Reference on EC 5.4.99.7 - Lanosterol synthase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Willett, J.D.; Sharpless, K.B.; Lord, K.E.; van Tamelen, E.E.; Clayton, R.B.
Squalene-2,3-oxide, an intermediate in the enzymatic conversion of squalene to lanosterol and cholesterol
J. Biol. Chem.
242
4182-4191
1967
Rattus norvegicus
Dean, P.D.G.; Ortiz de Montellano, P.R.; Bloch, K.; Corey, E.J.
A soluble 2,3-oxidosqualene sterol cyclase
J. Biol. Chem.
242
3014-3015
1967
Sus scrofa
Yamamoto, S.; Lin, K.; Bloch, K.
Some properties of the microsomal 2,3-oxidosqualene sterol cyclase
Proc. Natl. Acad. Sci. USA
63
110-117
1969
Sus scrofa
Balliano, G.; Milla, P.; Ceruti, M.; Viola, F.; Carrano, L.; Cattel, L.
Differential inhibition of fungal oxidosqualene cyclase by 6E and 6Z isomers of 2,3-epoxy-10-aza-10,11-dihydrosqualene
FEBS Lett.
320
203-206
1993
Saccharomyces cerevisiae, Candida albicans
Shi, Z.; Buntel, C.J.; Griffin, J.H.
Isolation and characterization of the gene encoding 2,3-oxidosqualene-lanosterol cyclase from Saccharomyces cerevisiae
Proc. Natl. Acad. Sci. USA
91
7370-7374
1994
Saccharomyces cerevisiae
Tabacik, C.; Descomps, B.; Crastles de Paulet, A.
The squalene epoxide-cyclase activity of human term placenta
FEBS Lett.
34
238-242
1973
Homo sapiens
Saat, Y.A.; Bloch, K.E.
Effect of a supernatant protein on microsomal squalene epoxidase and 2,3-oxidosqualene-lanosterol cyclase
J. Biol. Chem.
251
5155-5160
1976
Rattus norvegicus
Chang, T.Y.; Schiavoni, E.S.; McCrae, K.R.; Nelson, J.A.; Spencer, T.A.
Inhibition of cholesterol biosynthesis in Chinese hamster ovary cells by 4,4,10beta-trimethyl-trans-decal-3beta-ol
J. Biol. Chem.
254
11258-11263
1979
Mesocricetus auratus
Chen, H.W.; Leonard, D.A.
Chloroquine inhibits cyclization of squalene oxide to lanosterol in mammalian cells
J. Biol. Chem.
259
8156-8162
1984
Mus musculus
Taton, M.; Benveniste, P.; Rahier, A.
N-[(1,5,9)-Trimethyl-decyl]-4alpha,10-dimethyl-8-aza-trans-decal-3beta-ol a novel potent inhibitor of 2,3-oxidosqualene cycloartenol and lanosterol cyclases
Biochem. Biophys. Res. Commun.
138
764-770
1986
Rattus norvegicus
Corey, E.J.; Matsuda, S.P.T.; Bartel, B.
Molecular cloning, characterization, and overexpression of ERG7, the Saccharomyces cerevisiae gene encoding lanosterol synthase
Proc. Natl. Acad. Sci. USA
91
2211-2215
1994
Saccharomyces cerevisiae
Duriatti, A.; Schuber, F.
Partial purification of 2,3-oxidosqualene-lanosterol cyclase from hog-liver. Evidence for functional thiol residue
Biochem. Biophys. Res. Commun.
151
1378-1385
1988
Sus scrofa
Balliano, G.; Viola, F.; Ceruti, M.; Cattel, L.
Inhibition of sterol biosynthesis in Saccharomyces cerevisiae by N,N-diethylazasqualene and derivatives
Biochim. Biophys. Acta
959
9-19
1988
Saccharomyces cerevisiae
Rohmer, M.; Bouvier, P.; Ourisson, G.
Non-specific lanosterol and hopanoid biosynthesis by a cell-free system from the bacterium Methylococcus capsulatus
Eur. J. Biochem.
112
557-560
1980
Methylococcus capsulatus
Hoshino, T.; Williams, H.J.; Chung, Y.; Ian Scott, A.
Partial purification and characterization of oxidosqualene-lanosterol cyclase from baker's yeast
Tetrahedron
47
5925-5932
1991
Saccharomyces cerevisiae
-
Corey, E.J.; Matsuda, S.P.T.
