Literature summary for 6.1.1.15 extracted from

Jain, V.; Yogavel, M.; Oshima, Y.; Kikuchi, H.; Touquet, B.; Hakimi, M.A.; Sharma, A.
Structure of prolyl-tRNA synthetase-halofuginone complex provides basis for development of drugs against malaria and toxoplasmosis (2015), Structure, 23, 819-829 .

Search for more literature for 6.1.1.15

Crystallization (Commentary)

Crystallization (Comment)	Organism
hanging drop vapor diffusion method, using 0.1 M Bis-Tris (pH 6.5), 2 % (v/v) Tacsimate (pH 5.0), and 12% (w/v) polyethylene glycol 3350	Plasmodium falciparum

Inhibitors

Inhibitors	Comment	Organism	Structure
6-fluoro-febrifugine	-	Plasmodium falciparum
6-fluoro-febrifugine	-	Toxoplasma gondii
7-bromo-6-chloro-3-[3-[3-hydroxy-2-piperidinyl]-2-oxopropyl]-4-quinazolinone	-	Plasmodium falciparum
7-bromo-6-chloro-3-[3-[3-hydroxy-2-piperidinyl]-2-oxopropyl]-4-quinazolinone	-	Toxoplasma gondii
febrifugine	-	Plasmodium falciparum
febrifugine	-	Toxoplasma gondii
halofuginone	-	Plasmodium falciparum
halofuginone	-	Toxoplasma gondii
tetrahydrofebrifugine	-	Plasmodium falciparum
tetrahydrofebrifugine	-	Toxoplasma gondii

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
ATP + L-proline + tRNAPro	Toxoplasma gondii	-	AMP + diphosphate + L-prolyl-tRNAPro	-	?
ATP + L-proline + tRNAPro	Plasmodium falciparum	-	AMP + diphosphate + L-prolyl-tRNAPro	-	?

Organism

Organism	UniProt	Comment	Textmining
Plasmodium falciparum	Q8I5R7	-	-
Toxoplasma gondii	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
adenosine 5'-(beta,gamma-imido)triphosphate + L-proline + tRNAPro	-	Toxoplasma gondii	?	-	?
adenosine 5'-(beta,gamma-imido)triphosphate + L-proline + tRNAPro	-	Plasmodium falciparum	?	-	?
ATP + L-proline + tRNAPro	-	Toxoplasma gondii	AMP + diphosphate + L-prolyl-tRNAPro	-	?
ATP + L-proline + tRNAPro	-	Plasmodium falciparum	AMP + diphosphate + L-prolyl-tRNAPro	-	?

Synonyms

Synonyms	Comment	Organism
Prolyl-tRNA synthetase	-	Toxoplasma gondii
Prolyl-tRNA synthetase	-	Plasmodium falciparum
PRS	-	Toxoplasma gondii
PRS	-	Plasmodium falciparum

Cofactor

Cofactor	Comment	Organism	Structure
ATP	-	Toxoplasma gondii
ATP	-	Plasmodium falciparum

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.000009	-	at pH 7.4 and 37°C	Plasmodium falciparum	halofuginone
0.000013	-	at pH 7.4 and 37°C	Plasmodium falciparum	6-fluoro-febrifugine
0.000024	-	at pH 7.4 and 37°C	Plasmodium falciparum	febrifugine
0.000352	-	at pH 7.4 and 37°C	Plasmodium falciparum	tetrahydrofebrifugine

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Release 2023.1 (January 2023)