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0.0004 - 0.0015
(14-trans)-28-methylidene-2,3:14,15-dioxidoundecanorsqualene
0.0015 - 0.0035
(18E)-29-Methylidene-2,3-oxidohexanorsqualene
0.0015 - 0.0035
(18E)-29-methylidene-2,3-oxidosqualene
0.03 - 0.05
(18E)-29-methylidene-20,21,22,23,24,30-hexanor-2,3-oxidosqualene
0.015 - 0.02
(18Z)-29-Methylidene-2,3-oxidohexanorsqualene
0.0004 - 0.001
(18Z)-29-methylidene-2,3-oxidosqualene
0.05 - 0.06
(18Z)-29-methylidene-20,21,22,23,24,30-hexanor-2,3-oxidosqualene
0.05 - 0.1
(2-trans)-1-methylidene-2,3-oxido-1'-norsqualene
0.1
(22E)-24-methylidene-30-nor-2,3-oxidosqualene
0.1
(22Z)-24-methylidene-30-nor-2,3-oxidosqualene
0.0017 - 0.0074
(2E,6E)-10-(dimethylamino)-3,7-dimethyl-2,6-decadien-1-yl 3-biphenyl-4-ylpropyl ether
0.00033 - 0.0011
(2E,6E)-10-(dimethylamino)-3,7-dimethyl-2,6-decadien-1-yl 3-phenylpropyl ether
0.00036 - 0.0027
(2E,6E)-10-(dimethylamino)-3,7-dimethyl-2,6-decadien-1-yl hexyl ether
0.0015 - 0.0025
(3-trans-7E,11E,15E)-3,4:19,20-diepoxy-7,12,16,20-tetramethyl-1,7,11,15-henicosatetraene
0.012 - 0.025
(3R,4S,7E)-15,16-epoxy-3-ethylthio-8,12,16-trimethyl-1,7,11-heptadecatrien-4-ol
0.0075 - 0.04
(3R,4S,7E,11E)-15,16-epoxy-8,12,16-trimethyl-3-phenylthio-1,7,11-heptadecatrien-4-ol
0.001 - 0.0025
(3R,4S,7E,11E,15E)-19,20-epoxy-3-ethylthio-7,12,16,20-tetramethyl-1,7,11,15-henicosatetraen-4-ol
0.000143 - 0.000326
(4-Benzenesulfonyl-piperazin-1-yl)-(3,4,5,6-tetrahydro-2H-[1,4']bipyridinyl-4-yl)-methanone
0.0000318
(4-bromophenyl)[4-[6-(cyclopropylmethylmethylamino)hexyloxy]phenyl]methanone
Homo sapiens
-
IC50: 31.8 nM
0.0000157
(4-bromophenyl)[4-[6-[(3-hydroxypropyl)methylamino]-hexyloxy]phenyl]methanone
Homo sapiens
-
IC50: 15.7 nM
0.0015 - 0.005
(5E,9E)-13,14-epoxy-6,10,14-trimethyl-1-methylthio-1,5,9-pentadecatriene
0.00005 - 0.001
(5E,9E,13E)-17,18-epoxy-5,10,14,18-tetramethyl-1-methylthio-1,5,9,13-nonadecatetraene
0.06
(5E,9E,13E,17E)-21,22-epoxy-2,9,14,18,22-pentamethyl-5-(trimethylsilylethynyl)tricosa-2,5,9,13,17-pentaene
Sus scrofa
-
+ (5Z,9E,13E,17E)-21,22-epoxy-2,9,14,18,22-pentamethyl-5-(trimethylsilylethynyl)tricosa-2,5,9,13,17-pentaene, IC50: 0.06 mM
0.018 - 0.032
(5E,9E,13E,17E)-21,22-epoxy-2,9,14,18,22-pentamethyl-5-vinyl-2,5,9,13,17-tricosapentaene
0.02 - 0.05
(5E,9E,13E,17E)-21,22-epoxy-5-ethynyl-2,9,14,18,22-pentamethyltricosa-2,5,9,13,17-pentaene
0.06
(5Z,9E,13E,17E)-21,22-epoxy-2,9,14,18,22-pentamethyl-5-(trimethylsilylethynyl)tricosa-2,5,9,13,17-pentaene
Sus scrofa
-
+ (5E,9E,13E,17E)-21,22-epoxy-2,9,14,18,22-pentamethyl-5-(trimethylsilylethynyl)tricosa-2,5,9,13,17-pentaene, IC50: 0.06 mM
0.02 - 0.05
(5Z,9E,13E,17E)-21,22-epoxy-5-ethynyl-2,9,14,18,22-pentamethyltricosa-2,5,9,13,17-pentaene
0.003 - 0.005
(6E)-10-Aza-10,11-dihydrosqualene-2,3-epoxide
0.004 - 0.005
(6E,10E,14E,18E)-22,23-epoxy-2,10,15,19,23-pentamethyl-6-vinyl-2,6,10,14,18-tetracosapentaene
0.03
(6E,10E,14E,18E)-22,23-epoxy-6-ethynyl-2,10,15,19,23-pentamethyltetracosa-2,6,10,14,18-pentaene
0.02 - 0.1
(6Z)-10-aza-10,11-dihydrosqualene-2,3-epoxide
0.0022 - 0.012