Purification of the 2,3-oxidosqualene-lanosterol cyclase from Saccharomyces cerevisiae
J. Am. Chem. Soc.
113
8172-8174
1991
Saccharomyces cerevisiae
-
Balliano, G.; Viola, F.; Ceruti, M.; Cattel, L.
Characterization and partial purification of squalene-2,3-oxide cyclase from Saccharomyces cerevisiae
Arch. Biochem. Biophys.
293
122-129
1992
Saccharomyces cerevisiae
Kelly, R.; Miller, S.M.; Lai, M.H.; Kirsch, D.R.
Cloning and characterization of the 2,3-oxidosqualene cyclase-coding gene of Candida albicans
Gene
87
177-183
1990
Candida albicans
Abad, J.L.; Guardiola, M.; Casas, J.; Sanchez-Baeza, F.; Messeguer, A.
2,3,18,19-Dioxidosqualene stereoisomers: characterization and activity as inhibitors of purified pig liver 2,3-oxidosqualene-lanosterol cyclase
J. Org. Chem.
61
7603-7607
1996
Sus scrofa
Cattel, L.; Ceruti, M.; Balliano, G.; Viola, F.; Grosa, G.; Rocco, F.; Brusa, P.
2,3-Oxidosqualene cyclase: from azasqualenes to new site-directed inhibitors
Lipids
30
235-246
1995
Saccharomyces cerevisiae, Candida albicans, Rattus norvegicus, Sus scrofa
Viola, F.; Brusa, P.; Balliano, G.; Ceruti, M.; Boutaud, O.; Schuber, F.; Cattel, L.
Inhibition of 2,3-oxidosqualene cyclase and sterol biosynthesis by 10- and 19-azasqualene derivatives
Biochem. Pharmacol.
50
787-796
1995
Saccharomyces cerevisiae, Candida albicans, Homo sapiens, Rattus norvegicus, Sus scrofa
Jolidon, S.; Polak, A.M.; Guerry, P.; Hartman, P.G.
Inhibitors of 2,3-oxidosqualene lanosterol-cyclase as potential antifungal agents
Biochem. Soc. Trans.
18
47-48
1990
Candida albicans, Rattus norvegicus
Kusano, M.; Abe, I.; Sankawa, U.; Ebizuka, Y.
Purification and some properties of squalene 2,3-epoxide: lanosterol cyclase from rat liver
Chem. Pharm. Bull.
39
239-241
1991
Rattus norvegicus
Wannamaker, M.W.; Waid, P.P.; van Sickle, W.A.; McCarthy, J.R.; Wilson, P.K.; Schatzman, G.L.; Moore, W.R.
N-(1-Oxododecyl)-4alpha,10-dimethyl-8-aza-trans-decal-3beta-ol: a potent competitive inhibitor of 2,3-oxidosqualene cyclase
J. Med. Chem.
35
3581-3583
1992
Rattus norvegicus
Barth, M.M.; Binet, J.L.; Thomas, D.M.; de Fornel, D.C.; Samreth, S.; Schuber, F.J.; Renaut, P.P.
Structural and stereoelectronic requirements for the inhibition of mammalian oxidosqualene cyclase by substituted isoquinoline derivatives
J. Med. Chem.
39
2302-2312
1996
Rattus norvegicus
Stach, D.; Zheng, Y.F.; Perez, A.L.; Oehlschlager, A.C.; Abe, I.; Prestwich, G.D.; Hartman, P.G.
Synthesis and inhibition studies of sulfur-substituted squalene oxide analogues as mechanism-based inhibitors of 2,3-oxidosqualene-lanosterol cyclase
J. Med. Chem.
40
201-209
1997
Candida albicans, Rattus norvegicus, Sus scrofa
Ceruti, M.; Rocco, F.; Viola, F.; Balliano, G.; Milla, P.; Arpicco, S.; Cattel, L.
9-Methylidine-2,3-oxidosqualene derivatives as stereospecific mechanism-based inhibitors of liver and yeast oxidosqualene cyclase
J. Med. Chem.
41
540-554
1998
Saccharomyces cerevisiae, Sus scrofa
Moore, W.R.; Schatzman, G.L.
