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Disease on EC 3.4.24.80 - membrane-type matrix metalloproteinase-1

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DISEASE
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Acquired Immunodeficiency Syndrome
Looking at the proteases from a simple perspective.
Adenocarcinoma
Bioinformatics analysis identified MMP14 and COL12A1 as immune-related biomarkers associated with pancreatic adenocarcinoma prognosis.
Differential expression of matrix metalloproteinase (MMP)-2, MMP-9, and membrane type 1-MMP in hepatocellular and pancreatic adenocarcinoma: implications for tumor progression and clinical prognosis.
Expression of matrix metalloproteinase 2 (MMP-2), membrane-type 1 MMP and tissue inhibitor of metalloproteinase 2 and activation of proMMP-2 in pancreatic duct adenocarcinomas in hamsters treated with N-nitrosobis(2-oxopropyl)amine.
Expression of membrane-type matrix metalloproteinase-1 in human pancreatic adenocarcinomas.
Identifying MMP14 and COL12A1 as a potential combination of prognostic biomarkers in pancreatic ductal adenocarcinoma using integrated bioinformatics analysis.
Increased membrane type 1 matrix metalloproteinase expression from adenoma to colon cancer: a possible mechanism of neoplastic progression.
LncRNA TP73-AS1 enhances the malignant properties of pancreatic ductal adenocarcinoma by increasing MMP14 expression through miRNA -200a sponging.
Overexpression of membrane-type matrix metalloproteinase-1 gene induces mammary gland abnormalities and adenocarcinoma in transgenic mice.
Small adenocarcinoma of the lung: prognostic significance of central fibrosis chiefly because of its association with angiogenesis and lymphangiogenesis.
Adenocarcinoma of Lung
FAM83A-AS1 promotes lung adenocarcinoma cell migration and invasion by targeting miR-150-5p and modifying MMP14.
Adenoma
Gelatinase A and membrane-type 1 matrix metalloproteinase mRNA: expressed in adrenocortical cancers but not in adenomas.
Increased membrane type 1 matrix metalloproteinase expression from adenoma to colon cancer: a possible mechanism of neoplastic progression.
Intravital imaging of mouse colonic adenoma using MMP-based molecular probes with multi-channel fluorescence endoscopy.
Adrenal Cortex Neoplasms
Gelatinase A and membrane-type 1 matrix metalloproteinase mRNA: expressed in adrenocortical cancers but not in adenomas.
Alzheimer Disease
Matrix metalloproteinase 14 modulates diabetes and Alzheimer's disease cross-talk: a meta-analysis.
Aneurysm
Matrix metalloproteinase 14 and 19 expression is associated with thoracic aortic aneurysms.
Membrane-type 1 matrix metalloproteinase regulates macrophage-dependent elastolytic activity and aneurysm formation in vivo.
Aneurysm, Dissecting
Up-regulation of matrix metalloproteinase-2 and membrane-type 1-matrix metalloproteinase were coupled with that of type I procollagen in granulation tissue response after the onset of aortic dissection.
Anthrax
Membrane type-1 matrix metalloproteinase (MT1-MMP) protects malignant cells from tumoricidal activity of re-engineered anthrax lethal toxin.
Aortic Aneurysm, Abdominal
Early MT-1 MMP expression following elastase exposure is associated with increased cleaved MMP-2 activity in experimental rodent aortic aneurysms.
The expression and localization of membrane type-1 matrix metalloproteinase in human abdominal aortic aneurysms.
Aortic Aneurysm, Thoracic
Alterations in membrane type-1 matrix metalloproteinase abundance following induction of thoracic aortic aneurysm in a murine model.
Matrix metalloproteinase 14 and 19 expression is associated with thoracic aortic aneurysms.
Regulation of membrane type-1 matrix metalloproteinase activity and intracellular localization in clinical thoracic aortic aneurysms.
Aortic Valve Stenosis
Extracellular matrix metalloproteinase inducer (CD147) and membrane type 1-matrix metalloproteinase are expressed on tissue macrophages in calcific aortic stenosis and induce transmigration in an artificial valve model.
Arthritis
Membrane type 1 matrix metalloproteinase (MT1-MMP) cleaves the recombinant aggrecan substrate rAgg1mut at the 'aggrecanase' and the MMP sites. Characterization of MT1-MMP catabolic activities on the interglobular domain of aggrecan.
Selective Inhibition of Membrane Type 1 Matrix Metalloproteinase Abrogates Progression of Experimental Inflammatory Arthritis: Synergy With Tumor Necrosis Factor Blockade.
Arthritis, Experimental
Selective Inhibition of Membrane Type 1 Matrix Metalloproteinase Abrogates Progression of Experimental Inflammatory Arthritis: Synergy With Tumor Necrosis Factor Blockade.
Arthritis, Rheumatoid
Characterisation of the cell type-specificity of collagenase 3 mRNA expression in comparison with membrane type 1 matrix metalloproteinase and gelatinase A in the synovial membrane in rheumatoid arthritis.
Expression and localisation of the new metalloproteinase inhibitor RECK (reversion inducing cysteine-rich protein with Kazal motifs) in inflamed synovial membranes of patients with rheumatoid arthritis.
Membrane type 1 matrix metalloproteinase is a crucial promoter of synovial invasion in human rheumatoid arthritis.
New collagenolytic enzymes/cascade identified at the pannus-hard tissue junction in rheumatoid arthritis: destruction from above.
Retroviral gene transfer of an antisense construct against membrane type 1 matrix metalloproteinase reduces the invasiveness of rheumatoid arthritis synovial fibroblasts.
Therapeutic Potential of Mesenchymal Cell-Derived miRNA-150-5p-Expressing Exosomes in Rheumatoid Arthritis Mediated by the Modulation of MMP14 and VEGF.
Asthma
Increased airway epithelial cell-derived exosomes activate macrophage-mediated allergic inflammation via CD100 shedding.
Soluble membrane-type 1 matrix metalloproteinase (MT1-MMP) and gelatinase A (MMP-2) in induced sputum and bronchoalveolar lavage fluid of human bronchial asthma and bronchiectasis.
Atherosclerosis
Coexpression of cyclooxygenase-2 and matrix metalloproteinases in human aortic atherosclerotic lesions.
Distribution profiles of membrane Type-1 matrix metalloproteinase (MT1-MMP), matrix metalloproteinase-2 (MMP-2) and cyclooxygenase-2 (COX-2) in rabbit atherosclerosis: comparison with plaque instability analysis.
LOX-1-MT1-MMP axis is crucial for RhoA and Rac1 activation induced by oxidized low-density lipoprotein in endothelial cells.
Membrane type 1 matrix metalloproteinase promotes LDL receptor shedding and accelerates the development of atherosclerosis.
Bicuspid Aortic Valve Disease
Expression of matrix metalloproteinases and endogenous inhibitors within ascending aortic aneurysms of patients with bicuspid or tricuspid aortic valves.
Blister
Novel Proteolytic Microvesicles Released from Human Macrophages after Exposure to Tobacco Smoke.
Proteomics characterization of cell membrane blebs in human retinal pigment epithelium cells.
Bone Diseases
Cherubism mice also deficient in c-Fos exhibit inflammatory bone destruction executed by macrophages that express MMP14 despite the absence of TRAP+ osteoclasts.
Bone Diseases, Metabolic
MT1-MMP: A novel component of the macrophage cell fusion machinery.
Bone Resorption
1alpha,25-dihydroxyvitamin D3 regulates the expression of membrane-type matrix metalloproteinase-1 in normal human osteoblast-like cells.
Effects of 17beta-estradiol on the expression of membrane type 1 matrix metalloproteinase (MT1-MMP) and MMP-2 in human osteoblastic MG-63 cell cultures.
Global age-dependent differences in gene expression in response to calvarial injury.
Human breast adenocarcinoma (MDA-231) and human lung squamous cell carcinoma (Hara) do not have the ability to cause bone resorption by themselves during the establishment of bone metastasis.
Osteoclast-mediated bone resorption is controlled by a compensatory network of secreted and membrane-tethered metalloproteinases.
Parathyroid hormone inhibits the expression of membrane-type matrix metalloproteinase-1 (MT1-MMP) in osteoblast-like MG-63 cells.
Brain Ischemia
Angiotensin type 1 receptor blockage improves ischemic injury following transient focal cerebral ischemia.
Brain Neoplasms
A role for MT1-MMP as a cell death sensor/effector through the regulation of endoplasmic reticulum stress in U87 glioblastoma cells.
Concanavalin-A-induced autophagy biomarkers requires membrane type-1 matrix metalloproteinase intracellular signaling in glioblastoma cells.
Hematopoietic stem cell gene therapy targeting TGF? enhances the efficacy of irradiation therapy in a preclinical glioblastoma model.
MT1-MMP silencing by an shRNA-armed glioma-targeted conditionally replicative adenovirus (CRAd) improves its anti-glioma efficacy in vitro and in vivo.
The lectin concanavalin-A signals MT1-MMP catalytic independent induction of COX-2 through an IKKgamma/NF-kappaB-dependent pathway.
Tip60 regulates MT1-MMP transcription and invasion of glioblastoma cells through NF-?B pathway.
Tumor environment dictates medulloblastoma cancer stem cell expression and invasive phenotype.
Breast Neoplasms
Bioinformatic Prediction of Possible Targets and Mechanisms of Action of the Green Tea Compound Epigallocatechin-3-Gallate Against Breast Cancer.
Blockade of MMP14 Activity in Murine Breast Carcinomas: Implications for Macrophages, Vessels, and Radiotherapy.
CLIC3 controls recycling of late endosomal MT1-MMP and dictates invasion and metastasis in breast cancer.
Degradation of HER2/neu by ANT2 shRNA suppresses migration and invasiveness of breast cancer cells.
Dynamic interactions of cortactin and membrane type 1 matrix metalloproteinase at invadopodia: defining the stages of invadopodia formation and function.
Dynamics of internalization and recycling of the prometastatic membrane type 4 matrix metalloproteinase (MT4-MMP) in breast cancer cells.
ELK3 Expression Correlates With Cell Migration, Invasion, and Membrane Type 1-Matrix Metalloproteinase Expression in MDA-MB-231 Breast Cancer Cells.
Enhanced membrane-type 1 matrix metalloproteinase expression by hyaluronan oligosaccharides in breast cancer cells facilitates CD44 cleavage and tumor cell migration.
EphA2 cleavage by MT1-MMP triggers single cancer cell invasion via homotypic cell repulsion.
Expression of membrane type-1 matrix metalloproteinase, MT1-MMP in human breast cancer and its impact on invasiveness of breast cancer cells.
Expression of tissue levels of matrix metalloproteinases and their inhibitors in breast cancer.
Functional activation of integrin alpha V beta 3 in tumor cells expressing membrane-type 1 matrix metalloproteinase.
Gelatin zymography and substrate cleavage assays of matrix metalloproteinase-2 in breast carcinoma cells overexpressing membrane type-1 matrix metalloproteinase.
Gelatinase A, membrane type 1 matrix metalloproteinase, and extracellular matrix metalloproteinase inducer mRNA expression: correlation with invasive growth of breast cancer.
Immunological characterization of cell-surface and soluble forms of membrane type 1 matrix metalloproteinase in human breast cancer cells and in fibroblasts.
Implication of collagen type I-induced membrane-type 1-matrix metalloproteinase expression and matrix metalloproteinase-2 activation in the metastatic progression of breast carcinoma.
In vitro anti-metastatic activity of enterolactone, a mammalian lignan derived from flax lignan, and down-regulation of matrix metalloproteinases in MCF-7 and MDA MB 231 cell lines.
Increased serum level of membrane type 1-matrix metalloproteinase (MT1-MMP/MMP-14) in patients with breast cancer.
Inhibiting the SUMO Pathway Represses the Cancer Stem Cell Population in Breast and Colorectal Carcinomas.
KLF8 and FAK cooperatively enrich the active MMP14 on the cell surface required for the metastatic progression of breast cancer.
LIMK Regulates Tumor-Cell Invasion and Matrix Degradation Through Tyrosine Phosphorylation of MT1-MMP.
Many new down- and up-regulatory signaling pathways, from known cancer progression suppressors to matrix metalloproteinases, differ widely in cells of various cancers.
mDia1 regulates breast cancer invasion by controlling membrane type 1-matrix metalloproteinase localization.
Membrane protease proteomics: Isotope-coded affinity tag MS identification of undescribed MT1-matrix metalloproteinase substrates.
Membrane type 1 matrix metalloproteinase-mediated stromal syndecan-1 shedding stimulates breast carcinoma cell proliferation.
