6.1.1.15: proline-tRNA ligase

This is an abbreviated version!
For detailed information about proline-tRNA ligase, go to the full flat file.

Word Map on EC 6.1.1.15

6.1.1.15

synthetases

aminoacylation

halofuginone

ala-trnapro

anticodons

mischarged

aarss

misactivated

multisynthetase

misacylated

trans-editing

cys-trnapro

trnacys

thrrs

mistranslation

thermautotrophicus

multi-trna

glnrs

leucyl-trna

lysyl-trna

leurs

asprs

febrifugine

post-transfer

transcript-selective

drug development

pharmacology

Reaction

Synonyms

bifunctional aminoacyl-tRNA synthetase, bifunctional glutamate/proline-tRNA ligase, class II prolyl-tRNA synthetase, class II ProRS, dual-specificity prolyl-cysteinyl-tRNA synthetase, dual-specificity prolyl-tRNA synthetase, EPRS, Global RNA synthesis factor, GluProRS, glutamyl-/prolyl-tRNA synthetase, glutamyl-prolyl tRNA synthetase, glutamyl-prolyl-tRNA synthetase, More, MSMEG_2621, Pro-tRNA synthetase, ProCysRS, Proline translase, Proline--tRNA ligase, proline/cysteine-tRNA ligase, Prolyl RNA synthetase, prolyl tRNA synthetase, prolyl-cysteinyl-tRNA synthetase, Prolyl-transfer ribonucleate synthetase, Prolyl-transfer ribonucleic acid synthetase, Prolyl-transfer RNA synthetase, Prolyl-tRNA synthetase, ProRS, ProRS-Cyt, ProRS-Org, ProRSTT, proS, PRS

ECTree

6 Ligases

6.1 Forming carbon-oxygen bonds

6.1.1 Ligases forming aminoacyl-tRNA and related compounds

6.1.1.15 proline-tRNA ligase

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Results	in table
2	Activating Compound
53727	AA Sequence
3	Application
1	CAS Registry Number
33	Cloned(Commentary)
67	Cofactor
14	Crystallization (Commentary)
63	Disease/ Diagnostics
7	Expression
19	General Information
28	General Stability
35	IC50 Value
171	Inhibitors
27	kcat/KM [mM/s]
4	Ki Value [mM]
131	KM Value [mM]
17	Localization
29	Metals/Ions
11	Molecular Weight [Da]
88	Natural Substrates/ Products (Substrates)
232	Organism
4	Pathway
144	PDB ID
43	pH Optimum
2	pH Range
1	pH Stability
6	Posttranslational Modification
83	Protein Variants
47	Purification (Commentary)
13	Reaction
66	Reaction Type
133	Reference
30	Source Tissue
15	Specific Activity [micromol/min/mg]
3	Storage Stability
294	Substrates and Products (Substrate)
21	Subunits
450	Synonyms
1	Systematic Name
36	Temperature Optimum [°C]
1	Temperature Range [°C]
37	Temperature Stability [°C]
83	Turnover Number [1/s]

Expression

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Expression on EC 6.1.1.15 - proline-tRNA ligase

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both enzyme mRNA and protein are slightly upregulated following viral infection

2 entries

requirement for sensing by the immune system in the induction of EPRS expression during infection with an RNA virus

Homo sapiens

P07814

745867

requirement for sensing by the immune system in the induction of EPRS expression during infection with an RNA virus, VSV Indiana strain

2 entries

the translation of the glutamyl-prolyl-tRNA synthetase gene EPRS is enhanced in response to phosphorylated eukaryotic initiation factor 2, eIF2alpha-P, mechanism of translation control involving increased translation initiation stringency during stress-induced eIF2alpha-P, facilitated ribosome bypass of upstream ORFs, allowing for increased translation of the EPRS coding region, overview. Both halofuginone and thapsigargin treatment result in a 2.5fold induction of EPRS expression

Mus musculus

745339

UUG1 and CUG2 are overall repressing elements in EPRS translation control

Mus musculus

745339