(6Z,10E,14E,18E)-22,23-epoxy-2,10,15,19,23-pentamethyl-6-(2-methylthiovinyl)-2,6,10,14,18-tetracosapentaene
0.0004 - 0.001
(6Z,10E,14E,18E)-22,23-epoxy-2,10,15,19,23-pentamethyl-6-vinyl-2,6,10,14,18-tetracosapentaene
0.03
(6Z,10E,14E,18E)-22,23-epoxy-6-ethynyl-2,10,15,19,23-pentamethyltetracosa-2,6,10,14,18-pentaene
0.000083 - 0.000124
(Z)-3-[4-(4-bromobenzoyl)phenacylidene]quinuclidine
0.000112 - 0.000398
1-(2-methyl-4-pyrimidinyl)-4-(1-(4-bromophenylsulfonyl)piperazin-4-ylcarbonyl)piperidine
0.000082
1-(4-iodophenylsulfonyl)-4-(1-(4-pyridyl)piperidon-4-ylcarbonyl)piperazine
Rattus norvegicus
-
IC50: 82 nM
0.000037 - 0.000116
1-(4-pyrimidinyl)-4-(1-(4-bromophenylsulfonyl)piperazin-4-ylcarbonyl)piperidine
0.00002
1-[4-(trifluoromethoxy)phenylcarbonyl]-4-[4-(dimethylaminomethyl)phenylmeth yl]-piperazine
Homo sapiens
-
-
0.000316
1-[4-chlorobenzyl]-4-[4-(pyridin-4-yl)phenylmethyl]-piperazine
Homo sapiens
-
-
0.0002
1-[4-chlorophenylcarbonyl]-4-[4-(1-methyl-pyrazol-4-yl)phenylmethyl]-piperazine
Homo sapiens
-
-
0.0002
1-[4-chlorophenylcarbonyl]-4-[4-(5-methyl-1,2,4-oxadiazol-3-yl)phenylmethyl]-piperazine
Homo sapiens
-
-
0.00004
1-[4-chlorophenylcarbonyl]-4-[4-(dimethylaminomethyl)phenylmethyl]-piperazine
Homo sapiens
-
-
0.000032
1-[4-chlorophenylcarbonyl]-4-[4-(imidazol-1-yl)phenylmethyl]-piperazine
Homo sapiens
-
-
0.0002
1-[4-chlorophenylcarbonyl]-4-[4-(pyrazol-1-yl)phenylmethyl]-piperazine
Homo sapiens
-
-
0.0002
1-[4-chlorophenylcarbonyl]-4-[4-(pyrazol-3-yl)phenylmethyl]-piperazine
Homo sapiens
-
-
0.000003
1-[4-chlorophenylcarbonyl]-4-[4-(pyridin-4-yl)phenylmethyl]-piperazine
Homo sapiens
-
-
0.0005
1-[4-chlorophenylsulfonyl]-4-[3-(pyridin-4-yl)phenylmethyl]-piperazine
Homo sapiens
-
-
0.000006
1-[4-chlorophenylsulfonyl]-4-[4-(4-methylpiperazin-1-yl)phenylmethyl]-piperazine
Homo sapiens
-
-
0.000032
1-[4-chlorophenylsulfonyl]-4-[4-(dimethylaminomethyl)phenylmethyl]-piperazine
Homo sapiens
-
-
0.000013
1-[4-chlorophenylsulfonyl]-4-[4-(pyridin-4-yl)phenylmethyl]-piperazine
Homo sapiens
-
-
0.002511
1-[4-methoxyphenylcarbonyl]-4-[4-(pyridin-4-yl)phenylmethyl]-piperazine
Homo sapiens
-
-
0.0002
1-[4-trifluoroacetyl]-4-[4-(imidazol-1-yl)phenylmethyl]-piperazine
Homo sapiens
-
-
0.1
18,19-dihydro-29-methylidene-2,3-oxidosqualene
Sus scrofa
-
IC50: 0.1 mM
0.015 - 0.07
18-heptanor-2,3-oxidosqualene
0.0015 - 0.035
19-aza-18,19,22,23-tetrahydrosqualene-2,3-epoxide
0.15 - 10
2-Aza-2,3-dihydrosqualene
3.3 - 16
2-Aza-2,3-dihydrosqualene N-oxide
0.0025 - 0.006
2-[(4E,8E)-12,13-epoxy-5,9,13-trimethyl-4,8-tetradecadienylidene]-1,3-dithiane
0.0035 - 0.012
2-[(4E,8E,12E)-16,17-epoxy-4,9,13,17-tetramethyl-4,8,12-octadecatrienylidene]-1,3-benzodithiole
0.00017 - 0.00035
2-[(4E,8E,12E)-16,17-epoxy-4,9,13,17-tetramethyl-4,8,12-octadecatrienylidene]-1,3-dithiane
0.035 - 0.1
2-[(4E,8E,12E,16E)-20,21-epoxy-4,8,13,17,21-pentamethyl-4,8,12,16-docosatetraenylidene]-1,3-dithiane
0.18
27-norsqualene
Sus scrofa
-
pH 7.4, 37°C, liver microsomes
0.076
29-norsqualene
Sus scrofa
-
pH 7.4, 37°C, liver microsomes
0.0015 - 0.0035
