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5.4.99.7: Lanosterol synthase

This is an abbreviated version!
For detailed information about Lanosterol synthase, go to the full flat file.

Word Map on EC 5.4.99.7

Reaction

(3S)-2,3-epoxy-2,3-dihydrosqualene
=
lanosterol

Synonyms

2,3 oxidosqualene:lanosterol cyclase, 2,3-Epoxysqualene lanosterol-cyclase, 2,3-epoxysqualene--lanosterol cyclase, 2,3-Epoxysqualene-lanosterol cyclase, 2,3-Oxidosqualene cyclase, 2,3-oxidosqualene cyclase-lanosterol synthase, 2,3-Oxidosqualene sterol cyclase, 2,3-Oxidosqualene-lanosterol cyclase, 2,3-oxidosqualene:lanosterol cyclase, AtLAS, Cyclase, 2,3-oxidosqualene-lanosterol, ERG7, Erg7p, hOSC, Lanosterol 2,3-oxidosqualene cyclase, lanosterol synthase, LAS, LAS1, Lss, OSC, OSLC, Oxidosqualene cyclase, oxidosqualene cyclase/lanosterol synthase, Oxidosqualene--lanosterol cyclase, Oxidosqualene-lanosterol cyclase, oxidosqualene:lanosterol cyclase, SceOSC, Squalene 2,3-epoxide:lanosterol cyclase, Squalene 2,3-oxide-lanosterol cyclase, Squalene epoxidase-cyclase, Squalene-2,3-oxide-lanosterol cyclase, tuber-specific StLAS-like

ECTree

     5 Isomerases
         5.4 Intramolecular transferases
             5.4.99 Transferring other groups
                5.4.99.7 Lanosterol synthase

