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Literature summary for 3.5.1.114 extracted from

  • Newman, D.; Abuladze, N.; Scholz, K.; Dekant, W.; Tsuprun, V.; Ryazantsev, S.; Bondar, G.; Sassani, P.; Kurtz, I.; Pushkin, A.
    Specificity of aminoacylase III-mediated deacetylation of mercapturic acids (2007), Drug Metab. Dispos., 35, 43-50.
    View publication on PubMed
Search for more literature for 3.5.1.114

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.25
-
 N-acetyl-S-(1,1,2,2-tetrafluoroethyl)-L-cysteine pH 7.5, 37°C Mus musculus
0.28
-
 N-acetyl-S-(2-chloro-1,1,2-trifluoroethyl)-L-cysteine pH 7.5, 37°C Mus musculus
0.3
-
 N-acetyl-S-(4-chlorobenzyl)-L-cysteine pH 7.5, 37°C Mus musculus
0.3
-
 N-acetyl-S-(2,2-difluoro-1,1-dichloroethyl)-L-cysteine pH 7.5, 37°C Mus musculus
0.4
-
 N-acetyl-S-(2,2-dichlorovinyl)-L-cysteine pH 7.5, 37°C Mus musculus
0.5
-
 N-acetyl-S-(4-bromobenzyl)-L-cysteine pH 7.5, 37°C Mus musculus
0.6
-
 N-acetyl-S-(3-fluorobenzyl)-L-cysteine pH 7.5, 37°C Mus musculus
0.8
-
 N-acetyl-S-(4-methoxybenzyl)-L-cysteine pH 7.5, 37°C Mus musculus
0.9
-
 N-acetyl-S-(1,2-dichlorovinyl)-L-cysteine pH 7.5, 37°C Mus musculus
1
-
 N-acetyl-S-(1,2,3,4,4-pentachlorobutadienyl)-L-cysteine pH 7.5, 37°C Mus musculus
1.1
-
 N-acetyl-S-benzyl-L-cysteine pH 7.5, 37°C Mus musculus
1.2
-
 N-acetyl-L-tryptophan pH 7.5, 37°C Mus musculus
1.2
-
 N-acetyl-S-(1,2,2-trichlorovinyl)-L-cysteine pH 7.5, 37°C Mus musculus
1.3
-
 N-acetyl-L-lysine pH 7.5, 37°C Mus musculus
1.3
-
 N-acetyl-S-(2-fluorobenzyl)-L-cysteine pH 7.5, 37°C Mus musculus
1.4
-
 N-acetyl-L-tyrosine pH 7.5, 37°C Mus musculus
1.45
-
 N-acetyl-S-(2-chlorobenzyl)-L-cysteine pH 7.5, 37°C Mus musculus
1.6
-
 N-acetyl-L-phenylalanine pH 7.5, 37°C Mus musculus
1.8
-
 N-acetyl-L-histidine pH 7.5, 37°C Mus musculus
5.3
-
 N-acetyl-S-(2,2-dichloro-1,1-difluoroethyl)-L-cysteine pH 7.5, 37°C Mus musculus

Metals/Ions

Metals/Ions Comment Organism Structure
additional information enzyme does not require metal ions Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Mus musculus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information no activity with N-acetyl-L-cysteine, N-acetyl-L-aspartic acid and Nepsilon-acetyl-L-lysine Mus musculus ?
-
 ?
N-acetyl-L-histidine + H2O
-
 Mus musculus acetate + L-histidine
-
 ?
N-acetyl-L-lysine + H2O
-
 Mus musculus acetate + L-lysine
-
 ?
N-acetyl-L-phenylalanine + H2O
-
 Mus musculus acetate + L-phenylalanine
-
 ?
N-acetyl-L-tryptophan + H2O
-
 Mus musculus acetate + L-tryptophan
-
 ?
N-acetyl-L-tyrosine + H2O
-
 Mus musculus acetate + L-tyrosine
-
 ?
N-acetyl-S-(1,1,2,2-tetrafluoroethyl)-L-cysteine + H2O
-
 Mus musculus acetate + S-(1,1,2,2-tetrafluoroethyl)-L-cysteine
-
 ?
N-acetyl-S-(1,2,2-trichlorovinyl)-L-cysteine + H2O
-
 Mus musculus acetate + S-(1,2,2-trichlorovinyl)-L-cysteine
-
 ?
N-acetyl-S-(1,2,3,4,4-pentachlorobutadienyl)-L-cysteine + H2O good substrate Mus musculus acetate + S-(1,2,3,4,4-pentachlorobutadienyl)-L-cysteine
-
 ?
N-acetyl-S-(1,2-dichlorovinyl)-L-cysteine + H2O
-
 Mus musculus acetate + S-(1,2-dichlorovinyl)-L-cysteine
-
 ?
N-acetyl-S-(2,2-dichloro-1,1-difluoroethyl)-L-cysteine + H2O
-
 Mus musculus acetate + S-(2,2-dichloro-1,1-difluoroethyl)-L-cysteine
-
 ?
N-acetyl-S-(2,2-dichlorovinyl)-L-cysteine + H2O good substrate Mus musculus acetate + S-(2,2-dichlorovinyl)-L-cysteine
-
 ?
N-acetyl-S-(2,2-difluoro-1,1-dichloroethyl)-L-cysteine + H2O
-
 Mus musculus acetate + S-(2,2-difluoro-1,1-dichloroethyl)-L-cysteine
-
 ?
N-acetyl-S-(2-chloro-1,1,2-trifluoroethyl)-L-cysteine + H2O
-
 Mus musculus acetate + S-(2-chloro-1,1,2-trifluoroethyl)-L-cysteine
-
 ?
N-acetyl-S-(2-chlorobenzyl)-L-cysteine + H2O
-
 Mus musculus acetate + S-(2-chlorobenzyl)-L-cysteine
-
 ?
N-acetyl-S-(2-fluorobenzyl)-L-cysteine + H2O
-
 Mus musculus acetate + S-(2-fluorobenzyl)-L-cysteine
-
 ?
N-acetyl-S-(3-fluorobenzyl)-L-cysteine + H2O
-
 Mus musculus acetate + S-(3-fluorobenzyl)-L-cysteine
-
 ?
N-acetyl-S-(4-bromobenzyl)-L-cysteine + H2O good substrate Mus musculus acetate + S-(4-bromobenzyl)-L-cysteine
-
 ?
N-acetyl-S-(4-chlorobenzyl)-L-cysteine + H2O good substrate Mus musculus acetate + S-(4-chlorobenzyl)-L-cysteine
-
 ?
N-acetyl-S-(4-methoxybenzyl)-L-cysteine + H2O
-
 Mus musculus acetate + S-(4-methoxybenzyl)-L-cysteine
-
 ?
N-acetyl-S-benzyl-L-cysteine + H2O
-
 Mus musculus acetate + S-benzyl-L-cysteine
-
 ?

Subunits

Subunits Comment Organism
tetramer
-
 Mus musculus

Synonyms

Synonyms Comment Organism
AAIII
-
 Mus musculus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
40
-
-
 Mus musculus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5 7.7 in 50 mM Na-phosphate buffer Mus musculus

General Information

General Information Comment Organism
physiological function the enzyme mediates deacetylation of the mercapturic acids derived from the metabolism of trichloroethylene in the proximal tubule cells, and this process is involved in their toxicity Mus musculus