6.1.1.10: methionine-tRNA ligase

This is an abbreviated version!
For detailed information about methionine-tRNA ligase, go to the full flat file.

Reaction

Synonyms

hcMetRS, hmMetRS, let-65, MARS, mars-1, MetG, Methionine translase, Methionine--tRNA ligase, Methionyl tRNA synthetase, Methionyl-transfer ribonucleate synthetase, Methionyl-transfer ribonucleic acid synthetase, Methionyl-transfer RNA synthetase, methionyl-tRNA synthetase, methionyl-tRNA synthetase1, methionyl-tRNA-synthetase, MetRS, MetRS1, MetRS2, MetS, More, MRS, MRSapi, MRScyt, Synthetase, methionyl-transfer ribonucleate

ECTree

     6 Ligases

         6.1 Forming carbon-oxygen bonds

             6.1.1 Ligases forming aminoacyl-tRNA and related compounds

                6.1.1.10 methionine-tRNA ligase

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Results	in table
15	Activating Compound
54326	AA Sequence
15	Application
1	CAS Registry Number
41	Cloned(Commentary)
74	Cofactor
25	Crystallization (Commentary)
175	Disease/ Diagnostics
5	General Information
4	General Stability
175	IC50 Value
387	Inhibitors
9	kcat/KM [mM/s]
39	Ki Value [mM]
159	KM Value [mM]
29	Localization
46	Metals/Ions
37	Molecular Weight [Da]
92	Natural Substrates/ Products (Substrates)
397	Organism
6	Pathway
154	PDB ID
23	pH Optimum
1	Posttranslational Modification
109	Protein Variants
41	Purification (Commentary)
15	Reaction
64	Reaction Type
127	Reference
1	Renatured (Commentary)
28	Source Tissue
14	Specific Activity [micromol/min/mg]
5	Storage Stability
211	Substrates and Products (Substrate)
45	Subunits
338	Synonyms
1	Systematic Name
22	Temperature Optimum [°C]
1	Temperature Range [°C]
4	Temperature Stability [°C]
110	Turnover Number [1/s]

Organism

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Organism on EC 6.1.1.10 - methionine-tRNA ligase

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ORGANISM

COMMENTARY

LITERATURE

UNIPROT

SEQUENCE DB

SOURCE

Acanthamoeba polyphaga Mimivirus

-

675706

-

-

brenda

Aquifex aeolicus

-

662940

-

-

brenda

Arabidopsis thaliana

2 entries

Bacillus anthracis

UM23C1-1and GRI strains, genes metS1 and metS2

671376

-

-

brenda

Brucella melitensis

biovar Abortus

746209

Q2YQ76

UniProt

brenda

Brucella melitensis 2308

biovar Abortus

746209

Q2YQ76

UniProt

brenda

Burkholderia thailandensis

-

745189

Q2T087

UniProt

brenda

Caenorhabditis elegans

-

716855, 745685

-

-

brenda

Caenorhabditis elegans N2 Bristol

-

745685

-

-

brenda

Candida albicans

class I enzyme

651401

O74634

SwissProt

brenda

Clostridioides difficile

3 entries

Clostridioides difficile 1813

-

745457

-

-

brenda

Clostridioides difficile 630

-

715969

Q181D9

UniProt

brenda

Cricetulus griseus

-

32

-

-

brenda

Enterococcus faecalis

-

661336, 661338

-

-

brenda

Enterococcus faecium

-

661338

-

-

brenda

Escherichia coli

15 entries

Escherichia coli EM

-

35

-

-

brenda

Geobacillus stearothermophilus

MS534, purified recombinant dimeric wild-type and monomeric truncated mutant enzymes expressed in Escherichia coli

653028

-

-

brenda

Haemophilus influenzae

-

701744, 704223

-

-

brenda

Haloferax volcanii

-

652179

-

-

brenda

Haloferax volcanii WFD11

-

652179

-

-

brenda

Homo sapiens

4 entries

Leishmania donovani

-

743928

-

-

brenda

Leishmania major

-

714377

-

-

brenda

Lupinus sp.

yellow lupin

63

-

-

brenda

Mus musculus

-

32, 744596

-

-

brenda

Mycobacterium tuberculosis

2 entries

Mycolicibacterium smegmatis

3 entries

Nanoarchaeum equitans

-

745574

Q74MZ1

UniProt

brenda

Oryza sativa

enzyme contains a supplementary C-terminal domain related to endothelial monocyte activating polypeptide II, i.e. EMAPII, a cytokine