IC50 Value

IC50 Value on EC 5.4.99.7 - Lanosterol synthase

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IC50 VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.0004 - 0.0015
(14-trans)-28-methylidene-2,3:14,15-dioxidoundecanorsqualene
0.0015 - 0.0035
(18E)-29-Methylidene-2,3-oxidohexanorsqualene
0.0015 - 0.0035
(18E)-29-methylidene-2,3-oxidosqualene
0.03 - 0.05
(18E)-29-methylidene-20,21,22,23,24,30-hexanor-2,3-oxidosqualene
0.015 - 0.02
(18Z)-29-Methylidene-2,3-oxidohexanorsqualene
0.0004 - 0.001
(18Z)-29-methylidene-2,3-oxidosqualene
0.05 - 0.06
(18Z)-29-methylidene-20,21,22,23,24,30-hexanor-2,3-oxidosqualene
0.05 - 0.1
(2-trans)-1-methylidene-2,3-oxido-1'-norsqualene
0.1
(22E)-24-methylidene-30-nor-2,3-oxidosqualene
0.1
(22Z)-24-methylidene-30-nor-2,3-oxidosqualene
0.0017 - 0.0074
(2E,6E)-10-(dimethylamino)-3,7-dimethyl-2,6-decadien-1-yl 3-biphenyl-4-ylpropyl ether
0.00033 - 0.0011
(2E,6E)-10-(dimethylamino)-3,7-dimethyl-2,6-decadien-1-yl 3-phenylpropyl ether
0.00036 - 0.0027
(2E,6E)-10-(dimethylamino)-3,7-dimethyl-2,6-decadien-1-yl hexyl ether
0.0015 - 0.0025
(3-trans-7E,11E,15E)-3,4:19,20-diepoxy-7,12,16,20-tetramethyl-1,7,11,15-henicosatetraene
0.012 - 0.025
(3R,4S,7E)-15,16-epoxy-3-ethylthio-8,12,16-trimethyl-1,7,11-heptadecatrien-4-ol
0.0075 - 0.04
(3R,4S,7E,11E)-15,16-epoxy-8,12,16-trimethyl-3-phenylthio-1,7,11-heptadecatrien-4-ol
0.001 - 0.0025
(3R,4S,7E,11E,15E)-19,20-epoxy-3-ethylthio-7,12,16,20-tetramethyl-1,7,11,15-henicosatetraen-4-ol
0.000143 - 0.000326
(4-Benzenesulfonyl-piperazin-1-yl)-(3,4,5,6-tetrahydro-2H-[1,4']bipyridinyl-4-yl)-methanone
0.0000318
(4-bromophenyl)[4-[6-(cyclopropylmethylmethylamino)hexyloxy]phenyl]methanone
Homo sapiens
-
IC50: 31.8 nM
0.0000157
(4-bromophenyl)[4-[6-[(3-hydroxypropyl)methylamino]-hexyloxy]phenyl]methanone
Homo sapiens
-
IC50: 15.7 nM
0.0015 - 0.005
(5E,9E)-13,14-epoxy-6,10,14-trimethyl-1-methylthio-1,5,9-pentadecatriene
0.00005 - 0.001
(5E,9E,13E)-17,18-epoxy-5,10,14,18-tetramethyl-1-methylthio-1,5,9,13-nonadecatetraene
0.06
(5E,9E,13E,17E)-21,22-epoxy-2,9,14,18,22-pentamethyl-5-(trimethylsilylethynyl)tricosa-2,5,9,13,17-pentaene
Sus scrofa
-
+ (5Z,9E,13E,17E)-21,22-epoxy-2,9,14,18,22-pentamethyl-5-(trimethylsilylethynyl)tricosa-2,5,9,13,17-pentaene, IC50: 0.06 mM
0.018 - 0.032
(5E,9E,13E,17E)-21,22-epoxy-2,9,14,18,22-pentamethyl-5-vinyl-2,5,9,13,17-tricosapentaene
0.02 - 0.05
(5E,9E,13E,17E)-21,22-epoxy-5-ethynyl-2,9,14,18,22-pentamethyltricosa-2,5,9,13,17-pentaene
0.06
(5Z,9E,13E,17E)-21,22-epoxy-2,9,14,18,22-pentamethyl-5-(trimethylsilylethynyl)tricosa-2,5,9,13,17-pentaene
Sus scrofa
-
+ (5E,9E,13E,17E)-21,22-epoxy-2,9,14,18,22-pentamethyl-5-(trimethylsilylethynyl)tricosa-2,5,9,13,17-pentaene, IC50: 0.06 mM
0.02 - 0.05
(5Z,9E,13E,17E)-21,22-epoxy-5-ethynyl-2,9,14,18,22-pentamethyltricosa-2,5,9,13,17-pentaene
0.003 - 0.005
(6E)-10-Aza-10,11-dihydrosqualene-2,3-epoxide
0.004 - 0.005
(6E,10E,14E,18E)-22,23-epoxy-2,10,15,19,23-pentamethyl-6-vinyl-2,6,10,14,18-tetracosapentaene
0.03
(6E,10E,14E,18E)-22,23-epoxy-6-ethynyl-2,10,15,19,23-pentamethyltetracosa-2,6,10,14,18-pentaene
0.02 - 0.1
(6Z)-10-aza-10,11-dihydrosqualene-2,3-epoxide
0.0022 - 0.012
(6Z,10E,14E,18E)-22,23-epoxy-2,10,15,19,23-pentamethyl-6-(2-methylthiovinyl)-2,6,10,14,18-tetracosapentaene
0.0004 - 0.001
(6Z,10E,14E,18E)-22,23-epoxy-2,10,15,19,23-pentamethyl-6-vinyl-2,6,10,14,18-tetracosapentaene
0.03
