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Literature summary for 5.4.99.7 extracted from

  • Wu, T.K.; Chang, C.H.; Liu, Y.T.; Wang, T.T.
    Saccharomyces cerevisiae oxidosqualene-lanosterol cyclase: a chemistry-biology interdisciplinary study of the proteins structure-function-reaction mechanism relationships (2008), Chem. Rec., 8, 302-325.
    View publication on PubMed

Protein Variants

Protein Variants Comment Organism
F699T the mutant produces novel protosta-13(17),24-dien-3beta-ol as the sole truncated rearrangement product from (S)-2,3-oxidosqualene Saccharomyces cerevisiae
H234W/Y510V the mutant produces achilleol A, (13H)-isomalabarica-14(26),17E,21-trien-3beta-ol, and lanosterol at a 2:8:90 ratio from (S)-2,3-oxidosqualene Saccharomyces cerevisiae
H234W/Y510W mutant produces achilleol A from (S)-2,3-oxidosqualene Saccharomyces cerevisiae
H234Y/Y510A the mutant produces lanosterol from (S)-2,3-oxidosqualene (wild type reaction) Saccharomyces cerevisiae
Y510K inactive Saccharomyces cerevisiae
Y510W inactive Saccharomyces cerevisiae
Y707X the mutant produces (9R,10S)-polypoda-8(26),13E,17E,21-tetraen-3beta-ol, in addition to lanosterol, parkeol, and 9beta-lanosta-7,24-dien-3beta-ol from (S)-2,3-oxidosqualene Saccharomyces cerevisiae

Inhibitors

Inhibitors Comment Organism Structure
10,15-desdimethyl-2,3-oxidosqualene
-
Saccharomyces cerevisiae
10-desmethyl-2,3-oxidosqualene
-
Saccharomyces cerevisiae
6-desmethyl-2,3-oxidosqualene
-
Saccharomyces cerevisiae

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(S)-2,3-oxidosqualene
-
Saccharomyces cerevisiae lanosterol
-
?
2,3:22,23-diepoxysqualene
-
Saccharomyces cerevisiae 24(S),25-epoxylanosterol
-
?

Synonyms

Synonyms Comment Organism
ERG7
-
Saccharomyces cerevisiae
Oxidosqualene-lanosterol cyclase
-
Saccharomyces cerevisiae