Any feedback?
Please rate this page
(all_enzymes.php)
(0/150)

BRENDA support

6.1.1.15: proline-tRNA ligase

This is an abbreviated version!
For detailed information about proline-tRNA ligase, go to the full flat file.

Word Map on EC 6.1.1.15

Reaction

ATP
+
L-proline
+
tRNAPro
=
AMP
+
diphosphate
+
L-prolyl-tRNAPro

Synonyms

bifunctional aminoacyl-tRNA synthetase, bifunctional glutamate/proline-tRNA ligase, class II prolyl-tRNA synthetase, class II ProRS, dual-specificity prolyl-cysteinyl-tRNA synthetase, dual-specificity prolyl-tRNA synthetase, EPRS, Global RNA synthesis factor, GluProRS, glutamyl-/prolyl-tRNA synthetase, glutamyl-prolyl tRNA synthetase, glutamyl-prolyl-tRNA synthetase, More, MSMEG_2621, Pro-tRNA synthetase, ProCysRS, Proline translase, Proline--tRNA ligase, proline/cysteine-tRNA ligase, Prolyl RNA synthetase, prolyl tRNA synthetase, prolyl-cysteinyl-tRNA synthetase, Prolyl-transfer ribonucleate synthetase, Prolyl-transfer ribonucleic acid synthetase, Prolyl-transfer RNA synthetase, Prolyl-tRNA synthetase, ProRS, ProRS-Cyt, ProRS-Org, ProRSTT, proS, PRS

ECTree

     6 Ligases
         6.1 Forming carbon-oxygen bonds
             6.1.1 Ligases forming aminoacyl-tRNA and related compounds
                6.1.1.15 proline-tRNA ligase

KM Value

KM Value on EC 6.1.1.15 - proline-tRNA ligase

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
6.25 - 55
2-selenaproline
-
0.28 - 2.2
3,4-dehydro-DL-proline
1.4
3-thiaproline
66
4-thiaproline
-
ATP-diphosphate exchange
0.049 - 0.6
ATP
2 - 7.1
cis(exo)-3,4-Methano-L-proline
53 - 55
cis-4-hydroxyproline
12.5
gamma-thiaproline
-
ATP-diphosphate exchange
79 - 1360
L-alanine
1.43 - 5.3
L-azetidine-2-carboxylic acid
0.01 - 0.26
L-cysteine
0.137 - 0.625
L-Pro
0.0046 - 50
L-proline
20 - 50
L-thiazolidine-4-carboxylic acid
-
ATP-diphosphate exchange
68
N-Methyl-L-alanine
-
ATP-diphosphate exchange
45 - 300
N-methylglycine
0.12 - 3.1
Pro
20
thiazolidine-4-carboxylic acid
-
ATP-diphosphate exchange
2 - 37
trans-4-hydroxyproline
-
pH 7.0, 37°C, recombinant wild-type enzyme, amino acid activation
0.00003 - 0.01414
tRNAPro
additional information
additional information
-