Membrane type-1 matrix metalloproteinase (MT1-MMP) processing of pro-alphav integrin regulates cross-talk between alphavbeta3 and alpha2beta1 integrins in breast carcinoma cells.
Membrane-type 1 matrix metalloproteinase expression is regulated by zonula occludens-1 in human breast cancer cells.
Membrane-type matrix metalloproteinase 1 is a gelatinolytic enzyme and is secreted in a complex with tissue inhibitor of metalloproteinases 2.
MMP-9 secretion and MMP-2 activation distinguish invasive and metastatic sublines of a mouse mammary carcinoma system showing epithelial-mesenchymal transition traits.
MMP14 empowers tumor-initiating breast cancer cells under hypoxic nutrient-depleted conditions.
MT1-MMP is required for efficient tumor dissemination in experimental metastatic disease.
MT1-MMP protects breast carcinoma cells against type I collagen-induced apoptosis.
MT1-MMP-dependent ECM processing regulates laminB1 stability and mediates replication fork restart.
Mutation analysis of membrane type-1 matrix metalloproteinase (MT1-MMP). The role of the cytoplasmic tail Cys(574), the active site Glu(240), and furin cleavage motifs in oligomerization, processing, and self-proteolysis of MT1-MMP expressed in breast carcinoma cells.
Nck deficiency is associated with delayed breast carcinoma progression and reduced metastasis.
NEDD9 depletion leads to MMP14 inactivation by TIMP2 and prevents invasion and metastasis.
NEDD9/Arf6-dependent endocytic trafficking of matrix metalloproteinase 14: a novel mechanism for blocking mesenchymal cell invasion and metastasis of breast cancer.
New signaling pathways from cancer progression modulators to mRNA expression of matrix metalloproteinases in breast cancer cells.
Pharmacoproteomics of a metalloproteinase hydroxamate inhibitor in breast cancer cells: dynamics of membrane type 1 matrix metalloproteinase-mediated membrane protein shedding.
Pro-matrix metalloproteinase-2 transfection increases orthotopic primary growth and experimental metastasis of MDA-MB-231 human breast cancer cells in nude mice.
Processing of integrin alpha(v) subunit by membrane type 1 matrix metalloproteinase stimulates migration of breast carcinoma cells on vitronectin and enhances tyrosine phosphorylation of focal adhesion kinase.
Protease degradomics: mass spectrometry discovery of protease substrates and the CLIP-CHIP, a dedicated DNA microarray of all human proteases and inhibitors.
Protein Tyrosine Kinase 7 Regulates EGFR/Akt Signaling Pathway and Correlates With Malignant Progression in Triple-Negative Breast Cancer.
PROX1 is a transcriptional regulator of MMP14.
Restricted expression of membrane type 1-matrix metalloproteinase by myofibroblasts adjacent to human breast cancer cells.
RNA interference-mediated silencing of ppGalNAc-T1 and ppGalNAc-T2 inhibits invasion and increases chemosensitivity potentially by reducing terminal ?2,3 sialylation and MMP14 expression in triple?negative breast cancer cells.
Shedding of membrane type 1 matrix metalloproteinase in a human breast carcinoma cell line.
Significance of membrane type 1 matrix metalloproteinase expression in breast cancer.
TC10 regulates breast cancer invasion and metastasis by controlling membrane type-1 matrix metalloproteinase at invadopodia.
The clinicopathological and prognostic significance of membrane type 1 matrix metalloproteinase (MT1-MMP) and MMP-9 according to their localization in invasive breast carcinoma.
The emerging role of MMP14 in brain tumorigenesis and future therapeutics.
The membrane tethered matrix metalloproteinase MT1-MMP triggers an outside-in DNA damage response that impacts chemo- and radiotherapy responses of breast cancer.
The overexpression membrane type 1 matrix metalloproteinase is associated with the progression and prognosis in breast cancer.
Tumor cell invasion through matrigel is regulated by activated matrix metalloproteinase-2.
Tyrosine phosphorylation mediates ConA-induced membrane type 1-matrix metalloproteinase expression and matrix metalloproteinase-2 activation in MDA-MB-231 human breast carcinoma cells.
[Effects of MT1-MMP on the in vitro invasiveness of breast cancer cells]
[Expression pattern of membrane type-1 matrix metalloproteinase in primary breast carcinomas].
[Significance of membrane type-1 matrix metalloproteinase expression in breast cancer]
Bronchiectasis
Soluble membrane-type 1 matrix metalloproteinase (MT1-MMP) and gelatinase A (MMP-2) in induced sputum and bronchoalveolar lavage fluid of human bronchial asthma and bronchiectasis.
Carcinogenesis
A role of MMP-14 in the regulation of invasiveness of nasopharyngeal carcinoma.
AID modulates carcinogenesis network via DNA demethylation in bladder urothelial cell carcinoma.
Centrosomal pericentrin is a direct cleavage target of membrane type-1 matrix metalloproteinase in humans but not in mice: potential implications for tumorigenesis.
Down-regulation of MT1-MMP expression suppresses tumor cell invasion in metastatic human SW626 ovarian cancer cells.
Dual functions of ARP101 in targeting membrane type-1 matrix metalloproteinase: Impact on U87 glioblastoma cell invasion and autophagy signaling.
Expression of matrix metalloproteinase 2 (MMP-2), membrane-type 1 MMP and tissue inhibitor of metalloproteinase 2 and activation of proMMP-2 in pancreatic duct adenocarcinomas in hamsters treated with N-nitrosobis(2-oxopropyl)amine.
Expression of membrane type 1 matrix metalloproteinase in medullary thyroid carcinoma: Prognostic implications.
Genetic association of MMP14 promoter variants and their functional significance in gallbladder cancer pathogenesis.
Hepatocyte nuclear factor 4 alpha promotes the invasion, metastasis and angiogenesis of neuroblastoma cells via targeting matrix metalloproteinase 14.
Matrix metalloproteinase-14 (MMP-14) downregulation inhibits esophageal squamous cell carcinoma cell migration, invasion, and proliferation.
microRNA-26a Directly Targeting MMP14 and MMP16 Inhibits the Cancer Cell Proliferation, Migration and Invasion in Cutaneous Squamous Cell Carcinoma.
miRNA-337-3p inhibits gastric cancer progression through repressing myeloid zinc finger 1-facilitated expression of matrix metalloproteinase 14.
miRNA-337-3p suppresses neuroblastoma progression by repressing the transcription of matrix metalloproteinase 14.
miRNA-584-5p exerts tumor suppressive functions in human neuroblastoma through repressing transcription of matrix metalloproteinase 14.
MMP14 regulates cell migration and invasion through epithelial-mesenchymal transition in nasopharyngeal carcinoma.
Overexpression of membrane-type matrix metalloproteinase-1 gene induces mammary gland abnormalities and adenocarcinoma in transgenic mice.
The emerging role of MMP14 in brain tumorigenesis and future therapeutics.
Carcinoma
Activation of WNT family expression and signaling in squamous cell carcinomas of the oral cavity.
Anti-invasive effect of MMI-166, a new selective matrix metalloproteinase inhibitor, in cervical carcinoma cell lines.
Augmented membrane type 1 matrix metalloproteinase (MT1-MMP):MMP-2 messenger RNA ratio in gastric carcinomas with poor prognosis.
Clinical significance of AJUBA, YAP1, and MMP14 expression in esophageal squamous cell carcinoma.
Clinical significance of expression of membrane type 1 matrix metalloproteinase and matrix metalloproteinase-2 in human head and neck squamous cell carcinoma.
Co-localisation of intra-nuclear membrane type-1 matrix metalloproteinase and hypoxia inducible factor-2? in osteosarcoma and prostate carcinoma cells.
Collagenase-3 (MMP-13) is expressed by tumor cells in invasive vulvar squamous cell carcinomas.
Control of MT1-MMP transport by atypical PKC during breast-cancer progression.
Discretionary Transduction of MMP-Sensitized Tousled in Head and Neck Cancer.
Downregulation of matrix metalloproteinase 14 by the antitumor miRNA, miR-150-5p, inhibits the aggressiveness of lung squamous cell carcinoma cells.
Dual over-expression pattern of membrane-type metalloproteinase-1 in cancer and stromal cells in human gastrointestinal carcinoma revealed by in situ hybridization and immunoelectron microscopy.
Enhanced constitutive invasion activity in human nontumorigenic keratinocytes exposed to a low level of barium for a long time.
Enhanced production and activation of progelatinase A mediated by membrane-type 1 matrix metalloproteinase in human oral squamous cell carcinomas: implications for lymph node metastasis.
Epidermal growth factor receptor-mediated membrane type 1 matrix metalloproteinase endocytosis regulates the transition between invasive versus expansive growth of ovarian carcinoma cells in three-dimensional collagen.
Ets-1 messenger RNA expression is a novel marker of poor survival in ovarian carcinoma.
Expression of matrix metalloprotease-2 (MMP-2) and the activator membrane type 1 (MT1-MMP) in canine mammary carcinomas.
Expression of matrix metalloproteinase 2 (MMP-2), membrane-type 1 MMP and tissue inhibitor of metalloproteinase 2 and activation of proMMP-2 in pancreatic duct adenocarcinomas in hamsters treated with N-nitrosobis(2-oxopropyl)amine.
Expression of membrane type 1 matrix metalloproteinase (MMP-14) in epithelial ovarian cancer: high level expression in clear cell carcinoma.
Expression of membrane type 1 matrix metalloproteinase is associated with cervical carcinoma progression and invasion.
Expression of membrane type 1 matrix metalloproteinase, matrix metalloproteinase 2 and tissue inhibitor of metalloproteinase 2 in human cartilaginous tumors with special emphasis on mesenchymal and dedifferentiated chondrosarcoma.
Expression of membrane type 1-matrix metalloproteinase in laryngeal carcinoma.
Fibroblast growth factor-1 transcriptionally induces membrane type-1 matrix metalloproteinase expression in prostate carcinoma cell line.
Front-cell-specific expression of membrane-type 1 matrix metalloproteinase and gelatinase A during cohort migration of colon carcinoma cells induced by hepatocyte growth factor/scatter factor.
Graded activation of the MEK1/MT1-MMP axis determines renal epithelial cell tumor phenotype.
Granulocyte-macrophage colony-stimulating factor upregulates matrix metalloproteinase-2 (MMP-2) and membrane type-1 MMP (MT1-MMP) in human head and neck cancer cells.
Identification of membrane type-1 matrix metalloproteinase as a target of hypoxia-inducible factor-2 alpha in von Hippel-Lindau renal cell carcinoma.
Increased expression of matrix metalloproteinase 7 and 9 and membrane type 1-matrix metalloproteinase in esophageal squamous cell carcinomas.
Increased expression of membrane type 1-matrix metalloproteinase in head and neck carcinoma.
Increased membrane type 1 matrix metalloproteinase expression from adenoma to colon cancer: a possible mechanism of neoplastic progression.
Lack of Association between Membrane-Type 1 Matrix Metalloproteinase Expression and Clinically Relevant Molecular or Morphologic Tumor Characteristics at the Leading Edge of Invasive Colorectal Carcinoma.
Matrix metalloproteinase-14 (MMP-14) downregulation inhibits esophageal squamous cell carcinoma cell migration, invasion, and proliferation.
Matrix metalloproteinase-14 expression and its prognostic value in cervical carcinoma.
Membrane type 1-matrix metalloproteinase induces epithelial-to-mesenchymal transition in esophageal squamous cell carcinoma: Observations from clinical and in vitro analyses.
Membrane type-1 matrix metalloproteinase (MT1-MMP) protects malignant cells from tumoricidal activity of re-engineered anthrax lethal toxin.
Membrane-type matrix metalloproteinases (MT-MMPs) in tumor metastasis.
Microenvironmental regulation of membrane type 1 matrix metalloproteinase activity in ovarian carcinoma cells via collagen-induced EGR1 expression.
microRNA-26a Directly Targeting MMP14 and MMP16 Inhibits the Cancer Cell Proliferation, Migration and Invasion in Cutaneous Squamous Cell Carcinoma.
miR-34a inhibits migration and invasion of tongue squamous cell carcinoma via targeting MMP9 and MMP14.
MMP and TIMP gene expression in head and neck squamous cell carcinomas and adjacent tissues.
MMPs, TIMP-2, and TGF-beta1 in the cancerization of oral lichen planus.
Mutation analysis of membrane type-1 matrix metalloproteinase (MT1-MMP). The role of the cytoplasmic tail Cys(574), the active site Glu(240), and furin cleavage motifs in oligomerization, processing, and self-proteolysis of MT1-MMP expressed in breast carcinoma cells.
