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6.1.1.10: methionine-tRNA ligase

This is an abbreviated version!
For detailed information about methionine-tRNA ligase, go to the full flat file.

Word Map on EC 6.1.1.10

Reaction

ATP
+
L-methionine
+
tRNAMet
=
AMP
+
diphosphate
+
L-methionyl-tRNAMet

Synonyms

hcMetRS, hmMetRS, let-65, MARS, mars-1, MetG, Methionine translase, Methionine--tRNA ligase, Methionyl tRNA synthetase, Methionyl-transfer ribonucleate synthetase, Methionyl-transfer ribonucleic acid synthetase, Methionyl-transfer RNA synthetase, methionyl-tRNA synthetase, methionyl-tRNA synthetase1, methionyl-tRNA-synthetase, MetRS, MetRS1, MetRS2, MetS, More, MRS, MRSapi, MRScyt, Synthetase, methionyl-transfer ribonucleate

ECTree

     6 Ligases
         6.1 Forming carbon-oxygen bonds
             6.1.1 Ligases forming aminoacyl-tRNA and related compounds
                6.1.1.10 methionine-tRNA ligase

Application

Application on EC 6.1.1.10 - methionine-tRNA ligase

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APPLICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
drug development
-
parasite MetRS is an attractive drug target due to its essential role in protein synthesis and cell survival. Comparative sequence analysis discloses differences between the trypanosome and mammalian methionyl-tRNA synthetases
medicine
pharmacology
-
the enzyme is an important antibiotic target