3.4.24.B7: matrix metalloproteinase-26
This is an abbreviated version!
For detailed information about matrix metalloproteinase-26, go to the full flat file.
Word Map on EC 3.4.24.B7
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3.4.24.B7
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endometrial
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timp-4
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mmp-1
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matrilysins
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menstrual
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medicine
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pro-mmp-9
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olomouc
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metalloelastase
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palacky
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metalloproteinase-4
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prodomain
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diagnostics
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synthesis
- 3.4.24.B7
- endometrial
- timp-4
- mmp-1
- matrilysins
-
menstrual
- medicine
- pro-mmp-9
-
olomouc
- metalloelastase
-
palacky
-
metalloproteinase-4
- prodomain
- diagnostics
- synthesis
Reaction
proteolytic degradation of proteins =
Synonyms
endometase, endometase/matrilysin-2, M10.029, matrilysin 2, matrilysin-2, matrilysis-2/MMP-26, matrix metalloproteinase-26, metalloproteinases-26, MMP-26, MMP-26/endometase/matrilysin-2, More
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Posttranslational Modification
Posttranslational Modification on EC 3.4.24.B7 - matrix metalloproteinase-26
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glycoprotein
proteolytic modification
additional information
glycoprotein
two (N64, N221) of the three possible N-glycosylation sites in MMP-26 are N-glycosylated, and N-glycosylation is not required for ER localization
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autoactivation by autocleavage of the proform at sequence Lys-Lys-Gln59-Gln60-Phe-His, His81 plays a significant role in functional modification
proteolytic modification
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two of the major autolytic sites are Leu49/-Thr50 and Ala75/-Leu76, which still left the cysteine switch sequence intact
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no activation of the proform by organomercurial treatment
additional information
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MMP-26 is only active after treatement with reducing agents