3-(3,7-Dimethyl-octadeca-3,7,11,15-tetraenyl)-2,2-dimethyl-oxirane
0.00028 - 0.016
3-(biphenyl-4-yloxy)-N,N-dimethylpropan-1-amine
0.00016
3-[(4-chlorobenzoyl)-4-phenoxy]quinuclidine
Rattus norvegicus
-
IC50: 160 nM
0.0000041
allyl-6-[4-(4-bromophenyl)-1H-benzo[d][1,2]oxazin-7-yloxy]hexylmethylamine
Homo sapiens
-
IC50: 4.1 nM
0.0000079
allyl[6-[1-(4-bromophenyl)-3,4-dihydroisoquinolin-6-yloxy]hexyl]methylamine
Homo sapiens
-
IC50: 7.9 nM
0.0000035
allyl[6-[1-(4-bromophenyl)isoquinolin-6-yloxy]hexyl]methylamine
Homo sapiens
-
IC50: 3.5 nM
0.0000196
allyl[6-[3-(4-bromophenyl)-1-methyl-1H-indazol-6-yloxy]hexyl]methylamine
Homo sapiens
-
IC50: 19.6 nM
0.0000056
allyl[6-[3-(4-bromophenyl)benzo[b]thiophen-6-yloxy]hexyl]methylamine
Homo sapiens
-
IC50: 5.6 nM
0.0000029
allyl[6-[3-(4-bromophenyl)benzo[d]isothiazol-6-yloxy]hexyl]methylamine
Homo sapiens
-
IC50: 2.9 nM
0.0000114
allyl[6-[4-(4-bromophenyl)-2H-chromen-7-yloxy]hexyl]methylamine
Homo sapiens
-
IC50: 11.4 nM
0.0000123
allyl[6-[4-(4-bromophenyl)quinazolin-7-yloxy]hexyl]methylamine
Homo sapiens
-
IC50: 12.3 nM
0.0000078
allyl[6-[4-(6-bromo-1,1-dioxobenzo[d]isothiazol-3-yl)phenoxy]hexyl]methylamine
Homo sapiens
-
IC50: 7.8 nM
0.055
azasqualene alcohol N-oxide
0.00000585
BIBB 515
Homo sapiens
-
-
1.5 - 14
diethyl-(4,8,13,17,21-pentamethyl-docosa-4,8,12,16,20-pentaenyl)-aminoxide
3.2 - 12.5
Diethyl-(4,8,13,17,21-pentamethyl-docosa-4,8,12,16,20-pentaenyl)-ammonium
0.005
N,N-dimethyl-N-(4-methylenebenzophenonyl)amine
Bos taurus
-
IC50: 0.005 mM
0.059
N-(2-methylenebenzophenonyl)pyridinium
Bos taurus
-
IC50: 0.059 mM
0.016
N-(3-methylenebenzophenonyl)pyridinium bromide
Bos taurus
-
IC50: 0.016 mM
0.00079
N-(4-methylenebenzophenonyl)pyridinium bromide
Bos taurus
-
IC50: 0.00079 mM
0.0002
N-[2-(4-(3-dimethylaminomethylphenyl)phenyl)ethyl]-4-cyanobenzenesulfonamide
Homo sapiens
-
-
0.000063
N-[2-(4-(4-((pyrrolidin-1-yl)methyl)phenyl)phenyl)ethyl]-4-chlorobenzenesulfonamide
Homo sapiens
-
-
0.000028
N-[2-(4-(4-dimethylaminomethylphenyl)phenyl)ethyl]-4-cyanobenzenesulfonamide
Homo sapiens
-
-
0.0025
N-[3-(1,1'-biphenyl-4-yloxy)propyl]-N,N-dimethylamine
Rattus norvegicus
-
IC50: 2500 nM
0.0000065 - 0.000008
Ro 48-8071
0.000022
Ro48-8071
Bos taurus
-
IC50: 22 nM
5.1 - 13.3
Trimethyl-(4,8,13,17,21-pentamethyl-docosa-4,8,12,16,20-pentaenyl)-ammonium
0.000022 - 0.0004
[4-(1-azabicyclo[2.2.2]oct-3-yloxy)phenyl](4-chlorophenyl)methanone
0.000161 - 0.000228
[4-(4-Bromo-benzenesulfonyl)-piperazin-1-yl]-(3,4,5,6-tetrahydro-2H-[1,4']bipyridinyl-4-yl)-methanone
0.0000063
[4-[6-(allylmethylamino)hexyloxy]-2-hydroxyphenyl](4-bromophenyl)methanone
Homo sapiens
-
IC50: 6.3 nM
0.0000046
[4-[6-(allylmethylamino)hexyloxy]-2-methoxyphenyl](4-bromophenyl)methanone
Homo sapiens
-
IC50: 4.6 nM
0.0000041
[4-[6-(allylmethylamino)hexyloxy]-2-methylaminophenyl](4-bromophenyl)methanone
Homo sapiens
-
IC50: 4.1 nM
0.0000062
[4-[6-(allylmethylamino)hexyloxy]-2-methylsulfanylphenyl](4-bromophenyl)methanone
Homo sapiens
-
IC50: 6.2 nM
0.0000054
[4-[6-(allylmethylamino)hexyloxy]phenyl](4-bromophenol)methanone
Homo sapiens
