6.1.1.10: methionine-tRNA ligase

This is an abbreviated version!
For detailed information about methionine-tRNA ligase, go to the full flat file.

Reaction

Synonyms

hcMetRS, hmMetRS, let-65, MARS, mars-1, MetG, Methionine translase, Methionine--tRNA ligase, Methionyl tRNA synthetase, Methionyl-transfer ribonucleate synthetase, Methionyl-transfer ribonucleic acid synthetase, Methionyl-transfer RNA synthetase, methionyl-tRNA synthetase, methionyl-tRNA synthetase1, methionyl-tRNA-synthetase, MetRS, MetRS1, MetRS2, MetS, More, MRS, MRSapi, MRScyt, Synthetase, methionyl-transfer ribonucleate

ECTree

     6 Ligases

         6.1 Forming carbon-oxygen bonds

             6.1.1 Ligases forming aminoacyl-tRNA and related compounds

                6.1.1.10 methionine-tRNA ligase

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Results	in table
15	Activating Compound
54326	AA Sequence
15	Application
1	CAS Registry Number
41	Cloned(Commentary)
74	Cofactor
25	Crystallization (Commentary)
175	Disease/ Diagnostics
5	General Information
4	General Stability
175	IC50 Value
387	Inhibitors
9	kcat/KM [mM/s]
39	Ki Value [mM]
159	KM Value [mM]
29	Localization
46	Metals/Ions
37	Molecular Weight [Da]
92	Natural Substrates/ Products (Substrates)
397	Organism
6	Pathway
154	PDB ID
23	pH Optimum
1	Posttranslational Modification
109	Protein Variants
41	Purification (Commentary)
15	Reaction
64	Reaction Type
127	Reference
1	Renatured (Commentary)
28	Source Tissue
14	Specific Activity [micromol/min/mg]
5	Storage Stability
211	Substrates and Products (Substrate)
45	Subunits
338	Synonyms
1	Systematic Name
22	Temperature Optimum [°C]
1	Temperature Range [°C]
4	Temperature Stability [°C]
110	Turnover Number [1/s]

General Stability

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General Stability on EC 6.1.1.10 - methionine-tRNA ligase

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GENERAL STABILITY

ORGANISM

UNIPROT

LITERATURE

bovine serum albumin has no effect on the enzyme

Homo sapiens

P56192

661156

Mg2+, required for stability, enzyme loses 80% of its activity when stored at -20°C for 3 days in buffer lacking Mg2+

Triticum aestivum

-

55

several cycles of freezing and thawing, cause no loss of activity of wild-type enzyme in crude extract

Escherichia coli

-

54

stability is increased by presence of a reducing agent. In the presence of 5 mM DTT purified enzyme is stable for at least 8 months at -15°C

Paracoccus denitrificans

-

58