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Literature summary for 3.5.3.1 extracted from

  • Hrabak, A.; Bajor, T.; Meszaros, G.
    The inhibitory effect of various indolyl amino acid derivatives on arginase activity in macrophages (2008), Amino Acids, 34, 293-300.
    View publication on PubMed
Search for more literature for 3.5.3.1

Inhibitors

Inhibitors Comment Organism Structure
2-(1H-indol-3-yl)ethanol
-
 Bos taurus
2-(1H-indol-3-yl)ethanol
-
 Mus musculus
5-hydroxy-L-tryptophan
-
 Bos taurus
5-hydroxy-L-tryptophan
-
 Mus musculus
5-hydroxytryptamine
-
 Bos taurus
5-hydroxytryptamine
-
 Mus musculus
D-tryptophan
-
 Bos taurus
D-tryptophan
-
 Mus musculus
imidazole-3-lactate
-
 Bos taurus
imidazole-3-lactate
-
 Mus musculus
indole
-
 Bos taurus
indole
-
 Mus musculus
indole-3-L-lactic acid
-
 Bos taurus
indole-3-L-lactic acid
-
 Mus musculus
indole-propionic acid
-
 Mus musculus
Indolepropionic acid
-
 Bos taurus
L-tryptophan
-
 Bos taurus
L-tryptophan
-
 Mus musculus
N-acetyl-5-hydroxytryptamine
-
 Bos taurus
N-acetyl-5-hydroxytryptamine
-
 Mus musculus
tryptamine
-
 Bos taurus
tryptamine
-
 Mus musculus
tyramine
-
 Bos taurus
tyramine
-
 Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-arginine + H2O Mus musculus
-
 L-ornithine + urea
-
 ?
L-arginine + H2O Bos taurus
-
 L-ornithine + urea
-
 ?

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Bos taurus
-
macrophage
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-arginine + H2O
-
 Mus musculus L-ornithine + urea
-
 ?
L-arginine + H2O
-
 Bos taurus L-ornithine + urea
-
 ?

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
2.8
-
 in the presence of 0.5 mM MnCl2, at 37°C Mus musculus Indolepropionic acid
2.8
-
 in the presence of 0.5 mM MnCl2, at 37°C Bos taurus Indolepropionic acid
3.2
-
 in the presence of 0.5 mM MnCl2, at 37°C Bos taurus tryptamine
3.3
-
 in the presence of 0.5 mM MnCl2, at 37°C Bos taurus 5-hydroxytryptamine
3.4
-
 in the presence of 0.5 mM MnCl2, at 37°C Mus musculus tryptamine
3.4
-
 in the presence of 0.5 mM MnCl2, at 37°C Bos taurus indole-3-L-lactic acid
3.6
-
 in the presence of 0.5 mM MnCl2, at 37°C Mus musculus 5-hydroxy-L-tryptophan
3.6
-
 in the presence of 0.5 mM MnCl2, at 37°C Mus musculus 5-hydroxytryptamine
3.6
-
 in the presence of 0.5 mM MnCl2, at 37°C Mus musculus indole-3-L-lactic acid
3.9
-
 in the presence of 0.5 mM MnCl2, at 37°C Bos taurus 5-hydroxy-L-tryptophan
4.8
-
 in the presence of 0.5 mM MnCl2, at 37°C Mus musculus 2-(1H-indol-3-yl)ethanol
5.3
-
 in the presence of 0.5 mM MnCl2, at 37°C Bos taurus 2-(1H-indol-3-yl)ethanol
7.5
-
 in the presence of 0.5 mM MnCl2, at 37°C Mus musculus L-tryptophan
8.4
-
 in the presence of 0.5 mM MnCl2, at 37°C Bos taurus L-tryptophan
8.4
-
 in the presence of 0.5 mM MnCl2, at 37°C Mus musculus D-tryptophan
10
-
 in the presence of 0.5 mM MnCl2, at 37°C Bos taurus D-tryptophan
20
-
 IC50 above 20 mM, in the presence of 0.5 mM MnCl2, at 37°C Mus musculus tyramine
20
-
 IC50 above 20 mM, in the presence of 0.5 mM MnCl2, at 37°C Bos taurus tyramine
20
-
 IC50 above 20 mM, in the presence of 0.5 mM MnCl2, at 37°C Mus musculus indole
20
-
 IC50 above 20 mM, in the presence of 0.5 mM MnCl2, at 37°C Bos taurus indole
20
-
 IC50 above 20 mM, in the presence of 0.5 mM MnCl2, at 37°C Bos taurus N-acetyl-5-hydroxytryptamine
20
-
 IC50 above 20 mM, in the presence of 0.5 mM MnCl2, at 37°C Mus musculus imidazole-3-lactate
20
-
 IC50 above 20 mM, in the presence of 0.5 mM MnCl2, at 37°C Bos taurus imidazole-3-lactate