Protein Variants | Comment | Organism |
---|---|---|
F699T | the mutant produces novel protosta-13(17),24-dien-3beta-ol as the sole truncated rearrangement product from (S)-2,3-oxidosqualene | Saccharomyces cerevisiae |
H234W/Y510V | the mutant produces achilleol A, (13H)-isomalabarica-14(26),17E,21-trien-3beta-ol, and lanosterol at a 2:8:90 ratio from (S)-2,3-oxidosqualene | Saccharomyces cerevisiae |
H234W/Y510W | mutant produces achilleol A from (S)-2,3-oxidosqualene | Saccharomyces cerevisiae |
H234Y/Y510A | the mutant produces lanosterol from (S)-2,3-oxidosqualene (wild type reaction) | Saccharomyces cerevisiae |
Y510K | inactive | Saccharomyces cerevisiae |
Y510W | inactive | Saccharomyces cerevisiae |
Y707X | the mutant produces (9R,10S)-polypoda-8(26),13E,17E,21-tetraen-3beta-ol, in addition to lanosterol, parkeol, and 9beta-lanosta-7,24-dien-3beta-ol from (S)-2,3-oxidosqualene | Saccharomyces cerevisiae |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
10,15-desdimethyl-2,3-oxidosqualene | - |
Saccharomyces cerevisiae | |
10-desmethyl-2,3-oxidosqualene | - |
Saccharomyces cerevisiae | |
6-desmethyl-2,3-oxidosqualene | - |
Saccharomyces cerevisiae |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Saccharomyces cerevisiae | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
(S)-2,3-oxidosqualene | - |
Saccharomyces cerevisiae | lanosterol | - |
? | |
2,3:22,23-diepoxysqualene | - |
Saccharomyces cerevisiae | 24(S),25-epoxylanosterol | - |
? |
Synonyms | Comment | Organism |
---|---|---|
ERG7 | - |
Saccharomyces cerevisiae |
Oxidosqualene-lanosterol cyclase | - |
Saccharomyces cerevisiae |