-
IC50: 5.4 nM
0.0000019
[4-[6-(allylmethylamino)hexyloxy]phenyl](4-nitrophenyl)methanone
Homo sapiens
-
IC50: 1.9 nM
0.0000067
[4-[6-(allylmethylamino)hexyloxy]phenyl]-(4-fluorophenyl)methanone
Homo sapiens
-
IC50: 6.7 nM
0.0000225
[4-[6-(allylmethylamino)hexyloxy]phenyl]phenylmethanone
Homo sapiens
-
IC50: 22.5 nM
0.000049
[5-(4-(4-chloro-benzoyl)-3-fluoro-phenoxy)-pentyl]-methyl-propyl-ammonium fumarate
Rattus norvegicus
-
IC50: 49 nM
0.0000087
[6-[6-(allylmethylamino)hexyloxy]pyridin-3-yl](4-bromophenyl)methanone
Homo sapiens
-
IC50: 8.7 nM
0.0000353
[6-[6-(cyclopropylmethylamino)hexyloxy]phenyl](4-bromophenyl)methanone
Homo sapiens
-
IC50: 35.3 nM
0.00009
{4-[4-(4,5-Dihydro-oxazol-2-yl)-benzylidene]-piperidin-1-yl}-(4-trifluoromethyl-phenyl)-methanone
Rattus norvegicus
-
IC50: 90 nM, complete inhibition at 0.001 nM
0.0000043 - 0.000071
{4-[6-(allyl-methyl-amino)-hexyloxy]-2-fluoro-phenyl}-(4-chloro-phenyl)-methanone
0.0004
(14-trans)-28-methylidene-2,3:14,15-dioxidoundecanorsqualene
Sus scrofa
-
IC50: 0.0004 mM
0.0015
(14-trans)-28-methylidene-2,3:14,15-dioxidoundecanorsqualene
Saccharomyces cerevisiae
-
IC50: 0.0015 mM
0.0015
(18E)-29-Methylidene-2,3-oxidohexanorsqualene
Saccharomyces cerevisiae
-
IC50: 0.0015 mM, irreversible
0.0035
(18E)-29-Methylidene-2,3-oxidohexanorsqualene
Sus scrofa
-
IC50: 0.0035 mM, irreversible
0.0015
(18E)-29-methylidene-2,3-oxidosqualene
Saccharomyces cerevisiae
-
IC50: 0.0015 mM
0.0035
(18E)-29-methylidene-2,3-oxidosqualene
Sus scrofa
-
IC50: 0.0035 mM
0.03
(18E)-29-methylidene-20,21,22,23,24,30-hexanor-2,3-oxidosqualene
Saccharomyces cerevisiae
-
IC50: 0.03 mM
0.05
(18E)-29-methylidene-20,21,22,23,24,30-hexanor-2,3-oxidosqualene
Sus scrofa
-
IC50: 0.05 mM
0.015
(18Z)-29-Methylidene-2,3-oxidohexanorsqualene
Saccharomyces cerevisiae
-
IC50: 0.015 mM
0.02
(18Z)-29-Methylidene-2,3-oxidohexanorsqualene
Sus scrofa
-
IC50: 0.02 mM
0.0004
(18Z)-29-methylidene-2,3-oxidosqualene
Sus scrofa
-
IC50: 0.0004 mM
0.001
(18Z)-29-methylidene-2,3-oxidosqualene
Saccharomyces cerevisiae
-
IC50: 0.001 mM
0.05
(18Z)-29-methylidene-20,21,22,23,24,30-hexanor-2,3-oxidosqualene
Saccharomyces cerevisiae
-
IC50: 0.05 mM
0.06
(18Z)-29-methylidene-20,21,22,23,24,30-hexanor-2,3-oxidosqualene
Sus scrofa
-
IC50: 0.06 mM
0.05
(2-trans)-1-methylidene-2,3-oxido-1'-norsqualene
Saccharomyces cerevisiae
-
IC50: 0.05 mM
0.1
(2-trans)-1-methylidene-2,3-oxido-1'-norsqualene
Sus scrofa
-
IC50: 0.1 mM
0.1
(22E)-24-methylidene-30-nor-2,3-oxidosqualene
Sus scrofa
-
IC50: above 0.1 mM
0.1
(22E)-24-methylidene-30-nor-2,3-oxidosqualene
Saccharomyces cerevisiae
-
IC50: above 0.1 mM
0.1
(22Z)-24-methylidene-30-nor-2,3-oxidosqualene
Sus scrofa
-
IC50: above 0.1 mM
0.1
(22Z)-24-methylidene-30-nor-2,3-oxidosqualene
Saccharomyces cerevisiae
-
IC50: above 0.1 mM
0.0017
(2E,6E)-10-(dimethylamino)-3,7-dimethyl-2,6-decadien-1-yl 3-biphenyl-4-ylpropyl ether
Pneumocystis carinii
-
-
0.0045
(2E,6E)-10-(dimethylamino)-3,7-dimethyl-2,6-decadien-1-yl 3-biphenyl-4-ylpropyl ether
Homo sapiens
-
-
0.0074
