3.4.24.B7: matrix metalloproteinase-26
This is an abbreviated version!
For detailed information about matrix metalloproteinase-26, go to the full flat file.
Word Map on EC 3.4.24.B7
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3.4.24.B7
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endometrial
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timp-4
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mmp-1
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matrilysins
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menstrual
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medicine
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pro-mmp-9
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olomouc
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metalloelastase
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palacky
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metalloproteinase-4
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prodomain
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diagnostics
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synthesis
- 3.4.24.B7
- endometrial
- timp-4
- mmp-1
- matrilysins
-
menstrual
- medicine
- pro-mmp-9
-
olomouc
- metalloelastase
-
palacky
-
metalloproteinase-4
- prodomain
- diagnostics
- synthesis
Reaction
proteolytic degradation of proteins =
Synonyms
endometase, endometase/matrilysin-2, M10.029, matrilysin 2, matrilysin-2, matrilysis-2/MMP-26, matrix metalloproteinase-26, metalloproteinases-26, MMP-26, MMP-26/endometase/matrilysin-2, More
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3.4.24.B7 matrix metalloproteinase-26Advanced search results
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Application on EC 3.4.24.B7 - matrix metalloproteinase-26
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APPLICATION 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
medicine
synthesis
use of Brevibacillus choshinensis as the host system for the soluble and active expression of MMP26. The enzyme is secreted in soluble form in the supernatant of cell culture medium. The yields of purified proform of MMP26 and catalytic form of MMP-26 are 12 and 18 mg/L, respectively, with high purity and homogeneity. Both pro- and catalytic form show gelatin zymography activity and the purified catalytic form has high enzymatic activity against DQ-gelatin substrate. Expression using several widely used expression vectors in Escheriochia coli cells results in insoluble expressions or soluble expressions with little catalytic activity
medicine
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expression of matrilysin-2 is significantly correlated with nuclear beta-catenin expression and MMP-9 expression. Patients with matrilysin-2-positive cancer have significantly shorter overall and disease-free survival periods than those with matrilysin-2 negative cancer. Matrilysin-2 expression retains its significant predictive value for overall and disease-free survival in multivariate analysis. Patients with concomitant expression of matrilysin-2 and MMP-9 have the worst prognosis
medicine
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MMP-26 is a valuable cancer marker, that contributers favorably to the survival of the estrogen receptor alpha/beta-positive cohort of breast cancer patients
medicine
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MMP-26 may play an integral role during the conversion of HGPIN to invasive cancer and may also serve as marker for early prostate cancer diagnosis
medicine
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matrix metalloproteinase-26 is a marker of melanomas and estrogen-dependent carcinomas
medicine
matrix metalloproteinase MMP26 level is significantly higher in the resected chondrosarcoma than in the adjacent healthy chondral tissue from patients. Overexpression of MMP26 in SW-1353 cells increases cell invasiveness, while inhibition of MMP26 decreases cell invasiveness. Inhibition of Wnt signaling significantly decreases the effect of MMP26 on cancer cell invasion. A strong correlation is detected between MMP26 levels and the ratio of phosphorylated/total beta-catenin in chondrosarcoma from the patients
medicine
slight, but significant, downregulation of MMP-26 in more degenerated intervertebral discs (Thompson grades III, IV and V) compared to healthier discs, while both TGF-beta and latent transforming growth factor-beta binding protein 2 are significantly and strongly upregulated
medicine
all umbilical cord tissues, both control and preeclamptic, express MMP-26 and issue inhibitor of matrix metalloproteinase TIMP-4 in macromolecular complexes. Preeclampsia induces a significant increase in the content and actual activity of MMP-26 in umbilical cord vein and Wharton's jelly. The content of TIMP-4 in preeclamptic umbilical cord vein and Wharton's jelly is reduced. The content of MMP-26 mRNA is lower in umbilical cord arteries and veins, whereas higher in Wharton's jelly in preeclampsia
medicine
in astrocytic glioma, MMP-26 expression is significantly associated with the World Health Organization grade. MMP-26 expression is an independent factor for evaluating the prognosis of astrocytic glioma patients
medicine
MMP-26 expression levels in androgen-repressed human prostate cancer cells, transfected with sense or anti-sense MMP-26 cDNA, and in benign, neoplastic, and invasive prostate cancer tissues are directly correlated with those of the pro-apoptotic marker Bax. The MMP-26 protein levels are upregulated in high grade prostate intraepithelial neoplasia and decrease during the course of disease progression
