Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 5.4.99.7 extracted from

  • Galli, U.; Oliaro-Bosso, S.; Taramino, S.; Venegoni, S.; Pastore, E.; Tron, G.C.; Balliano, G.; Viola, F.; Sorba, G.
    Design, synthesis, and biological evaluation of new (2E,6E)-10-(dimethylamino)-3,7-dimethyl-2,6-decadien-1-ol ethers as inhibitors of human and Trypanosoma cruzi oxidosqualene cyclase (2007), Bioorg. Med. Chem. Lett., 17, 220-224.
    View publication on PubMed
Search for more literature for 5.4.99.7

Cloned(Commentary)

Cloned (Comment) Organism
expression in Pichia pastoris Homo sapiens
expression in Saccharomyces cerevisiae Trypanosoma cruzi
expression in Saccharomyces cerevisiae Pneumocystis carinii

Inhibitors

Inhibitors Comment Organism Structure
(2E,6E)-10-(dimethylamino)-3,7-dimethyl-2,6-decadien-1-yl 3-biphenyl-4-ylpropyl ether comparison with inhibitory effect on Trypanosoma cruzi, Saccharomyces cerevisiae, and Pneumocystis carinii enzyme Homo sapiens
(2E,6E)-10-(dimethylamino)-3,7-dimethyl-2,6-decadien-1-yl 3-biphenyl-4-ylpropyl ether comparison with inhibitory effect on Trypanosoma cruzi, Saccharomyces cerevisiae, and human enzyme Pneumocystis carinii
(2E,6E)-10-(dimethylamino)-3,7-dimethyl-2,6-decadien-1-yl 3-biphenyl-4-ylpropyl ether comparison with inhibitory effect on Trypanosoma cruzi, Pneumocystis carini, and human enzyme Saccharomyces cerevisiae
(2E,6E)-10-(dimethylamino)-3,7-dimethyl-2,6-decadien-1-yl 3-biphenyl-4-ylpropyl ether comparison with inhibitory effect on Pneumocystis carinii, Saccharomyces cerevisiae, and human enzyme Trypanosoma cruzi
(2E,6E)-10-(dimethylamino)-3,7-dimethyl-2,6-decadien-1-yl 3-phenylpropyl ether comparison with inhibitory effect on Trypanosoma cruzi, Saccharomyces cerevisiae, and Pneumocystis carinii enzyme Homo sapiens
(2E,6E)-10-(dimethylamino)-3,7-dimethyl-2,6-decadien-1-yl 3-phenylpropyl ether comparison with inhibitory effect on Trypanosoma cruzi, Saccharomyces cerevisiae, and human enzyme Pneumocystis carinii
(2E,6E)-10-(dimethylamino)-3,7-dimethyl-2,6-decadien-1-yl 3-phenylpropyl ether comparison with inhibitory effect on Trypanosoma cruzi, Pneumocystis carini, and human enzyme Saccharomyces cerevisiae
(2E,6E)-10-(dimethylamino)-3,7-dimethyl-2,6-decadien-1-yl 3-phenylpropyl ether comparison with inhibitory effect on Pneumocystis carinii, Saccharomyces cerevisiae, and human enzyme Trypanosoma cruzi
(2E,6E)-10-(dimethylamino)-3,7-dimethyl-2,6-decadien-1-yl hexyl ether comparison with inhibitory effect on Trypanosoma cruzi, Saccharomyces cerevisiae, and Pneumocystis carinii enzyme Homo sapiens
(2E,6E)-10-(dimethylamino)-3,7-dimethyl-2,6-decadien-1-yl hexyl ether comparison with inhibitory effect on Trypanosoma cruzi, Saccharomyces cerevisiae, and human enzyme Pneumocystis carinii
(2E,6E)-10-(dimethylamino)-3,7-dimethyl-2,6-decadien-1-yl hexyl ether comparison with inhibitory effect on Trypanosoma cruzi, Pneumocystis carini, and human enzyme Saccharomyces cerevisiae
(2E,6E)-10-(dimethylamino)-3,7-dimethyl-2,6-decadien-1-yl hexyl ether comparison with inhibitory effect on Pneumocystis carinii, Saccharomyces cerevisiae, and human enzyme Trypanosoma cruzi

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Pneumocystis carinii
-
-
-
Saccharomyces cerevisiae
-
-
-
Trypanosoma cruzi
-
-
-

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00033
-
-
 Pneumocystis carinii (2E,6E)-10-(dimethylamino)-3,7-dimethyl-2,6-decadien-1-yl 3-phenylpropyl ether
0.00036
-
-
 Pneumocystis carinii (2E,6E)-10-(dimethylamino)-3,7-dimethyl-2,6-decadien-1-yl hexyl ether
0.00045
-
-
 Saccharomyces cerevisiae (2E,6E)-10-(dimethylamino)-3,7-dimethyl-2,6-decadien-1-yl 3-phenylpropyl ether
0.00047
-
-
 Trypanosoma cruzi (2E,6E)-10-(dimethylamino)-3,7-dimethyl-2,6-decadien-1-yl 3-phenylpropyl ether
0.00085
-
-
 Homo sapiens (2E,6E)-10-(dimethylamino)-3,7-dimethyl-2,6-decadien-1-yl hexyl ether
0.0011
-
-
 Homo sapiens (2E,6E)-10-(dimethylamino)-3,7-dimethyl-2,6-decadien-1-yl 3-phenylpropyl ether
0.0017
-
-
 Pneumocystis carinii (2E,6E)-10-(dimethylamino)-3,7-dimethyl-2,6-decadien-1-yl 3-biphenyl-4-ylpropyl ether
0.00178
-
-
 Saccharomyces cerevisiae (2E,6E)-10-(dimethylamino)-3,7-dimethyl-2,6-decadien-1-yl hexyl ether
0.0027
-
-
 Trypanosoma cruzi (2E,6E)-10-(dimethylamino)-3,7-dimethyl-2,6-decadien-1-yl hexyl ether
0.0045
-
-
 Homo sapiens (2E,6E)-10-(dimethylamino)-3,7-dimethyl-2,6-decadien-1-yl 3-biphenyl-4-ylpropyl ether
0.0074
-
-
 Trypanosoma cruzi (2E,6E)-10-(dimethylamino)-3,7-dimethyl-2,6-decadien-1-yl 3-biphenyl-4-ylpropyl ether