(2E,6E)-10-(dimethylamino)-3,7-dimethyl-2,6-decadien-1-yl 3-biphenyl-4-ylpropyl ether
Trypanosoma cruzi
-
-
0.00033
(2E,6E)-10-(dimethylamino)-3,7-dimethyl-2,6-decadien-1-yl 3-phenylpropyl ether
Pneumocystis carinii
-
-
0.00045
(2E,6E)-10-(dimethylamino)-3,7-dimethyl-2,6-decadien-1-yl 3-phenylpropyl ether
Saccharomyces cerevisiae
-
-
0.00047
(2E,6E)-10-(dimethylamino)-3,7-dimethyl-2,6-decadien-1-yl 3-phenylpropyl ether
Trypanosoma cruzi
-
-
0.0011
(2E,6E)-10-(dimethylamino)-3,7-dimethyl-2,6-decadien-1-yl 3-phenylpropyl ether
Homo sapiens
-
-
0.00036
(2E,6E)-10-(dimethylamino)-3,7-dimethyl-2,6-decadien-1-yl hexyl ether
Pneumocystis carinii
-
-
0.00085
(2E,6E)-10-(dimethylamino)-3,7-dimethyl-2,6-decadien-1-yl hexyl ether
Homo sapiens
-
-
0.00178
(2E,6E)-10-(dimethylamino)-3,7-dimethyl-2,6-decadien-1-yl hexyl ether
Saccharomyces cerevisiae
-
-
0.0027
(2E,6E)-10-(dimethylamino)-3,7-dimethyl-2,6-decadien-1-yl hexyl ether
Trypanosoma cruzi
-
-
0.0015
(3-trans-7E,11E,15E)-3,4:19,20-diepoxy-7,12,16,20-tetramethyl-1,7,11,15-henicosatetraene
Saccharomyces cerevisiae
-
IC50: 0.0015 mM
0.0025
(3-trans-7E,11E,15E)-3,4:19,20-diepoxy-7,12,16,20-tetramethyl-1,7,11,15-henicosatetraene
Sus scrofa
-
IC50: 0.0025 mM
0.012
(3R,4S,7E)-15,16-epoxy-3-ethylthio-8,12,16-trimethyl-1,7,11-heptadecatrien-4-ol
Sus scrofa
-
IC50: 0.012 mM
0.025
(3R,4S,7E)-15,16-epoxy-3-ethylthio-8,12,16-trimethyl-1,7,11-heptadecatrien-4-ol
Saccharomyces cerevisiae
-
IC50: 0.025 mM
0.0075
(3R,4S,7E,11E)-15,16-epoxy-8,12,16-trimethyl-3-phenylthio-1,7,11-heptadecatrien-4-ol
Sus scrofa
-
IC50: 0.0075 mM
0.04
(3R,4S,7E,11E)-15,16-epoxy-8,12,16-trimethyl-3-phenylthio-1,7,11-heptadecatrien-4-ol
Saccharomyces cerevisiae
-
IC50: 0.04 mM
0.001
(3R,4S,7E,11E,15E)-19,20-epoxy-3-ethylthio-7,12,16,20-tetramethyl-1,7,11,15-henicosatetraen-4-ol
Sus scrofa
-
IC50: 0.001 mM
0.0025
(3R,4S,7E,11E,15E)-19,20-epoxy-3-ethylthio-7,12,16,20-tetramethyl-1,7,11,15-henicosatetraen-4-ol
Saccharomyces cerevisiae
-
IC50: 0.0025 mM
0.000143
(4-Benzenesulfonyl-piperazin-1-yl)-(3,4,5,6-tetrahydro-2H-[1,4']bipyridinyl-4-yl)-methanone
Homo sapiens
-
IC50: 143 nM
0.000326
(4-Benzenesulfonyl-piperazin-1-yl)-(3,4,5,6-tetrahydro-2H-[1,4']bipyridinyl-4-yl)-methanone
Rattus norvegicus
-
IC50: 326 nM
0.0015
(5E,9E)-13,14-epoxy-6,10,14-trimethyl-1-methylthio-1,5,9-pentadecatriene
Saccharomyces cerevisiae
-
IC50: 0.0015 mM
0.005
(5E,9E)-13,14-epoxy-6,10,14-trimethyl-1-methylthio-1,5,9-pentadecatriene
Sus scrofa
-
IC50: 0.005 mM
0.00005
(5E,9E,13E)-17,18-epoxy-5,10,14,18-tetramethyl-1-methylthio-1,5,9,13-nonadecatetraene
Saccharomyces cerevisiae
-
IC50: 0.00005 mM
0.001
(5E,9E,13E)-17,18-epoxy-5,10,14,18-tetramethyl-1-methylthio-1,5,9,13-nonadecatetraene
Sus scrofa
-
IC50: 0.001 mM
0.018
(5E,9E,13E,17E)-21,22-epoxy-2,9,14,18,22-pentamethyl-5-vinyl-2,5,9,13,17-tricosapentaene
Saccharomyces cerevisiae
-
IC50: 0.018 mM
0.032
(5E,9E,13E,17E)-21,22-epoxy-2,9,14,18,22-pentamethyl-5-vinyl-2,5,9,13,17-tricosapentaene
Sus scrofa
-
IC50: 0.032 mM
0.02
(5E,9E,13E,17E)-21,22-epoxy-5-ethynyl-2,9,14,18,22-pentamethyltricosa-2,5,9,13,17-pentaene
