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Reference on EC 6.1.1.15 - proline-tRNA ligase

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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Ogata, K.; Kurahashi, A.; Tanaka, S.; Ohsue, H.; Terao, K.
Occurence of 5SrRNA in high molecular weight complexes of aminoacyl-tRNA synthetases in a rat liver supernatant
J. Biochem.
110
1030-1036
1991
Rattus norvegicus
Manually annotated by BRENDA team
Walker, E.J.; Treacy, G.B.; Jeffrey, P.D.
Molecular weights of mitochondrial and cytoplasmic aminoacyl-tRNA synthetases of beef liver and their complexes
Biochemistry
22
1934-1941
1983
Bos taurus
Manually annotated by BRENDA team
Norcum, M.T.
Isolation and electron microscopic characterization of the high molecular mass aminoacyl-tRNA synthetase complex from murine erythroleukemia cells
J. Biol. Chem.
264
15043-15051
1989
Mus musculus
Manually annotated by BRENDA team
Heacock, D.; Forsyth, C.J.; Shiba, K.; Musier-Forsyth, K.
Synthesis and aminoacyl-tRNA synthetase inhibitory activity of prolyl adenylate analogs
Bioorg. Chem.
24
273-289
1996
Escherichia coli
-
Manually annotated by BRENDA team
Kerjan, P.; Triconnet, M.; Waller, J.P.
Mammalian prolyl-tRNA synthetase corresponds to the approximately 150 kDa subunit of the high-Mr aminoacyl-tRNA synthetase complex
Biochimie
74
195-205
1992
Homo sapiens, Mammalia, Ovis aries
Manually annotated by BRENDA team
Ting, S.M.; Bogner, P.; Dignam, J.D.
Isolation of prolyl-tRNA synthetase as a free form and as a form associated with glutamyl-tRNA synthetase
J. Biol. Chem.
267
17701-17709
1992
Rattus norvegicus
Manually annotated by BRENDA team
Stehlin, C.; Heacock, D.H.; Liu, H.; Musier-Forsyth, K.
Chemical modification and site-directed mutagenesis of the single cysteine in motif 3 of class II Escherichia coli prolyl-tRNA synthetase
Biochemistry
36
2932-2938
1997
Escherichia coli
Manually annotated by BRENDA team
Bianchi, C.; Perego R.; Del Monte, U.
Polypeptide composition of the 8S form of prolyl-tRNA synthetase from rat liver
Biochem. Biophys. Res. Commun.
187
1071-1076
1992
Rattus norvegicus
Manually annotated by BRENDA team
Rivera, J.A.; Wang, Q.S.; Wong, J.T.F.
A highly thermostable proline:tRNA ligase from Thermus aquaticus. Purification and enzyme-tRNA recognition at elevated temperatures
Can. J. Biochem. Cell Biol.
62
507-515
1984
Thermus aquaticus
Manually annotated by BRENDA team
Busiello, V.; Di Girolamo, M.; Cini, C.; De Marco, C.
beta-Selenaproline as competitive inhibitor of proline activation
Biochim. Biophys. Acta
606
347-352
1980
Escherichia coli, Rattus norvegicus
Manually annotated by BRENDA team
Arbeeny, C.M.; Briden, K.L.; Stirewalt, W.S.
The activity and sedimentation properties of the aminoacyl-tRNA synthetases of rat skeletal muscle
Biochim. Biophys. Acta
564
191-201
1979
Rattus norvegicus
Manually annotated by BRENDA team
Jeannin, G.; Burkard, G.; Weil, J.H.
Aminoacylation of Phaseolus vulgaris cytoplasmic, chloroplastic and mitochondrial tRNAsPro and tRNAsLys by homologous and heterologous enzymes
Biochim. Biophys. Acta
442
24-31
1976
Escherichia coli, Phaseolus vulgaris
Manually annotated by BRENDA team
Norris, R.D.; Fowden, L.
Cold-lability of prolyl-tRNA synthetase from higher plants
Phytochemistry
13
1677-1687
1974
Delonix regia, Phaseolus vulgaris
-
Manually annotated by BRENDA team
Norris, R.D.; Fowden, L.
