3.5.3.1: arginase
This is an abbreviated version!
For detailed information about arginase, go to the full flat file.
Word Map on EC 3.5.3.1
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3.5.3.1
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endothelial
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tnf
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polyamines
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myeloid-derived
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necrosis
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myeloid
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monocyte
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arterial
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lps
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lipopolysaccharide
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peritoneal
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l-ornithine
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mdscs
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pulmonary
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microglia
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ammonia
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t-cells
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argininosuccinate
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airway
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leishmania
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hypertension
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asthma
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putrescine
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immunotherapy
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marrow-derived
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tumor-associated
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leishmaniasis
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transcarbamylase
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vasodilation
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neuroinflammation
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l-citrulline
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dimethylarginine
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interleukin-10
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tregs
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l-name
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endothelium-dependent
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urease
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agmatine
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m2-like
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hyperammonemia
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no-dependent
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amazonensis
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erectile
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no-synthase
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medicine
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dimethylaminohydrolase
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ng-monomethyl-l-arginine
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bmdms
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carbamoylphosphate
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il-4-induced
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analysis
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synthesis
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pharmacology
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food industry
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drug development
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nutrition
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phosphodiesterase-5
- 3.5.3.1
- endothelial
- tnf
- polyamines
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myeloid-derived
- necrosis
- myeloid
- monocyte
- arterial
- lps
- lipopolysaccharide
- peritoneal
- l-ornithine
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mdscs
- pulmonary
- microglia
- ammonia
- t-cells
- argininosuccinate
- airway
- leishmania
- hypertension
- asthma
- putrescine
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immunotherapy
-
marrow-derived
-
tumor-associated
- leishmaniasis
-
transcarbamylase
-
vasodilation
-
neuroinflammation
- l-citrulline
- dimethylarginine
- interleukin-10
-
tregs
-
l-name
-
endothelium-dependent
- urease
- agmatine
-
m2-like
- hyperammonemia
-
no-dependent
- amazonensis
-
erectile
- no-synthase
- medicine
-
dimethylaminohydrolase
- ng-monomethyl-l-arginine
-
bmdms
- carbamoylphosphate
-
il-4-induced
- analysis
- synthesis
- pharmacology
- food industry
- drug development
- nutrition
- phosphodiesterase-5
Reaction
Synonyms
ARG, Arg I, Arg II, ARG1, ARG2, ARGAH1, ARGAH2, ArgI, arginase, arginase 1, arginase 1a, arginase 1b, arginase 2a, arginase 2b, arginase I, arginase II, arginase type I, arginase-1, arginase-2, arginase1, arginine amidinase, arginine amidohydrolase-1, arginine amidohydrolase-2, arginine transamidinase, canavanase, human arginase type I, Kidney-type arginase, L-arginase, L-arginine amidino hydrolase, L-arginine amidinohydrolase, L-arginine amidohydrolase, L-arginine ureahydrolase, Liver-type arginase, mitochondrial arginase, More, Non-hepatic arginase, PMN arginase, recombinant human arginase I, rhArg-PEG, rhArg1, RocF, serum arginase, SmARG, tissue arginase, type II arginase
ECTree
3.5.3.1 arginaseAdvanced search results
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results (Substrates Products
Substrates Products on EC 3.5.3.1 - arginase
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
1-nitro-3-guanidinobenzene + H2O
3-nitrobenzenamine + urea
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synthetic chromophoric substrate, low activity
-
-
?
4-guanidino-2-nitrophenylacetic acid + H2O
4-amino-2-nitrophenylacetate + urea
-
-
-
-
?
4-guanidino-3-nitrobenzoic acid + H2O
4-amino-3-nitrobenzoate + urea
-
-
-
-
?
D-arginine + H2O
D-ornithine + urea
isoform LeARG1, 2.2% of the activity with L-arginine, LeARG2, 3.6% of the activity with L-arginine
-
-
?
L-homoarginine + H2O
L-2,6-diaminohexanoate + urea
isoform LeARG1, 14% of the activity with L-arginine, LeARG2, 13% of the activity with L-arginine
-
-
?
agmatine + H2O
1,4-diaminobutane + urea
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for wild-type, no substrate. Hydrolysis by mutant N149D
-
-
?
agmatine + H2O
1,4-diaminobutane + urea
isoform LeARG1, 0.5% of the activity with L-arginine, LeARG2, 0.6% of the activity with L-arginine
-
-
?
agmatine + H2O
1,4-diaminobutane + urea
Vigna catjang
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16% of the activity with L-arginine
-
-
?
canavanine + H2O
urea + NH2OCH2CH2CH(NH2)COOH
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9.6% of the activity with L-arginine
-
-
?
canavanine + H2O
urea + NH2OCH2CH2CH(NH2)COOH
Vigna catjang
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12.7% of the activity with L-arginine
-
-
?
L-arginine + H2O
L-ornithine + urea
-
-
-
-
?
L-arginine + H2O
L-ornithine + urea
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the enzyme involved in urea cycle
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-
?
L-arginine + H2O
L-ornithine + urea
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the enzyme does not hydrolyse D-arginine and other arginine analogues (L-agmatine, L-canavanine, L-argininamide and L-homoarginine)
-
-
?
L-arginine + H2O
L-ornithine + urea
the enzyme catalyses the catabolism of L-arginine to L-ornithine and urea
-
-
?
