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EC Number	Application	Commentary	Reference
3.5.1.114	medicine	expression is significantly elevated in the livers of hepatocellular carcinoma patients and hepatocellular carcinoma cell lines. Treatment of HepG2 cells with AA3 inhibitors, and HepG2 and HuH7 with AA3 siRNA significantly decreases Ras membrane association and is toxic to these HCC cell lines. AA3 inhibition may be an effective approach in the therapy of hepatocellular carcinoma and elevated AA3 expression in hepatocellular carcinoma is potentially an important diagnostic marker	754228

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Release 2023.1 (January 2023)