Pro-tRNA synthetase from Phaseolus aureus and Delonix regia
Phytochemistry
12
2829-2841
1973
Delonix regia, Phaseolus vulgaris
-
Manually annotated by BRENDA team
Norris, R.D.; Fowden, L.
A Comparison of the thermal stability and substrate binding constants of prolyl-tRNA synthetase from Phaseolus aureus and Delonix regia
Phytochemistry
12
2109-2121
1973
Delonix regia, Phaseolus vulgaris
-
Manually annotated by BRENDA team
Norris, R.D.; Fowden, L.
Substrate discrimination by prolyl-tRNA synthetase from various higher plants
Phytochemistry
11
2921-2935
1972
Beta vulgaris, Convallaria majalis, Delonix regia, Hemerocallis fulva, Parkinsonia aculeata, Phaseolus vulgaris, Polygonatum multiflorum, Ranunculus bulbosus
-
Manually annotated by BRENDA team
Papas, T.S.; Mehler, A.H.
Kinetic studies of the prolyl transfer ribonucleic acid synthetase of Escherichia coli. Order of addition of substrates and release of products
J. Biol. Chem.
246
5924-5928
1971
Escherichia coli
Manually annotated by BRENDA team
Norton, S.J.
Purification and properties of the prolyl RNA synthetase of Escherichia coli
Arch. Biochem. Biophys.
106
147-152
1964
Escherichia coli, Escherichia coli 9723
Manually annotated by BRENDA team
Peterson, P.J.; Fowden, L.
Purification, properties and comparative specificities of the enzyme prolyl-transfer ribonucleic acid synthetase from Phaseolus aureus and Polygonatum multiflorum
Biochem. J.
97
112-124
1965
Asparagus officinalis, Convallaria majalis, Phaseolus vulgaris, Pisum sativum, Polygonatum multiflorum
Manually annotated by BRENDA team
Yaremchuk, A.; Kriklivyi, I.; Cusack, S.; Tukalo, M.
Improved crystals of Thermus thermophilus prolyl-tRNA synthetase complexed with cognate tRNA obtained by crystallization from precipitate
Acta Crystallogr. Sect. D
56
197-199
2000
Thermus thermophilus
Manually annotated by BRENDA team
Stathopoulos, C.; Jacquin-Becker, C.; Becker, H.D.; Li, T.; Ambrogelly, A.; Longman, R.; Soll, D.
Methanococcus jannaschii prolyl-cysteinyl-tRNA synthetase possesses overlapping amino acid binding sites
Biochemistry
40
46-52
2001
Methanocaldococcus jannaschii (Q58635), Methanocaldococcus jannaschii, Methanocaldococcus jannaschii DSM 2661 (Q58635)
Manually annotated by BRENDA team
Wong, F.C.; Beuning, P.J.; Nagan, M.; Shiba, K.; Musier-Forsyth, K.
Functional role of the prokaryotic proline-tRNA synthetase insertion domain in amino acid editing
Biochemistry
41
7108-7115
2002
Escherichia coli
Manually annotated by BRENDA team
Yu, X.Y.; Hill, J.M.; Yu, G.; Yang, Y.; Kluge, A.F.; Keith, D.; Finn, J.; Gallant, P.; Silverman, J.; Lim, A.
A series of quinoline analogues as potent inhibitors of C. albicans prolyl tRNA synthetase
Bioorg. Med. Chem. Lett.
11
541-544
2001
Candida albicans, Homo sapiens
Manually annotated by BRENDA team
Yaremchuk, A.; Cusack, S.; Tukalo, M.
Crystal structure of a eukaryote/archaeon-like protyl-tRNA synthetase and its complex with tRNAPro(CGG)
EMBO J.
19
4745-4758
2000
Thermus thermophilus
Manually annotated by BRENDA team
Jacquin-Becker, C.; Ahel, I.; Ambrogelly, A.; Ruan, B.; Soll, D.; Stathopoulos, C.
Cysteinyl-tRNA formation and prolyl-tRNA synthetase
FEBS Lett.
514
34-36
2002
Thermus thermophilus, Giardia intestinalis, Methanocaldococcus jannaschii, Methanococcus maripaludis
Manually annotated by BRENDA team
Norcum, M.T.; Dignam, J.D.
