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6.1.1.15: proline-tRNA ligase

This is an abbreviated version!
For detailed information about proline-tRNA ligase, go to the full flat file.

Word Map on EC 6.1.1.15

Reaction

ATP
+
L-proline
 +
tRNAPro
=
AMP
 +
diphosphate
 +
L-prolyl-tRNAPro

Synonyms

bifunctional aminoacyl-tRNA synthetase, bifunctional glutamate/proline-tRNA ligase, class II prolyl-tRNA synthetase, class II ProRS, dual-specificity prolyl-cysteinyl-tRNA synthetase, dual-specificity prolyl-tRNA synthetase, EPRS, Global RNA synthesis factor, GluProRS, glutamyl-/prolyl-tRNA synthetase, glutamyl-prolyl tRNA synthetase, glutamyl-prolyl-tRNA synthetase, More, MSMEG_2621, Pro-tRNA synthetase, ProCysRS, Proline translase, Proline--tRNA ligase, proline/cysteine-tRNA ligase, Prolyl RNA synthetase, prolyl tRNA synthetase, prolyl-cysteinyl-tRNA synthetase, Prolyl-transfer ribonucleate synthetase, Prolyl-transfer ribonucleic acid synthetase, Prolyl-transfer RNA synthetase, Prolyl-tRNA synthetase, ProRS, ProRS-Cyt, ProRS-Org, ProRSTT, proS, PRS

ECTree

     6 Ligases
         6.1 Forming carbon-oxygen bonds
             6.1.1 Ligases forming aminoacyl-tRNA and related compounds
                6.1.1.15 proline-tRNA ligase

Disease

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Disease on EC 6.1.1.15 - proline-tRNA ligase

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Aneurysm
Validation of the Simbionix PROcedure Rehearsal Studio sizing module: A comparison of software for endovascular aneurysm repair sizing and planning.
Carcinogenesis
EPRS is a critical regulator of cell proliferation and estrogen signaling in ER+ breast cancer.
Coccidiosis
Targeting Prolyl-tRNA Synthetase to Accelerate Drug Discovery against Malaria, Leishmaniasis, Toxoplasmosis, Cryptosporidiosis, and Coccidiosis.
Coinfection
A potent prolyl tRNA synthetase inhibitor antagonizes Chikungunya and Dengue viruses.
COVID-19
The Prolyl-tRNA Synthetase Inhibitor Halofuginone Inhibits SARS-CoV-2 Infection.
Cryptosporidiosis
Targeting Prolyl-tRNA Synthetase to Accelerate Drug Discovery against Malaria, Leishmaniasis, Toxoplasmosis, Cryptosporidiosis, and Coccidiosis.
Dengue
A potent prolyl tRNA synthetase inhibitor antagonizes Chikungunya and Dengue viruses.
Diffuse Cerebral Sclerosis of Schilder
The genotypic and phenotypic spectrum of PARS2-related infantile-onset encephalopathy.
Whole exome sequencing reveals mutations in NARS2 and PARS2, encoding the mitochondrial asparaginyl-tRNA synthetase and prolyl-tRNA synthetase, in patients with Alpers syndrome.
Gastroenteritis
Identification of a gamma interferon-activated inhibitor of translation-like RNA motif at the 3' end of the transmissible gastroenteritis coronavirus genome modulating innate immune response.
Idiopathic Pulmonary Fibrosis
Glutamyl-Prolyl-tRNA Synthetase Regulates Epithelial Expression of Mesenchymal Markers and Extracellular Matrix Proteins: Implications for Idiopathic Pulmonary Fibrosis.
Intestinal Volvulus
Genomic analyses of aminoacyl tRNA synthetases from human-infecting helminths.
Leishmaniasis
Targeting Prolyl-tRNA Synthetase to Accelerate Drug Discovery against Malaria, Leishmaniasis, Toxoplasmosis, Cryptosporidiosis, and Coccidiosis.
Malaria
Biochemical and Structural Characterization of Selective Allosteric Inhibitors of the Plasmodium falciparum Drug Target, Prolyl-tRNA-synthetase.
Halofuginone - the multifaceted molecule.
Structural and functional analysis of the anti-malarial drug target prolyl-tRNA synthetase.
Targeting Prolyl-tRNA Synthetase to Accelerate Drug Discovery against Malaria, Leishmaniasis, Toxoplasmosis, Cryptosporidiosis, and Coccidiosis.
The cytoplasmic prolyl-tRNA synthetase of the malaria parasite is a dual-stage target of febrifugine and its analogs.
Neoplasms
EPRS is a critical regulator of cell proliferation and estrogen signaling in ER+ breast cancer.
EPRS/GluRS promotes gastric cancer development via WNT/GSK-3?/?-catenin signaling pathway.
Specific protein carbonylation in human breast cancer tissue compared to adjacent healthy epithelial tissue.
The tumor antigen repertoire identified in tumor-bearing neu transgenic mice predicts human tumor antigens.
Neurodegenerative Diseases
The genotypic and phenotypic spectrum of PARS2-related infantile-onset encephalopathy.
Starvation
Halofuginone - the multifaceted molecule.
Halofuginone-induced amino acid starvation regulates Stat3-dependent Th17 effector function and reduces established autoimmune inflammation.
Toxoplasmosis
Targeting Prolyl-tRNA Synthetase to Accelerate Drug Discovery against Malaria, Leishmaniasis, Toxoplasmosis, Cryptosporidiosis, and Coccidiosis.
Virus Diseases
Infection-specific phosphorylation of glutamyl-prolyl tRNA synthetase induces antiviral immunity.