3.5.1.114: N-acyl-aromatic-L-amino acid amidohydrolase

This is an abbreviated version!
For detailed information about N-acyl-aromatic-L-amino acid amidohydrolase, go to the full flat file.

Reaction

Synonyms

AA3, AAIII, Acy3, aminoacylase 3, aminoacylase III

ECTree

     3 Hydrolases

         3.5 Acting on carbon-nitrogen bonds, other than peptide bonds

             3.5.1 In linear amides

                3.5.1.114 N-acyl-aromatic-L-amino acid amidohydrolase

Advanced search results

Do not include text mining results

Include results (more...)

Include results (more...)

Results	in table
14	AA Sequence
1	Application
8	Cloned(Commentary)
1	Crystallization (Commentary)
4	Disease/ Diagnostics
1	Expression
11	General Information
8	IC50 Value
19	Inhibitors
8	kcat/KM [mM/s]
77	KM Value [mM]
2	Localization
9	Metals/Ions
5	Molecular Weight [Da]
4	Natural Substrates/ Products (Substrates)
10	Organism
6	pH Optimum
1	Posttranslational Modification
7	Protein Variants
7	Purification (Commentary)
2	Reaction
10	Reference
35	Source Tissue
44	Substrates and Products (Substrate)
4	Subunits
17	Synonyms
1	Systematic Name
3	Temperature Optimum [°C]
10	Turnover Number [1/s]

Application

print visible entries

print all entries

Go back to the abbreviated version
of the Enzyme Summary Page.

Application on EC 3.5.1.114 - N-acyl-aromatic-L-amino acid amidohydrolase

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.

top print hide show all columns Go to Application Search

Please wait a moment until the data is sorted. This message will disappear when the data is sorted.

APPLICATION

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

medicine

Homo sapiens

Q96HD9

expression is significantly elevated in the livers of hepatocellular carcinoma patients and hepatocellular carcinoma cell lines. Treatment of HepG2 cells with AA3 inhibitors, and HepG2 and HuH7 with AA3 siRNA significantly decreases Ras membrane association and is toxic to these HCC cell lines. AA3 inhibition may be an effective approach in the therapy of hepatocellular carcinoma and elevated AA3 expression in hepatocellular carcinoma is potentially an important diagnostic marker

754228