Immunoelectron microscopic localization of glutamyl-/prolyl-tRNA synthetase within the eukaryotic multisynthetase complex
J. Biol. Chem.
274
12205-12208
1999
Oryctolagus cuniculus
Manually annotated by BRENDA team
Nathanson, L.; Deutscher, M.P.
Active aminoacyl-tRNA synthetases are present in nuclei as a high molecular weight multienzyme complex
J. Biol. Chem.
275
31559-31562
2000
Cricetulus griseus
Manually annotated by BRENDA team
Burke, B.; Lipman, R.S.A.; Shiba, K.; Musier-Forsyth, K.; Hou, Y.M.
Divergent adaptation of tRNA recognition by Methanococcus jannaschii prolyl-tRNA synthetase
J. Biol. Chem.
276
20286-20291
2001
Methanocaldococcus jannaschii (Q58635), Methanocaldococcus jannaschii, Methanocaldococcus jannaschii DSM 2661 (Q58635)
Manually annotated by BRENDA team
Beuning, P.J.; Musier-Forsyth, K.
Species-specific differences in amino acid editing by class II prolyl-tRNA synthetase
J. Biol. Chem.
276
30779-30785
2001
Escherichia coli, Homo sapiens, Methanocaldococcus jannaschii
Manually annotated by BRENDA team
Ahel, I.; Stathopoulos, C.; Ambrogelly, A.; Sauerwald, A.; Toogood, H.; Hartsch, T.; Soll, D.
Cysteine activation is an inherent in vitro property of prolyl-tRNA synthetases
J. Biol. Chem.
277
34743-34748
2002
Acetoanaerobium sticklandii, Aquifex aeolicus, Borreliella burgdorferi, Cytophaga hutchinsonii, Deinococcus radiodurans, Escherichia coli, Magnetospirillum magnetotacticum, Methanocaldococcus jannaschii, Methanothermobacter thermautotrophicus, Novosphingobium aromaticivorans, Rhodopseudomonas palustris, Saccharomyces cerevisiae, Thermus thermophilus
Manually annotated by BRENDA team
Ambrogelly, A.; Ahel, I.; Polycarpo, C.; Bunjun-Srihari, S.; Krett, B.; Jacquin-Becker, C.; Ruan, B.; Kohrer, C.; Stathopoulos, C.; RajBhandary, U.L.; Soll, D.
Methanocaldococcus jannaschii prolyl-tRNA synthetase charges tRNA(Pro) with cysteine
J. Biol. Chem.
277
34749-34754
2002
Methanocaldococcus jannaschii
Manually annotated by BRENDA team
Yaremchuk, A.; Tukalo, M.; Grotli, M.; Cusack, S.
A succession of substrate induced conformational changes ensures the amino acid specificity of Thermus thermophilus prolyl-tRNA synthetase: comparison with histidyl-tRNA synthetase
J. Mol. Biol.
309
989-1002
2001
Thermus thermophilus
Manually annotated by BRENDA team
Kamtekar, S.; Kennedy, W.D.; Wang, J.; Stathopoulos, C.; Soll, D.; Steitz, T.A.
The structural basis of cysteine aminoacylation of tRNAPro by prolyl-tRNA synthetases
Proc. Natl. Acad. Sci. USA
100
1673-1678
2003
Methanocaldococcus jannaschii, Methanothermobacter thermautotrophicus
Manually annotated by BRENDA team
Stathopoulos, C.; Kim, W.; Li, T.; Anderson, I.; Deutsch, B.; Palioura, S.; Whitman, W.; Soll, D.
Cysteinyl-tRNA synthetase is not essential for viability of the archaeon Methanococcus maripaludis
Proc. Natl. Acad. Sci. USA
98
14292-14297
2001
Methanococcus maripaludis (Q6LZD3), Methanococcus maripaludis
Manually annotated by BRENDA team
Cusack, S.; Yaremchuk, A.; Krikliviy, I.; Tukalo, M.
tRNAPro anticodon recognition by Thermus thermophilus prolyl-tRNA synthetase
Structure
6
101-108
1998
Thermus thermophilus, Thermus thermophilus HB8 / ATCC 27634 / DSM 579
Manually annotated by BRENDA team
Murayama, K.; Kato-Murayama, M.; Katsura, K.; Uchikubo-Kamo, T.; Yamaguchi-Hirafuji, M.; Kawazoe, M.; Akasaka, R.; Hanawa-Suetsugu, K.; Hori-Takemoto, C.; Terada, T.; Shirouzu, M.; Yokoyama, S.
