6.1.1.15: proline-tRNA ligase
This is an abbreviated version!
For detailed information about proline-tRNA ligase, go to the full flat file.
Word Map on EC 6.1.1.15
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6.1.1.15
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synthetases
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aminoacylation
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halofuginone
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ala-trnapro
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anticodons
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mischarged
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aarss
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misactivated
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multisynthetase
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misacylated
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trans-editing
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cys-trnapro
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trnacys
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thrrs
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mistranslation
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thermautotrophicus
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multi-trna
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glnrs
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leucyl-trna
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lysyl-trna
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leurs
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asprs
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febrifugine
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post-transfer
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transcript-selective
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drug development
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pharmacology
- 6.1.1.15
- synthetases
- aminoacylation
- halofuginone
-
ala-trnapro
-
anticodons
-
mischarged
-
aarss
-
misactivated
-
multisynthetase
-
misacylated
-
trans-editing
-
cys-trnapro
- trnacys
- thrrs
-
mistranslation
- thermautotrophicus
-
multi-trna
- glnrs
- leucyl-trna
- lysyl-trna
- leurs
- asprs
- febrifugine
-
post-transfer
-
transcript-selective
- drug development
- pharmacology
Reaction
Synonyms
bifunctional aminoacyl-tRNA synthetase, bifunctional glutamate/proline-tRNA ligase, class II prolyl-tRNA synthetase, class II ProRS, dual-specificity prolyl-cysteinyl-tRNA synthetase, dual-specificity prolyl-tRNA synthetase, EPRS, Global RNA synthesis factor, GluProRS, glutamyl-/prolyl-tRNA synthetase, glutamyl-prolyl tRNA synthetase, glutamyl-prolyl-tRNA synthetase, More, MSMEG_2621, Pro-tRNA synthetase, ProCysRS, Proline translase, Proline--tRNA ligase, proline/cysteine-tRNA ligase, Prolyl RNA synthetase, prolyl tRNA synthetase, prolyl-cysteinyl-tRNA synthetase, Prolyl-transfer ribonucleate synthetase, Prolyl-transfer ribonucleic acid synthetase, Prolyl-transfer RNA synthetase, Prolyl-tRNA synthetase, ProRS, ProRS-Cyt, ProRS-Org, ProRSTT, proS, PRS
ECTree
6.1.1.15 proline-tRNA ligaseAdvanced search results
results (
results (General Stability
General Stability on EC 6.1.1.15 - proline-tRNA ligase
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GENERAL STABILITY 
ORGANISM
UNIPROT
LITERATURE
at pH 8, in absence of Mg2+, ATP does not protect against thermal inactivation
ATP, Pro and several Pro analogues prevent inactivation at 0°C
bovine serum albumin and glycerol partially protect against thermal denaturation at 45°C and 50°C respectively
furan and tetrahydrothiophen, only in presence of ATP protect against thermal inactivation
inclusion of a polyol together with the sulfhydryl-reducing reagent appears to synergistically enhance the stability on storage at 2°C
L-azetidine-2-carboxylic acid, cis(exo)-3,4-methano-L-proline, 3,4-dehydro-DL-proline, L-thiazolidine-4-carboxylic acid, N-methylglycine, N-methyl-L-alanine or trans-3-hydroxy-L-proline protect against inactivation at 70°C and 40°C
photoinactivation in presence of methylene blue or rose bengal. Pro or several imino analogues protect, ATP is ineffective. In absence of methylene blue the enzyme is stable to light
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Pro or ATP markedly stabilizes against heat inactivation
rapid and reversible photoinactivation in absence of methylene blue. ATP or Pro protects
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several analogues of Pro protect against thermal inactivation
the time taken for 4 M urea to reduced the activity by 50% is increased in presence of 15% glycerol from 0.7 min to 7 min and from 0.3 min to 1.5 min for the Phaseolus and Delonix enzymes respectively
at pH 8, in absence of Mg2+, ATP does not protect against thermal inactivation
-
bovine serum albumin and glycerol partially protect against thermal denaturation at 45°C and 50°C respectively
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bovine serum albumin and glycerol partially protect against thermal denaturation at 45°C and 50°C respectively
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furan and tetrahydrothiophen, only in presence of ATP protect against thermal inactivation
-
furan and tetrahydrothiophen, only in presence of ATP protect against thermal inactivation
-
inclusion of a polyol together with the sulfhydryl-reducing reagent appears to synergistically enhance the stability on storage at 2°C
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inclusion of a polyol together with the sulfhydryl-reducing reagent appears to synergistically enhance the stability on storage at 2°C
-
L-azetidine-2-carboxylic acid, cis(exo)-3,4-methano-L-proline, 3,4-dehydro-DL-proline, L-thiazolidine-4-carboxylic acid, N-methylglycine, N-methyl-L-alanine or trans-3-hydroxy-L-proline protect against inactivation at 70°C and 40°C
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L-azetidine-2-carboxylic acid, cis(exo)-3,4-methano-L-proline, 3,4-dehydro-DL-proline, L-thiazolidine-4-carboxylic acid, N-methylglycine, N-methyl-L-alanine or trans-3-hydroxy-L-proline protect against inactivation at 70°C and 40°C
-
the time taken for 4 M urea to reduced the activity by 50% is increased in presence of 15% glycerol from 0.7 min to 7 min and from 0.3 min to 1.5 min for the Phaseolus and Delonix enzymes respectively
-
the time taken for 4 M urea to reduced the activity by 50% is increased in presence of 15% glycerol from 0.7 min to 7 min and from 0.3 min to 1.5 min for the Phaseolus and Delonix enzymes respectively
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