-difluorophenyl)-1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl]-N'-(4-fluorophenyl)urea

Plasmodium falciparum

Q8I5R7

IC50 above 0.05 mM, at pH 7.0 and 37°C

743927

0.05

N-[4-(4-fluorophenyl)-1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl]-N'-(4-methoxyphenyl)urea

Plasmodium falciparum

Q8I5R7

IC50 above 0.05 mM, at pH 7.0 and 37°C

743927

0.05

N-[4-(4-fluorophenyl)-1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl]-N'-[2-(morpholin-4-yl)pyridin-4-yl]urea

Plasmodium falciparum

Q8I5R7

IC50 above 0.05 mM, at pH 7.0 and 37°C

743927

0.05

N-[4-bromo-1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl]-N'-(4-fluorophenyl)urea

Plasmodium falciparum

Q8I5R7

IC50 above 0.05 mM, at pH 7.0 and 37°C

743927

0.005

TCMDC-124506

Plasmodium falciparum

Q8I5R7

at pH 7.0 and 37°C

743927

0.000352

tetrahydrofebrifugine

Plasmodium falciparum

Q8I5R7

at pH 7.4 and 37°C

746514