Any feedback?
Please rate this page
(all_enzymes.php)
(0/150)

BRENDA support

3.4.24.80: membrane-type matrix metalloproteinase-1

This is an abbreviated version!
For detailed information about membrane-type matrix metalloproteinase-1, go to the full flat file.

Word Map on EC 3.4.24.80

Reaction

endopeptidase activity. Activates progelatinase A by cleavage of the propeptide at Asn37-/-Leu. Other bonds hydrolysed include Gly35-/-Ile in the propeptide of collagenase 3, and Asn341-/-Phe, Asp441-/-Leu and Gln354-/-Thr in the aggrecan interglobular domain =

Synonyms

ectMMP-14, gelatinase A, interstitial MT1-MMP, matrix metalloprotease 14, matrix metalloproteinase 14, matrix metalloproteinase MT 1, matrix metalloproteinase MT-MMP-1, matrix metalloproteinase MT1-MMP, matrix metalloproteinase-14, membrane type 1 matrix, membrane type 1 matrix metalloproteinase, membrane type 1 MMP, membrane type 1-matrix metalloproteinase, membrane type 1-MMP, membrane type I MMP, membrane type matrix metalloproteinase, membrane type MMP-1, membrane type MT1-MMP, membrane type-1 matrix metalloprotease, membrane type-1 matrix metalloprotease 1, membrane type-1 matrix metalloproteinase, membrane type-1 MMP, membrane type-I matrix metalloproteinase, membrane type-I MMP, membrane-anchored matrix metalloproteinase 14, membrane-type 1 matrix metalloproteinase, membrane-type 1 matrix metalloproteinase 1, membrane-type 1 MMP, membrane-type 1-matrix metalloproteinase, membrane-type I matrix metalloproteinase, membrane-type matrix metalloproteinase MT1-MMP, membrane-type matrix metalloproteinase-1, membrane-type metalloproteinase MT1-MMP, membrane-type MMP, metalloproteinase, MMP-14, MMP-2, MMP-8, MMP14, mmp14a, mmp14b, More, MT-MMP-1, MT-MMP1, MT1-MMP, MT1-MMP/MMP-14, MT1-MPP, MTI-MMP, pericellular collagenase, proteinase, matrix metallo-, sMT1-MMP

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.24 Metalloendopeptidases
                3.4.24.80 membrane-type matrix metalloproteinase-1

Molecular Weight

Molecular Weight on EC 3.4.24.80 - membrane-type matrix metalloproteinase-1

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
130000
-
dimeric mutant MT1EADELTATM, native PAGE
18000
-
immunoblot analysis of untreated cells, soluble MT1-MMP species, product of autocatalytic processing
21000
x * 21000, catalytic domain, SDS-PAGE
22000
catalytic and hinge domain
27000
-
immunoblot analysis of cells regardless of TAPI-1 treatment, contains haemopexin-like domain, formed by autocatalytic processing of the 57 kDa active form
32000
-
immunoblot analysis of untreated cells
39000
-
Western blot analysis, stable, catalytically inactive ectodomain form
42000
-
Western blot analysis, stable, catalytically inactive ectodomain form
43000
-
autolysis product, Western blot analysis
475000
truncated form, SDS-PAGE
50000
50000 - 64000
truncated forms, SDS-PAGE
53000
54000
55000
56000
x * 56000, SDS-PAGE
57000
570000
active form, SDS-PAGE
58000
x * 58000, SDS-PAGE
60000
600000
-
oligomeric mutant MT1EADELTATM, native PAGE
62000
63000
64000
purified protein, SDS-PAGE
65000
-
immunoprecipitation, post-translationally modified unprocessed form, glycopeptidase F-resistant and also present if treated with inhibitors of N- and O-glycosylation
66000
70000
72000
-
x * 72000, mono-ubiquitinated full-length enzyme, SDS-PAGE
90000
-
MT1-GFP fusion protein, Western blot analysis