Sus scrofa
-
+ (5Z,9E,13E,17E)-21,22-epoxy-5-ethynyl-2,9,14,18,22-pentamethyltricosa-2,5,9,13,17-pentaene, IC50: 0.02 mM
0.05
(5E,9E,13E,17E)-21,22-epoxy-5-ethynyl-2,9,14,18,22-pentamethyltricosa-2,5,9,13,17-pentaene
Saccharomyces cerevisiae
-
+ (5Z,9E,13E,17E)-21,22-epoxy-5-ethynyl-2,9,14,18,22-pentamethyltricosa-2,5,9,13,17-pentaene, IC50: 0.05 mM
0.02
(5Z,9E,13E,17E)-21,22-epoxy-5-ethynyl-2,9,14,18,22-pentamethyltricosa-2,5,9,13,17-pentaene
Sus scrofa
-
+ (5E,9E,13E,17E)-21,22-epoxy-5-ethynyl-2,9,14,18,22-pentamethyltricosa-2,5,9,13,17-pentaene, IC50: 0.02 mM
0.05
(5Z,9E,13E,17E)-21,22-epoxy-5-ethynyl-2,9,14,18,22-pentamethyltricosa-2,5,9,13,17-pentaene
Saccharomyces cerevisiae
-
+ (5E,9E,13E,17E)-21,22-epoxy-5-ethynyl-2,9,14,18,22-pentamethyltricosa-2,5,9,13,17-pentaene, IC50: 0.05 mM
0.003
(6E)-10-Aza-10,11-dihydrosqualene-2,3-epoxide
Candida albicans
-
IC50: 0.003 mM, at a protein concentration of 3 mg/ml
0.0048
(6E)-10-Aza-10,11-dihydrosqualene-2,3-epoxide
Rattus norvegicus
-
IC50: 0.0048 mM, at a protein concentration of 5 mg/ml
0.005
(6E)-10-Aza-10,11-dihydrosqualene-2,3-epoxide
Sus scrofa
-
IC50: 0.005 mM, at a protein concentration of 1 mg/ml
0.005
(6E)-10-Aza-10,11-dihydrosqualene-2,3-epoxide
Saccharomyces cerevisiae
-
IC50: 0.005 mM, at a protein concentration of 2 mg/ml
0.004
(6E,10E,14E,18E)-22,23-epoxy-2,10,15,19,23-pentamethyl-6-vinyl-2,6,10,14,18-tetracosapentaene
Sus scrofa
-
IC50: 0.004 mM
0.005
(6E,10E,14E,18E)-22,23-epoxy-2,10,15,19,23-pentamethyl-6-vinyl-2,6,10,14,18-tetracosapentaene
Saccharomyces cerevisiae
-
IC50: 0.005 mM
0.03
(6E,10E,14E,18E)-22,23-epoxy-6-ethynyl-2,10,15,19,23-pentamethyltetracosa-2,6,10,14,18-pentaene
Sus scrofa
-
+ (6Z,10E,14E,18E)-22,23-epoxy-6-ethynyl-2,10,15,19,23-pentamethyltetracosa-2,6,10,14,18-pentaene, IC50: 0.03 mM
0.03
(6E,10E,14E,18E)-22,23-epoxy-6-ethynyl-2,10,15,19,23-pentamethyltetracosa-2,6,10,14,18-pentaene
Saccharomyces cerevisiae
-
+ (6Z,10E,14E,18E)-22,23-epoxy-6-ethynyl-2,10,15,19,23-pentamethyltetracosa-2,6,10,14,18-pentaene, IC50: 0.03 mM
0.02
(6Z)-10-aza-10,11-dihydrosqualene-2,3-epoxide
Rattus norvegicus
-
IC50: above 0.02 mM, at a protein concentration of 5 mg/ml
0.1
(6Z)-10-aza-10,11-dihydrosqualene-2,3-epoxide
Saccharomyces cerevisiae
-
IC50: above 0.1 mM, at a protein concentration of 2 mg/ml
0.1
(6Z)-10-aza-10,11-dihydrosqualene-2,3-epoxide
Candida albicans
-
IC50: above 0.1 mM, at a protein concentration of 3 mg/ml
0.0022
(6Z,10E,14E,18E)-22,23-epoxy-2,10,15,19,23-pentamethyl-6-(2-methylthiovinyl)-2,6,10,14,18-tetracosapentaene
Sus scrofa
-
IC50: 0.0022 mM
0.012
(6Z,10E,14E,18E)-22,23-epoxy-2,10,15,19,23-pentamethyl-6-(2-methylthiovinyl)-2,6,10,14,18-tetracosapentaene
Saccharomyces cerevisiae
-
IC50: 0.012 mM
0.0004
(6Z,10E,14E,18E)-22,23-epoxy-2,10,15,19,23-pentamethyl-6-vinyl-2,6,10,14,18-tetracosapentaene
Sus scrofa
-
IC50: 0.0004 mM
0.001
(6Z,10E,14E,18E)-22,23-epoxy-2,10,15,19,23-pentamethyl-6-vinyl-2,6,10,14,18-tetracosapentaene
Saccharomyces cerevisiae
-
IC50: 0.001 mM
0.03
