Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.5.3.1 extracted from

  • Moon, J.; Do, H.J.; Cho, Y.; Shin, M.J.
    Arginase inhibition ameliorates hepatic metabolic abnormalities in obese mice (2014), PLoS ONE, 9, e103048.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.5.3.1

Inhibitors

Inhibitors Comment Organism Structure
Nomega-hydroxy-nor-L-arginine
-
 Homo sapiens
Nomega-hydroxy-nor-L-arginine
-
 Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-arginine + H2O Mus musculus
-
 L-ornithine + urea
-
 ?
L-arginine + H2O Homo sapiens
-
 L-ornithine + urea
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
Hep-G2 cell
-
 Homo sapiens
-
liver
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-arginine + H2O
-
 Mus musculus L-ornithine + urea
-
 ?
L-arginine + H2O
-
 Homo sapiens L-ornithine + urea
-
 ?

General Information

General Information Comment Organism
malfunction arginase inhibition increases hepatic nitric oxide in HepG2 cells, and reverses the elevated mRNA expression of hepatic genes in lipid metabolism. The expression of phosphorylated 5' adenosine monophosphate-activated protein kinase alpha is increased by arginase inhibition in HepG2 cells Homo sapiens
malfunction arginase inhibition increases hepatic nitric oxide in high fat diet-fed mice and reverses the elevated mRNA expression of hepatic genes in lipid metabolism. The expression of phosphorylated 5' adenosine monophosphate-activated protein kinase alpha is increased by arginase inhibition in the mouse liver. Arginase inhibition prevents diet-induced obesity and reduces liver weight Mus musculus