(6Z,10E,14E,18E)-22,23-epoxy-6-ethynyl-2,10,15,19,23-pentamethyltetracosa-2,6,10,14,18-pentaene
0.000083 - 0.000124
(Z)-3-[4-(4-bromobenzoyl)phenacylidene]quinuclidine
0.000112 - 0.000398
1-(2-methyl-4-pyrimidinyl)-4-(1-(4-bromophenylsulfonyl)piperazin-4-ylcarbonyl)piperidine
0.000082
1-(4-iodophenylsulfonyl)-4-(1-(4-pyridyl)piperidon-4-ylcarbonyl)piperazine
Rattus norvegicus
-
IC50: 82 nM
0.000037 - 0.000116
1-(4-pyrimidinyl)-4-(1-(4-bromophenylsulfonyl)piperazin-4-ylcarbonyl)piperidine
0.00002
1-[4-(trifluoromethoxy)phenylcarbonyl]-4-[4-(dimethylaminomethyl)phenylmeth yl]-piperazine
Homo sapiens
-
-
0.000316
1-[4-chlorobenzyl]-4-[4-(pyridin-4-yl)phenylmethyl]-piperazine
Homo sapiens
-
-
0.0002
1-[4-chlorophenylcarbonyl]-4-[4-(1-methyl-pyrazol-4-yl)phenylmethyl]-piperazine
Homo sapiens
-
-
0.0002
1-[4-chlorophenylcarbonyl]-4-[4-(5-methyl-1,2,4-oxadiazol-3-yl)phenylmethyl]-piperazine
Homo sapiens
-
-
0.00004
1-[4-chlorophenylcarbonyl]-4-[4-(dimethylaminomethyl)phenylmethyl]-piperazine
Homo sapiens
-
-
0.000032
1-[4-chlorophenylcarbonyl]-4-[4-(imidazol-1-yl)phenylmethyl]-piperazine
Homo sapiens
-
-
0.0002
1-[4-chlorophenylcarbonyl]-4-[4-(pyrazol-1-yl)phenylmethyl]-piperazine
Homo sapiens
-
-
0.0002
1-[4-chlorophenylcarbonyl]-4-[4-(pyrazol-3-yl)phenylmethyl]-piperazine
Homo sapiens
-
-
0.000003
1-[4-chlorophenylcarbonyl]-4-[4-(pyridin-4-yl)phenylmethyl]-piperazine
Homo sapiens
-
-
0.0005
1-[4-chlorophenylsulfonyl]-4-[3-(pyridin-4-yl)phenylmethyl]-piperazine
Homo sapiens
-
-
0.000006
1-[4-chlorophenylsulfonyl]-4-[4-(4-methylpiperazin-1-yl)phenylmethyl]-piperazine
Homo sapiens
-
-
0.000032
1-[4-chlorophenylsulfonyl]-4-[4-(dimethylaminomethyl)phenylmethyl]-piperazine
Homo sapiens
-
-
0.000013
1-[4-chlorophenylsulfonyl]-4-[4-(pyridin-4-yl)phenylmethyl]-piperazine
Homo sapiens
-
-
0.002511
1-[4-methoxyphenylcarbonyl]-4-[4-(pyridin-4-yl)phenylmethyl]-piperazine
Homo sapiens
-
-
0.0002
1-[4-trifluoroacetyl]-4-[4-(imidazol-1-yl)phenylmethyl]-piperazine
Homo sapiens
-
-
0.1
18,19-dihydro-29-methylidene-2,3-oxidosqualene
Sus scrofa
-
IC50: 0.1 mM
0.015 - 0.07
18-heptanor-2,3-oxidosqualene
0.0015 - 0.035
19-aza-18,19,22,23-tetrahydrosqualene-2,3-epoxide
0.15 - 10
2-Aza-2,3-dihydrosqualene
3.3 - 16
2-Aza-2,3-dihydrosqualene N-oxide
0.0025 - 0.006
2-[(4E,8E)-12,13-epoxy-5,9,13-trimethyl-4,8-tetradecadienylidene]-1,3-dithiane
0.0035 - 0.012
2-[(4E,8E,12E)-16,17-epoxy-4,9,13,17-tetramethyl-4,8,12-octadecatrienylidene]-1,3-benzodithiole
0.00017 - 0.00035
2-[(4E,8E,12E)-16,17-epoxy-4,9,13,17-tetramethyl-4,8,12-octadecatrienylidene]-1,3-dithiane
0.035 - 0.1
2-[(4E,8E,12E,16E)-20,21-epoxy-4,8,13,17,21-pentamethyl-4,8,12,16-docosatetraenylidene]-1,3-dithiane
0.18
27-norsqualene
Sus scrofa
-
pH 7.4, 37°C, liver microsomes
0.076
29-norsqualene
Sus scrofa
-
pH 7.4, 37°C, liver microsomes
0.0015 - 0.0035
3-(3,7-Dimethyl-octadeca-3,7,11,15-tetraenyl)-2,2-dimethyl-oxirane
0.00028 - 0.016
3-(biphenyl-4-yloxy)-N,N-dimethylpropan-1-amine
0.00016
3-[(4-chlorobenzoyl)-4-phenoxy]quinuclidine
Rattus norvegicus
-
IC50: 160 nM
0.0000041
allyl-6-[4-(4-bromophenyl)-1H-benzo[d][1,2]oxazin-7-yloxy]hexylmethylamine
Homo sapiens
-
IC50: 4.1 nM
0.0000079
allyl[6-[1-(4-bromophenyl)-3,4-dihydroisoquinolin-6-yloxy]hexyl]methylamine
Homo sapiens
-
IC50: 7.9 nM
0.0000035
allyl[6-[1-(4-bromophenyl)isoquinolin-6-yloxy]hexyl]methylamine
Homo sapiens
-
IC50: 3.5 nM
0.0000196
allyl[6-[3-(4-bromophenyl)-1-methyl-1H-indazol-6-yloxy]hexyl]methylamine
