3.4.24.B7: matrix metalloproteinase-26

This is an abbreviated version!
For detailed information about matrix metalloproteinase-26, go to the full flat file.

Reaction

proteolytic degradation of proteins =

Synonyms

endometase, endometase/matrilysin-2, M10.029, matrilysin 2, matrilysin-2, matrilysis-2/MMP-26, matrix metalloproteinase-26, metalloproteinases-26, MMP-26, MMP-26/endometase/matrilysin-2, More

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.24 Metalloendopeptidases

                3.4.24.B7 matrix metalloproteinase-26

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Results	in table
6	Activating Compound
2	AA Sequence
11	Application
1	CAS Registry Number
11	Cloned(Commentary)
499	Disease/ Diagnostics
5	Expression
14	General Information
6	IC50 Value
26	Inhibitors
16	Ki Value [mM]
2	Localization
8	Metals/Ions
5	Molecular Weight [Da]
23	Natural Substrates/ Products (Substrates)
39	Organism
5	pH Optimum
9	Posttranslational Modification
11	Protein Variants
5	Purification (Commentary)
4	Reaction
5	Reaction Type
38	Reference
4	Renatured (Commentary)
134	Source Tissue
3	Specific Activity [micromol/min/mg]
60	Substrates and Products (Substrate)
6	Subunits
62	Synonyms
6	Temperature Optimum [°C]
1	Temperature Stability [°C]

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Cloned on EC 3.4.24.B7 - matrix metalloproteinase-26

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CLONED (Commentary)

ORGANISM

UNIPROT

LITERATURE

DNA and amino acid sequence determination and analysis, chromosomal mapping to the short arm of chromosome 11 around 11p15, expression in Escherichia coli as His-tagged protein

Homo sapiens

Q9NRE1

650768

DNA and amino acid sequence determination and analysis, chromosome mapping to 11p15.3, expression of the enzymes catalytic domain in Escherichia coli BL21 (DE3)

Homo sapiens

Q9NRE1

649708

DNA sequence determination and analysis, expression of the zymogen in Escherichia coli

Homo sapiens

Q9NRE1

652014

expression in Brevibacillus choshinensis

Homo sapiens

Q9NRE1

735215

expression in Escherichia coli. Human breast cancer cell line, MDA-MB-231, transfected with wild-type MMP-26 cDNA shows a calcium-dependent invasive potential when compared with controls that were transfected with an inactive form of MMP-26 (E209A)

Homo sapiens

-

684968

expression in HeLa cell, HEK-293T cell

Homo sapiens

Q9NRE1

755387

expression of proenzyme MMP-26 in Escherichia coli

Homo sapiens

-

668149

expression of proMMP-26 in Escherichia coli in inclusion bodies

Homo sapiens

-

707115

MMP-26 real-time PCR expression analysis

Homo sapiens

-

713493

transfection of MCF-7 cells

Homo sapiens

Q9NRE1

734817

U251 cells wae transfected with a proMMP-26 cDNA encoding vector, establishment of an MMP-26 overexpressing U251 cell model, overview

Homo sapiens

-

713160