6.1.1.10: methionine-tRNA ligase
This is an abbreviated version!
For detailed information about methionine-tRNA ligase, go to the full flat file.
Word Map on EC 6.1.1.10
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6.1.1.10
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synthetases
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aminoacyl-trna
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aminoacylation
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anticodons
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homocysteine
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trnafmet
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thiolactone
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aarss
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isoleucyl-trna
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trypsin-modified
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isoleucylation
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noncognate
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tyrosyl-trna
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arc1p
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atp-ppi
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formylmethionine
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medicine
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leucyl-trna
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kmsks
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misacylation
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hcy-thiolactone
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ilers
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lysyl-trna
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trna-binding
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valrs
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valyl-trna
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cysteinyl-trna
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drug development
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pharmacology
- 6.1.1.10
- synthetases
- aminoacyl-trna
- aminoacylation
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anticodons
- homocysteine
- trnafmet
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thiolactone
-
aarss
-
isoleucyl-trna
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trypsin-modified
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isoleucylation
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noncognate
- tyrosyl-trna
- arc1p
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atp-ppi
- formylmethionine
- medicine
- leucyl-trna
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kmsks
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misacylation
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hcy-thiolactone
- ilers
- lysyl-trna
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trna-binding
- valrs
- valyl-trna
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cysteinyl-trna
- drug development
- pharmacology
Reaction
Synonyms
hcMetRS, hmMetRS, let-65, MARS, mars-1, MetG, Methionine translase, Methionine--tRNA ligase, Methionyl tRNA synthetase, Methionyl-transfer ribonucleate synthetase, Methionyl-transfer ribonucleic acid synthetase, Methionyl-transfer RNA synthetase, methionyl-tRNA synthetase, methionyl-tRNA synthetase1, methionyl-tRNA-synthetase, MetRS, MetRS1, MetRS2, MetS, More, MRS, MRSapi, MRScyt, Synthetase, methionyl-transfer ribonucleate
ECTree
6.1.1.10 methionine-tRNA ligaseAdvanced search results
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results (Turnover Number
Turnover Number on EC 6.1.1.10 - methionine-tRNA ligase
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TURNOVER NUMBER [1/s] 
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
IMAGE
1.35
(S)-2-aminohex-5-enoic acid
ATP-diphosphate exchange reaction, pH 7.6
2.6
(S)-2-aminohex-5-ynoic acid
ATP-diphosphate exchange reaction, pH 7.6
23
ATP
mutant D666A, pH and temperature not specified in the publication
0.7
CoA
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methionylation reaction, cytoplasmic isozyme, pH 7.8, 25°C
1.6
CoA
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methionylation reaction, mitochondrial isozyme, pH 7.8, 25°C
0.5
L-homocysteine
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editing reaction, mitochondrial isozyme, pH 7.8, 25°C
0.69
L-homocysteine
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editing reaction, cytoplasmic isozyme, pH 7.8, 25°C
6.08
L-homocysteine
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editing reaction, cytoplasmic isozyme, pH 7.8, 25°C
3.1
L-methionine
mutant D666A, pH and temperature not specified in the publication
4
L-methionine
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mutant G54S, first step of reaction, methionyl-adenylate formation
6
L-methionine
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mutant I57N/H101N, first step of reaction, methionyl-adenylate formation
8
L-methionine
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mutant H101N/G213C, first step of reaction, methionyl-adenylate formation
15
L-methionine
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mutant G54S/L203S, first step of reaction, methionyl-adenylate formation
15
L-methionine
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mutant H101D, first step of reaction, methionyl-adenylate formation
15
L-methionine
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mutant I57N, first step of reaction, methionyl-adenylate formation
23
L-methionine
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wild-type, first step of reaction, methionyl-adenylate formation
25
L-methionine
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mutant V216A, first step of reaction, methionyl-adenylate formation
25
L-methionine
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mutant V216F/L203S, first step of reaction, methionyl-adenylate formation
33
L-methionine
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mutant D229E, first step of reaction, methionyl-adenylate formation
1.82
L-trans-alpha-crotylglycine
ATP-diphosphate exchange reaction, pH 7.6
2.94
L-trans-alpha-crotylglycine
ATP-diphosphate exchange reaction, pH 7.6
0.26
tRNA fraction from Saccharomyces cerevisiae
pH 7.5, 25°C, truncated mutant
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0.53
tRNA fraction from Saccharomyces cerevisiae
pH 7.5, 25°C, wild-type enzyme
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6.08
tRNA fraction from Saccharomyces cerevisiae
pH 7.5, 25°C, wild-type enzyme
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0.006
tRNAMet
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mutant V216F/L203S, second step of reaction, tRNA aminoacylation
0.01
tRNAMet
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mutant G54S, second step of reaction, tRNA aminoacylation
0.011
tRNAMet
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mutant G54S/L203S, second step of reaction, tRNA aminoacylation
0.013
tRNAMet
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mutant I57N/H101N, second step of reaction, tRNA aminoacylation
0.017
tRNAMet
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mutant I57N, second step of reaction, tRNA aminoacylation
0.019
tRNAMet
pH 8.2, 37°C, mitochondrial tRNAMet from Bos taurus, recombinant enzyme
0.021
tRNAMet
pH 8.2, 37°C, human mitochondrial wild-type tRNAMet, recombinant enzyme
0.023
tRNAMet
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mutant D229E, second step of reaction, tRNA aminoacylation
0.055
tRNAMet
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mutant V216A, second step of reaction, tRNA aminoacylation
0.08
tRNAMet
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wild-type, second step of reaction, tRNA aminoacylation
0.2
tRNAMet
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recombinant mitochondrial isozyme as GST-fusion protein, pH 7.8, 25°C
0.29
tRNAMet
in vitro synthesized tRNAMet from Saccharomyces cerevisiae, pH 7.5, 25°C, wild-type enzyme
0.36
tRNAMet
in vitro synthesized tRNAMet from Saccharomyces cerevisiae, pH 7.5, 25°C, truncated mutant
1
tRNAMet
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recombinant cytoplasmic isozyme as GST-fusion protein, pH 7.8, 25°C
11
tRNAMet
pH 8.2, 37°C, initiator tRNA from Escherichia coli, recombinant enzyme
47
tRNAMet
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ATP-diphosphate exchange reaction, C-terminally truncated mutant
additional information
additional information
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turnover numbers of mutant enzymes
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additional information
additional information
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turnover numbers of mutant enzymes
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additional information
additional information
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in ATP-diphosphate exchange reaction
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