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Literature summary for 5.4.99.7 extracted from
- A putative precursor of isomalabaricane triterpenoids from lanosterol synthase mutants (2006), Org. Lett., 8, 439-442.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expression in yeast strains RXY6 and SMY8 | Saccharomyces cerevisiae |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| Y510F | produces lanosterol and isomalabaricatrienol in a 95:5 ratio in strain RXY6, while in strain SMY8, the ratio is 10:90 | Saccharomyces cerevisiae |
| Y510H | incomplete cyclization, produces achilleol (45%), lanosterol (42%), parkeol (9%), and isomalabaricatrienol (4%) | Saccharomyces cerevisiae |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| (S)-2,3-oxidosqualene | Saccharomyces cerevisiae | - |
lanosterol | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Saccharomyces cerevisiae | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| (S)-2,3-oxidosqualene | - |
Saccharomyces cerevisiae | lanosterol | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| lanosterol synthase | - |
Saccharomyces cerevisiae |
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Release 2023.1 (January 2023)
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