Ovarian cancer cell detachment and multicellular aggregate formation are regulated by membrane type 1 matrix metalloproteinase: a potential role in I.p. metastatic dissemination.
Ovarian carcinoma regulation of matrix metalloproteinase-2 and membrane type 1 matrix metalloproteinase through beta1 integrin.
Predictive value of laminin-5 and membrane type 1-matrix metalloproteinase expression for cervical lymph node metastasis in T1 and T2 squamous cell carcinomas of the tongue and floor of the mouth.
Proteolytic activation of heparin-binding EGF-like growth factor by membrane-type matrix metalloproteinase-1 in ovarian carcinoma cells.
Rho-ROCK-myosin signaling mediates membrane type 1 matrix metalloproteinase-induced cellular aggregation of keratinocytes.
Role of membrane type 1-matrix metalloproteinase and gelatinase A in head and neck squamous cell carcinoma invasion in vitro.
Shedding of membrane type 1 matrix metalloproteinase in a human breast carcinoma cell line.
Strong significant correlation between MMP-9 and systemic symptoms in patients with localized renal cell carcinoma.
Transformation of epithelial Madin-Darby canine kidney cells with p60(v-src) induces expression of membrane-type 1 matrix metalloproteinase and invasiveness.
Tumor cell invasion of von Hippel Lindau renal cell carcinoma cells is mediated by membrane type-1 matrix metalloproteinase.
Visual and automated assessment of matrix metalloproteinase-14 tissue expression for the evaluation of ovarian cancer prognosis.
[Effect of bone morphogenetic protein-2 on the expression of membrane Type 1-matrix metalloproteinase in human A549 lung carcinoma cells]
[Gene expression of matrix mettallo-proteinase 14 in laryngeal squamous cell carcinoma]
[Membrane type 1 matrix metalloproteinase (MT1-MMP) and the regulators of its activity as invasive factors in squamous cell cervical carcinomas.]
[Tissue collagenase MMP-14 and endogenous regulators of its activity in the corpus uteri in squamous cell carcinoma of the cervix].
Carcinoma in Situ
Increased membrane type 1 matrix metalloproteinase expression from adenoma to colon cancer: a possible mechanism of neoplastic progression.
Carcinoma, Hepatocellular
A new pseudo-peptide of Arg-Gly-Asp (RGD) inhibits intrahepatic metastasis of orthotopically implanted murine hepatocellular carcinoma.
Atypical localization of membrane type 1-matrix metalloproteinase in the nucleus is associated with aggressive features of hepatocellular carcinoma.
Differential expression of matrix metalloproteinase (MMP)-2, MMP-9, and membrane type 1-MMP in hepatocellular and pancreatic adenocarcinoma: implications for tumor progression and clinical prognosis.
Gene Polymorphism of MUC15, MMP14, BRAF, and COL1A1 Is Associated with Capsule Formation in Hepatocellular Carcinoma.
High MMP14 expression is predictive of poor prognosis in resectable hepatocellular carcinoma.
Increased expression of membrane type 1 matrix metalloproteinase and matrix metalloproteinase-2 with tumor dedifferentiation in hepatocellular carcinomas.
Inhibition of hepatocellular carcinoma invasion by suppression of claudin-10 in HLE cells.
Invasiveness of hepatocellular carcinoma cell lines: contribution of membrane-type 1 matrix metalloproteinase.
Mechanism of metastasis by membrane type 1-matrix metalloproteinase in hepatocellular carcinoma.
Membrane-type matrix metalloproteinase-1(MT1-MTP) gene is overexpressed in highly invasive hepatocellular carcinomas.
miR-150-5p inhibits hepatoma cell migration and invasion by targeting MMP14.
PROX1 is a transcriptional regulator of MMP14.
Relation of enhanced secretion of active matrix metalloproteinases with tumor spread in human hepatocellular carcinoma.
Role of MMP14 Gene Polymorphisms in Susceptibility and Pathological Development to Hepatocellular Carcinoma.
Tetracycline derivative minocycline inhibits autophagy and inflammation in concanavalin-a-activated human hepatoma cells.
[The role of membrane-type 1 matrix metalloproteinase in the invasion and metastasis of hepatocellular carcinoma]
Carcinoma, Intraductal, Noninfiltrating
Expression of metalloproteases and their inhibitors by tumor and stromal cells in ductal carcinoma in situ of the breast and their relationship with microinvasive events.
Role of COX-2 in epithelial-stromal cell interactions and progression of ductal carcinoma in situ of the breast.
Carcinoma, Non-Small-Cell Lung
Regulation of matrix metalloproteinase genes by E2F transcription factors: Rb-Raf-1 interaction as a novel target for metastatic disease.
Carcinoma, Ovarian Epithelial
Expression of membrane type 1 matrix metalloproteinase (MMP-14) in epithelial ovarian cancer: high level expression in clear cell carcinoma.
Functional role of matrix metalloproteinases in ovarian tumor cell plasticity.
Loss of HOXD10 expression induced by upregulation of miR-10b accelerates the migration and invasion activities of ovarian cancer cells.
Matrix rigidity activates Wnt signaling through down-regulation of Dickkopf-1 protein.
Carcinoma, Renal Cell
Effects of CoCl2-simulated hypoxia on the expression levels of matrix metalloproteinases in renal adenocarcinoma cells and renal tubular epithelial cells.
Graded activation of the MEK1/MT1-MMP axis determines renal epithelial cell tumor phenotype.
Identification of membrane type-1 matrix metalloproteinase as a target of hypoxia-inducible factor-2 alpha in von Hippel-Lindau renal cell carcinoma.
Strong significant correlation between MMP-9 and systemic symptoms in patients with localized renal cell carcinoma.
Targeting a Designer TIMP-1 to the Cell Surface for Effective MT1-MMP Inhibition: A Potential Role for the Prion Protein in Renal Carcinoma Therapy.
Tumor cell invasion of von Hippel Lindau renal cell carcinoma cells is mediated by membrane type-1 matrix metalloproteinase.
Carcinoma, Squamous Cell
Clinical significance of expression of membrane type 1 matrix metalloproteinase and matrix metalloproteinase-2 in human head and neck squamous cell carcinoma.
Discretionary Transduction of MMP-Sensitized Tousled in Head and Neck Cancer.
Downregulation of matrix metalloproteinase 14 by the antitumor miRNA, miR-150-5p, inhibits the aggressiveness of lung squamous cell carcinoma cells.
Enhanced constitutive invasion activity in human nontumorigenic keratinocytes exposed to a low level of barium for a long time.
Enhancement of membrane-type 1-matrix metalloproteinase (MT1-MMP) production and sequential activation of progelatinase A on human squamous carcinoma cells co-cultured with human dermal fibroblasts.
Granulocyte-macrophage colony-stimulating factor upregulates matrix metalloproteinase-2 (MMP-2) and membrane type-1 MMP (MT1-MMP) in human head and neck cancer cells.
Heat shock-mediated transient increase in intracellular 3',5'-cyclic AMP results in tumor specific suppression of membrane type 1-matrix metalloproteinase production and progelatinase A activation.
Increased expression of matrix metalloproteinase 7 and 9 and membrane type 1-matrix metalloproteinase in esophageal squamous cell carcinomas.
microRNA-26a Directly Targeting MMP14 and MMP16 Inhibits the Cancer Cell Proliferation, Migration and Invasion in Cutaneous Squamous Cell Carcinoma.
miR-34a inhibits migration and invasion of tongue squamous cell carcinoma via targeting MMP9 and MMP14.
MMP and TIMP gene expression in head and neck squamous cell carcinomas and adjacent tissues.
Predictive value of laminin-5 and membrane type 1-matrix metalloproteinase expression for cervical lymph node metastasis in T1 and T2 squamous cell carcinomas of the tongue and floor of the mouth.
Rho-ROCK-myosin signaling mediates membrane type 1 matrix metalloproteinase-induced cellular aggregation of keratinocytes.
Role of membrane type 1-matrix metalloproteinase and gelatinase A in head and neck squamous cell carcinoma invasion in vitro.
[Tissue collagenase MMP-14 and endogenous regulators of its activity in the corpus uteri in squamous cell carcinoma of the cervix].
Cardiomyopathies
Extracellular matrix metalloproteinase inducer (CD147) and membrane type 1-matrix metalloproteinase are expressed on tissue macrophages in calcific aortic stenosis and induce transmigration in an artificial valve model.
Cardiomyopathy, Dilated
A quantitative gene expression profile of matrix metalloproteinases (MMPS) and their inhibitors (TIMPS) in the myocardium of patients with deteriorating heart failure requiring left ventricular assist device support.
PGE2 reduces MMP-14 and increases plasminogen activator inhibitor-1 in cardiac fibroblasts.
Cardiovascular Diseases
MMP-14 degrades tropoelastin and elastin.
Cerebral Infarction
[Association of MMP-14 gene polymorphism with cerebral infarction - a case-control study].
Chagas Disease
Looking at the proteases from a simple perspective.
Cherubism
Cherubism mice also deficient in c-Fos exhibit inflammatory bone destruction executed by macrophages that express MMP14 despite the absence of TRAP+ osteoclasts.
Cholangiocarcinoma
Expression of matrix metalloproteinase 7 is an unfavorable postoperative prognostic factor in cholangiocarcinoma of the perihilar, hilar, and extrahepatic bile ducts.
Chondrosarcoma
Expression of membrane type 1 matrix metalloproteinase, matrix metalloproteinase 2 and tissue inhibitor of metalloproteinase 2 in human cartilaginous tumors with special emphasis on mesenchymal and dedifferentiated chondrosarcoma.
Choriocarcinoma
HSPC117 is regulated by epigenetic modification and is involved in the migration of JEG-3 cells.
Colonic Neoplasms
Increased membrane type 1 matrix metalloproteinase expression from adenoma to colon cancer: a possible mechanism of neoplastic progression.
[Identification of protein markers for serum diagnosis of cancer based on microRNA expression profiling].
Colorectal Neoplasms
How the matrix metalloproteinase MMP14 contributes to the progression of colorectal cancer.
Identification of membrane-type matrix metalloproteinase-1 as a target of the beta-catenin/Tcf4 complex in human colorectal cancers.
Lack of Association between Membrane-Type 1 Matrix Metalloproteinase Expression and Clinically Relevant Molecular or Morphologic Tumor Characteristics at the Leading Edge of Invasive Colorectal Carcinoma.
Membrane-type 1 matrix metalloproteinase mRNA expression in colorectal cancer.
MMP-14 Is Expressed in Preeclamptic Placentas and Mediates Release of Soluble Endoglin.
MMP14 predicts a poor prognosis in patients with colorectal cancer.
Overexpression of MT1-MMP is insufficient to increase experimental liver metastasis of human colon cancer cells.
Congenital Abnormalities
Potential relation of aberrant proteolysis of human protein tyrosine kinase 7 (PTK7) chuzhoi by membrane type 1 matrix metalloproteinase (MT1-MMP) to congenital defects.
Corneal Dystrophies, Hereditary
Downregulation of IL-7 and IL-7R Reduces Membrane-Type Matrix Metalloproteinase 14 in Granular Corneal Dystrophy Type 2 Keratocyte.
Corneal Neovascularization
Evidence for the involvement of MMP14 in MMP2 processing and recruitment in exosomes of corneal fibroblasts.
Membrane type-1 matrix metalloproteinase potentiates basic fibroblast growth factor-induced corneal neovascularization.
MMP14 Cleavage of VEGFR1 in the Cornea Leads to a VEGF-Trap Antiangiogenic Effect.
Proangiogenic Interactions of Vascular Endothelial MMP14 With VEGF Receptor 1 in VEGFA-Mediated Corneal Angiogenesis.
Proteomics-based Characterization of the Effects of MMP14 on the Protein Content of Exosomes from Corneal Fibroblasts.
When MT1-MMP meets ADAMs.
Corneal Opacity
Matrix metalloproteinase 14 overexpression reduces corneal scarring.
Cystadenocarcinoma, Mucinous
Expression of membrane-type matrix metalloproteinase-1 in human pancreatic adenocarcinomas.
Dental Caries
Genetic Association of MMP10, MMP14, and MMP16 with Dental Caries.
Diabetes Mellitus, Type 1
Inhibition of membrane type-1 matrix metalloproteinase by cancer drugs interferes with the homing of diabetogenic T cells into the pancreas.
Sequential IL-23 and IL-17 and increased Mmp8 and Mmp14 expression characterize the progression of an experimental model of periodontal disease in type 1 diabetes.
Diabetes Mellitus, Type 2
A case of 14q11.2 microdeletion with autistic features, severe obesity and facial dysmorphisms suggestive of Wolf-Hirschhorn syndrome.