L-arginine + H2O
L-ornithine + urea
the biosynthesis yield of L-ornithine by the purified enzyme is 36.9 g/l, and the molar yield is 97.2%
-
-
?
L-arginine + H2O
L-ornithine + urea
the biosynthesis yield of L-ornithine by the purified enzyme is 36.9 g/l, and the molar yield is 97.2%
-
-
?
L-arginine + H2O
L-ornithine + urea
-
-
-
-
?
L-arginine + H2O
L-ornithine + urea
-
enzyme is involved in acid resistance and inhibits host nitric oxide production
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-
?
L-arginine + H2O
L-ornithine + urea
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enzyme is involved in acid resistance and inhibits host nitric oxide production
-
-
?
L-arginine + H2O
L-ornithine + urea
-
-
-
-
?
L-arginine + H2O
L-ornithine + urea
-
enzyme is involved in net production of ornithine, a precursor of polyamines, glutamate, and proline, enzyme is also involved in regulation of nitric oxide biosynthesis by modulating arginine availability for nitric oxide synthase
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-
?
L-arginine + H2O
L-ornithine + urea
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enzyme is involved in regulating L-arginine bioavailability to NO synthase in human penile corpus cavernosum smooth muscle, and in clitoral corpus cavernosum and vagina, enzyme plays a role in both female and male sexual arousal
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-
ir
L-arginine + H2O
L-ornithine + urea
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enzyme is involved in regulation of nitric oxide biosynthesis by modulating arginine availability for nitric oxide synthase
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-
?
L-arginine + H2O
L-ornithine + urea
-
reaction intermediate is Nomega-hydroxy-L-arginine
-
-
?
L-arginine + H2O
L-ornithine + urea
-
arginase competes with nitric oxide synthases for L-arginine as the common substrate
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-
?
L-arginine + H2O
L-ornithine + urea
arginase catalyzes the first committed step in the biosynthesis of polyamines
-
-
?
L-arginine + H2O
L-ornithine + urea
-
-
-
-
?
L-arginine + H2O
L-ornithine + urea
-
-
-
-
?
L-arginine + H2O
L-ornithine + urea
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arginase competes with nitric oxide synthases for L-arginine as the common substrate
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-
?
L-arginine + H2O
L-ornithine + urea
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mechanism of positive cooperativity. The kinetic characterization of arginase from yeast crude extract indicates that both fermentation temperature and timing clearly affect enzymatic activity, which gradually increases after the inoculum, reaching the highest Vmax value when yeast assimilable nitrogen is nearly completely exhausted and the arginine added to the semi-synthetic grape juice is significantly consumed (approximately 40-50% of its initial level). Yeast arginase shows the best catalytic properties when alcoholic fermentation occurrs at 20°C approximately 3 days after the inoculum
-
-
?
L-phenylalanine + H2O
2-oxo-3-phenylpropanoate + NH3
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-
-
-
?
additional information
?
-
-
no substrate: agmatine, D-arginine, L-homoarginine, L-argininic acid, gamma-guanidinobutyric acid, beta-guanidinopropionic acid, streptomycin
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-
?
additional information
?
-
-
isozyme selectivity in binding and substrate, products, and inhibitors
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-
?
additional information
?
-
-
presence of arginine pools, which are accessible to NO synthase and enzyme, but not exchangeable
-
-
?
additional information
?
-
-
the wild type enzyme does not hydrolyze 1-amino-4-guanidinobutane (agmatine)
-
-
?
additional information
?
-
-
complex regulation of natural killer cell functions by arginine availability
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-
?
additional information
?
-
hereditary defects in arginase compromise structure and catalysis, which results in an accumulation of arginine in the blood known as hyperarginemia. Arginase deficiency can also result in the accumulation of nitrogen in the form of ammonia, which results in hyperammonemia
-
-
?
additional information
?
-
hereditary defects in arginase compromise structure and catalysis, which results in an accumulation of arginine in the blood known as hyperarginemia. Arginase deficiency can also result in the accumulation of nitrogen in the form of ammonia, which results in hyperammonemia
-
-
?
additional information
?
-
-
recombinant human arginase I (rhArg-PEG), an arginine-depleting enzyme, can inhibit the growth of arginine-dependent tumors
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-
?
additional information
?
-
-
arginase II is constitutively expressed in the airways of normal mice, whereas arginase I is undetectable in normal airways, while its expression is increased in airways of mice exposed to ovalbumin
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-
?
additional information
?
-
-
enzyme may be involved in cellular proliferation in atherosclerosis, inhibiton of enzyme expression by 17beta-estradiol as mechanism in attenuating atherogenensis
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-
?
additional information
?
-
-
mitochondrial isoform arginase II negatively regulates NO synthase 1 activity by limiting substrate availability in its microdomain
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-
?
additional information
?
-
-
model cluster used to simulate the active site of arginase is built starting from the 1.7 A X-ray structure of rat liver arginase complexed with the inhibitor 2(S)-amino-6-boronohexanoic acid (ABH)
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-
?
additional information
?
-
infection of mice with Schistosoma mansoni cercariae elevates arginase activity
-
-
?
additional information
?
-
-
infection of mice with Schistosoma mansoni cercariae elevates arginase activity
-
-
?
additional information
?
-
Vigna catjang
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no substrate: D-arginine, L-homoarginine, L-argininic acid, gamma-guanidinobutyric acid, beta-guanidinopropionic acid, streptomycin
-
-
?
