Application | Comment | Organism |
---|---|---|
medicine | slight, but significant, downregulation of MMP-26 in more degenerated intervertebral discs (Thompson grades III, IV and V) compared to healthier discs, while both TGF-beta and latent transforming growth factor-beta binding protein 2 are significantly and strongly upregulated | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
activated pro-MMP-9 + H2O | Homo sapiens | - |
? | - |
? | |
denatured collagen type I + H2O | Homo sapiens | - |
? | - |
? | |
denatured collagen type II + H2O | Homo sapiens | - |
? | - |
? | |
denatured collagen type III + H2O | Homo sapiens | - |
? | - |
? | |
denatured collagen type IV + H2O | Homo sapiens | - |
? | - |
? | |
Fibrinogen + H2O | Homo sapiens | - |
? | - |
? | |
Fibronectin + H2O | Homo sapiens | - |
? | - |
? | |
insulin-like growth factor binding protein 1 + H2O | Homo sapiens | - |
? | - |
? | |
Type IV collagen + H2O | Homo sapiens | - |
? | - |
? | |
Vitronectin + H2O | Homo sapiens | - |
? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Homo sapiens | Q9NRE1 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
annulus fibrosus disci intervertebralis | - |
Homo sapiens | - |
intervertebral disc | in the outer and inner annulus and in the nucleus pulposus | Homo sapiens | - |
intervertebral disc | constitutive expression. Protein is found in both disc cells and in the disc extracellular matrix. MMP-26 is identified in the outer and inner annulus and in the nucleus pulposus. Fewer cells show localization in the inner vs. outer annulus, and localization is sparse in the nucleus | Homo sapiens | - |
nucleus pulposus | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
activated pro-MMP-9 + H2O | - |
Homo sapiens | ? | - |
? | |
denatured collagen type I + H2O | - |
Homo sapiens | ? | - |
? | |
denatured collagen type II + H2O | - |
Homo sapiens | ? | - |
? | |
denatured collagen type III + H2O | - |
Homo sapiens | ? | - |
? | |
denatured collagen type IV + H2O | - |
Homo sapiens | ? | - |
? | |
Fibrinogen + H2O | - |
Homo sapiens | ? | - |
? | |
Fibronectin + H2O | - |
Homo sapiens | ? | - |
? | |
insulin-like growth factor binding protein 1 + H2O | - |
Homo sapiens | ? | - |
? | |
Type IV collagen + H2O | - |
Homo sapiens | ? | - |
? | |
Vitronectin + H2O | - |
Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
endometase | - |
Homo sapiens |
matrilysin-2 | - |
Homo sapiens |
MMP-26 | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | there is significant downregulation of expression of MMP-26 in more degenerated discs vs. healthier discs | down |
Homo sapiens | significant downregulation of expression of MMP-26, and significant 9.8fold upregulation of TGF-beta in more degenerated discs versus healthier discs | down |
General Information | Comment | Organism |
---|---|---|
physiological function | MMP-26 plays an important role of in matrix modulation during disc health and degeneration | Homo sapiens |