6.1.1.10: methionine-tRNA ligase
This is an abbreviated version!
For detailed information about methionine-tRNA ligase, go to the full flat file.
Word Map on EC 6.1.1.10
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6.1.1.10
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synthetases
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aminoacyl-trna
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aminoacylation
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anticodons
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homocysteine
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trnafmet
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thiolactone
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aarss
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isoleucyl-trna
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trypsin-modified
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isoleucylation
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noncognate
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tyrosyl-trna
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arc1p
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atp-ppi
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formylmethionine
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medicine
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leucyl-trna
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kmsks
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misacylation
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hcy-thiolactone
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ilers
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lysyl-trna
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trna-binding
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valrs
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valyl-trna
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cysteinyl-trna
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drug development
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pharmacology
- 6.1.1.10
- synthetases
- aminoacyl-trna
- aminoacylation
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anticodons
- homocysteine
- trnafmet
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thiolactone
-
aarss
-
isoleucyl-trna
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trypsin-modified
-
isoleucylation
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noncognate
- tyrosyl-trna
- arc1p
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atp-ppi
- formylmethionine
- medicine
- leucyl-trna
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kmsks
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misacylation
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hcy-thiolactone
- ilers
- lysyl-trna
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trna-binding
- valrs
- valyl-trna
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cysteinyl-trna
- drug development
- pharmacology
Reaction
Synonyms
hcMetRS, hmMetRS, let-65, MARS, mars-1, MetG, Methionine translase, Methionine--tRNA ligase, Methionyl tRNA synthetase, Methionyl-transfer ribonucleate synthetase, Methionyl-transfer ribonucleic acid synthetase, Methionyl-transfer RNA synthetase, methionyl-tRNA synthetase, methionyl-tRNA synthetase1, methionyl-tRNA-synthetase, MetRS, MetRS1, MetRS2, MetS, More, MRS, MRSapi, MRScyt, Synthetase, methionyl-transfer ribonucleate
ECTree
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Natural Substrates Products
Natural Substrates Products on EC 6.1.1.10 - methionine-tRNA ligase
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REACTION DIAGRAM
ATP + azidonorleucine + tRNAMet
AMP + diphosphate + azidonorleucyl-tRNAMet
activity of mutant L13G, overview
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?
ATP + L-homocysteine + tRNAMet
?
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edition and aminoacylation by cytoplasmic and mitochondrial isozyme
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?
AMP + diphosphate + L-methionyl-tRNAMet
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the MetRS specificity for methionine and conformity with the identity rules for tRNAMet for archea/eukarya, anticodon binding site, overview
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-
?
ATP + L-methionine + tRNAMet
AMP + diphosphate + L-methionyl-tRNAMet
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r
ATP + L-methionine + tRNAMet
AMP + diphosphate + L-methionyl-tRNAMet
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essentiality of the metS1, nonessentiality of the metS2 for vegetative growth
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?
ATP + L-methionine + tRNAMet
AMP + diphosphate + L-methionyl-tRNAMet
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-
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?
ATP + L-methionine + tRNAMet
AMP + diphosphate + L-methionyl-tRNAMet
Brucella melitensis 2308
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?
ATP + L-methionine + tRNAMet
AMP + diphosphate + L-methionyl-tRNAMet
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-
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?
ATP + L-methionine + tRNAMet
AMP + diphosphate + L-methionyl-tRNAMet
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?
ATP + L-methionine + tRNAMet
AMP + diphosphate + L-methionyl-tRNAMet
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MetRS specifically binds tRNAMet and catalyzes the synthesis of methionyl-tRNAMet. The C-terminal appended domain causes a slow release of aminoacyl-tRNA and establishes a limiting step in the global aminoacylation reaction
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?
ATP + L-methionine + tRNAMet
AMP + diphosphate + L-methionyl-tRNAMet
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?
ATP + L-methionine + tRNAMet
AMP + diphosphate + L-methionyl-tRNAMet
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?
ATP + L-methionine + tRNAMet
AMP + diphosphate + L-methionyl-tRNAMet
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?
ATP + L-methionine + tRNAMet
AMP + diphosphate + L-methionyl-tRNAMet
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-
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?
ATP + L-methionine + tRNAMet
AMP + diphosphate + L-methionyl-tRNAMet
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?
ATP + L-methionine + tRNAMet
AMP + diphosphate + L-methionyl-tRNAMet
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?
ATP + L-methionine + tRNAMet
AMP + diphosphate + L-methionyl-tRNAMet
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-
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?
ATP + L-methionine + tRNAMet
AMP + diphosphate + L-methionyl-tRNAMet
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-
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?
ATP + L-methionine + tRNAMet
AMP + diphosphate + L-methionyl-tRNAMet
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-
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?
ATP + L-methionine + tRNAMet
AMP + diphosphate + L-methionyl-tRNAMet
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-
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?
ATP + L-methionine + tRNAMet
AMP + diphosphate + L-methionyl-tRNAMet
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-
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?
ATP + L-methionine + tRNAMet
AMP + diphosphate + L-methionyl-tRNAMet
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?
ATP + L-methionine + tRNAMet
AMP + diphosphate + L-methionyl-tRNAMet
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?
ATP + L-methionine + tRNAMet
AMP + diphosphate + L-methionyl-tRNAMet
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?
ATP + L-methionine + tRNAMet
AMP + diphosphate + L-methionyl-tRNAMet
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?
ATP + L-methionine + tRNAMet
AMP + diphosphate + L-methionyl-tRNAMet
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r
ATP + L-methionine + tRNAMet
AMP + diphosphate + L-methionyl-tRNAMet
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?