Diabetic Retinopathy
Hypoxia induces the expression of membrane-type 1 matrix metalloproteinase in retinal glial cells.
Matrix metalloproteinase-14 is a biomarker of angiogenic activity in proliferative diabetic retinopathy.
Endometriosis
Matrix metalloproteinase-13 and membrane type-1 matrix metalloproteinase in peritoneal fluid of women with endometriosis.
Endotoxemia
Matrix metalloproteinase-14 triggers an anti-inflammatory proteolytic cascade in endotoxemia.
Ependymoma
Prognostic value of tumor microinvasion and metalloproteinases expression in intracranial pediatric ependymomas.
Esophageal Neoplasms
MicroRNA-133a regulates the mRNAs of two invadopodia-related proteins, FSCN1 and MMP14, in esophageal cancer.
Esophageal Squamous Cell Carcinoma
Clinical significance of AJUBA, YAP1, and MMP14 expression in esophageal squamous cell carcinoma.
Matrix metalloproteinase-14 (MMP-14) downregulation inhibits esophageal squamous cell carcinoma cell migration, invasion, and proliferation.
Membrane type 1-matrix metalloproteinase induces epithelial-to-mesenchymal transition in esophageal squamous cell carcinoma: Observations from clinical and in vitro analyses.
Fibromatosis, Aggressive
Malignant Fibrous Histiocytoma, Aggressive Fibromatosis and Benign Fibrous Tumors Express mRNA for the Metalloproteinase Inducer EMMPRIN and the Metalloproteinases MMP-2 and MT1-MMP.
Fibrosarcoma
Antimetastatic activity of pinosylvin, a natural stilbenoid, is associated with the suppression of matrix metalloproteinases.
CD97 inhibits cell migration in human fibrosarcoma cells by modulating TIMP-2/MT1- MMP/MMP-2 activity--role of GPS autoproteolysis and functional cooperation between the N- and C-terminal fragments.
Cellular cholesterol regulates MT1 MMP dependent activation of MMP 2 via MEK-1 in HT1080 fibrosarcoma cells.
Characterization of Normal Murine Carpal Bone Development Prompts Re-Evaluation of Pathologic Osteolysis as the Cause of Human Carpal-Tarsal Osteolysis Disorders.
Curcumin, demethoxycurcumin and bisdemethoxycurcumin differentially inhibit cancer cell invasion through the down-regulation of MMPs and uPA.
Heat shock suppresses membrane type 1-matrix metalloproteinase production and progelatinase A activation in human fibrosarcoma HT-1080 cells and thereby inhibits cellular invasion.
Heat shock-mediated transient increase in intracellular 3',5'-cyclic AMP results in tumor specific suppression of membrane type 1-matrix metalloproteinase production and progelatinase A activation.
Inhibitory effects of a benz[f]indole-4,9-dione analog on cancer cell metastasis mediated by the down-regulation of matrix metalloproteinase expression in human HT1080 fibrosarcoma cells.
Membrane type-1 matrix metalloproteinase (MT1-MMP) protects malignant cells from tumoricidal activity of re-engineered anthrax lethal toxin.
Regulation of matrix metalloproteinase-2 (gelatinase A, MMP-2), membrane-type matrix metalloproteinase-1 (MT1-MMP) and tissue inhibitor of metalloproteinases-2 (TIMP-2) expression by elastin-derived peptides in human HT-1080 fibrosarcoma cell line.
Regulation of membrane-type matrix metalloproteinase-1 expression by growth factors and phorbol 12-myristate 13-acetate.
Tumor cell invasion through matrigel is regulated by activated matrix metalloproteinase-2.
Gallbladder Neoplasms
Genetic association of MMP14 promoter variants and their functional significance in gallbladder cancer pathogenesis.
Gastrointestinal Neoplasms
Dual over-expression pattern of membrane-type metalloproteinase-1 in cancer and stromal cells in human gastrointestinal carcinoma revealed by in situ hybridization and immunoelectron microscopy.
Giant Cell Tumor of Bone
Differential Expression of ADAM23, CDKN2A (P16), MMP14 and VIM Associated with Giant Cell Tumor of Bone.
Giant Cell Tumors
Differential Expression of ADAM23, CDKN2A (P16), MMP14 and VIM Associated with Giant Cell Tumor of Bone.
Glioblastoma
Calmodulin inhibitors trigger the proteolytic processing of membrane type-1 matrix metalloproteinase, but not its shedding in glioblastoma cells.
Concanavalin-A-induced autophagy biomarkers requires membrane type-1 matrix metalloproteinase intracellular signaling in glioblastoma cells.
CRN2 binds to TIMP4 and MMP14 and promotes perivascular invasion of glioblastoma cells.
Dual functions of ARP101 in targeting membrane type-1 matrix metalloproteinase: Impact on U87 glioblastoma cell invasion and autophagy signaling.
Induction of autophagy biomarker BNIP3 requires a JAK2/STAT3 and MT1-MMP signaling interplay in Concanavalin-A-activated U87 glioblastoma cells.
MicroRNA-133b inhibits cell migration and invasion by targeting matrix metalloproteinase 14 in glioblastoma.
Protein kinase C activation by phorbol ester increases in vitro invasion through regulation of matrix metalloproteinases/tissue inhibitors of metalloproteinases system in D54 human glioblastoma cells.
Regulation of matrix metalloproteinase-2 (MMP-2) by hepatocyte growth factor/scatter factor (HGF/SF) in human glioma cells: HGF/SF enhances MMP-2 expression and activation accompanying up-regulation of membrane type-1 MMP.
Silencing of the MT1-MMP/ G6PT axis suppresses calcium mobilization by sphingosine-1-phosphate in glioblastoma cells.
The influence of the penetrating peptide iRGD on the effect of paclitaxel-loaded MT1-AF7p-conjugated nanoparticles on glioma cells.
Glioma
A MT1-MMP/NF-kappaB signaling axis as a checkpoint controller of COX-2 expression in CD133+ U87 glioblastoma cells.
Expressions of matrix metalloproteinase-7 and matrix metalloproteinase-14 associated with the activation of extracellular signal-regulated kinase1/2 in human brain gliomas of different pathological grades.
Glioma-associated microglial MMP9 expression is upregulated by TLR2 signaling and sensitive to minocycline.
Human astrocytes secrete IL-6 to promote glioma migration and invasion through upregulation of cytomembrane MMP14.
Inhibition of MMP14 potentiates the therapeutic effect of temozolomide and radiation in gliomas.
Matrix metalloproteinase-2 activation modulates glioma cell migration.
Mechanisms of action of rapamycin in gliomas.
Membrane type-1 matrix metalloproteinase (MT1-MMP) protects malignant cells from tumoricidal activity of re-engineered anthrax lethal toxin.
Membrane-type matrix metalloproteinases (MT-MMPs): expression and function during glioma invasion.
Methylation-mediated miR-155-FAM133A axis contributes to the attenuated invasion and migration of IDH mutant gliomas.
MFI2-AS1 regulates the aggressive phenotypes in glioma by modulating MMP14 via a positive feedback loop.
Minocycline reduces glioma expansion and invasion by attenuating microglial MT1-MMP expression.
Modulation of phorbol ester-induced regulation of matrix metalloproteinases and tissue inhibitors of metalloproteinases by SB203580, a specific inhibitor of p38 mitogen-activated protein kinase.
MT1-MMP silencing by an shRNA-armed glioma-targeted conditionally replicative adenovirus (CRAd) improves its anti-glioma efficacy in vitro and in vivo.
Neoplastic Cells are the Major Source of MT-MMPs in IDH1-Mutant Glioma, Thus Enhancing Tumor-Cell Intrinsic Brain Infiltration.
Neurokinin-1 receptor directly mediates glioma cell migration by up-regulation of matrix metalloproteinase-2 (MMP-2) and membrane type 1-matrix metalloproteinase (MT1-MMP).
Probing the infiltrating character of brain tumors: inhibition of RhoA/ROK-mediated CD44 cell surface shedding from glioma cells by the green tea catechin EGCg.
Regulation of matrix metalloproteinase-2 (MMP-2) by hepatocyte growth factor/scatter factor (HGF/SF) in human glioma cells: HGF/SF enhances MMP-2 expression and activation accompanying up-regulation of membrane type-1 MMP.
Roles of membrane type 1 matrix metalloproteinase and tissue inhibitor of metalloproteinases 2 in invasion and dissemination of human malignant glioma.
SUMOylation of IGF2BP2 promotes vasculogenic mimicry of glioma via regulating OIP5-AS1/miR-495-3p axis.
The emerging role of MMP14 in brain tumorigenesis and future therapeutics.
The influence of the penetrating peptide iRGD on the effect of paclitaxel-loaded MT1-AF7p-conjugated nanoparticles on glioma cells.
Tip60 regulates MT1-MMP transcription and invasion of glioblastoma cells through NF-?B pathway.
TMZ regulates GBM stemness via MMP14-DLL4-Notch3 pathway.
Toll-like receptor 2 mediates microglia/brain macrophage MT1-MMP expression and glioma expansion.
Tumor cell invasion through matrigel is regulated by activated matrix metalloproteinase-2.
Up-regulation of angiopoietin-2, matrix metalloprotease-2, membrane type 1 metalloprotease, and laminin 5 gamma 2 correlates with the invasiveness of human glioma.
Up-regulation of vascular endothelial growth factor by membrane-type 1 matrix metalloproteinase stimulates human glioma xenograft growth and angiogenesis.
Glomerulonephritis
Enhanced expression of membrane type-1 matrix metalloproteinase in mesangial proliferative glomerulonephritis.
Hajdu-Cheney Syndrome
Characterization of Normal Murine Carpal Bone Development Prompts Re-Evaluation of Pathologic Osteolysis as the Cause of Human Carpal-Tarsal Osteolysis Disorders.
Head and Neck Neoplasms
Granulocyte-macrophage colony-stimulating factor upregulates matrix metalloproteinase-2 (MMP-2) and membrane type-1 MMP (MT1-MMP) in human head and neck cancer cells.
High expression of MMP14 is associated with progression and poor short-term prognosis in muscle-invasive bladder cancer.
Hemangiosarcoma
Activation of matrix metalloproteinase (MMP)-2 by membrane type 1-MMP and abnormal immunolocalization of the basement membrane components laminin and type IV collagen in canine spontaneous hemangiosarcomas.
Hepatitis B
The hepatitis B virus X protein promotes hepatocellular carcinoma metastasis by upregulation of matrix metalloproteinases.
The hepatitis B virus X protein promotes tumor cell invasion by inducing membrane-type matrix metalloproteinase-1 and cyclooxygenase-2 expression.
Hepatitis C
Interaction between hepatic membrane type 1 matrix metalloproteinase and acireductone dioxygenase 1 regulates hepatitis C virus infection.
Histiocytoma, Malignant Fibrous
Malignant Fibrous Histiocytoma, Aggressive Fibromatosis and Benign Fibrous Tumors Express mRNA for the Metalloproteinase Inducer EMMPRIN and the Metalloproteinases MMP-2 and MT1-MMP.
Hyperalgesia
Reciprocal relationship between membrane type 1 matrix metalloproteinase and the algesic peptides of myelin basic protein contributes to chronic neuropathic pain.
Hyperinsulinism
Effects of insulin and free fatty acids on matrix metalloproteinases.
In vivo effects of insulin and free fatty acids on matrix metalloproteinases in rat aorta.
Infections
Looking at the proteases from a simple perspective.
Matrix metalloproteinase 14 regulates HSV-1 infection in neuroblastoma cells.
Matrix metalloproteinase-14 regulates collagen degradation and migration of mononuclear cells during infection with genotype VII Newcastle disease virus.
Mayaro Virus Infects Human Chondrocytes and Induces the Expression of Arthritis-Related Genes Associated with Joint Degradation.
RNAi-mediated gene silencing in tumour tissue using replication-competent retroviral vectors.
Inflammatory Breast Neoplasms
Membrane type-1 matrix metalloproteinase (MT1-MMP) correlates with the expression and activation of matrix metalloproteinase-2 (MMP-2) in inflammatory breast cancer.
Intervertebral Disc Degeneration
Downregulation of microRNA-193a-3p is involved in invertebral disc degeneration by targeting MMP14.
The role of matrix metalloproteinase 14 polymorphisms in susceptibility to intervertebral disc degeneration in the Chinese Han population.
Joint Diseases
Characterization of Normal Murine Carpal Bone Development Prompts Re-Evaluation of Pathologic Osteolysis as the Cause of Human Carpal-Tarsal Osteolysis Disorders.
