5.4.99.7: Lanosterol synthase
This is an abbreviated version!
For detailed information about Lanosterol synthase, go to the full flat file.
Word Map on EC 5.4.99.7
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5.4.99.7
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anatomical
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subtypes
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omnibus
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metastasis
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adenocarcinoma
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kaplan-meier
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univariate
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download
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posterior
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lncrnas
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neck
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clinicopathological
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anatomy
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high-risk
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tumorigenesis
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worse
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tomography
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encyclopedia
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glioblastoma
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immunotherapy
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glioma
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manual
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automat
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nomogram
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lasso
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checkpoint
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arch
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fracture
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spine
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immune-related
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radiograph
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transverse
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disease-free
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occipital
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cernas
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probabilistic
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hnscc
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neuroimaging
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ccrcc
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vertebra
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stereotactic
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skull
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tumor-infiltrating
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tensor
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sagittal
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screw
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c-index
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medicine
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synthesis
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drug development
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nutrition
- 5.4.99.7
-
anatomical
- subtypes
-
omnibus
- metastasis
- adenocarcinoma
-
kaplan-meier
-
univariate
-
download
- posterior
- lncrnas
- neck
-
clinicopathological
-
anatomy
-
high-risk
- tumorigenesis
-
worse
-
tomography
-
encyclopedia
- glioblastoma
-
low-risk
-
registration
-
immunotherapy
- glioma
-
kyoto
-
manual
-
automat
-
nomogram
-
lasso
-
checkpoint
- arch
- fracture
- spine
-
immune-related
-
radiograph
-
transverse
-
disease-free
-
occipital
-
cernas
-
probabilistic
- hnscc
-
neuroimaging
-
ccrcc
- vertebra
-
stereotactic
- skull
-
tumor-infiltrating
-
tensor
-
sagittal
-
screw
-
c-index
- medicine
- synthesis
- drug development
- nutrition
Reaction
Synonyms
2,3 oxidosqualene:lanosterol cyclase, 2,3-Epoxysqualene lanosterol-cyclase, 2,3-epoxysqualene--lanosterol cyclase, 2,3-Epoxysqualene-lanosterol cyclase, 2,3-Oxidosqualene cyclase, 2,3-oxidosqualene cyclase-lanosterol synthase, 2,3-Oxidosqualene sterol cyclase, 2,3-Oxidosqualene-lanosterol cyclase, 2,3-oxidosqualene:lanosterol cyclase, AtLAS, Cyclase, 2,3-oxidosqualene-lanosterol, ERG7, Erg7p, hOSC, Lanosterol 2,3-oxidosqualene cyclase, lanosterol synthase, LAS, LAS1, Lss, OSC, OSLC, Oxidosqualene cyclase, oxidosqualene cyclase/lanosterol synthase, Oxidosqualene--lanosterol cyclase, Oxidosqualene-lanosterol cyclase, oxidosqualene:lanosterol cyclase, SceOSC, Squalene 2,3-epoxide:lanosterol cyclase, Squalene 2,3-oxide-lanosterol cyclase, Squalene epoxidase-cyclase, Squalene-2,3-oxide-lanosterol cyclase, tuber-specific StLAS-like
ECTree
5.4.99.7 Lanosterol synthaseAdvanced search results
results (
results (Substrates Products
Substrates Products on EC 5.4.99.7 - Lanosterol synthase
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
(3S)-2,3-epoxy-2,3-dihydrosqualene
lanosterol + (13alphaH)-isomalabarica-14(26),17E,21-trien-3beta-ol
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reaction of mutant V454I
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?
(3S)-2,3-epoxy-2,3-dihydrosqualene
lanosterol + (13alphaH)-isomalabarica-14(26),17E,21-trien-3beta-ol + protosta-16,24-dien-3beta-ol
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reaction of mutant Q450H/V454I
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-
?
(3S)-2,3-epoxy-2,3-dihydrosqualene
lanosterol + achilleol A
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reaction of C457G/T509G
achilleol A is the main product
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?