ATP + L-methionine + tRNAMet
AMP + diphosphate + L-methionyl-tRNAMet
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?
ATP + L-methionine + tRNAMet
AMP + diphosphate + L-methionyl-tRNAMet
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?
ATP + L-methionine + tRNAMet
AMP + diphosphate + L-methionyl-tRNAMet
L-methionine and methionine analogue substrates are incorporated in proteins, overview
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?
ATP + L-methionine + tRNAMet
AMP + diphosphate + L-methionyl-tRNAMet
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?
ATP + L-methionine + tRNAMet
AMP + diphosphate + L-methionyl-tRNAMet
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?
ATP + L-methionine + tRNAMet
AMP + diphosphate + L-methionyl-tRNAMet
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protein biosynthesis in archaea is initiated with methionine not with formylmethionine
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r
ATP + L-methionine + tRNAMet
AMP + diphosphate + L-methionyl-tRNAMet
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protein biosynthesis in archaea is initiated with methionine not with formylmethionine
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r
ATP + L-methionine + tRNAMet
AMP + diphosphate + L-methionyl-tRNAMet
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?
ATP + L-methionine + tRNAMet
AMP + diphosphate + L-methionyl-tRNAMet
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r
ATP + L-methionine + tRNAMet
AMP + diphosphate + L-methionyl-tRNAMet
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?
ATP + L-methionine + tRNAMet
AMP + diphosphate + L-methionyl-tRNAMet
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r
ATP + L-methionine + tRNAMet
AMP + diphosphate + L-methionyl-tRNAMet
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the nucleolar located enzyme is related to rRNA synthesis, the cytoplasmic enzyme is involved in protein biosynthesis
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?
ATP + L-methionine + tRNAMet
AMP + diphosphate + L-methionyl-tRNAMet
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?
ATP + L-methionine + tRNAMet
AMP + diphosphate + L-methionyl-tRNAMet
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?
ATP + L-methionine + tRNAMet
AMP + diphosphate + L-methionyl-tRNAMet
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?
ATP + L-methionine + tRNAMet
AMP + diphosphate + L-methionyl-tRNAMet
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?
ATP + L-methionine + tRNAMet
AMP + diphosphate + L-methionyl-tRNAMet
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?
ATP + L-methionine + tRNAMet
AMP + diphosphate + L-methionyl-tRNAMet
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?
ATP + L-methionine + tRNAMet
AMP + diphosphate + L-methionyl-tRNAMet
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?
ATP + L-methionine + tRNAMet
AMP + diphosphate + L-methionyl-tRNAMet
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?
ATP + L-methionine + tRNAMet
AMP + diphosphate + L-methionyl-tRNAMet
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?
ATP + L-methionine + tRNAMet
AMP + diphosphate + L-methionyl-tRNAMet
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?
ATP + L-methionine + tRNAMet
AMP + diphosphate + L-methionyl-tRNAMet
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?
ATP + L-methionine + tRNAMet
AMP + diphosphate + L-methionyl-tRNAMet
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?
ATP + L-methionine + tRNAMet
AMP + diphosphate + L-methionyl-tRNAMet
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r
ATP + L-methionine + tRNAMet
AMP + diphosphate + L-methionyl-tRNAMet
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?
ATP + L-methionine + tRNAMet
AMP + diphosphate + L-methionyl-tRNAMet
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initiator and elongation tRNAMet, cytoplasmic and mitochondrial isozyme
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?
ATP + L-methionine + tRNAMet
AMP + diphosphate + L-methionyl-tRNAMet
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?
ATP + L-methionine + tRNAMet
AMP + diphosphate + L-methionyl-tRNAMet
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?
ATP + L-methionine + tRNAMet
AMP + diphosphate + L-methionyl-tRNAMet
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?
ATP + L-methionine + tRNAMet
AMP + diphosphate + L-methionyl-tRNAMet
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?
ATP + L-methionine + tRNAMet
AMP + diphosphate + L-methionyl-tRNAMet
Thermus thermophilus HB8 / ATCC 27634 / DSM 579
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?
ATP + L-methionine + tRNAMet
AMP + diphosphate + L-methionyl-tRNAMet
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?
ATP + L-methionine + tRNAMet
AMP + diphosphate + L-methionyl-tRNAMet
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?
ATP + L-methionine + tRNAMet
AMP + diphosphate + L-methionyl-tRNAMet
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?
ATP + L-methionine + tRNAMet
AMP + diphosphate + L-methionyl-tRNAMet
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?
ATP + L-methionine + tRNAMet
AMP + diphosphate + L-methionyl-tRNAMet
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?
AMP + diphosphate + L-valyl-tRNAMetG34C36
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CAU to GAC anticodon mutant initiator tRNAMet, reduced reverse, i.e. deacetylation, reaction
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r
ATP + L-valine + tRNAMetG34C36
AMP + diphosphate + L-valyl-tRNAMetG34C36
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CAU to GAC anticodon mutant initiator tRNAMet, reduced reverse, i.e. deacetylation, reaction
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r
?
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mimivirus aminoacyl-tRNA synthetases function as regular translation enzymes in infected amoebas
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?
additional information
?
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L-homocysteine is a natural competitor to L-methionine, its activation by the enzyme is prevented by a proof-reading mechanism, structural requirements are determined form the crystal structure
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?
additional information
?
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no activity with the CAU to CUA initiator tRNAMet mutant in vivo
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?
additional information
?
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no activity with the CAU to CUA initiator tRNAMet mutant in vivo
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?