(6Z,10E,14E,18E)-22,23-epoxy-6-ethynyl-2,10,15,19,23-pentamethyltetracosa-2,6,10,14,18-pentaene
Sus scrofa
-
+ (6E,10E,14E,18E)-22,23-epoxy-6-ethynyl-2,10,15,19,23-pentamethyltetracosa-2,6,10,14,18-pentaene, IC50: 0.03 mM
0.03
(6Z,10E,14E,18E)-22,23-epoxy-6-ethynyl-2,10,15,19,23-pentamethyltetracosa-2,6,10,14,18-pentaene
Saccharomyces cerevisiae
-
+ (6E,10E,14E,18E)-22,23-epoxy-6-ethynyl-2,10,15,19,23-pentamethyltetracosa-2,6,10,14,18-pentaene, IC50: 0.03 mM
0.000083
(Z)-3-[4-(4-bromobenzoyl)phenacylidene]quinuclidine
Homo sapiens
-
IC50: 83 nM, oral and selective inhibition of cholesterol biosynthesis derived from enzyme inhibition
0.000124
(Z)-3-[4-(4-bromobenzoyl)phenacylidene]quinuclidine
Rattus norvegicus
-
IC50: 124 nM, oral and selective inhibition of cholesterol biosynthesis derived from enzyme inhibition
0.000112
1-(2-methyl-4-pyrimidinyl)-4-(1-(4-bromophenylsulfonyl)piperazin-4-ylcarbonyl)piperidine
Homo sapiens
-
IC50: 112 nM
0.000398
1-(2-methyl-4-pyrimidinyl)-4-(1-(4-bromophenylsulfonyl)piperazin-4-ylcarbonyl)piperidine
Rattus norvegicus
-
76% inhibition at 0.001 mM, IC50: 398 nM
0.000037
1-(4-pyrimidinyl)-4-(1-(4-bromophenylsulfonyl)piperazin-4-ylcarbonyl)piperidine
Homo sapiens
-
IC50: 37 nM
0.000116
1-(4-pyrimidinyl)-4-(1-(4-bromophenylsulfonyl)piperazin-4-ylcarbonyl)piperidine
Rattus norvegicus
-
complete inhibition at 0.001 mM, IC50: 116 nM
0.015
18-heptanor-2,3-oxidosqualene
Sus scrofa
-
IC50: 0.015 mM
0.07
18-heptanor-2,3-oxidosqualene
Saccharomyces cerevisiae
-
IC50: 0.07 mM
0.0015
19-aza-18,19,22,23-tetrahydrosqualene-2,3-epoxide
Sus scrofa
-
IC50: 0.0015 mM
0.0075
19-aza-18,19,22,23-tetrahydrosqualene-2,3-epoxide
Rattus norvegicus
-
IC50: 0.0075 mM, protein concentration of 5 mg/ml
0.022
19-aza-18,19,22,23-tetrahydrosqualene-2,3-epoxide
Candida albicans
-
IC50: 0.022 mM, protein concentration of 3 mg/ml
0.035
19-aza-18,19,22,23-tetrahydrosqualene-2,3-epoxide
Saccharomyces cerevisiae
-
IC50: 0.035 mM, at a protein concentration of 2 mg/ml
0.15
2-Aza-2,3-dihydrosqualene
Sus scrofa
-
IC50: 2.3 mM, pig microsomes. IC50: 0.15 mM, solubilized enzyme
6.5
2-Aza-2,3-dihydrosqualene
Candida albicans
-
IC50: 6.5 mM
7.5
2-Aza-2,3-dihydrosqualene
Rattus norvegicus
-
IC50: 7.5 mM
10
2-Aza-2,3-dihydrosqualene
Saccharomyces cerevisiae
-
IC50: 10 mM
3.3
2-Aza-2,3-dihydrosqualene N-oxide
Sus scrofa
-
IC50: 7 mM, pig microsomes. IC50: 3.3 mM, solubilized enzyme
3.7
2-Aza-2,3-dihydrosqualene N-oxide
Rattus norvegicus
-
IC50: 3.7 mM
16
2-Aza-2,3-dihydrosqualene N-oxide
Saccharomyces cerevisiae
-
IC50: 16 mM
0.0025
2-[(4E,8E)-12,13-epoxy-5,9,13-trimethyl-4,8-tetradecadienylidene]-1,3-dithiane
Saccharomyces cerevisiae
-
IC50: 0.0025 mM
0.006
2-[(4E,8E)-12,13-epoxy-5,9,13-trimethyl-4,8-tetradecadienylidene]-1,3-dithiane
Sus scrofa
-
IC50: 0.006 mM
0.0035
2-[(4E,8E,12E)-16,17-epoxy-4,9,13,17-tetramethyl-4,8,12-octadecatrienylidene]-1,3-benzodithiole
Saccharomyces cerevisiae
-
IC50: 0.0035 mM
0.012
2-[(4E,8E,12E)-16,17-epoxy-4,9,13,17-tetramethyl-4,8,12-octadecatrienylidene]-1,3-benzodithiole
Sus scrofa
-
IC50: 0.012 mM
0.00017
