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3.4.24.B7: matrix metalloproteinase-26

This is an abbreviated version!
For detailed information about matrix metalloproteinase-26, go to the full flat file.

Word Map on EC 3.4.24.B7

Reaction

proteolytic degradation of proteins =

Synonyms

endometase, endometase/matrilysin-2, M10.029, matrilysin 2, matrilysin-2, matrilysis-2/MMP-26, matrix metalloproteinase-26, metalloproteinases-26, MMP-26, MMP-26/endometase/matrilysin-2, More

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.24 Metalloendopeptidases
                3.4.24.B7 matrix metalloproteinase-26

Engineering

Engineering on EC 3.4.24.B7 - matrix metalloproteinase-26

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PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
D114A
D165A
-
very low rates of hydrolysis that are less than 5% of that seen for wild-type MMP-26
E191A
-
very low rates of hydrolysis that are less than 5% of that seen for wild-type MMP-26
E209A
-
inactive mutant enzyme
H81R
-
mutation restores the conventional cysteine-switch in the prodomain but fails to induce the cysteine-swich activation
K189E
V184D
-
mutant enzyme shows high rates of fluorescent synthetic peptide hydrolysis
additional information
exchanging residues 88-123 of secretory MMP-7 with the same region in MMP-26 causes localization of this MMP-7 construct to the ER