Keloid
Promoted activation of matrix metalloproteinase (MMP)-2 in keloid fibroblasts and increased expression of MMP-2 in collagen bundle regions: implications for mechanisms of keloid progression.
Keratoconus
Expression of membrane-type 1 matrix metalloproteinase (MT1-MMP) and MMP-2 in normal and keratoconus corneas.
Kidney Neoplasms
High expression of MMP14 is associated with progression and poor short-term prognosis in muscle-invasive bladder cancer.
Laryngeal Neoplasms
[Gene expression of matrix mettallo-proteinase 14 in laryngeal squamous cell carcinoma]
Leiomyoma
Expression Levels of Myostatin and Matrix Metalloproteinase 14 mRNAs in Uterine Leiomyoma are Correlated With Dysmenorrhea.
Extracellular matrix remodeling and inflammatory pathway in human endometrium: insights from uterine leiomyomas.
Selective progesterone receptor modulator asoprisnil down-regulates collagen synthesis in cultured human uterine leiomyoma cells through up-regulating extracellular matrix metalloproteinase inducer.
Leukemia
The essential roles of matrix metalloproteinase-2, membrane type 1 metalloproteinase and tissue inhibitor of metalloproteinase-2 in the invasive capacity of acute monocytic leukemia SHI-1 cells.
[Effect of TIMP-2, MT1-MMP and MMP-2 expression on the in vitro invasive capacity of acute monocytic leukemia SHI-1 cells.]
Leukemia, Monocytic, Acute
The essential roles of matrix metalloproteinase-2, membrane type 1 metalloproteinase and tissue inhibitor of metalloproteinase-2 in the invasive capacity of acute monocytic leukemia SHI-1 cells.
[Effect of TIMP-2, MT1-MMP and MMP-2 expression on the in vitro invasive capacity of acute monocytic leukemia SHI-1 cells.]
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Matrix metalloproteinase production by bone marrow mononuclear cells from normal individuals and patients with acute and chronic myeloid leukemia or myelodysplastic syndromes.
Leukemia, Myeloid, Acute
Matrix metalloproteinase production by bone marrow mononuclear cells from normal individuals and patients with acute and chronic myeloid leukemia or myelodysplastic syndromes.
Membrane Type-1 Matrix Metalloproteinase Expression in Acute Myeloid Leukemia and Its Upregulation by Tumor Necrosis Factor-?.
Lichen Planus
MMPs, TIMP-2, and TGF-beta1 in the cancerization of oral lichen planus.
Lichen Planus, Oral
MMPs, TIMP-2, and TGF-beta1 in the cancerization of oral lichen planus.
Lipedema
The MMP14-caveolin axis and its potential relevance for lipoedema.
Liver Cirrhosis
Dynamic change of cells expressing MMP-2 mRNA and MT1-MMP mRNA in the recovery from liver fibrosis in the rat.
Secreted matrix metalloproteinase-14 is a predictor for antifibrotic effect of IC-2-engineered mesenchymal stem cell sheets on liver fibrosis in mice.
Lung Diseases
Increased matrix metalloproteinase-2 and membrane type 1 matrix metalloproteinase activity and expression in heterotopically transplanted murine tracheas.
Lung Injury
Matrix metalloproteinase-14 triggers an anti-inflammatory proteolytic cascade in endotoxemia.
Prediction of repurposed drugs for treating lung injury in COVID-19.
Lung Neoplasms
Alterations in gene expression of proprotein convertases in human lung cancer have a limited number of scenarios.
CK2 inhibitor CX4945 induces sequential inactivation of proteins in the signaling pathways related with cell migration and suppresses metastasis of A549 human lung cancer cells.
Matrix Metalloproteinase 14 promotes lung cancer by cleavage of Heparin-Binding EGF-like Growth Factor.
Microvesicles derived from activated platelets induce metastasis and angiogenesis in lung cancer.
Noninvasive Bioluminescence Imaging of Matrix Metalloproteinase-14 Activity in Lung Cancer Using a Membrane-Bound Biosensor.
Regulation of matrix metalloproteinase genes by E2F transcription factors: Rb-Raf-1 interaction as a novel target for metastatic disease.
Regulation of membrane-type 1 matrix metalloproteinase expression by zonula occludens-2 in human lung cancer cells.
Lymphatic Metastasis
Enhanced production and activation of progelatinase A mediated by membrane-type 1 matrix metalloproteinase in human oral squamous cell carcinomas: implications for lymph node metastasis.
Increased expression of MMP14 correlates with the poor prognosis of Chinese patients with gastric cancer.
Membrane-type 1 matrix metalloproteinase enhances lymph node metastasis of gastric cancer.
miR-34a inhibits migration and invasion of tongue squamous cell carcinoma via targeting MMP9 and MMP14.
MMP14 regulates cell migration and invasion through epithelial-mesenchymal transition in nasopharyngeal carcinoma.
Overexpression of MMP14 predicts the poor prognosis in gastric cancer: Meta-analysis and database validation.
Predictive value of laminin-5 and membrane type 1-matrix metalloproteinase expression for cervical lymph node metastasis in T1 and T2 squamous cell carcinomas of the tongue and floor of the mouth.
Upregulation of cyclin-dependent kinase 7 and matrix metalloproteinase-14 expression contribute to metastatic properties of gastric cancer.
[Gene expression of matrix mettallo-proteinase 14 in laryngeal squamous cell carcinoma]
Lymphoma, B-Cell
Matrix Metallopeptidase 14: A Candidate Prognostic Biomarker for Diffuse Large B-Cell Lymphoma.
Lymphoma, Large B-Cell, Diffuse
Matrix Metallopeptidase 14: A Candidate Prognostic Biomarker for Diffuse Large B-Cell Lymphoma.
Melanoma
ADAM10 is the constitutive functional sheddase of CD44 in human melanoma cells.
Downregulation of reversion-inducing cysteine-rich protein with Kazal motifs in malignant melanoma: inverse correlation with membrane-type 1-matrix metalloproteinase and tissue inhibitor of metalloproteinase 2.
Elastin-elastases and inflamm-aging.
Emerging Roles of PAR-1 and PAFR in Melanoma Metastasis.
Expression and activation of matrix metalloproteinase-2 (MMP-2) and its co-localization with membrane-type 1 matrix metalloproteinase (MT1-MMP) correlate with melanoma progression.
Expression and prognostic role of MMP2, MMP9, MMP13, and MMP14 matrix metalloproteinases in sinonasal and oral malignant melanomas.
Expression of integrin alpha(v)beta(3) correlates with activation of membrane-type matrix metalloproteinase-1 (MT1-MMP) and matrix metalloproteinase-2 (MMP-2) in human melanoma cells in vitro and in vivo.
Expression of matrix metalloproteinase-2 and -9 and membrane-type 1 matrix metalloproteinase in melanocytic tumors of dogs and canine melanoma cell lines.
Expression of membrane type 1 matrix metalloproteinase (MT1-MMP) in A2058 melanoma cells is associated with MMP-2 activation and increased tumor growth and vascularization.
Fibroblast MMP14-Dependent Collagen Processing Is Necessary for Melanoma Growth.
Functional role of MIA in melanocytes and early development of melanoma.
Long non-coding RNA MALAT1 acts as a competing endogenous RNA to promote malignant melanoma growth and metastasis by sponging miR-22.
Loss of dipeptidyl peptidase IV immunostaining discriminates malignant melanomas from deep penetrating nevi.
Lymphatic endothelium stimulates melanoma metastasis and invasion via MMP14-dependent Notch3 and ?1-integrin activation.
mda-9/Syntenin regulates the metastatic phenotype in human melanoma cells by activating nuclear factor-kappaB.
Membrane type-1 matrix metalloproteinase promotes human melanoma invasion and growth.
MMP16 Mediates a Proteolytic Switch to Promote Cell-Cell Adhesion, Collagen Alignment, and Lymphatic Invasion in Melanoma.
MT1-MMP dependent repression of the tumor suppressor SPRY4 contributes to MT1-MMP driven melanoma cell motility.
Noncanonical Activation of Notch1 Protein by Membrane Type 1 Matrix Metalloproteinase (MT1-MMP) Controls Melanoma Cell Proliferation.
Osteopontin induces nuclear factor kappa B-mediated promatrix metalloproteinase-2 activation through I kappa B alpha /IKK signaling pathways, and curcumin (diferulolylmethane) down-regulates these pathways.
Osteopontin stimulates tumor growth and activation of promatrix metalloproteinase-2 through nuclear factor-kappa B-mediated induction of membrane type 1 matrix metalloproteinase in murine melanoma cells.
Phosphoinositide 3-kinase regulates membrane Type 1-matrix metalloproteinase (MMP) and MMP-2 activity during melanoma cell vasculogenic mimicry.
Protein Tyrosine Phosphatase 4A3 (PTP4A3) Promotes Human Uveal Melanoma Aggressiveness Through Membrane Accumulation of Matrix Metalloproteinase 14 (MMP14).
Shedding light on proteolytic cleavage of CD44: the responsible sheddase and functional significance of shedding.
Stromal cell-derived factor-1alpha promotes melanoma cell invasion across basement membranes involving stimulation of membrane-type 1 matrix metalloproteinase and Rho GTPase activities.
The gene expression profiles of primary and metastatic melanoma yields a transition point of tumor progression and metastasis.
The membrane tethered matrix metalloproteinase MT1-MMP at the forefront of melanoma cell invasion and metastasis.
The tetraspanin CD81 protein increases melanoma cell motility by up-regulating metalloproteinase MT1-MMP expression through the pro-oncogenic Akt-dependent Sp1 activation signaling pathways.
Tissue inhibitor of matrix metalloproteinase-2 regulates matrix metalloproteinase-2 activation by modulation of membrane-type 1 matrix metalloproteinase activity in high and low invasive melanoma cell lines.
Transmembrane/cytoplasmic domain-mediated membrane type 1-matrix metalloprotease docking to invadopodia is required for cell invasion.
membrane-type matrix metalloproteinase-1 deficiency
Loss of MT1-MMP in Alveolar Epithelial Cells Exacerbates Pulmonary Fibrosis.
Meningioma
Comparative gene expression profiling of ADAMs, MMPs, TIMPs, EMMPRIN, EGF-R and VEGFA in low grade meningioma.
Mesothelioma
Genetic variants associated with increased risk of malignant pleural mesothelioma: a genome-wide association study.
Global gene expression profiling of human pleural mesotheliomas: identification of matrix metalloproteinase 14 (MMP-14) as potential tumour target.
Mouth Neoplasms
Gene expression profiles of cell adhesion molecules, matrix metalloproteinases and their tissue inhibitors in canine oral tumors.
Myelodysplastic Syndromes
Matrix metalloproteinase production by bone marrow mononuclear cells from normal individuals and patients with acute and chronic myeloid leukemia or myelodysplastic syndromes.
Myocardial Infarction
Cardiac restricted overexpression of membrane type-1 matrix metalloproteinase causes adverse myocardial remodeling following myocardial infarction.
Direct Regulation of Membrane Type-1 Matrix Metalloproteinase Following Myocardial Infarction Causes Changes in Survival, Cardiac Function and Remodeling.
Myocardial Ischemia
Interruption of endothelin signaling modifies membrane type 1 matrix metalloproteinase activity during ischemia and reperfusion.
Nasopharyngeal Carcinoma
A role of MMP-14 in the regulation of invasiveness of nasopharyngeal carcinoma.
Matrix Metalloproteinase 14 Overexpression Is Correlated with the Progression and Poor Prognosis of Nasopharyngeal Carcinoma.
MMP14 regulates cell migration and invasion through epithelial-mesenchymal transition in nasopharyngeal carcinoma.
Study on the Drug Targets and Molecular Mechanisms of Rhizoma Curcumae in the Treatment of Nasopharyngeal Carcinoma Based on Network Pharmacology.
Neoplasm Metastasis
(-)-Epigallocatechin gallate inhibits membrane-type 1 matrix metalloproteinase, MT1-MMP, and tumor angiogenesis.
A large-scale study of MT1-MMP as a marker for isolated tumor cells in peripheral blood and bone marrow in gastric cancer cases.
A new pseudo-peptide of Arg-Gly-Asp (RGD) inhibits intrahepatic metastasis of orthotopically implanted murine hepatocellular carcinoma.
A novel immunotherapy targeting MMP-14 limits hypoxia, immune suppression and metastasis in triple-negative breast cancer models.
A novel strategy to tag matrix metalloproteinases-positive cells for in vivo imaging of invasive and metastatic activity of tumor cells.
A role for MT1-MMP as a cell death sensor/effector through the regulation of endoplasmic reticulum stress in U87 glioblastoma cells.
