3.5.3.1: arginase This is an abbreviated version! For detailed information about arginase, go to the full flat file .
Reaction
L-arginine +
H2O =
L-ornithine +
Urea
Synonyms ARG, Arg I, Arg II, ARG1, ARG2, ARGAH1, ARGAH2, ArgI, arginase, arginase 1, arginase 1a, arginase 1b, arginase 2a, arginase 2b, arginase I, arginase II, arginase type I, arginase-1, arginase-2, arginase1, arginine amidinase, arginine amidohydrolase-1, arginine amidohydrolase-2, arginine transamidinase, canavanase, human arginase type I, Kidney-type arginase, L-arginase, L-arginine amidino hydrolase, L-arginine amidinohydrolase, L-arginine amidohydrolase, L-arginine ureahydrolase, Liver-type arginase, mitochondrial arginase, More, Non-hepatic arginase, PMN arginase, recombinant human arginase I, rhArg-PEG, rhArg1, RocF, serum arginase, SmARG, tissue arginase, type II arginase
ECTree
Natural Substrates Products
Natural Substrates Products on EC 3.5.3.1 - arginase
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L-arginine + H2O
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L-arginine + H2O
L-ornithine + urea
additional information
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L-arginine + H2O
L-ornithine + urea
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L-arginine + H2O
L-ornithine + urea
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L-arginine + H2O
L-ornithine + urea
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L-arginine + H2O
L-ornithine + urea
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L-arginine + H2O
L-ornithine + urea
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the enzyme involved in urea cycle
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L-arginine + H2O
L-ornithine + urea
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L-arginine + H2O
L-ornithine + urea
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L-arginine + H2O
L-ornithine + urea
the enzyme catalyses the catabolism of L-arginine to L-ornithine and urea
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L-arginine + H2O
L-ornithine + urea
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L-arginine + H2O
L-ornithine + urea
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L-arginine + H2O
L-ornithine + urea
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enzyme is involved in acid resistance and inhibits host nitric oxide production
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L-arginine + H2O
L-ornithine + urea
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enzyme is involved in acid resistance and inhibits host nitric oxide production
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L-arginine + H2O
L-ornithine + urea
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L-arginine + H2O
L-ornithine + urea
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L-arginine + H2O
L-ornithine + urea
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L-arginine + H2O
L-ornithine + urea
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L-arginine + H2O
L-ornithine + urea
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L-arginine + H2O
L-ornithine + urea
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L-arginine + H2O
L-ornithine + urea
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enzyme is involved in net production of ornithine, a precursor of polyamines, glutamate, and proline, enzyme is also involved in regulation of nitric oxide biosynthesis by modulating arginine availability for nitric oxide synthase
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L-arginine + H2O
L-ornithine + urea
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enzyme is involved in regulating L-arginine bioavailability to NO synthase in human penile corpus cavernosum smooth muscle, and in clitoral corpus cavernosum and vagina, enzyme plays a role in both female and male sexual arousal
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L-arginine + H2O
L-ornithine + urea
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enzyme is involved in regulation of nitric oxide biosynthesis by modulating arginine availability for nitric oxide synthase
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L-arginine + H2O
L-ornithine + urea
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arginase competes with nitric oxide synthases for L-arginine as the common substrate
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L-arginine + H2O
L-ornithine + urea
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L-arginine + H2O
L-ornithine + urea
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L-arginine + H2O
L-ornithine + urea
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L-arginine + H2O
L-ornithine + urea
arginase catalyzes the first committed step in the biosynthesis of polyamines
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L-arginine + H2O
L-ornithine + urea
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L-arginine + H2O
L-ornithine + urea
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L-arginine + H2O
L-ornithine + urea
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L-arginine + H2O
L-ornithine + urea
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L-arginine + H2O
L-ornithine + urea
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L-arginine + H2O
L-ornithine + urea
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ir
L-arginine + H2O
L-ornithine + urea
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L-arginine + H2O
L-ornithine + urea
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L-arginine + H2O
L-ornithine + urea
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L-arginine + H2O
L-ornithine + urea
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L-arginine + H2O
L-ornithine + urea
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arginase competes with nitric oxide synthases for L-arginine as the common substrate
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L-arginine + H2O
L-ornithine + urea
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L-arginine + H2O
L-ornithine + urea
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L-arginine + H2O
L-ornithine + urea
Vigna catjang
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L-arginine + H2O
L-ornithine + urea
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additional information
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presence of arginine pools, which are accessible to NO synthase and enzyme, but not exchangeable
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additional information
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the wild type enzyme does not hydrolyze 1-amino-4-guanidinobutane (agmatine)
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additional information
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complex regulation of natural killer cell functions by arginine availability
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additional information
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hereditary defects in arginase compromise structure and catalysis, which results in an accumulation of arginine in the blood known as hyperarginemia. Arginase deficiency can also result in the accumulation of nitrogen in the form of ammonia, which results in hyperammonemia
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additional information
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hereditary defects in arginase compromise structure and catalysis, which results in an accumulation of arginine in the blood known as hyperarginemia. Arginase deficiency can also result in the accumulation of nitrogen in the form of ammonia, which results in hyperammonemia
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additional information
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recombinant human arginase I (rhArg-PEG), an arginine-depleting enzyme, can inhibit the growth of arginine-dependent tumors
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additional information
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arginase II is constitutively expressed in the airways of normal mice, whereas arginase I is undetectable in normal airways, while its expression is increased in airways of mice exposed to ovalbumin
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additional information
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enzyme may be involved in cellular proliferation in atherosclerosis, inhibiton of enzyme expression by 17beta-estradiol as mechanism in attenuating atherogenensis
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additional information
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mitochondrial isoform arginase II negatively regulates NO synthase 1 activity by limiting substrate availability in its microdomain
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additional information
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infection of mice with Schistosoma mansoni cercariae elevates arginase activity
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additional information
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infection of mice with Schistosoma mansoni cercariae elevates arginase activity
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