Purification of 2,3-oxidosqualene cyclase from rat liver
J. Biol. Chem.
267
22003-22006
1992
Rattus norvegicus
Abe, I.; Prestwich, G.D.
Molecular cloning, characterization, and functional expression of rat oxidosqualene cyclase cDNA
Proc. Natl. Acad. Sci. USA
92
9274-9278
1995
Rattus norvegicus
Astruc, M.; Tabacik, C.; Descomps, B.; Crastes de Paulet, A.
Squalene epoxidase and oxidosqualene lanosterol-cyclase activities in cholesterogenic and non-cholesterogenic tissues
Biochim. Biophys. Acta
487
204-211
1977
Rattus norvegicus
Ceruti, M.; Balliano, G.; Rocco, F.; Milla, P.; Arpicco, S.; Cattel, L.; Viola, F.
Vinyl sulfide derivatives of truncated oxidosqualene as selective inhibitors of oxidosqualene and squalene-hopene cyclases
Lipids
36
629-636
2001
Saccharomyces cerevisiae, Sus scrofa
Wu, T.K.; Huang, C.Y.; Ko, C.Y.; Chang, C.H.; Chen, Y.J.; Liao, H.K.
Purification, tandem mass characterization, and inhibition studies of oxidosqualene-lanosterol cyclase enzyme from bovine liver
Arch. Biochem. Biophys.
421
42-53
2004
Bos taurus
Ruf, A.; Muller, F.; D'Arcy, B.; Stihle, M.; Kusznir, E.; Handschin, C.; Morand, O.H.; Thoma, R.
The monotopic membrane protein human oxidosqualene cyclase is active as monomer
Biochem. Biophys. Res. Commun.
315
247-254
2004
Homo sapiens
Viola, F.; Balliano, G.; Milla, P.; Cattel, L.; Rocco, F.; Ceruti, M.
Stereospecific syntheses of trans-vinyldioxidosqualene and 3-hydroxysulfide derivatives, as potent and time-dependent 2,3-oxidosqualene cyclase inhibitors
Bioorg. Med. Chem.
8
223-232
2000
Saccharomyces cerevisiae, Sus scrofa
Cattel, L.; Ceruti, M.
Inhibitors of 2,3-oxidosqualene cyclase as tools for studying the mechanism and function of the enzyme
Crit. Rev. Biochem. Mol. Biol.
33
353-373
1998
Candida albicans, Canis lupus familiaris, Rattus norvegicus, Saccharomyces cerevisiae, Sus scrofa
Ceruti, M.; Viola, F.; Balliano, G.; Milla, P.; Roma, G.; Grossi, G.; Rocco, F.
Synthesis of (E)- and (Z)-29-methylidyne-2,3-oxidosqualene derivatives as inhibitors of liver and yeast oxidosqualene cyclase
J. Chem. Soc. Perkin Trans.
1
1477-1486
2002
Saccharomyces cerevisiae, Sus scrofa
-
Brown, G.R.; Hollinshead, D.M.; Stokes, E.S.; Clarke, D.S.; Eakin, M.A.; Foubister, A.J.; Glossop, S.C.; Griffiths, D.; Johnson, M.C.; McTaggart, F.; Mirrlees, D.J.; Smith, G.J.; Wood, R.
Quinuclidine inhibitors of 2,3-oxidosqualene cyclase-lanosterol synthase: optimization from lipid profiles
J. Med. Chem.
42
1306-1311
1999
Homo sapiens, Rattus norvegicus
Brown, G.R.; Hollinshead, D.M.; Stokes, E.S.; Waterson, D.; Clarke, D.S.; Foubister, A.J.; Glossop, S.C.; McTaggart, F.; Mirrlees, D.J.; Smith, G.J.; Wood, R.
A novel series of 4-piperidinopyridine and 4-piperidinopyrimidine inhibitors of 2,3-oxidosqualene cyclase-lanosterol synthase
J. Med. Chem.
43
4964-4972
2000
Homo sapiens, Rattus norvegicus
Dehmlow, H.; Aebi, J.D.; Jolidon, S.; Ji, Y.H.; von der Mark, E.M.; Himber, J.; Morand, O.H.
