6.1.1.15: proline-tRNA ligase

This is an abbreviated version!
For detailed information about proline-tRNA ligase, go to the full flat file.

Reaction

Synonyms

bifunctional aminoacyl-tRNA synthetase, bifunctional glutamate/proline-tRNA ligase, class II prolyl-tRNA synthetase, class II ProRS, dual-specificity prolyl-cysteinyl-tRNA synthetase, dual-specificity prolyl-tRNA synthetase, EPRS, Global RNA synthesis factor, GluProRS, glutamyl-/prolyl-tRNA synthetase, glutamyl-prolyl tRNA synthetase, glutamyl-prolyl-tRNA synthetase, More, MSMEG_2621, Pro-tRNA synthetase, ProCysRS, Proline translase, Proline--tRNA ligase, proline/cysteine-tRNA ligase, Prolyl RNA synthetase, prolyl tRNA synthetase, prolyl-cysteinyl-tRNA synthetase, Prolyl-transfer ribonucleate synthetase, Prolyl-transfer ribonucleic acid synthetase, Prolyl-transfer RNA synthetase, Prolyl-tRNA synthetase, ProRS, ProRS-Cyt, ProRS-Org, ProRSTT, proS, PRS

ECTree

     6 Ligases

         6.1 Forming carbon-oxygen bonds

             6.1.1 Ligases forming aminoacyl-tRNA and related compounds

                6.1.1.15 proline-tRNA ligase

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Results	in table
2	Activating Compound
53727	AA Sequence
3	Application
1	CAS Registry Number
33	Cloned(Commentary)
67	Cofactor
14	Crystallization (Commentary)
63	Disease/ Diagnostics
7	Expression
19	General Information
28	General Stability
35	IC50 Value
171	Inhibitors
27	kcat/KM [mM/s]
4	Ki Value [mM]
131	KM Value [mM]
17	Localization
29	Metals/Ions
11	Molecular Weight [Da]
88	Natural Substrates/ Products (Substrates)
232	Organism
4	Pathway
144	PDB ID
43	pH Optimum
2	pH Range
1	pH Stability
6	Posttranslational Modification
83	Protein Variants
47	Purification (Commentary)
13	Reaction
66	Reaction Type
133	Reference
30	Source Tissue
15	Specific Activity [micromol/min/mg]
3	Storage Stability
294	Substrates and Products (Substrate)
21	Subunits
450	Synonyms
1	Systematic Name
36	Temperature Optimum [°C]
1	Temperature Range [°C]
37	Temperature Stability [°C]
83	Turnover Number [1/s]

Posttranslational Modification

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Posttranslational Modification on EC 6.1.1.15 - proline-tRNA ligase

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POSTTRANSLATIONAL MODIFICATION

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

phosphoprotein

6 entries

phosphoprotein

Homo sapiens

-

glutamyl-prolyl-tRNA synthetase is phosphorylated in response to interferon-gamma

661440

phosphoprotein

Homo sapiens

P07814

infection-specific phosphorylation of EPRS at a Ser induces its dissociation from the MSC, after which it is guided to the antiviral signaling pathway, where it interacts with PCBP2, a negative regulator of mitochondrial antiviral signaling protein (MAVS) that is critical for antiviral immunity

745867

phosphoprotein

Mus musculus

Q8CGC7

-

745867

phosphoprotein

Mus musculus

Q8CGC7

infection-specific phosphorylation of EPRS at Ser990 induces its dissociation from the MSC, after which it is guided to the antiviral signaling pathway, where it interacts with PCBP2, a negative regulator of mitochondrial antiviral signaling protein (MAVS) that is critical for antiviral immunity

745867

phosphoprotein

Mus musculus C57BL/6

-

-

-

phosphoprotein

Mus musculus C57BL/6

-

infection-specific phosphorylation of EPRS at Ser990 induces its dissociation from the MSC, after which it is guided to the antiviral signaling pathway, where it interacts with PCBP2, a negative regulator of mitochondrial antiviral signaling protein (MAVS) that is critical for antiviral immunity

-