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Literature summary for 5.4.99.7 extracted from

  • Viola, F.; Balliano, G.; Milla, P.; Cattel, L.; Rocco, F.; Ceruti, M.
    Stereospecific syntheses of trans-vinyldioxidosqualene and 3-hydroxysulfide derivatives, as potent and time-dependent 2,3-oxidosqualene cyclase inhibitors (2000), Bioorg. Med. Chem., 8, 223-232.
    View publication on PubMed
Search for more literature for 5.4.99.7

Inhibitors

Inhibitors Comment Organism Structure
(14-trans)-28-methylidene-2,3:14,15-dioxidoundecanorsqualene IC50: 0.0015 mM Saccharomyces cerevisiae
(14-trans)-28-methylidene-2,3:14,15-dioxidoundecanorsqualene IC50: 0.0004 mM Sus scrofa
(18E)-29-methylidene-2,3-oxidosqualene IC50: 0.0015 mM Saccharomyces cerevisiae
(18E)-29-methylidene-2,3-oxidosqualene IC50: 0.0035 mM Sus scrofa
(18Z)-29-methylidene-2,3-oxidosqualene IC50: 0.001 mM Saccharomyces cerevisiae
(18Z)-29-methylidene-2,3-oxidosqualene IC50: 0.0004 mM Sus scrofa
(2-trans)-1-methylidene-2,3-oxido-1'-norsqualene IC50: 0.05 mM Saccharomyces cerevisiae
(2-trans)-1-methylidene-2,3-oxido-1'-norsqualene IC50: 0.1 mM Sus scrofa
(3-trans-7E,11E,15E)-3,4:19,20-diepoxy-7,12,16,20-tetramethyl-1,7,11,15-henicosatetraene IC50: 0.0015 mM Saccharomyces cerevisiae
(3-trans-7E,11E,15E)-3,4:19,20-diepoxy-7,12,16,20-tetramethyl-1,7,11,15-henicosatetraene IC50: 0.0025 mM Sus scrofa
(3R,4S,7E)-15,16-epoxy-3-ethylthio-8,12,16-trimethyl-1,7,11-heptadecatrien-4-ol IC50: 0.025 mM Saccharomyces cerevisiae
(3R,4S,7E)-15,16-epoxy-3-ethylthio-8,12,16-trimethyl-1,7,11-heptadecatrien-4-ol IC50: 0.012 mM Sus scrofa
(3R,4S,7E,11E)-15,16-epoxy-8,12,16-trimethyl-3-phenylthio-1,7,11-heptadecatrien-4-ol IC50: 0.04 mM Saccharomyces cerevisiae
(3R,4S,7E,11E)-15,16-epoxy-8,12,16-trimethyl-3-phenylthio-1,7,11-heptadecatrien-4-ol IC50: 0.0075 mM Sus scrofa
(3R,4S,7E,11E,15E)-19,20-epoxy-3-ethylthio-7,12,16,20-tetramethyl-1,7,11,15-henicosatetraen-4-ol IC50: 0.0025 mM Saccharomyces cerevisiae
(3R,4S,7E,11E,15E)-19,20-epoxy-3-ethylthio-7,12,16,20-tetramethyl-1,7,11,15-henicosatetraen-4-ol IC50: 0.001 mM Sus scrofa

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae
-
-
-
Sus scrofa
-
-
-

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0004
-
 IC50: 0.0004 mM Sus scrofa (18Z)-29-methylidene-2,3-oxidosqualene
0.0004
-
 IC50: 0.0004 mM Sus scrofa (14-trans)-28-methylidene-2,3:14,15-dioxidoundecanorsqualene
0.001
-
 IC50: 0.001 mM Saccharomyces cerevisiae (18Z)-29-methylidene-2,3-oxidosqualene
0.001
-
 IC50: 0.001 mM Sus scrofa (3R,4S,7E,11E,15E)-19,20-epoxy-3-ethylthio-7,12,16,20-tetramethyl-1,7,11,15-henicosatetraen-4-ol
0.0015
-
 IC50: 0.0015 mM Saccharomyces cerevisiae (18E)-29-methylidene-2,3-oxidosqualene
0.0015
-
 IC50: 0.0015 mM Saccharomyces cerevisiae (3-trans-7E,11E,15E)-3,4:19,20-diepoxy-7,12,16,20-tetramethyl-1,7,11,15-henicosatetraene
0.0015
-
 IC50: 0.0015 mM Saccharomyces cerevisiae (14-trans)-28-methylidene-2,3:14,15-dioxidoundecanorsqualene
0.0025
-
 IC50: 0.0025 mM Saccharomyces cerevisiae (3R,4S,7E,11E,15E)-19,20-epoxy-3-ethylthio-7,12,16,20-tetramethyl-1,7,11,15-henicosatetraen-4-ol
0.0025
-
 IC50: 0.0025 mM Sus scrofa (3-trans-7E,11E,15E)-3,4:19,20-diepoxy-7,12,16,20-tetramethyl-1,7,11,15-henicosatetraene
0.0035
-
 IC50: 0.0035 mM Sus scrofa (18E)-29-methylidene-2,3-oxidosqualene
0.0075
-
 IC50: 0.0075 mM Sus scrofa (3R,4S,7E,11E)-15,16-epoxy-8,12,16-trimethyl-3-phenylthio-1,7,11-heptadecatrien-4-ol
0.012
-
 IC50: 0.012 mM Sus scrofa (3R,4S,7E)-15,16-epoxy-3-ethylthio-8,12,16-trimethyl-1,7,11-heptadecatrien-4-ol
0.025
-
 IC50: 0.025 mM Saccharomyces cerevisiae (3R,4S,7E)-15,16-epoxy-3-ethylthio-8,12,16-trimethyl-1,7,11-heptadecatrien-4-ol
0.04
-
 IC50: 0.04 mM Saccharomyces cerevisiae (3R,4S,7E,11E)-15,16-epoxy-8,12,16-trimethyl-3-phenylthio-1,7,11-heptadecatrien-4-ol
0.05
-
 IC50: 0.05 mM Saccharomyces cerevisiae (2-trans)-1-methylidene-2,3-oxido-1'-norsqualene
0.1
-
 IC50: 0.1 mM Sus scrofa (2-trans)-1-methylidene-2,3-oxido-1'-norsqualene