2-[(4E,8E,12E)-16,17-epoxy-4,9,13,17-tetramethyl-4,8,12-octadecatrienylidene]-1,3-dithiane
Saccharomyces cerevisiae
-
IC50: 0.00017 mM
0.00035
2-[(4E,8E,12E)-16,17-epoxy-4,9,13,17-tetramethyl-4,8,12-octadecatrienylidene]-1,3-dithiane
Sus scrofa
-
IC50: 0.00035 mM
0.035
2-[(4E,8E,12E,16E)-20,21-epoxy-4,8,13,17,21-pentamethyl-4,8,12,16-docosatetraenylidene]-1,3-dithiane
Saccharomyces cerevisiae
-
IC50: 0.035 mM
0.1
2-[(4E,8E,12E,16E)-20,21-epoxy-4,8,13,17,21-pentamethyl-4,8,12,16-docosatetraenylidene]-1,3-dithiane
Sus scrofa
-
IC50: 0.1 mM
0.0015
3-(3,7-Dimethyl-octadeca-3,7,11,15-tetraenyl)-2,2-dimethyl-oxirane
Saccharomyces cerevisiae
-
IC50: 0.0015 mM
0.0035
3-(3,7-Dimethyl-octadeca-3,7,11,15-tetraenyl)-2,2-dimethyl-oxirane
Sus scrofa
-
IC50: 0.0035 mM
0.00028
3-(biphenyl-4-yloxy)-N,N-dimethylpropan-1-amine
Trypanosoma brucei
-
IC50: 280 nM
0.00075
3-(biphenyl-4-yloxy)-N,N-dimethylpropan-1-amine
Trypanosoma cruzi
-
IC50: 750 nM
0.016
3-(biphenyl-4-yloxy)-N,N-dimethylpropan-1-amine
Pneumocystis carinii
-
IC50: 0.016 mM
0.055
azasqualene alcohol N-oxide
Saccharomyces cerevisiae
-
IC50: 0.055 mM, at a protein concentration of 2 mg/ml
0.055
azasqualene alcohol N-oxide
Candida albicans
-
IC50: 0.055 mM, at a protein concentration of 3 mg/ml
1.5
diethyl-(4,8,13,17,21-pentamethyl-docosa-4,8,12,16,20-pentaenyl)-aminoxide
Rattus norvegicus
-
IC50: 1.5 mM
14
diethyl-(4,8,13,17,21-pentamethyl-docosa-4,8,12,16,20-pentaenyl)-aminoxide
Saccharomyces cerevisiae
-
IC50: 14 mM
3.2
Diethyl-(4,8,13,17,21-pentamethyl-docosa-4,8,12,16,20-pentaenyl)-ammonium
Rattus norvegicus
-
IC50: 3.2 mM
12.5
Diethyl-(4,8,13,17,21-pentamethyl-docosa-4,8,12,16,20-pentaenyl)-ammonium
Saccharomyces cerevisiae
-
IC50: 12.5 mM
0.0000065
Ro 48-8071
Homo sapiens
-
IC50: 6.5 nM for the human liver enzyme
0.000008
Ro 48-8071
Homo sapiens
-
IC50: 8.0 nM for the recombinant enzyme
5.1
Trimethyl-(4,8,13,17,21-pentamethyl-docosa-4,8,12,16,20-pentaenyl)-ammonium
Rattus norvegicus
-
IC50: 5.1 mM
13.3
Trimethyl-(4,8,13,17,21-pentamethyl-docosa-4,8,12,16,20-pentaenyl)-ammonium
Candida albicans
-
IC50: 13.3 mM
0.000022
[4-(1-azabicyclo[2.2.2]oct-3-yloxy)phenyl](4-chlorophenyl)methanone
Trypanosoma brucei
-
IC50: 22 nM
0.000092
[4-(1-azabicyclo[2.2.2]oct-3-yloxy)phenyl](4-chlorophenyl)methanone
Pneumocystis carinii
-
IC50: 92 nM
0.0004
[4-(1-azabicyclo[2.2.2]oct-3-yloxy)phenyl](4-chlorophenyl)methanone
Trypanosoma cruzi
-
IC50: 400 nM
0.000161
[4-(4-Bromo-benzenesulfonyl)-piperazin-1-yl]-(3,4,5,6-tetrahydro-2H-[1,4']bipyridinyl-4-yl)-methanone
Homo sapiens
-
IC50: 161 nM
0.000228
[4-(4-Bromo-benzenesulfonyl)-piperazin-1-yl]-(3,4,5,6-tetrahydro-2H-[1,4']bipyridinyl-4-yl)-methanone
Rattus norvegicus
-
IC50: 228 nM
0.0000043
{4-[6-(allyl-methyl-amino)-hexyloxy]-2-fluoro-phenyl}-(4-chloro-phenyl)-methanone
Trypanosoma brucei
-
IC50: 4.3 nM
0.0000046
{4-[6-(allyl-methyl-amino)-hexyloxy]-2-fluoro-phenyl}-(4-chloro-phenyl)-methanone
Pneumocystis carinii
-
IC50: 4.6 nM
0.000071
{4-[6-(allyl-methyl-amino)-hexyloxy]-2-fluoro-phenyl}-(4-chloro-phenyl)-methanone
Trypanosoma cruzi
-
IC50: 71 nM