Synthesis and structure-activity studies of novel orally active non-terpenoic 2,3-oxidosqualene cyclase inhibitors
J. Med. Chem.
46
3354-3370
2003
Homo sapiens
Hinshaw, J.C.; Suh, D.Y.; Garnier, P.; Buckner, F.S.; Eastman, R.T.; Matsuda, S.P.; Joubert, B.M.; Coppens, I.; Joiner, K.A.; Merali, S.; Nash, T.E.; Prestwich, G.D.
Oxidosqualene cyclase inhibitors as antimicrobial agents
J. Med. Chem.
46
4240-4243
2003
Pneumocystis carinii, Rattus norvegicus, Trypanosoma brucei, Trypanosoma cruzi
Joubert, B.M.; Buckner, F.S.; Matsuda, S.P.T.
Trypanosome and animal lanosterol synthases use different catalytic motifs
Org. Lett.
3
1957-1960
2001
Trypanosoma cruzi (Q964Q1), Trypanosoma cruzi
Venteclef, N.; Guillard, R.; Issandou, M.
The imidazoline-like drug S23515 affects lipid metabolism in hepatocyte by inhibiting the oxidosqualene: lanosterol cyclase activity
Biochem. Pharmacol.
69
1041-1048
2005
Macaca fascicularis, Homo sapiens, Rattus norvegicus
Sakano, Y.; Mutsuga, M.; Tanaka, R.; Suganuma, H.; Inakuma, T.; Toyoda, M.; Goda, Y.; Shibuya, M.; Ebizuka, Y.
Inhibition of human lanosterol synthase by the constituents of Colocasia esculenta (taro)
Biol. Pharm. Bull.
28
299-304
2005
Homo sapiens
Tanaka, R.; Sakano, Y.; Nagatsu, A.; Shibuya, M.; Ebizuka, Y.; Goda, Y.
Synthesis of digalactosyl diacylglycerols and their structure-inhibitory activity on human lanosterol synthase
Bioorg. Med. Chem. Lett.
15
159-162
2005
Homo sapiens
Wu, T.K.; Chang, C.H.
Enzymatic formation of multiple triterpenes by mutation of tyrosine 510 of the oxidosqualene-lanosterol cyclase from Saccharomyces cerevisiae
ChemBioChem
5
1712-1715
2004
Saccharomyces cerevisiae
Oliaro-Bosso, S.; Schulz-Gasch, T.; Balliano, G.; Viola, F.
Access of the substrate to the active site of yeast oxidosqualene cyclase: an inhibition and site-directed mutagenesis approach
ChemBioChem
6
2221-2228
2005
Saccharomyces cerevisiae, Saccharomyces cerevisiae SMY8
Mori, M.; Li, G.; Abe, I.; Nakayama, J.; Guo, Z.; Sawashita, J.; Ugawa, T.; Nishizono, S.; Serikawa, T.; Higuchi, K.; Shumiya, S.
Lanosterol synthase mutations cause cholesterol deficiency-associated cataracts in the Shumiya cataract rat
J. Clin. Invest.
116
395-404
2006
Rattus norvegicus (P48450)
Oliaro-Bosso, S.; Viola, F.; Matsuda, S.; Cravotto, G.; Tagliapietra, S.; Balliano, G.
Umbelliferone aminoalkyl derivatives as inhibitors of oxidosqualene cyclases from Saccharomyces cerevisiae, Trypanosoma cruzi, and Pneumocystis carinii
Lipids
39
1007-1012
2004
Pneumocystis carinii, Saccharomyces cerevisiae, Trypanosoma cruzi
Thoma, R.; Schulz-Gasch, T.; D'Arcy, B.; Benz, J.; Aebi, J.; Dehmlow, H.; Hennig, M.; Stihle, M.; Ruf, A.
Insight into steroid scaffold formation from the structure of human oxidosqualene cyclase
Nature
432
118-122
2004
Homo sapiens (P48449), Homo sapiens
Lodeiro, S.; Wilson, W.K.; Shan, H.; Matsuda, S.P.
A putative precursor of isomalabaricane triterpenoids from lanosterol synthase mutants
Org. Lett.
8
439-442
2006
Saccharomyces cerevisiae
Huff, M.W.; Telford, D.E.
Lord of the rings--the mechanism for oxidosqualene:lanosterol cyclase becomes crystal clear
Trends Pharmacol. Sci.
26
335-340
2005
Homo sapiens, Sus scrofa
Kolesnikova, M.D.; Xiong, Q.; Lodeiro, S.; Hua, L.; Matsuda, S.P.
