3.5.1.114: N-acyl-aromatic-L-amino acid amidohydrolase

This is an abbreviated version!
For detailed information about N-acyl-aromatic-L-amino acid amidohydrolase, go to the full flat file.

Reaction

Synonyms

AA3, AAIII, Acy3, aminoacylase 3, aminoacylase III

ECTree

     3 Hydrolases

         3.5 Acting on carbon-nitrogen bonds, other than peptide bonds

             3.5.1 In linear amides

                3.5.1.114 N-acyl-aromatic-L-amino acid amidohydrolase

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Results	in table
14	AA Sequence
1	Application
8	Cloned(Commentary)
1	Crystallization (Commentary)
4	Disease/ Diagnostics
1	Expression
11	General Information
8	IC50 Value
19	Inhibitors
8	kcat/KM [mM/s]
77	KM Value [mM]
2	Localization
9	Metals/Ions
5	Molecular Weight [Da]
4	Natural Substrates/ Products (Substrates)
10	Organism
6	pH Optimum
1	Posttranslational Modification
7	Protein Variants
7	Purification (Commentary)
2	Reaction
10	Reference
35	Source Tissue
44	Substrates and Products (Substrate)
4	Subunits
17	Synonyms
1	Systematic Name
3	Temperature Optimum [°C]
10	Turnover Number [1/s]

Natural Substrates Products

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Natural Substrates Products on EC 3.5.1.114 - N-acyl-aromatic-L-amino acid amidohydrolase

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NATURAL SUBSTRATE

NATURAL PRODUCT

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

REVERSIBILITY
r=reversible
ir=irreversible
?=not specified

N-acetyl-S-geranylgeranyl-L-cysteine + H2O

3-geranylgeranyl-L-cysteine + acetate

Homo sapiens

Q96HD9

the 90000-100000 Da AA3 form (that is detected in most hepatocellular carcinoma cell lines but not in normal hepatocytes) is functionally active and together with the normal 35000 Da AA3 form mediates the deacetylation of N-acetylfarnesylcysteine and N-acetylgeranylgeranylcysteine

754228

-

-

?

N-acetyl-S-[(2E,6E)-farnesyl]-L-cysteine + H2O

S-[(2E,6E)-farnesyl]-L-cysteine + acetate

Homo sapiens

Q96HD9

the 90000-100000 Da AA3 form (that is detected in most hepatocellular carcinoma cell lines but not in normal hepatocytes) is functionally active and together with the normal 35000 Da AA3 form mediates the deacetylation of N-acetylfarnesylcysteine and N-acetylgeranylgeranylcysteine

754228

-

-

?

Nalpha-acetylated peptide + H2O

acetate + peptide

Mus musculus

Q91XE4

N-terminal peptides derived from hepatitis C virus core protein

733862

-

-

?

additional information

?

-

Mus musculus

Q91XE4

the enzyme directly binds to the hepatitis C virus core protein and also reveals a weak endopeptidase activity towards the N-terminus of hepatitis C virus core protein, interaction analysis of the enzyme with N-terminal peptides derived from hepatitis C virus core protein via surface plasmon resonance method, overview

733862

-

-

?