Structure of a putative trans-editing enzyme for prolyl-tRNA synthetase from Aeropyrum pernix K1 at 1.7 A resolution
Acta Crystallogr. Sect. F
61
26-29
2005
Aeropyrum pernix
Manually annotated by BRENDA team
Sampath, P.; Mazumder, B.; Seshadri, V.; Gerber, C.A.; Chavatte, L.; Kinter, M.; Ting, S.M.; Dignam, J.D.; Kim, S.; Driscoll, D.M.; Fox, P.L.
Noncanonical function of glutamyl-prolyl-tRNA synthetase: Gene-specific silencing of translation
Cell
119
195-208
2004
Homo sapiens
Manually annotated by BRENDA team
Ambrogelly, A.; Kamtekar, S.; Stathopoulos, C.; Kennedy, D.; Soll, D.
Asymmetric behavior of archaeal prolyl-tRNA synthetase
FEBS Lett.
579
6017-6022
2005
Methanothermobacter thermautotrophicus, Methanocaldococcus jannaschii
Manually annotated by BRENDA team
Praetorius-Ibba, M.; Rogers, T.E.; Samson, R.; Kelman, Z.; Ibba, M.
Association between Archaeal prolyl- and leucyl-tRNA synthetases enhances tRNA(Pro) aminoacylation
J. Biol. Chem.
280
26099-26104
2005
Methanothermobacter thermautotrophicus
Manually annotated by BRENDA team
An, S.; Musier-Forsyth, K.
Cys-tRNA(Pro) editing by Haemophilus influenzae YbaK via a novel synthetase.YbaK.tRNA ternary complex
J. Biol. Chem.
280
34465-34472
2005
Haemophilus influenzae
Manually annotated by BRENDA team
Hati, S.; Ziervogel, B.; Sternjohn, J.; Wong, F.C.; Nagan, M.C.; Rosen, A.E.; Siliciano, P.G.; Chihade, J.W.; Musier-Forsyth, K.
Pre-transfer editing by class II prolyl-tRNA synthetase: role of aminoacylation active site in 'selective release' of noncognate amino acids
J. Biol. Chem.
281
27862-27872
2006
Saccharomyces cerevisiae, Escherichia coli, Methanothermobacter thermautotrophicus, Methanocaldococcus jannaschii, Methanococcus maripaludis
Manually annotated by BRENDA team
Praetorius-Ibba, M.; Hausmann, C.D.; Paras, M.; Rogers, T.E.; Ibba, M.
Functional association between three archaeal aminoacyl-tRNA synthetases
J. Biol. Chem.
282
3680-3687
2007
Methanothermobacter thermautotrophicus
Manually annotated by BRENDA team
Zhang, C.M.; Perona, J.J.; Ryu, K.; Francklyn, C.; Hou, Y.M.
Distinct kinetic mechanisms of the two classes of aminoacyl-tRNA synthetases
J. Mol. Biol.
361
300-311
2006
Deinococcus radiodurans
Manually annotated by BRENDA team
Crepin, T.; Yaremchuk, A.; Tukalo, M.; Cusack, S.
Structures of two bacterial prolyl-tRNA synthetases with and without a cis-editing domain
Structure
14
1511-1525
2006
Rhodopseudomonas palustris (Q6N5P6), Rhodopseudomonas palustris, Enterococcus faecalis (Q831W7), Enterococcus faecalis
Manually annotated by BRENDA team
Burke, B.; An, S.; Musier-Forsyth, K.
Functional guanine-arginine interaction between tRNAPro and prolyl-tRNA synthetase that couples binding and catalysis
Biochim. Biophys. Acta
1784
1222-1225
2008
Escherichia coli
Manually annotated by BRENDA team
Splan, K.E.; Ignatov, M.E.; Musier-Forsyth, K.