A specific subset of RabGTPases controls cell surface exposure of MT1-MMP, extracellular matrix degradation and three-dimensional invasion of macrophages.
A unique substrate binding mode discriminates membrane type-1 matrix metalloproteinase from other matrix metalloproteinases.
Activated EphA2 Processing by MT1-MMP Is Involved in Malignant Transformation of Ovarian Tumours In Vivo.
Assessment of the MT1-MMP expression level of different cell lines by the naked eye.
c-Myc expression and MEK1-induced Erk2 nuclear localization are required for TGF-beta induced epithelial-mesenchymal transition and invasion in prostate cancer.
Chloride intracellular channel protein 2 is secreted and inhibits MMP14 activity, while preventing tumor cell invasion and metastasis.
CK2 inhibitor CX4945 induces sequential inactivation of proteins in the signaling pathways related with cell migration and suppresses metastasis of A549 human lung cancer cells.
Co-localisation of intra-nuclear membrane type-1 matrix metalloproteinase and hypoxia inducible factor-2? in osteosarcoma and prostate carcinoma cells.
Coexpression of bone sialoprotein (BSP) and the pivotal transcriptional regulator of osteogenesis, Cbfa1/Runx2, in malignant melanoma.
Collagenase-3 (MMP-13) is expressed by tumor cells in invasive vulvar squamous cell carcinomas.
Coronin 1C promotes triple-negative breast cancer invasiveness through regulation of MT1-MMP traffic and invadopodia function.
DNMT1 recruited by EZH2-mediated silencing of miR-484 contributes to the malignancy of cervical cancer cells through MMP14 and HNF1A.
Enhanced production and activation of progelatinase A mediated by membrane-type 1 matrix metalloproteinase in human oral squamous cell carcinomas: implications for lymph node metastasis.
Epidermal growth factor receptor regulates MT1-MMP and MMP-2 synthesis in SiHa cells via both PI3-K/AKT and MAPK/ERK pathways.
Expression of membrane type 1 matrix metalloproteinase is associated with cervical carcinoma progression and invasion.
Expression of membrane type-1 matrix metalloproteinase, MT1-MMP in human breast cancer and its impact on invasiveness of breast cancer cells.
Expression of the reversion-inducing cysteine-rich protein with Kazal motifs and matrix metalloproteinase-14 in neuroblastoma and the role in tumour metastasis.
Expression profile of genes associated with antimetastatic gene: nm23-mediated metastasis inhibition in breast carcinoma cells.
FGF receptor-4 (FGFR4) polymorphism acts as an activity switch of a membrane type 1 matrix metalloproteinase-FGFR4 complex.
Gelatinase A and membrane-type 1 matrix metalloproteinase mRNA: expressed in adrenocortical cancers but not in adenomas.
Gelatinase A, membrane type 1 matrix metalloproteinase, and extracellular matrix metalloproteinase inducer mRNA expression: correlation with invasive growth of breast cancer.
Generation of inhibitory monoclonal antibodies targeting matrix metalloproteinase-14 by motif grafting and CDR optimization.
Genetically Encoded Fluorescent Biosensors for Live-Cell Imaging of MT1-MMP Protease Activity.
Glycosylation broadens the substrate profile of membrane type 1 matrix metalloproteinase.
Granulocyte-macrophage colony-stimulating factor upregulates matrix metalloproteinase-2 (MMP-2) and membrane type-1 MMP (MT1-MMP) in human head and neck cancer cells.
HDAC2 inhibits EMT-mediated cancer metastasis by downregulating the long noncoding RNA H19 in colorectal cancer.
Hepatocyte nuclear factor 4 alpha promotes the invasion, metastasis and angiogenesis of neuroblastoma cells via targeting matrix metalloproteinase 14.
High expression of Collagen Triple Helix Repeat Containing 1 (CTHRC1) facilitates progression of oesophageal squamous cell carcinoma through MAPK/MEK/ERK/FRA-1 activation.
High expression of MMP14 is associated with progression and poor short-term prognosis in muscle-invasive bladder cancer.
High serum MMP-14 predicts worse survival in gastric cancer.
High tissue MMP14 expression predicts worse survival in gastric cancer, particularly with a low PROX1.
Identification of cis-acting promoter elements that support expression of membrane-type 1 matrix metalloproteinase (MT1-MMP) in v-src transformed Madin-Darby canine kidney cells.
Identification of substrate sequences for membrane type-1 matrix metalloproteinase using bacteriophage peptide display library.
In vitro anti-metastatic activity of enterolactone, a mammalian lignan derived from flax lignan, and down-regulation of matrix metalloproteinases in MCF-7 and MDA MB 231 cell lines.
In vivo imaging of membrane type-1 matrix metalloproteinase with a novel activatable near-infrared fluorescence probe.
Increased expression of MMP14 correlates with the poor prognosis of Chinese patients with gastric cancer.
Increased serum level of membrane type 1-matrix metalloproteinase (MT1-MMP/MMP-14) in patients with breast cancer.
Inhibition of hepatocellular carcinoma invasion by suppression of claudin-10 in HLE cells.
Inhibition of membrane-type 1 matrix metalloproteinase at cell-matrix adhesions.
Inhibition of membrane-type 1 matrix metalloproteinase by hydroxamate inhibitors: an examination of the subsite pocket.
Inhibitory effect of green tea polyphenols on membrane-type 1 matrix metalloproteinase, MT1-MMP.
Interference with the complement system by tumor cell membrane type-1 matrix metalloproteinase plays a significant role in promoting metastasis in mice.
Involvement of syntaxin 4 in the transport of membrane-type 1 matrix metalloproteinase to the plasma membrane in human gastric epithelial cells.
KLF8 and FAK cooperatively enrich the active MMP14 on the cell surface required for the metastatic progression of breast cancer.
LIM kinase1 modulates function of membrane type matrix metalloproteinase 1: implication in invasion of prostate cancer cells.
Looking at the proteases from a simple perspective.
Lymphatic endothelium stimulates melanoma metastasis and invasion via MMP14-dependent Notch3 and ?1-integrin activation.
Matrix Metalloproteinase 14 Overexpression Is Correlated with the Progression and Poor Prognosis of Nasopharyngeal Carcinoma.
Matrix Metalloproteinase-14 Is a Negative Prognostic Marker for Patients with Gastric Cancer.
Mechanism of metastasis by membrane type 1-matrix metalloproteinase in hepatocellular carcinoma.
MeCP2 Promotes Colorectal Cancer Metastasis by Modulating ZEB1 Transcription.
Membrane type 1-matrix metalloproteinase promotes human prostate cancer invasion and metastasis.
Membrane-type 1 matrix metalloproteinase enhances lymph node metastasis of gastric cancer.
Membrane-type matrix metalloproteinases (MT-MMPs) in tumor metastasis.
MicroRNA-10b promotes migration and invasion through KLF4 and HOXD10 in human bladder cancer.
MicroRNA-22 inhibits tumor growth and metastasis in gastric cancer by directly targeting MMP14 and Snail.
microRNA-9 targets matrix metalloproteinase 14 to inhibit invasion, metastasis, and angiogenesis of neuroblastoma cells.
Microsphere-Based Nanoindentation for the Monitoring of Cellular Cortical Stiffness Regulated by MT1-MMP.
Miniaturized antibodies for imaging membrane type-1 matrix metalloproteinase in cancers.
miR-34a inhibits migration and invasion of tongue squamous cell carcinoma via targeting MMP9 and MMP14.
miRNA-mRNA network detects hub mRNAs and cancer specific miRNAs in lung cancer.
MMP-14 and TGF?-1 methylation in pituitary adenomas.
MMP-14 Triggered Fluorescence Contrast Agent.
MMP14 predicts a poor prognosis in patients with colorectal cancer.
MMP14 regulates cell migration and invasion through epithelial-mesenchymal transition in nasopharyngeal carcinoma.
MMP16 Mediates a Proteolytic Switch to Promote Cell-Cell Adhesion, Collagen Alignment, and Lymphatic Invasion in Melanoma.
Molecular and functional extracellular vesicle analysis using nanopatterned microchips monitors tumor progression and metastasis.
Molecular signature of response to preoperative radiotherapy in locally advanced breast cancer.
MT1-MMP Activation of TGF-? Signaling Enables Intercellular Activation of an Epithelial-mesenchymal Transition Program in Cancer.
MT1-MMP dependent repression of the tumor suppressor SPRY4 contributes to MT1-MMP driven melanoma cell motility.
MT1-MMP recruits the ER-Golgi SNARE Bet1 for efficient MT1-MMP transport to the plasma membrane.
MT1-MMP regulates urothelial cell invasion via transcriptional regulation of Dickkopf-3.
NEDD9 depletion leads to MMP14 inactivation by TIMP2 and prevents invasion and metastasis.
NEDD9/Arf6-dependent endocytic trafficking of matrix metalloproteinase 14: a novel mechanism for blocking mesenchymal cell invasion and metastasis of breast cancer.
Noninvasive Bioluminescence Imaging of Matrix Metalloproteinase-14 Activity in Lung Cancer Using a Membrane-Bound Biosensor.
Organelle Specific O-Glycosylation Drives MMP14 Activation, Tumor Growth, and Metastasis.
Ovarian cancer cell detachment and multicellular aggregate formation are regulated by membrane type 1 matrix metalloproteinase: a potential role in I.p. metastatic dissemination.
Overexpression of MMP14 predicts the poor prognosis in gastric cancer: Meta-analysis and database validation.
OXIDATIVE STRESS AND PROSTATE CANCER PROGRESSION ARE ELICITED BY MEMBRANE-TYPE 1 MATRIX METALLOPROTEINASE (MT1-MMP).
Predictive value of laminin-5 and membrane type 1-matrix metalloproteinase expression for cervical lymph node metastasis in T1 and T2 squamous cell carcinomas of the tongue and floor of the mouth.
Primary renal neuroblastoma with metastasis and matrix metalloproteinase-14 expression.
Prinomastat, a hydroxamate inhibitor of matrix metalloproteinases, has a complex effect on migration of breast carcinoma cells.
Prognostic targets recognition of rectal adenocarcinoma based on transcriptomics.
Protein Tyrosine Phosphatase 4A3 (PTP4A3) Promotes Human Uveal Melanoma Aggressiveness Through Membrane Accumulation of Matrix Metalloproteinase 14 (MMP14).
RABGTPases in MT1-MMP trafficking and cell invasion: Physiology versus pathology.
Radioimmunodetection of membrane type-1 matrix metalloproteinase relevant to tumor malignancy with a pre-targeting method.
Radioiodinated Peptidic Imaging Probes for in Vivo Detection of Membrane Type-1 Matrix Metalloproteinase in Cancers.
Reducing proteolytic liability of a MMP-14 inhibitory antibody by site-saturation mutagenesis.
Regulation of extracellular matrix degradation and metastatic spread by IQGAP1 through endothelin-1 receptor signalling in ovarian cancer.
Regulation of MT1-MMP and MMP-2 by the serpin PEDF: a promising new target for metastatic cancer.
Relation of MT1-MMP gene expression to outcomes in colorectal cancer.
Roles of membrane-type matrix metalloproteinase-1 in tumor invasion and metastasis.
Screening, Identification, and Characterization of an Affinity Peptide Specific to MT1-MMP and Its Application in Tumor Imaging.
Selective function-blocking monoclonal human antibody highlights the important role of membrane type-1 matrix metalloproteinase (MT1-MMP) in metastasis.
Simultaneous visualization of protumorigenic Src and MT1-MMP activities with fluorescence resonance energy transfer.
Strong significant correlation between MMP-9 and systemic symptoms in patients with localized renal cell carcinoma.
Targeting a Designer TIMP-1 to the Cell Surface for Effective MT1-MMP Inhibition: A Potential Role for the Prion Protein in Renal Carcinoma Therapy.
Targeting the MMP-14/MMP-2/integrin ?v?3 axis with multispecific N-TIMP2-based antagonists for cancer therapy.
TC10 regulates breast cancer invasion and metastasis by controlling membrane type-1 matrix metalloproteinase at invadopodia.
TGF-?-induced NKILA inhibits ESCC cell migration and invasion through NF-?B/MMP14 signaling.
The hemopexin domain of membrane-type matrix metalloproteinase-1 (MT1-MMP) Is not required for its activation of proMMP2 on cell surface but is essential for MT1-MMP-mediated invasion in three-dimensional type I collagen.
The membrane tethered matrix metalloproteinase MT1-MMP at the forefront of melanoma cell invasion and metastasis.
The Precise Diagnosis of Cancer Invasion/Metastasis via 2D Laser Ablation Mass Mapping of Metalloproteinase in Primary Cancer Tissue.
