3.4.24.B7: matrix metalloproteinase-26

This is an abbreviated version!
For detailed information about matrix metalloproteinase-26, go to the full flat file.

Reaction

proteolytic degradation of proteins =

Synonyms

endometase, endometase/matrilysin-2, M10.029, matrilysin 2, matrilysin-2, matrilysis-2/MMP-26, matrix metalloproteinase-26, metalloproteinases-26, MMP-26, MMP-26/endometase/matrilysin-2, More

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.24 Metalloendopeptidases

                3.4.24.B7 matrix metalloproteinase-26

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Results	in table
6	Activating Compound
2	AA Sequence
11	Application
1	CAS Registry Number
11	Cloned(Commentary)
499	Disease/ Diagnostics
5	Expression
14	General Information
6	IC50 Value
26	Inhibitors
16	Ki Value [mM]
2	Localization
8	Metals/Ions
5	Molecular Weight [Da]
23	Natural Substrates/ Products (Substrates)
39	Organism
5	pH Optimum
9	Posttranslational Modification
11	Protein Variants
5	Purification (Commentary)
4	Reaction
5	Reaction Type
38	Reference
4	Renatured (Commentary)
134	Source Tissue
3	Specific Activity [micromol/min/mg]
60	Substrates and Products (Substrate)
6	Subunits
62	Synonyms
6	Temperature Optimum [°C]
1	Temperature Stability [°C]

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RENATURED/Commentary

ORGANISM

UNIPROT

LITERATURE

recombinant zymogen from inclusion bodies expressed in Escherichia coli, partial activation of th proform during refolding

Homo sapiens

Q9NRE1

652014

refolding of recombinant catalytic domain from inclusion bodies expressed in Escherichia coli

Homo sapiens

Q9NRE1

649708

refolding of recombinant protein from inclusion bodies expressed in Escherichia coli

Homo sapiens

Q9NRE1

650768

solubilization of recombinant proMMP-26 from Escherichia coli inclusion bodies by 8 M urea, followed by dialysis against 4 M urea, 1 mM DTT, and 50 mM HEPES or Tricine at pH 7.5 for at least 1 h, and then folded by dialysis against buffer containing 50 mM Hepes, 0.2 M, NaCl, 10 mM CaCl2, 20 lM ZnSO4, and 0.05% Brij-35 at pH 7.5 for 12 h three times, MMP-26 autoactivates

Homo sapiens

-

707115