Transfer RNA modulates the editing mechanism used by class II prolyl-tRNA synthetase
J. Biol. Chem.
283
7128-7134
2008
Escherichia coli, Homo sapiens, Methanocaldococcus jannaschii
Manually annotated by BRENDA team
Wei, M.; Yang, Y.; Niu, M.; Desfosse, L.; Kennedy, R.; Musier-Forsyth, K.; Kleiman, L.
Inability of HIV-1 produced in murine cells to selectively incorporate primer tRNALys3
J. Virol.
82
12049-12059
2008
Moloney murine leukemia virus
Manually annotated by BRENDA team
Koehrer, C.; Rajbhandary, U.L.
The many applications of acid urea polyacrylamide gel electrophoresis to studies of tRNAs and aminoacyl-tRNA synthetases
Methods
44
129-138
2008
Methanothermobacter thermautotrophicus, Methanocaldococcus jannaschii, Methanopyrus kandleri
Manually annotated by BRENDA team
Jia, J.; Arif, A.; Ray, P.S.; Fox, P.L.
WHEP domains direct noncanonical function of glutamyl-prolyl tRNA synthetase in translational control of gene expression
Mol. Cell
29
679-690
2008
Homo sapiens
Manually annotated by BRENDA team
An, S.; Barany, G.; Musier-Forsyth, K.
Evolution of acceptor stem tRNA recognition by class II prolyl-tRNA synthetase
Nucleic Acids Res.
36
2514-2521
2008
Homo sapiens
Manually annotated by BRENDA team
Chatterjee, A.; Xiao, H.; Schultz, P.G.
Evolution of multiple, mutually orthogonal prolyl-tRNA synthetase/tRNA pairs for unnatural amino acid mutagenesis in Escherichia coli
Proc. Natl. Acad. Sci. USA
109
14841-14846
2012
Pyrococcus horikoshii
Manually annotated by BRENDA team
Larson, E.T.; Kim, J.E.; Napuli, A.J.; Verlinde, C.L.; Fan, E.; Zucker, F.H.; Van Voorhis, W.C.; Buckner, F.S.; Hol, W.G.; Merritt, E.A.
Structure of the prolyl-tRNA synthetase from the eukaryotic pathogen Giardia lamblia
Acta Crystallogr. Sect. D
68
1194-1200
2012
Giardia intestinalis (A8BR89), Giardia intestinalis, Giardia intestinalis WB / CC 30957 (A8BR89)
Manually annotated by BRENDA team
Son, J.; Lee, E.H.; Park, M.; Kim, J.H.; Kim, J.; Kim, S.; Jeon, Y.H.; Hwang, K.Y.
Conformational changes in human prolyl-tRNA synthetase upon binding of the substrates proline and ATP and the inhibitor halofuginone
Acta Crystallogr. Sect. D
69
2136-2145
2013
Homo sapiens (P07814), Homo sapiens
Manually annotated by BRENDA team
Sanford, B.; Cao, B.; Johnson, J.M.; Zimmerman, K.; Strom, A.M.; Mueller, R.M.; Bhattacharyya, S.; Musier-Forsyth, K.; Hati, S.
Role of coupled dynamics in the catalytic activity of prokaryotic-like prolyl-tRNA synthetases
Biochemistry
51
2146-2156
2012
Escherichia coli (P16659), Escherichia coli
Manually annotated by BRENDA team
Johnson, J.M.; Sanford, B.L.; Strom, A.M.; Tadayon, S.N.; Lehman, B.P.; Zirbes, A.M.; Bhattacharyya, S.; Musier-Forsyth, K.; Hati, S.
Multiple pathways promote dynamical coupling between catalytic domains in Escherichia coli prolyl-tRNA synthetase
Biochemistry
52
4399-4412
2013
Escherichia coli
Manually annotated by BRENDA team
Bartholow, T.G.; Sanford, B.L.; Cao, B.; Schmit, H.L.; Johnson, J.M.; Meitzner, J.; Bhattacharyya, S.; Musier-Forsyth, K.; Hati, S.