Lanosterol biosynthesis in plants
Arch. Biochem. Biophys.
447
87-95
2006
Arabidopsis thaliana
Galli, U.; Oliaro-Bosso, S.; Taramino, S.; Venegoni, S.; Pastore, E.; Tron, G.C.; Balliano, G.; Viola, F.; Sorba, G.
Design, synthesis, and biological evaluation of new (2E,6E)-10-(dimethylamino)-3,7-dimethyl-2,6-decadien-1-ol ethers as inhibitors of human and Trypanosoma cruzi oxidosqualene cyclase
Bioorg. Med. Chem. Lett.
17
220-224
2007
Saccharomyces cerevisiae, Homo sapiens, Pneumocystis carinii, Trypanosoma cruzi
Nakano, C.; Motegi, A.; Sato, T.; Onodera, M.; Hoshino, T.
Sterol biosynthesis by a prokaryote: first in vitro identification of the genes encoding squalene epoxidase and lanosterol synthase from Methylococcus capsulatus
Biosci. Biotechnol. Biochem.
71
2543-2550
2007
Methylococcus capsulatus (Q603D4), Methylococcus capsulatus
Wu, T.K.; Liu, Y.T.; Chang, C.H.; Yu, M.T.; Wang, H.J.
Site-saturated mutagenesis of histidine 234 of Saccharomyces cerevisiae oxidosqualene-lanosterol cyclase demonstrates dual functions in cyclization and rearrangement reactions
J. Am. Chem. Soc.
128
6414-6419
2006
Saccharomyces cerevisiae
Tanaka, R.; Sakano, Y.; Shimizu, K.; Shibuya, M.; Ebizuka, Y.; Goda, Y.
Constituents of Laurus nobilis L. inhibit recombinant human lanosterol synthase
J. Nat. Med.
60
78-81
2006
Homo sapiens
-
Lamb, D.C.; Jackson, C.J.; Warrilow, A.G.; Manning, N.J.; Kelly, D.E.; Kelly, S.L.
Lanosterol biosynthesis in the prokaryote Methylococcus capsulatus: insight into the evolution of sterol biosynthesis
Mol. Biol. Evol.
24
1714-1721
2007
Methylococcus capsulatus (Q603D4), Methylococcus capsulatus
Wu, T.K.; Yu, M.T.; Liu, Y.T.; Chang, C.H.; Wang, H.J.; Diau, E.W.
Tryptophan 232 within oxidosqualene-lanosterol cyclase from Saccharomyces cerevisiae influences rearrangement and deprotonation but not cyclization reactions
Org. Lett.
8
1319-1322
2006
Saccharomyces cerevisiae
Wu, T.K.; Liu, Y.T.; Chiu, F.H.; Chang, C.H.
Phenylalanine 445 within oxidosqualene-lanosterol cyclase from Saccharomyces cerevisiae influences C-Ring cyclization and deprotonation reactions
Org. Lett.
8
4691-4694
2006
Saccharomyces cerevisiae
Suzuki, M.; Xiang, T.; Ohyama, K.; Seki, H.; Saito, K.; Muranaka, T.; Hayashi, H.; Katsube, Y.; Kushiro, T.; Shibuya, M.; Ebizuka, Y.
Lanosterol synthase in dicotyledonous plants
Plant Cell Physiol.
47
565-571
2006
Arabidopsis thaliana (Q1G1A4)
Sawai, S.; Akashi, T.; Sakurai, N.; Suzuki, H.; Shibata, D.; Ayabe, S.; Aoki, T.
Plant lanosterol synthase: divergence of the sterol and triterpene biosynthetic pathways in eukaryotes
Plant Cell Physiol.
47
673-677
2006
Lotus japonicus
Teske, B.; Taramino, S.; Bhuiyan, M.S.; Kumaraswami, N.S.; Randall, S.K.; Barbuch, R.; Eckstein, J.; Balliano, G.; Bard, M.
Genetic analyses involving interactions between the ergosterol biosynthetic enzymes, lanosterol synthase (Erg7p) and 3-ketoreductase (Erg27p), in the yeast Saccharomyces cerevisiae
Biochim. Biophys. Acta
1781
359-366
2008
Saccharomyces cerevisiae, Saccharomyces cerevisiae SCY876
Fouchet, M.H.; Donche, F.; Martin, C.; Bouillot, A.; Junot, C.; Boullay, A.B.; Potvain, F.; Magny, S.D.; Coste, H.; Walker, M.; Issandou, M.; Dodic, N.
