6.1.1.10: methionine-tRNA ligase

This is an abbreviated version!
For detailed information about methionine-tRNA ligase, go to the full flat file.

Word Map on EC 6.1.1.10

6.1.1.10

synthetases

aminoacyl-trna

aminoacylation

anticodons

homocysteine

trnafmet

thiolactone

aarss

isoleucyl-trna

trypsin-modified

isoleucylation

noncognate

tyrosyl-trna

arc1p

atp-ppi

formylmethionine

medicine

leucyl-trna

kmsks

misacylation

hcy-thiolactone

ilers

lysyl-trna

trna-binding

valrs

valyl-trna

cysteinyl-trna

drug development

pharmacology

Reaction

Synonyms

hcMetRS, hmMetRS, let-65, MARS, mars-1, MetG, Methionine translase, Methionine--tRNA ligase, Methionyl tRNA synthetase, Methionyl-transfer ribonucleate synthetase, Methionyl-transfer ribonucleic acid synthetase, Methionyl-transfer RNA synthetase, methionyl-tRNA synthetase, methionyl-tRNA synthetase1, methionyl-tRNA-synthetase, MetRS, MetRS1, MetRS2, MetS, More, MRS, MRSapi, MRScyt, Synthetase, methionyl-transfer ribonucleate

ECTree

6 Ligases

6.1 Forming carbon-oxygen bonds

6.1.1 Ligases forming aminoacyl-tRNA and related compounds

6.1.1.10 methionine-tRNA ligase

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Results	in table
15	Activating Compound
54326	AA Sequence
15	Application
1	CAS Registry Number
41	Cloned(Commentary)
74	Cofactor
25	Crystallization (Commentary)
175	Disease/ Diagnostics
5	General Information
4	General Stability
175	IC50 Value
387	Inhibitors
9	kcat/KM [mM/s]
39	Ki Value [mM]
159	KM Value [mM]
29	Localization
46	Metals/Ions
37	Molecular Weight [Da]
92	Natural Substrates/ Products (Substrates)
397	Organism
6	Pathway
154	PDB ID
23	pH Optimum
1	Posttranslational Modification
109	Protein Variants
41	Purification (Commentary)
15	Reaction
64	Reaction Type
127	Reference
1	Renatured (Commentary)
28	Source Tissue
14	Specific Activity [micromol/min/mg]
5	Storage Stability
211	Substrates and Products (Substrate)
45	Subunits
338	Synonyms
1	Systematic Name
22	Temperature Optimum [°C]
1	Temperature Range [°C]
4	Temperature Stability [°C]
110	Turnover Number [1/s]

KI Value

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KI Value on EC 6.1.1.10 - methionine-tRNA ligase

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0.000018

2-[(3-[[(4,6-dichloro-1H-indol-2-yl)methyl]amino]propyl)amino]quinazolin-4(1H)-one

Leishmania donovani

at pH 8.0 and 25°C

743928

0.482

ATP

Leishmania donovani

at pH 8.0 and 25°C

743928

0.0196

L-methionine hydroxamate

Escherichia coli

pH 8.0

651818

0.000000017 - 0.02

REP3123

17 entries

0.00000001 - 0.02

REP8839

17 entries

additional information

2 entries