Strictly conserved lysine of prolyl-tRNA synthetase editing domain facilitates binding and positioning of misacylated tRNAPro
Biochemistry
53
1059-1068
2014
Escherichia coli
Manually annotated by BRENDA team
Feng, L.; Stathopoulos, C.; Ahel, I.; Mitra, A.; Tumbula-Hansen, D., Hartsch, T.; Sll, D.
Aminoacyl-tRNA formation in the extreme thermophile Thermus thermophilus
Extremophiles
6
167-174
2002
Thermus thermophilus (Q5SM28), Thermus thermophilus, Thermus thermophilus HB27 / ATCC BAA-163 / DSM 7039 (Q5SM28)
Manually annotated by BRENDA team
Kumar, S.; Das, M.; Hadad, C.M.; Musier-Forsyth, K.
Substrate specificity of bacterial prolyl-tRNA synthetase editing domain is controlled by a tunable hydrophobic pocket
J. Biol. Chem.
287
3175-3184
2012
Escherichia coli
Manually annotated by BRENDA team
Lipman, R.S.; Wang, J.; Sowers, K.R.; Hou, Y.M.
Prevention of mis-aminoacylation of a dual-specificity aminoacyl-tRNA synthetase
J. Mol. Biol.
315
943-999
2002
Methanocaldococcus jannaschii (Q58635), Methanocaldococcus jannaschii, Methanocaldococcus jannaschii DSM 2661 (Q58635)
Manually annotated by BRENDA team
Lipman, R.S.; Beuning, P.J.; Musier-Forsyth, K.; Hou, Y.M.
Amino acid activation of a dual-specificity tRNA synthetase is independent of tRNA
J. Mol. Biol.
316
421-427
2002
Methanocaldococcus jannaschii (Q58635), Methanocaldococcus jannaschii, Methanocaldococcus jannaschii DSM 2661 (Q58635)
Manually annotated by BRENDA team
Saravanan Prabhu, N.; Ayyadurai, N.; Deepankumar, K.; Chung, T.; Lim, D.; Yun, H.
Reassignment of sense codons: Designing and docking of proline analogs for Escherichia coli prolyl-tRNA synthetase to expand the genetic code
J. Mol. Catal. B
78
57-64
2012
Escherichia coli
-
Manually annotated by BRENDA team
Keller, T.L.; Zocco, D.; Sundrud, M.S.; Hendrick, M.; Edenius, M.; Yum, J.; Kim, Y.J.; Lee, H.K.; Cortese, J.F.; Wirth, D.F.; Dignam, J.D.; Rao, A.; Yeo, C.Y.; Mazitschek, R.; Whitman, M.
Halofuginone and other febrifugine derivatives inhibit prolyl-tRNA synthetase
Nat. Chem. Biol.
8
311-317
2012
Homo sapiens
Manually annotated by BRENDA team
Yokozawa, J.; Okamoto, K.; Kawarabayasi, Y.; Kuno, A.; Hasegawa, T.
Molecular recognition of proline tRNA by prolyl-tRNA synthetase from hyperthermophilic archaeon, Aeropyrum pernix K1
Nucleic Acids Res. Suppl.
2003
247-248
2003
Aeropyrum pernix (Q9Y9G0), Aeropyrum pernix, Aeropyrum pernix DSM 11879 (Q9Y9G0)
Manually annotated by BRENDA team
Bunjun, S.; Stathopoulos, C.; Graham, D.; Min, B.; Kitabatake, M.; Wang, A.L.; Wang, C.C.; Vivars, C.P.; Weiss, L.M.; Sll, D.
A dual-specificity aminoacyl-tRNA synthetase in the deep-rooted eukaryote Giardia lamblia
Proc. Natl. Acad. Sci. USA
97
12997-13002
2000
Giardia intestinalis (Q9GQI4), Giardia intestinalis
Manually annotated by BRENDA team
Hewitt, S.N.; Dranow, D.M.; Horst, B.G.; Abendroth, J.A.; Forte, B.; Hallyburton, I.; Jansen, C.; Baragana, B.; Choi, R.; Rivas, K.L.; Hulverson, M.A.; Dumais, M.; Edwards, T.E.; Lorimer, D.D.; Fairlamb, A.H.; Gray, D.W.; Read, K.D.; Lehane, A.M.; Kirk, K.; Myler, P.J.; Wernimont, A.; Walpole, C.; Stacy, R.; Bar, B.a.r.r.