Design and evaluation of a novel series of 2,3-oxidosqualene cyclase inhibitors with low systemic exposure, relationship between pharmacokinetic properties and ocular toxicity
Bioorg. Med. Chem.
16
6218-6232
2008
Homo sapiens
Wu, T.K.; Chang, C.H.; Liu, Y.T.; Wang, T.T.
Saccharomyces cerevisiae oxidosqualene-lanosterol cyclase: a chemistry-biology interdisciplinary study of the proteins structure-function-reaction mechanism relationships
Chem. Rec.
8
302-325
2008
Saccharomyces cerevisiae
Dang, H.; Liu, Y.; Pang, W.; Wang, N.; Shyy, J.Y.; Zhu, Y.
Suppression of 2,3-oxidosqualene cyclase by high-fat diet contributes to liver X receptor-alpha -mediated improvement of hepatic lipid profile
J. Biol. Chem.
284
6218-6226
2009
Mus musculus, Rattus norvegicus
Wu, T.K.; Wen, H.Y.; Chang, C.H.; Liu, Y.T.
Protein plasticity: a single amino acid substitution in the Saccharomyces cerevisiae oxidosqualene-lanosterol cyclase generates protosta-13(17),24-dien-3beta-ol, a rearrangement product
Org. Lett.
10
2529-2532
2008
Saccharomyces cerevisiae
Wu, T.K.; Wang, T.T.; Chang, C.H.; Liu, Y.T.; Shie, W.S.
Importance of Saccharomyces cerevisiae oxidosqualene-lanosterol cyclase tyrosine 707 residue for chair-boat bicyclic ring formation and deprotonation reactions
Org. Lett.
10
4959-4962
2008
Saccharomyces cerevisiae
Ohyama, K.; Suzuki, M.; Kikuchi, J.; Saito, K.; Muranaka, T.
Dual biosynthetic pathways to phytosterol via cycloartenol and lanosterol in Arabidopsis
Proc. Natl. Acad. Sci. USA
106
725-730
2009
Arabidopsis thaliana
Seiki, S.; Frishman, W.H.
Pharmacologic inhibition of squalene synthase and other downstream enzymes of the cholesterol synthesis pathway: a new therapeutic approach to treatment of hypercholesterolemia
Cardiol. Rev.
17
70-76
2009
Metazoa
Taramino, S.; Valachovic, M.; Oliaro-Bosso, S.; Viola, F.; Teske, B.; Bard, M.; Balliano, G.
Interactions of oxidosqualene cyclase (Erg7p) with 3-keto reductase (Erg27p) and other enzymes of sterol biosynthesis in yeast
Biochim. Biophys. Acta
1801
156-162
2010
Saccharomyces cerevisiae, Saccharomyces cerevisiae STY2
Duniec-Dmuchowski, Z.; Fang, H.L.; Strom, S.C.; Ellis, E.; Runge-Morris, M.; Kocarek, T.A.
Human pregnane X receptor activation and CYP3A4/CYP2B6 induction by 2,3-oxidosqualene:lanosterol cyclase inhibition
Drug Metab. Dispos.
37
900-908
2009
Homo sapiens
Joffrion, T.M.; Collins, M.S.; Sesterhenn, T.; Cushion, M.T.
Functional characterization and localization of Pneumocystis carinii lanosterol synthase
Eukaryot. Cell
9
107-115
2010
Pneumocystis carinii
Wu, T.K.; Chang, C.H.; Wen, H.Y.; Liu, Y.T.; Li, W.H.; Wang, T.T.; Shie, W.S.
Alteration of the substrates prefolded conformation and cyclization stereochemistry of oxidosqualene-lanosterol cyclase of Saccharomyces cerevisiae by substitution at phenylalanine 699
Org. Lett.
12
500-503
2010
Saccharomyces cerevisiae, Saccharomyces cerevisiae TKW14
Taramino, S.; Teske, B.; Oliaro-Bosso, S.; Bard, M.; Balliano, G.