(3S)-2,3-epoxy-2,3-dihydrosqualene
lanosterol + achilleol A + 13alphaH-isomalabarica-14(26),17E,21-trien-3beta-ol
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reaction of mutant H234W/Y510V
lanosterol is the main product
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?
(3S)-2,3-epoxy-2,3-dihydrosqualene
lanosterol + parkeol + 9beta-lanosta-7,24-dien-3beta-ol
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reaction of mutants T384Y, T384Y/Q450H, and T384Y/V454I
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?
(3S)-2,3-epoxy-2,3-dihydrosqualene
protosta-12,24-dien-3-beta-ol
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reaction of mutant H232T
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?
(3S)-2,3-oxidosqualene
?
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two essential histidine residues per active site are necessary for complete activity
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?
29-norsqualene
(2S,4aS,6aR,7R,10aR,12aR)-1,1,4a,6a,10a-pentamethyl-7-(4-methylpent-3-en-1-yl)-1,2,3,4,4a,5,6,6a,7,8,9,10,10a,11,12,12a-hexadecahydrochrysen-2-ol + (2S,4aS,6aS,7R,10aS,12aR)-1,1,4a,6a,10a-pentamethyl-7-(4-methylpent-3-en-1-yl)-1,2,3,4,4a,5,6,6a,7,8,9,10,10a,11,12,12a-hexadecahydrochrysen-2-ol
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?
3-[(3E,7E,15E)-16-ethyl-3,7,12,20-tetramethylhenicosa-3,7,11,15,19-pentaen-1-yl]-2,2-dimethyloxirane
?
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ethylation at C10 or C15
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-
?
(3S)-2,3-epoxy-2,3-dihydrosqualene
achilleol A
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reaction of mutant H234W/Y510W
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?
(3S)-2,3-epoxy-2,3-dihydrosqualene
achilleol A
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reaction of mutant Q450H
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?
(3S)-2,3-epoxy-2,3-dihydrosqualene
lanosterol
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reaction of wild-type enzyme, via intermediates parkeol and protosta-12,24-dien-3-beta-ol
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?
(3S)-2,3-epoxy-2,3-dihydrosqualene
lanosterol
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?
(3S)-2,3-epoxy-2,3-dihydrosqualene
lanosterol
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reaction of wild-type enzyme
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?
(3S)-2,3-epoxy-2,3-dihydrosqualene
lanosterol
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the enzyme performs the polycyclization reaction by folding the substrate in a chair-boat-chair-chair conformation
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?
(3S)-2,3-epoxy-2,3-dihydrosqualene
parkeol
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reaction of mutant T384Y/Q450H/V454I
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?
(3S)-2,3-oxidosqualene
lanosterol
reaction is completely regio- and stereospecific
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?
(S)-2,3-epoxysqualene
lanosterol
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formation of lanosterol the first sterol precursor of cholesterol in mammals
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?
(S)-2,3-epoxysqualene
lanosterol
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synthesis of about 0.1% parkeol as byproduct
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?
(S)-2,3-epoxysqualene
lanosterol
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no other product observed
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?
(S)-2,3-epoxysqualene
lanosterol
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lanosterol is the only product in wild-type
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?
(S)-2,3-oxidosqualene
lanosterol
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?
2,3:22,23-diepoxysqualene
24(S),25-epoxylanosterol
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this reaction is enhanced when OSC is inhibited
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?
2,3:22,23-diepoxysqualene
24(S),25-epoxylanosterol
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this reaction is enhanced when OSC is inhibited
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?
additional information
?
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central role in sterol biosynthesis
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?
additional information
?
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mutant enzyme display altered product profiles compared to the wild-type enzyme producing also e.g. achilleol A, camelliol C, 13alphaH-isomalabarica-14(26),17E,21-trien-3beta-ol, protosta-12(13),24-dien-3beta-ol, protosta-13(17),24-dien-3beta-ol, or parkeol, overview
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-
?
additional information
?
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trypanosome and animal lanosterol synthases use different catalytic motifs
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?
additional information
?
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trypanosome and animal lanosterol synthases use different catalytic motifs
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?