650978

Q9ZTS1

SwissProt

brenda

Ovis aries

-

61, 62

-

-

brenda

Paracoccus denitrificans

-

58

-

-

brenda

Paracoccus denitrificans 8944

-

58

-

-

brenda

Pisum sativum

-

653613

-

-

brenda

Plasmodium falciparum

-

744051

-

-

brenda

Pyrococcus abyssi

2 entries

Rattus norvegicus

-

25, 26, 27, 60

-

-

brenda

Saccharomyces cerevisiae

4 entries

Staphylococcus aureus

-

661336, 661338, 672551, 675486, 692176, 701744, 704223

-

-

brenda

Staphylococcus epidermidis

-

661338

-

-

brenda

Streptococcus pneumoniae

-

701744, 704223

-

-

brenda

Thermus thermophilus

3 entries

Thermus thermophilus HB8 / ATCC 27634 / DSM 579

2 entries

Triticum aestivum

-

55, 59, 65

-

-

brenda

Trypanosoma brucei

2 entries

Trypanosoma brucei 927

-

744840, 746175

Q38C91

UniProt

brenda

Vigna radiata var. radiata

-

64

-

-

brenda

Arabidopsis thaliana

a single gene of chloroplast origin codes for mitochondrial and chloroplastic isozyme

653613

-

-

brenda

Arabidopsis thaliana

a single gene of chloroplast origin codes for mitochondrial and chloroplastic isozyme

653613

O23761, Q9M2T9

SwissProt

brenda

Clostridioides difficile

-

704223, 704224

-

-

brenda

Clostridioides difficile

-

715969

Q181D9

UniProt

brenda

Clostridioides difficile

-

745457

-

-

brenda

Escherichia coli

-

30, 31, 32, 33, 34, 35, 36, 56, 66, 69, 649084, 650114, 650560, 651818, 652807, 652850

-

-

brenda

Escherichia coli

-

652925, 653960

P00959

SwissProt

brenda

Escherichia coli

-

672606

-

-

brenda

Escherichia coli

-

676799

P00959

SwissProt

brenda

Escherichia coli

-

676885, 701744, 704223

-

-

brenda

Escherichia coli

-

705170

P00959

SwissProt

brenda

Escherichia coli

-

714269

-

-

brenda

Escherichia coli

-

728671

P00959

SwissProt

brenda

Escherichia coli

-

728695, 745433

-

-

brenda

Escherichia coli

and mutant strains with an increased Km for methionine

54

-

-

brenda

Escherichia coli

class I enzyme

650559

-

-

brenda

Escherichia coli

gene metE

671332

-

-

brenda

Escherichia coli

M547 and mutant enzymes: L22A variant, G23A variant, G23P variant, H21N variant, H21Q variant, H24N variant, and H24Q variant

28

-

-

brenda

Escherichia coli

purified recombinant C-terminally truncated enzyme

651240

-

-

brenda

Escherichia coli

wild-type enzyme and mutants produced by site-directed mutagenesis

29

-

-

brenda

Homo sapiens

-

32, 650036, 652598, 701744, 704223

-

-

brenda

Homo sapiens

-

727252

P56192

Uniprot

brenda

Homo sapiens

-

728666, 744596, 745956

-

-

brenda

Homo sapiens

class I enzyme

661156

P56192

Uniprot

brenda

Mycobacterium tuberculosis

-

726879

-

-

brenda

Mycobacterium tuberculosis

non-typical class I enzyme lacking the Zn2+ binding motif and the C-terminal dimerization appendix which is found in enzymes from other organisms

651240

-

-

brenda

Mycolicibacterium smegmatis

-

57

-

-

brenda

Mycolicibacterium smegmatis

-

701527

A0R3E2

UniProt

brenda

Mycolicibacterium smegmatis

-

714961

-

-

brenda

Pyrococcus abyssi

-

650114, 744340

Q9V011

Uniprot

brenda

Pyrococcus abyssi

class I enzyme

661118

Q9V011

Uniprot

brenda

Saccharomyces cerevisiae

-

32

-

-

brenda

Saccharomyces cerevisiae

-

676213

P00958

SwissProt

brenda

Saccharomyces cerevisiae

2 cytoplasmic and mitochondrial isozymes

652862

-

-

brenda

Saccharomyces cerevisiae

a strain carrying the MES1 structure gene on a high copy number plasmid (pFL1)

70

-

-

brenda

Thermus thermophilus

class I enzyme

649084

-

-

brenda

Thermus thermophilus

class Ia enzyme

653938

-

-

brenda

Thermus thermophilus

HB8

67, 68

-

-

brenda

Thermus thermophilus HB8 / ATCC 27634 / DSM 579

class Ia enzyme

653938

-

-

brenda

Thermus thermophilus HB8 / ATCC 27634 / DSM 579

HB8

67, 68

-

-

brenda

Trypanosoma brucei

-

713772

-

-

brenda

Trypanosoma brucei

-

728811, 744840, 746175

Q38C91

UniProt

brenda