3.4.24.B7: matrix metalloproteinase-26

This is an abbreviated version!
For detailed information about matrix metalloproteinase-26, go to the full flat file.

Reaction

proteolytic degradation of proteins =

Synonyms

endometase, endometase/matrilysin-2, M10.029, matrilysin 2, matrilysin-2, matrilysis-2/MMP-26, matrix metalloproteinase-26, metalloproteinases-26, MMP-26, MMP-26/endometase/matrilysin-2, More

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.24 Metalloendopeptidases

                3.4.24.B7 matrix metalloproteinase-26

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Results	in table
6	Activating Compound
2	AA Sequence
11	Application
1	CAS Registry Number
11	Cloned(Commentary)
499	Disease/ Diagnostics
5	Expression
14	General Information
6	IC50 Value
26	Inhibitors
16	Ki Value [mM]
2	Localization
8	Metals/Ions
5	Molecular Weight [Da]
23	Natural Substrates/ Products (Substrates)
39	Organism
5	pH Optimum
9	Posttranslational Modification
11	Protein Variants
5	Purification (Commentary)
4	Reaction
5	Reaction Type
38	Reference
4	Renatured (Commentary)
134	Source Tissue
3	Specific Activity [micromol/min/mg]
60	Substrates and Products (Substrate)
6	Subunits
62	Synonyms
6	Temperature Optimum [°C]
1	Temperature Stability [°C]

Expression

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Expression on EC 3.4.24.B7 - matrix metalloproteinase-26

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EXPRESSION

ORGANISM

UNIPROT

LITERATURE

endometrial MMP26 expression is dependent on the presence of progesterone in the early secretory phase and then gradually becomes refractory to progesterone stimulation in the late secretory phase

Macaca mulatta

F6QMZ1

733957

preeclampsia induces a significant increase in the content and actual activity of MMP-26 in umbilical cord vein and Wharton's jelly

Homo sapiens

Q9NRE1

753498

regulatory effects of gonadotropin-releasing hormone I and gonadotropin-releasing hormone II, GnRH I and GnRH II, on the expression of MMP-26 in human immortalized cytotrophoblast-like cell line, B6Tert-1. The activation of JNK, but not ERK1/2, is required for GnRH I and II-stimulated MMP-26 production in B6Tert-1 cells and primary cytotrophoblasts

Homo sapiens

-

713493

significant downregulation of expression of MMP-26, and significant 9.8fold upregulation of TGF-beta in more degenerated discs versus healthier discs

Homo sapiens

Q9NRE1

719420

there is significant downregulation of expression of MMP-26 in more degenerated discs vs. healthier discs

Homo sapiens

Q9NRE1

719420