Tissue inhibitor of metalloproteinase (TIMP)-2 acts synergistically with synthetic matrix metalloproteinase (MMP) inhibitors but not with TIMP-4 to enhance the (Membrane type 1)-MMP-dependent activation of pro-MMP-2.
UCA1 functions as a competing endogenous RNA to suppress epithelial ovarian cancer metastasis.
Upregulation of cyclin-dependent kinase 7 and matrix metalloproteinase-14 expression contribute to metastatic properties of gastric cancer.
[Effects of ?1-PDX, a furin inhibitor, on growth, invasion, and tumorigenicity of cervical cancer HeLa cells].
[Gene expression of matrix mettallo-proteinase 14 in laryngeal squamous cell carcinoma]
[Inhibitory effect of MT1-MMP antisense nucleotide on invasion of human highly metastatic ovarian cancer cell line SW626.]
[Membrane type 1 matrix metalloproteinase (MT1-MMP) and the regulators of its activity as invasive factors in squamous cell cervical carcinomas.]
[The role of membrane-type 1 matrix metalloproteinase in the invasion and metastasis of hepatocellular carcinoma]
[Virtual screening and molecular simulations of antisense peptides targeting MT1-MMP].
Neoplasms
(-)-Epigallocatechin gallate inhibits membrane-type 1 matrix metalloproteinase, MT1-MMP, and tumor angiogenesis.
A conjugate of camptothecin and a somatostatin analog against prostate cancer cell invasion via a possible signaling pathway involving PI3K/Akt, alphaVbeta3/alphaVbeta5 and MMP-2/-9.
A DNA aptamer recognizing MMP14 for in vivo and in vitro imaging identified by cell-SELEX.
A membrane-type-1 matrix metalloproteinase (MT1-MMP)-discoidin domain receptor 1 axis regulates collagen-induced apoptosis in breast cancer cells.
A new front in cell invasion: The invadopodial membrane.
A novel and selective membrane type-1 matrix metalloproteinase (MT1-MMP) inhibitor reduces cancer cell motility and tumor growth.
A novel immunotherapy targeting MMP-14 limits hypoxia, immune suppression and metastasis in triple-negative breast cancer models.
A novel protein associated with membrane-type 1 matrix metalloproteinase binds p27(kip1) and regulates RhoA activation, actin remodeling, and matrigel invasion.
A novel strategy to tag matrix metalloproteinases-positive cells for in vivo imaging of invasive and metastatic activity of tumor cells.
A role for MT1-MMP as a cell death sensor/effector through the regulation of endoplasmic reticulum stress in U87 glioblastoma cells.
A role of MMP-14 in the regulation of invasiveness of nasopharyngeal carcinoma.
A small-molecule furin inhibitor inhibits cancer cell motility and invasiveness.
A specific subset of RabGTPases controls cell surface exposure of MT1-MMP, extracellular matrix degradation and three-dimensional invasion of macrophages.
A study on angiogenesis-related matrix metalloproteinase networks in primary hepatocellular carcinoma.
A Transcriptional Regulatory Role for the Membrane Type-1 Matrix Metalloproteinase in Carcinogen-Induced Inflammasome Gene Expression.
A unique substrate binding mode discriminates membrane type-1 matrix metalloproteinase from other matrix metalloproteinases.
AAC-11 overexpression induces invasion and protects cervical cancer cells from apoptosis.
Actin-associated protein palladin promotes tumor cell invasion by linking extracellular matrix degradation to cell cytoskeleton.
Activation of ALDH2 attenuates high glucose induced rat cardiomyocyte fibrosis and necroptosis.
Activation of fibroblast-derived matrix metalloproteinase-2 by colon-cancer cells in non-contact Co-cultures.
Activation of tumor cell matrix metalloproteinase-2 by neutrophil proteinases requires expression of membrane-type 1 matrix metalloproteinase.
Active-site MMP-selective antibody inhibitors discovered from convex paratope synthetic libraries.
ADAM10 is the constitutive functional sheddase of CD44 in human melanoma cells.
Alterations in gene expression of proprotein convertases in human lung cancer have a limited number of scenarios.
An alternative processing of integrin alpha(v) subunit in tumor cells by membrane type-1 matrix metalloproteinase.
Analysis of MT1-MMP and MMP2 expression in human gastric cancers.
Anti-neovascular therapy by liposomal drug targeted to membrane type-1 matrix metalloproteinase.
Antiangiogenic immunotherapy suppresses desmoplastic and chemoresistant intestinal tumors in mice.
ARF6-JIP3/4 regulate endosomal tubules for MT1-MMP exocytosis in cancer invasion.
Assessment of the MT1-MMP expression level of different cell lines by the naked eye.
Association of BCSC-1 and MMP-14 with human breast cancer.
Biochemical evidence of the interactions of membrane type-1 matrix metalloproteinase (MT1-MMP) with adenine nucleotide translocator (ANT): potential implications linking proteolysis with energy metabolism in cancer cells.
Bioinformatics analysis identified MMP14 and COL12A1 as immune-related biomarkers associated with pancreatic adenocarcinoma prognosis.
Broad antitumor and antiangiogenic activities of AG3340, a potent and selective MMP inhibitor undergoing advanced oncology clinical trials.
Cancer Cell Invasion in Three-dimensional Collagen Is Regulated Differentially by G?13 Protein and Discoidin Domain Receptor 1-Par3 Protein Signaling.
Cancer cells grown in 3D under fluid flow exhibit an aggressive phenotype and reduced responsiveness to the anti-cancer treatment doxorubicin.
Case of primary malignant hemangiopericytoma of the heart expressing basement membrane-degradable enzymes.
CD44 binding through the hemopexin-like domain is critical for its shedding by membrane-type 1 matrix metalloproteinase.
CD44 directs membrane-type 1 matrix metalloproteinase to lamellipodia by associating with its hemopexin-like domain.
CDCP1 regulates the function of MT1-MMP and invadopodia-mediated invasion of cancer cells.
Cellular membrane type-1 matrix metalloproteinase (MT1-MMP) cleaves C3b, an essential component of the complement system.
Characterization of the transcriptional regulation of the human MT1-MMP gene and association of risk reduction for focal-segmental glomerulosclerosis with two functional promoter SNPs.
Chloride intracellular channel protein 2 is secreted and inhibits MMP14 activity, while preventing tumor cell invasion and metastasis.
Cleavage of growth differentiation factor 15 (GDF15) by membrane type 1-matrix metalloproteinase abrogates GDF15-mediated suppression of tumor cell growth.
Cleavage of lumican by membrane-type matrix metalloproteinase-1 abrogates this proteoglycan-mediated suppression of tumor cell colony formation in soft agar.
Clinically compatible flexible wide-field multi-color fluorescence endoscopy with a porcine colon model.
CNK1 promotes invasion of cancer cells through NF-kappaB-dependent signaling.
Coexpression of bone sialoprotein (BSP) and the pivotal transcriptional regulator of osteogenesis, Cbfa1/Runx2, in malignant melanoma.
Collagenase-3 (MMP-13) is expressed by tumor cells in invasive vulvar squamous cell carcinomas.
Combination of Biochanin A and Temozolomide Impairs Tumor Growth by Modulating Cell Metabolism in Glioblastoma Multiforme.
Comparative expression of matrix metalloproteinases in internal malignancies and paired cutaneous metastatic lesions.
Competitive disruption of the tumor-promoting function of membrane type 1 matrix metalloproteinase/matrix metalloproteinase-14 in vivo.
Construction of antisense MT1-MMP vector and its inhibitory effects on invasion of human ovarian cancer cells.
Conversion of stationary to invasive tumor initiating cells (TICs): role of hypoxia in membrane type 1-matrix metalloproteinase (MT1-MMP) trafficking.
Coordinate action of membrane-type matrix metalloproteinase -1 (MT1-MMP) and MMP-2 enhances pericellular proteolysis and invasion.
Coronin 1C promotes triple-negative breast cancer invasiveness through regulation of MT1-MMP traffic and invadopodia function.
CRN2 binds to TIMP4 and MMP14 and promotes perivascular invasion of glioblastoma cells.
Cytoplasmic tail-dependent internalization of membrane-type 1 matrix metalloproteinase is important for its invasion-promoting activity.
Decreased MT1-MMP in gastric cancer suppressed cell migration and invasion via regulating MMPs and EMT.
Defining the roles of T cell membrane proteinase and CD44 in type 1 diabetes.
Development of a novel tumor-targeted vascular disrupting agent activated by membrane-type matrix metalloproteinases.
Development of a radiolabeled probe for detecting membrane type-1 matrix metalloproteinase on malignant tumors.
Development of an optimized activatable MMP-14 targeted SPECT imaging probe.
Development of membrane type-1 matrix metalloproteinase-specific activatable fluorescent probe for malignant tumor detection.
Development of PEGylated peptide probes conjugated with (18)F-labeled BODIPY for PET/optical imaging of MT1-MMP activity.
Differential Expression of ADAM23, CDKN2A (P16), MMP14 and VIM Associated with Giant Cell Tumor of Bone.
Differential expression of matrix metalloproteinase (MMP)-2, MMP-9, and membrane type 1-MMP in hepatocellular and pancreatic adenocarcinoma: implications for tumor progression and clinical prognosis.
Differential regulation of the expression of matrix metalloproteinases and tissue inhibitors of metalloproteinases by cytokines and growth factors in bovine endometrial stromal cells and trophoblast cell line BT-1 in vitro.
Discoidin domain receptor 2 mediates collagen-induced activation of membrane-type 1 matrix metalloproteinase in human fibroblasts.
Discretionary Transduction of MMP-Sensitized Tousled in Head and Neck Cancer.
Diverse roles of matrix metalloproteinases and tissue inhibitors of metalloproteinases in neuroinflammation and cerebral ischemia.
DNMT1 recruited by EZH2-mediated silencing of miR-484 contributes to the malignancy of cervical cancer cells through MMP14 and HNF1A.
Down-Regulation of MT1-MMP expression by the alpha3 chain of type IV collagen inhibits bronchial tumor cell line invasion.
Down-regulation of MT1-MMP expression suppresses tumor cell invasion in metastatic human SW626 ovarian cancer cells.
Downregulation of matrix metalloproteinase 14 by the antitumor miRNA, miR-150-5p, inhibits the aggressiveness of lung squamous cell carcinoma cells.
Dual over-expression pattern of membrane-type metalloproteinase-1 in cancer and stromal cells in human gastrointestinal carcinoma revealed by in situ hybridization and immunoelectron microscopy.
Early GalNAc O-Glycosylation: Pushing the Tumor Boundaries.
Effects of 17beta-estradiol on the expression of membrane type 1 matrix metalloproteinase (MT1-MMP) and MMP-2 in human osteoblastic MG-63 cell cultures.
Effects of bevacizumab in mouse model of endometrial cancer: Defining the molecular basis for resistance.
Effects of CoCl2-simulated hypoxia on the expression levels of matrix metalloproteinases in renal adenocarcinoma cells and renal tubular epithelial cells.
Emerging concepts in the regulation of membrane-type 1 matrix metalloproteinase activity.
Endothelin-1 down-regulates matrix metalloproteinase 14 and 15 expression in human first trimester trophoblasts via endothelin receptor type B.
Enhanced constitutive invasion activity in human nontumorigenic keratinocytes exposed to a low level of barium for a long time.
Enhanced membrane-type 1 matrix metalloproteinase expression by hyaluronan oligosaccharides in breast cancer cells facilitates CD44 cleavage and tumor cell migration.
Ensnaring membrane type 1-matrix metalloproteinase (MT1-MMP) with tissue inhibitor of metalloproteinase (TIMP)-2 using the haemopexin domain of the protease as a carrier: a targeted approach in cancer inhibition.
Epidermal growth factor receptor regulates MT1-MMP and MMP-2 synthesis in SiHa cells via both PI3-K/AKT and MAPK/ERK pathways.
Ets-1 messenger RNA expression is a novel marker of poor survival in ovarian carcinoma.
Expression of matrix metalloprotease-2 (MMP-2) and the activator membrane type 1 (MT1-MMP) in canine mammary carcinomas.
Expression of matrix metalloproteinase 2 (MMP-2), membrane-type 1 MMP and tissue inhibitor of metalloproteinase 2 and activation of proMMP-2 in pancreatic duct adenocarcinomas in hamsters treated with N-nitrosobis(2-oxopropyl)amine.
Expression of matrix metalloproteinase-2 and -9 and membrane-type 1 matrix metalloproteinase in melanocytic tumors of dogs and canine melanoma cell lines.
Expression of membrane type 1 matrix metalloproteinase (MMP-14) in epithelial ovarian cancer: high level expression in clear cell carcinoma.