Divergent interactions involving the oxidosqualene cyclase and the steroid-3-ketoreductase in the sterol biosynthetic pathway of mammals and yeasts
Biochim. Biophys. Acta
1801
1232-1237
2010
Homo sapiens, Saccharomyces cerevisiae, Saccharomyces cerevisiae SCY876 and BTY6-5-3
Kimura, M.; Kushiro, T.; Shibuya, M.; Ebizuka, Y.; Abe, I.
Protostadienol synthase from Aspergillus fumigatus: functional conversion into lanosterol synthase
Biochem. Biophys. Res. Commun.
391
899-902
2010
Aspergillus fumigatus
Shang, C.H.; Shi, L.; Ren, A.; Qin, L.; Zhao, M.W.
Molecular cloning, characterization, and differential expression of a lanosterol synthase gene from Ganoderma lucidum
Biosci. Biotechnol. Biochem.
74
974-978
2010
Ganoderma lucidum (D7NJ68), Ganoderma lucidum, Ganoderma lucidum HG (D7NJ68)
Wu, T.K.; Chang, Y.C.; Liu, Y.T.; Chang, C.H.; Wen, H.Y.; Li, W.H.; Shie, W.S.
Mutation of isoleucine 705 of the oxidosqualene-lanosterol cyclase from Saccharomyces cerevisiae affects lanosterols C/D-ring cyclization and 17alpha/beta-exocyclic side chain stereochemistry
Org. Biomol. Chem.
9
1092-1097
2011
Saccharomyces cerevisiae
Chang, C.H.; Chen, Y.C.; Tseng, S.W.; Liu, Y.T.; Wen, H.Y.; Li, W.H.; Huang, C.Y.; Ko, C.Y.; Wang, T.T.; Wu, T.K.
The cysteine 703 to isoleucine or histidine mutation of the oxidosqualene-lanosterol cyclase from Saccharomyces cerevisiae generates an iridal-type triterpenoid
Biochimie
94
2376-2381
2012
Saccharomyces cerevisiae
Hoshino, T.; Chiba, A.; Abe, N.
Lanosterol biosynthesis: the critical role of the methyl-29 group of 2,3-oxidosqualene for the correct folding of this substrate and for the construction of the five-membered D ring
Chemistry
18
13108-13116
2012
Sus scrofa
Tian, B.X.; Eriksson, L.A.
Catalytic mechanism and product specificity of oxidosqualene-lanosterol cyclase: a QM/MM study
J. Phys. Chem. B
116
13857-13862
2012
Homo sapiens
Chang, C.H.; Wen, H.Y.; Shie, W.S.; Lu, C.T.; Li, M.E.; Liu, Y.T.; Li, W.H.; Wu, T.K.
Protein engineering of oxidosqualene-lanosterol cyclase into triterpene monocyclase
Org. Biomol. Chem.
11
4214-4219
2013
Saccharomyces cerevisiae
Liu, Y.T.; Hu, T.C.; Chang, C.H.; Shie, W.S.; Wu, T.K.
Protein engineering of Saccharomyces cerevisiae oxidosqualene-lanosterol cyclase into parkeol synthase
Org. Lett.
14
5222-5225
2012
Saccharomyces cerevisiae
Zhang, D.H.; Li, N.; Yu, X.; Zhao, P.; Li, T.; Xu, J.W.
Overexpression of the homologous lanosterol synthase gene in ganoderic acid biosynthesis in Ganoderma lingzhi
Phytochemistry
134
46-53
2017
Ganoderma lucidum (A0A1L5JY50), Ganoderma lucidum CGMCC 5.616 (A0A1L5JY50)
Kumar, A.; Fogelman, E.; Weissberg, M.; Tanami, Z.; Veilleux, R.E.; Ginzberg, I.
Lanosterol synthase-like is involved with differential accumulation of steroidal glycoalkaloids in potato
Planta
246
1189-1202
2017
Arabidopsis thaliana (Q1G1A4), Solanum tuberosum (A0A1B0YWV6), Solanum tuberosum
Kang, L.; Shen, X.; Yang, M.; Zhang, G.; Zhang, J.; Qin, B.; Yang, L.; Hu, N.; Guan, H.
Distribution of lanosterol synthase and lanosterol in cornea, lens and retina tissue of rats
Zhonghua Shiyan Yanke Zazhi
35
201-206
2017
Rattus norvegicus
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