3.5.1.114: N-acyl-aromatic-L-amino acid amidohydrolase

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For detailed information about N-acyl-aromatic-L-amino acid amidohydrolase, go to the full flat file.

Word Map on EC 3.5.1.114

3.5.1.114

deacetylating

halogenated

beta-lyases

tetramer

mercapturate

n-acetylated

tubule

s-conjugate

alkenes

nephrotoxic

medicine

Reaction

Synonyms

AA3, AAIII, Acy3, aminoacylase 3, aminoacylase III

ECTree

3 Hydrolases

3.5 Acting on carbon-nitrogen bonds, other than peptide bonds

3.5.1 In linear amides

3.5.1.114 N-acyl-aromatic-L-amino acid amidohydrolase

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Results	in table
14	AA Sequence
1	Application
8	Cloned(Commentary)
1	Crystallization (Commentary)
4	Disease/ Diagnostics
1	Expression
11	General Information
8	IC50 Value
19	Inhibitors
8	kcat/KM [mM/s]
77	KM Value [mM]
2	Localization
9	Metals/Ions
5	Molecular Weight [Da]
4	Natural Substrates/ Products (Substrates)
10	Organism
6	pH Optimum
1	Posttranslational Modification
7	Protein Variants
7	Purification (Commentary)
2	Reaction
10	Reference
35	Source Tissue
44	Substrates and Products (Substrate)
4	Subunits
17	Synonyms
1	Systematic Name
3	Temperature Optimum [°C]
10	Turnover Number [1/s]

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Reference on EC 3.5.1.114 - N-acyl-aromatic-L-amino acid amidohydrolase

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679474

Newman, D.; Abuladze, N.; Scholz, K.; Dekant, W.; Tsuprun, V.; Ryazantsev, S.; Bondar, G.; Sassani, P.; Kurtz, I.; Pushkin, A.

Specificity of aminoacylase III-mediated deacetylation of mercapturic acids

Drug Metab. Dispos.

43-50

2007

Mus musculus

17012540

710809

Pushkin, A.; Carpenito, G.; Abuladze, N.; Newman, D.; Tsuprun, V.; Ryazantsev, S.; Motemoturu, S.; Sassani, P.; Solovieva, N.; Dukkipati, R.; Kurtz, I.

Structural characterization, tissue distribution, and functional expression of murine aminoacylase III

Am. J. Physiol. Cell Physiol.

286

C848-856

2003

Mus musculus (Q91XE4), Mus musculus

14656720

711284

Tsirulnikov, K.; Abuladze, N.; Newman, D.; Ryazantsev, S.; Wolak, T.; Magilnick, N.; Koag, M.C.; Kurtz, I.; Pushkin, A.

Mouse aminoacylase 3: a metalloenzyme activated by cobalt and nickel

Biochim. Biophys. Acta

1794

1049-1057

2009

Mus musculus (Q91XE4)

19362172

713420

Hsieh, J.M.; Tsirulnikov, K.; Sawaya, M.R.; Magilnick, N.; Abuladze, N.; Kurtz, I.; Abramson, J.; Pushkin, A.

Structures of aminoacylase 3 in complex with acetylated substrates

Proc. Natl. Acad. Sci. USA

107

17962-17967

2010

Mus musculus (Q91XE4)

20921362

723787

Tsirulnikov, K.; Abuladze, N.; Bragin, A.; Faull, K.; Cascio, D.; Damoiseaux, R.; Schibler, M.J.; Pushkin, A.

Inhibition of aminoacylase 3 protects rat brain cortex neuronal cells from the toxicity of 4-hydroxy-2-nonenal mercapturate and 4-hydroxy-2-nonenal

Toxicol. Appl. Pharmacol.

263

303-314

2012

Rattus norvegicus (Q5M876), Mus musculus (Q91XE4), Homo sapiens (Q96HD9), Rattus norvegicus Wistar (Q5M876)

22819785

733862

Tsirulnikov, K.; Abuladze, N.; Vahi, R.; Hasnain, H.; Phillips, M.; Ryan, C.; Atanasov, I.; Faull, K.; Kurtz, I.; Pushkin, A.

Aminoacylase 3 binds to and cleaves the N-terminus of the hepatitis C virus core protein

FEBS Lett.

586

3799-3804

2012

Mus musculus (Q91XE4)

23010594

754228

Tsirulnikov, K.; Duarte, S.; Ray, A.; Datta, N.; Zarrinpar, A.; Hwang, L.; Faull, K.; Pushkin, A.; Kurtz, I.

Aminoacylase 3 is a new potential marker and therapeutic target in hepatocellular carcinoma

J. Cancer

1-12

2018

Homo sapiens (Q96HD9), Homo sapiens

29290764