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6.1.1.15: proline-tRNA ligase

This is an abbreviated version!
For detailed information about proline-tRNA ligase, go to the full flat file.

Word Map on EC 6.1.1.15

Reaction

ATP
+
L-proline
+
tRNAPro
=
AMP
+
diphosphate
+
L-prolyl-tRNAPro

Synonyms

bifunctional aminoacyl-tRNA synthetase, bifunctional glutamate/proline-tRNA ligase, class II prolyl-tRNA synthetase, class II ProRS, dual-specificity prolyl-cysteinyl-tRNA synthetase, dual-specificity prolyl-tRNA synthetase, EPRS, Global RNA synthesis factor, GluProRS, glutamyl-/prolyl-tRNA synthetase, glutamyl-prolyl tRNA synthetase, glutamyl-prolyl-tRNA synthetase, More, MSMEG_2621, Pro-tRNA synthetase, ProCysRS, Proline translase, Proline--tRNA ligase, proline/cysteine-tRNA ligase, Prolyl RNA synthetase, prolyl tRNA synthetase, prolyl-cysteinyl-tRNA synthetase, Prolyl-transfer ribonucleate synthetase, Prolyl-transfer ribonucleic acid synthetase, Prolyl-transfer RNA synthetase, Prolyl-tRNA synthetase, ProRS, ProRS-Cyt, ProRS-Org, ProRSTT, proS, PRS

ECTree

     6 Ligases
         6.1 Forming carbon-oxygen bonds
             6.1.1 Ligases forming aminoacyl-tRNA and related compounds
                6.1.1.15 proline-tRNA ligase

Substrates Products

Substrates Products on EC 6.1.1.15 - proline-tRNA ligase

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
adenosine 5'-(beta,gamma-imido)triphosphate + L-proline + tRNAPro
?
show the reaction diagram
ATP + 2-selenaproline + tRNAPro
?
show the reaction diagram
ATP + 3,4-dehydro-DL-proline + tRNAPro
?
show the reaction diagram
ATP + 3-thiaproline + tRNAPro
?
show the reaction diagram
ATP + 4-amino-L-proline + tRNAPro
?
show the reaction diagram
-
-
-
-
?
ATP + 4-difluoro-L-proline + tRNAPro
?
show the reaction diagram
-
-
-
-
?
ATP + 4-fluoro-L-proline + tRNAPro
?
show the reaction diagram
-
-
-
-
?
ATP + 4-hydroxy-L-proline + tRNAPro
?
show the reaction diagram
-
-
-
-
?
ATP + azetidine-2-carboxylic acid + tRNAPro
?
show the reaction diagram
-
-
-
-
?
ATP + beta-thia-L-proline + tRNAPro
?
show the reaction diagram
-
-
-
-
?
ATP + cis(exo)-3,4-methano-L-proline + tRNAPro
?
show the reaction diagram
ATP + cis-4-hydroxyproline + tRNAPro
AMP + diphosphate + cis-4-hydroxyprolyl-tRNAPro
show the reaction diagram
-
-
-
-
?
ATP + dehydro-L-proline + tRNAPro
?
show the reaction diagram
-
-
-
-
?
ATP + gamma-thia-L-proline + tRNAPro
?
show the reaction diagram
-
-
-
-
?
ATP + gamma-thiaproline + tRNAPro
?
show the reaction diagram
-
-
-
-
?
ATP + L-alanine + tRNAPro
AMP + diphosphate + L-alanyl-tRNAPro
show the reaction diagram
ATP + L-azetidine-2-carboxylic acid + tRNAPro
?
show the reaction diagram
ATP + L-cysteine + tRNA
AMP + diphosphate + L-cysteinyl-tRNA
show the reaction diagram
ATP + L-cysteine + tRNACys
AMP + diphosphate + L-cysteinyl-tRNACys
show the reaction diagram
-
-
-
?
ATP + L-cysteine + tRNAPro
AMP + diphosphate + L-cysteinyl-tRNAPro
show the reaction diagram
ATP + L-cysteine + tRNAs
AMP + diphosphate + L-cysteinyl-tRNA
show the reaction diagram
in later work it is shown that cysteine is attached to tRNA(Pro) and thus constitutes a misaminoacylation event and not a dual specificity
-
-
?
ATP + L-glutamate + tRNAGlu
AMP + diphosphate + L-glutamyl-tRNAGlu
show the reaction diagram
ATP + L-proline + L-tRNAAla
AMP + diphosphate + L-prolyl-tRNAAla
show the reaction diagram
-
-
-
?
ATP + L-proline + L-tRNAPro
AMP + diphosphate + L-prolyl-tRNAPro
show the reaction diagram
-
-
-
?
ATP + L-proline + L-tRNAProAla
AMP + diphosphate + L-prolyl-tRNAProAla
show the reaction diagram
-
-
-
?
ATP + L-proline + tRNAGlu
AMP + diphosphate + L-prolylyl-tRNAGlu
show the reaction diagram
ATP + L-proline + tRNAPro
AMP + diphosphate + L-prolyl-tRNAPro
show the reaction diagram
ATP + L-thiazolidine-4-carboxylic acid + tRNAPro
?
show the reaction diagram
-
-
-
-
?
ATP + N-methyl-L-alanine + tRNAPro
?
show the reaction diagram
-
-
-
-
?
ATP + N-methylglycine + tRNAPro
?
show the reaction diagram
ATP + thiazolidine-4-carboxylic acid + tRNAPro
?
show the reaction diagram
-
-
-
-
?
ATP + trans-4-hydroxyproline + tRNAPro
AMP + diphosphate + trans-4-hydroxyprolyl-tRNAPro
show the reaction diagram
-
-
-
-
?
additional information
?
-