Homo sapiens
-
IC50: 19.6 nM
0.0000056
allyl[6-[3-(4-bromophenyl)benzo[b]thiophen-6-yloxy]hexyl]methylamine
Homo sapiens
-
IC50: 5.6 nM
0.0000029
allyl[6-[3-(4-bromophenyl)benzo[d]isothiazol-6-yloxy]hexyl]methylamine
Homo sapiens
-
IC50: 2.9 nM
0.0000114
allyl[6-[4-(4-bromophenyl)-2H-chromen-7-yloxy]hexyl]methylamine
Homo sapiens
-
IC50: 11.4 nM
0.0000123
allyl[6-[4-(4-bromophenyl)quinazolin-7-yloxy]hexyl]methylamine
Homo sapiens
-
IC50: 12.3 nM
0.0000078
allyl[6-[4-(6-bromo-1,1-dioxobenzo[d]isothiazol-3-yl)phenoxy]hexyl]methylamine
Homo sapiens
-
IC50: 7.8 nM
0.055
azasqualene alcohol N-oxide
0.00000585
BIBB 515
Homo sapiens
-
-
1.5 - 14
diethyl-(4,8,13,17,21-pentamethyl-docosa-4,8,12,16,20-pentaenyl)-aminoxide
3.2 - 12.5
Diethyl-(4,8,13,17,21-pentamethyl-docosa-4,8,12,16,20-pentaenyl)-ammonium
0.005
N,N-dimethyl-N-(4-methylenebenzophenonyl)amine
Bos taurus
-
IC50: 0.005 mM
0.059
N-(2-methylenebenzophenonyl)pyridinium
Bos taurus
-
IC50: 0.059 mM
0.016
N-(3-methylenebenzophenonyl)pyridinium bromide
Bos taurus
-
IC50: 0.016 mM
0.00079
N-(4-methylenebenzophenonyl)pyridinium bromide
Bos taurus
-
IC50: 0.00079 mM
0.0002
N-[2-(4-(3-dimethylaminomethylphenyl)phenyl)ethyl]-4-cyanobenzenesulfonamide
Homo sapiens
-
-
0.000063
N-[2-(4-(4-((pyrrolidin-1-yl)methyl)phenyl)phenyl)ethyl]-4-chlorobenzenesulfonamide
Homo sapiens
-
-
0.000028
N-[2-(4-(4-dimethylaminomethylphenyl)phenyl)ethyl]-4-cyanobenzenesulfonamide
Homo sapiens
-
-
0.0025
N-[3-(1,1'-biphenyl-4-yloxy)propyl]-N,N-dimethylamine
Rattus norvegicus
-
IC50: 2500 nM
0.0000065 - 0.000008
Ro 48-8071
0.000022
Ro48-8071
Bos taurus
-
IC50: 22 nM
5.1 - 13.3
Trimethyl-(4,8,13,17,21-pentamethyl-docosa-4,8,12,16,20-pentaenyl)-ammonium
0.000022 - 0.0004
[4-(1-azabicyclo[2.2.2]oct-3-yloxy)phenyl](4-chlorophenyl)methanone
0.000161 - 0.000228
[4-(4-Bromo-benzenesulfonyl)-piperazin-1-yl]-(3,4,5,6-tetrahydro-2H-[1,4']bipyridinyl-4-yl)-methanone
0.0000063
[4-[6-(allylmethylamino)hexyloxy]-2-hydroxyphenyl](4-bromophenyl)methanone
Homo sapiens
-
IC50: 6.3 nM
0.0000046
[4-[6-(allylmethylamino)hexyloxy]-2-methoxyphenyl](4-bromophenyl)methanone
Homo sapiens
-
IC50: 4.6 nM
0.0000041
[4-[6-(allylmethylamino)hexyloxy]-2-methylaminophenyl](4-bromophenyl)methanone
Homo sapiens
-
IC50: 4.1 nM
0.0000062
[4-[6-(allylmethylamino)hexyloxy]-2-methylsulfanylphenyl](4-bromophenyl)methanone
Homo sapiens
-
IC50: 6.2 nM
0.0000054
[4-[6-(allylmethylamino)hexyloxy]phenyl](4-bromophenol)methanone
Homo sapiens
-
IC50: 5.4 nM
0.0000019
[4-[6-(allylmethylamino)hexyloxy]phenyl](4-nitrophenyl)methanone
Homo sapiens
-
IC50: 1.9 nM
0.0000067
[4-[6-(allylmethylamino)hexyloxy]phenyl]-(4-fluorophenyl)methanone
Homo sapiens
-
IC50: 6.7 nM
0.0000225
[4-[6-(allylmethylamino)hexyloxy]phenyl]phenylmethanone
Homo sapiens
-
IC50: 22.5 nM
0.000049
[5-(4-(4-chloro-benzoyl)-3-fluoro-phenoxy)-pentyl]-methyl-propyl-ammonium fumarate
Rattus norvegicus
-
IC50: 49 nM
0.0000087
[6-[6-(allylmethylamino)hexyloxy]pyridin-3-yl](4-bromophenyl)methanone
Homo sapiens
-
IC50: 8.7 nM
0.0000353
[6-[6-(cyclopropylmethylamino)hexyloxy]phenyl](4-bromophenyl)methanone
Homo sapiens
-
IC50: 35.3 nM
0.00009
{4-[4-(4,5-Dihydro-oxazol-2-yl)-benzylidene]-piperidin-1-yl}-(4-trifluoromethyl-phenyl)-methanone
Rattus norvegicus
-
IC50: 90 nM, complete inhibition at 0.001 nM
0.0000043 - 0.000071
{4-[6-(allyl-methyl-amino)-hexyloxy]-2-fluoro-phenyl}-(4-chloro-phenyl)-methanone