Biochemical and Structural characterization of selective allosteric inhibitors of the Plasmodium falciparum drug target, prolyl-tRNA-synthetase
ACS Infect. Dis.
3
34-44
2017
Plasmodium falciparum (Q8I5R7), Plasmodium falciparum
Manually annotated by BRENDA team
Adachi, R.; Okada, K.; Skene, R.; Ogawa, K.; Miwa, M.; Tsuchinaga, K.; Ohkubo, S.; Henta, T.; Kawamoto, T.
Discovery of a novel prolyl-tRNA synthetase inhibitor and elucidation of its binding mode to the ATP site in complex with L-proline
Biochem. Biophys. Res. Commun.
488
393-399
2017
Homo sapiens (P07814), Homo sapiens
Manually annotated by BRENDA team
Young, S.K.; Baird, T.D.; Wek, R.C.
Translation regulation of the glutamyl-prolyl-tRNA synthetase gene EPRS through bypass of upstream open reading frames with noncanonical initiation codons
J. Biol. Chem.
291
10824-10835
2016
Mus musculus
Manually annotated by BRENDA team
Boyarshin, K.S.; Priss, A.E.; Rayevskiy, A.V.; Ilchenko, M.M.; Dubey, I.Y.; Kriklivyi, I.A.; Yaremchuk, A.D.; Tukalo, M.A.
A new mechanism of post-transfer editing by aminoacyl-tRNA synthetases catalysis of hydrolytic reaction by bacterial-type prolyl-tRNA synthetase
J. Biomol. Struct. Dyn.
35
669-682
2017
Enterococcus faecalis (Q831W7), Enterococcus faecalis
Manually annotated by BRENDA team
Jain, V.; Kikuchi, H.; Oshima, Y.; Sharma, A.; Yogavel, M.
Structural and functional analysis of the anti-malarial drug target prolyl-tRNA synthetase
J. Struct. Funct. Genomics
15
181-190
2014
Plasmodium falciparum (Q8I5R7), Plasmodium falciparum
Manually annotated by BRENDA team
Lee, E.Y.; Lee, H.C.; Kim, H.K.; Jang, S.Y.; Park, S.J.; Kim, Y.H.; Kim, J.H.; Hwang, J.; Kim, J.H.; Kim, T.H.; Arif, A.; Kim, S.Y.; Choi, Y.K.; Lee, C.; Lee, C.H.; Jung, J.U.; Fox, P.L.; Kim, S.; Lee, J.S.; Kim, M.H.
Infection-specific phosphorylation of glutamyl-prolyl tRNA synthetase induces antiviral immunity
Nat. Immunol.
17
1252-1262
2016
Homo sapiens (P07814), Mus musculus (Q8CGC7), Mus musculus C57BL/6 (Q8CGC7)
Manually annotated by BRENDA team
Lee, J.; Joshi, N.; Pasini, R.; Dobson, R.C.; Allison, J.; Leustek, T.
Inhibition of Arabidopsis growth by the allelopathic compound azetidine-2-carboxylate is due to the low amino acid specificity of cytosolic prolyl-tRNA synthetase
Plant J.
88
236-246
2016
Arabidopsis thaliana
Manually annotated by BRENDA team
Ravishankar, S.; Ambady, A.; Swetha, R.G.; Anbarasu, A.; Ramaiah, S.; Sambandamurthy, V.K.
Essentiality assessment of cysteinyl and lysyl-tRNA synthetases of Mycobacterium smegmatis
PLoS ONE
11
e0147188
2016
Mycolicibacterium smegmatis (A0QVM0), Mycolicibacterium smegmatis mc2155 / ATCC 700084 (A0QVM0)
Manually annotated by BRENDA team
Jain, V.; Yogavel, M.; Oshima, Y.; Kikuchi, H.; Touquet, B.; Hakimi, M.A.; Sharma, A.
Structure of prolyl-tRNA synthetase-halofuginone complex provides basis for development of drugs against malaria and toxoplasmosis
Structure
23
819-829
2015
Plasmodium falciparum (Q8I5R7), Toxoplasma gondii
Manually annotated by BRENDA team