Expression of membrane type 1 matrix metalloproteinase (MT1-MMP) in A2058 melanoma cells is associated with MMP-2 activation and increased tumor growth and vascularization.
Expression of membrane type 1 matrix metalloproteinase in medullary thyroid carcinoma: Prognostic implications.
Expression of membrane type 1 matrix metalloproteinase is associated with cervical carcinoma progression and invasion.
Expression of membrane type 1 matrix metalloproteinase, matrix metalloproteinase 2 and tissue inhibitor of metalloproteinase 2 in human cartilaginous tumors with special emphasis on mesenchymal and dedifferentiated chondrosarcoma.
Expression of membrane type-1 matrix metalloproteinase, MT1-MMP in human breast cancer and its impact on invasiveness of breast cancer cells.
Expression of membrane-type 1 matrix metalloproteinase (MT1-MMP) mRNA in trophoblast and endometrial epithelial cell populations of the synepitheliochorial placenta of goats (Capra hircus).
Expression of membrane-type matrix metalloproteinase in rabbit neointimal tissue and its correlation with matrix-metalloproteinase-2 activation.
Expression of membrane-type matrix metalloproteinase-1 in human pancreatic adenocarcinomas.
Expression of MMP-14 and prognosis in digestive system carcinoma: a meta-analysis and databases validation.
Expression of MMP14 in invasive pituitary adenomas: relationship to invasion and angiogenesis.
Expression of proteolytic enzymes in head and neck cancer-associated fibroblasts.
Expression of the reversion-inducing cysteine-rich protein with Kazal motifs and matrix metalloproteinase-14 in neuroblastoma and the role in tumour metastasis.
Extracellular matrix-mediated membrane-type 1 matrix metalloproteinase expression in pancreatic ductal cells is regulated by transforming growth factor-beta1.
FGF receptor-4 (FGFR4) polymorphism acts as an activity switch of a membrane type 1 matrix metalloproteinase-FGFR4 complex.
Fibroblast growth factor receptor 4 regulates tumor invasion by coupling fibroblast growth factor signaling to extracellular matrix degradation.
Fibroblast MMP14-Dependent Collagen Processing Is Necessary for Melanoma Growth.
Functional activation of integrin alpha V beta 3 in tumor cells expressing membrane-type 1 matrix metalloproteinase.
Functional role of matrix metalloproteinases in ovarian tumor cell plasticity.
Functional role of MIA in melanocytes and early development of melanoma.
Furin inhibition results in absent or decreased invasiveness and tumorigenicity of human cancer cells.
Furin regulates the intracellular activation and the uptake rate of cell surface-associated MT1-MMP.
Gelatinase A and membrane-type 1 matrix metalloproteinase mRNA: expressed in adrenocortical cancers but not in adenomas.
Gelatinase A, membrane type 1 matrix metalloproteinase, and extracellular matrix metalloproteinase inducer mRNA expression: correlation with invasive growth of breast cancer.
Gene expression profiles of cell adhesion molecules, matrix metalloproteinases and their tissue inhibitors in canine oral tumors.
Gene expression ratio stability evaluation in prepubertal bovine mammary tissue from calves fed different milk replacers reveals novel internal controls for quantitative polymerase chain reaction.
Generation of inhibitory monoclonal antibodies targeting matrix metalloproteinase-14 by motif grafting and CDR optimization.
Genetic association of MMP14 promoter variants and their functional significance in gallbladder cancer pathogenesis.
Genetically Encoded Fluorescent Biosensors for Live-Cell Imaging of MT1-MMP Protease Activity.
GI24 enhances tumor invasiveness by regulating cell surface membrane-type 1 matrix metalloproteinase.
Global gene expression profiling of human pleural mesotheliomas: identification of matrix metalloproteinase 14 (MMP-14) as potential tumour target.
Glycosylation broadens the substrate profile of membrane type 1 matrix metalloproteinase.
Heat shock suppresses membrane type 1-matrix metalloproteinase production and progelatinase A activation in human fibrosarcoma HT-1080 cells and thereby inhibits cellular invasion.
Heat shock-mediated transient increase in intracellular 3',5'-cyclic AMP results in tumor specific suppression of membrane type 1-matrix metalloproteinase production and progelatinase A activation.
High expression of MMP14 is associated with progression and poor short-term prognosis in muscle-invasive bladder cancer.
High MMP14 expression is predictive of poor prognosis in resectable hepatocellular carcinoma.
High tissue MMP14 expression predicts worse survival in gastric cancer, particularly with a low PROX1.
Hijacking a Morphogenesis Proteinase for Cancer Cell Invasion.
How the matrix metalloproteinase MMP14 contributes to the progression of colorectal cancer.
Human breast adenocarcinoma (MDA-231) and human lung squamous cell carcinoma (Hara) do not have the ability to cause bone resorption by themselves during the establishment of bone metastasis.
Hydrogen sulfide attenuates myocardial fibrosis in diabetic rats through the JAK/STAT signaling pathway.
Identification of cis-acting promoter elements that support expression of membrane-type 1 matrix metalloproteinase (MT1-MMP) in v-src transformed Madin-Darby canine kidney cells.
Identification of membrane type-1 matrix metalloproteinase as a target of hypoxia-inducible factor-2 alpha in von Hippel-Lindau renal cell carcinoma.
Identification of membrane-type 1 matrix metalloproteinase tyrosine phosphorylation in association with neuroblastoma progression.
Identification of Proteolytic Cleavage Sites of EphA2 by Membrane Type 1 Matrix Metalloproteinase on the Surface of Cancer Cells.
Identification of substrate sequences for membrane type-1 matrix metalloproteinase using bacteriophage peptide display library.
Identification of the membrane-type matrix metalloproteinase MT1-MMP in osteoclasts.
Immunogenicity moderation effect of interleukin-24 on myelogenous leukemia cells.
Immunohistochemical demonstration of EphA2 processing by MT1-MMP in invasive cutaneous squamous cell carcinoma.
Impaired tyrosine phosphorylation of membrane type 1-matrix metalloproteinase reduces tumor cell proliferation in three-dimensional matrices and abrogates tumor growth in mice.
In vitro efficacy of a sterically stabilized immunoliposomes targeted to membrane type 1 matrix metalloproteinase (MT1-MMP).
In vivo imaging of membrane type-1 matrix metalloproteinase with a novel activatable near-infrared fluorescence probe.
Increased Aggressiveness of Human Prostate PC-3 Tumor Cells Expressing Cell Surface Localized Membrane Type-1 Matrix Metalloproteinase (MT1-MMP).
Increased expression of membrane type 1 matrix metalloproteinase and matrix metalloproteinase-2 with tumor dedifferentiation in hepatocellular carcinomas.
Increased expression of MMP14 correlates with the poor prognosis of Chinese patients with gastric cancer.
Increased membrane type 1 matrix metalloproteinase expression from adenoma to colon cancer: a possible mechanism of neoplastic progression.
Increased serum level of membrane type 1-matrix metalloproteinase (MT1-MMP/MMP-14) in patients with breast cancer.
Influence of TGF-?1 on tumor transition in oral cancer cell and BMSC co-cultures.
Inhibition of matrix metalloproteinase-14 (MMP-14)-mediated cancer cell migration.
Inhibition of membrane type-1 matrix metalloproteinase by cancer drugs interferes with the homing of diabetogenic T cells into the pancreas.
Inhibition of membrane-type 1 matrix metalloproteinase at cell-matrix adhesions.
Inhibition of membrane-type 1 matrix metalloproteinase by hydroxamate inhibitors: an examination of the subsite pocket.
Inhibition of membrane-type 1 matrix metalloproteinase tyrosine phosphorylation blocks tumor progression in mice.
Inhibition of MMP14 potentiates the therapeutic effect of temozolomide and radiation in gliomas.
Inhibitory effect of green tea polyphenols on membrane-type 1 matrix metalloproteinase, MT1-MMP.
Insulin receptor substrate 1 regulates the cellular differentiation and the matrix metallopeptidase expression of preosteoblastic cells.
Integrated expression analysis identifies transcription networks in mouse and human gastric neoplasia.
Integrated functions of membrane-type 1 matrix metalloproteinase in regulating cancer malignancy: Beyond a proteinase.
Interference with the complement system by tumor cell membrane type-1 matrix metalloproteinase plays a significant role in promoting metastasis in mice.
Interleukin 10 blocks matrix metalloproteinase-2 and membrane type 1-matrix metalloproteinase synthesis in primary human prostate tumor lines.
Interleukin-6 increases matrix metalloproteinase-14 (MMP-14) levels via down-regulation of p53 to drive cancer progression.
Internal cleavages of the autoinhibitory prodomain are required for membrane type 1 matrix metalloproteinase activation, although furin cleavage alone generates inactive proteinase.
Involvement of syntaxin 4 in the transport of membrane-type 1 matrix metalloproteinase to the plasma membrane in human gastric epithelial cells.
Lack of Association between Membrane-Type 1 Matrix Metalloproteinase Expression and Clinically Relevant Molecular or Morphologic Tumor Characteristics at the Leading Edge of Invasive Colorectal Carcinoma.
Leptin-mediated regulation of MT1-MMP localization is KIF1B dependent and enhances gastric cancer cell invasion.
Limited processing of pro-matrix metalloprotease-2 (gelatinase A) overexpressed by transfection in PC-3 human prostate tumor cells: association with restricted cell surface localization of membrane-type matrix metalloproteinase-1.
Localization of membrane-type 1 matrix metalloproteinase in caveolae membrane domains.
Localized surface plasmon resonance based nanobiosensor for biomarker detection of invasive cancer cells.
Long non-coding RNA MALAT1 acts as a competing endogenous RNA to promote malignant melanoma growth and metastasis by sponging miR-22.
Looking at the proteases from a simple perspective.
Malignant Fibrous Histiocytoma, Aggressive Fibromatosis and Benign Fibrous Tumors Express mRNA for the Metalloproteinase Inducer EMMPRIN and the Metalloproteinases MMP-2 and MT1-MMP.
Many new down- and up-regulatory signaling pathways, from known cancer progression suppressors to matrix metalloproteinases, differ widely in cells of various cancers.
Matrix Metallopeptidase 14: A Candidate Prognostic Biomarker for Diffuse Large B-Cell Lymphoma.
Matrix metalloproteases in head and neck cancer.
Matrix Metalloproteinase 14 Overexpression Is Correlated with the Progression and Poor Prognosis of Nasopharyngeal Carcinoma.
Matrix Metalloproteinase 14 promotes lung cancer by cleavage of Heparin-Binding EGF-like Growth Factor.
Matrix metalloproteinase-14 (MMP-14) downregulation inhibits esophageal squamous cell carcinoma cell migration, invasion, and proliferation.
Matrix Metalloproteinase-14 (MT1-MMP)-Mediated Endoglin Shedding Inhibits Tumor Angiogenesis.
Matrix metalloproteinase-14 induces epithelial-to-mesenchymal transition in synovial sarcoma.
Matrix Metalloproteinase-14 Is a Negative Prognostic Marker for Patients with Gastric Cancer.
Matrix metalloproteinase-2 activation modulates glioma cell migration.
Matrix-metalloproteinases in head and neck carcinoma-cancer genome atlas analysis and fluorescence imaging in mice.
Mechanistic insights into targeting T cell membrane proteinase to promote islet beta-cell rejuvenation in type 1 diabetes.
Membrane type 1 matrix metalloproteinase (MT1-MMP/MMP-14) cleaves and releases a 22-kDa extracellular matrix metalloproteinase inducer (EMMPRIN) fragment from tumor cells.
Membrane type 1 matrix metalloproteinase detection in tumors, using the iodinated endogenous [123I]-tissue inhibitor 2 of metalloproteinases as imaging agent.
Membrane type 1 matrix metalloproteinase digests interstitial collagens and other extracellular matrix macromolecules.
Membrane Type 1 Matrix Metalloproteinase induces an epithelial to mesenchymal transition and cancer stem cell-like properties in SCC9 cells.
Membrane type 1 matrix metalloproteinase regulates anaplastic thyroid carcinoma cell growth and invasion into the collagen matrix.
Membrane type 1 matrix metalloproteinase regulates cellular invasiveness and survival in cutaneous epidermal cells.
Membrane type 1 matrix metalloproteinase-associated degradation of tissue inhibitor of metalloproteinase 2 in human tumor cell lines.
Membrane type 1-matrix metalloproteinase (MT1-MMP) and MMP-2 immunolocalization in human prostate: change in cellular localization associated with high-grade prostatic intraepithelial neoplasia.
Membrane type 1-matrix metalloproteinase cleaves off the NH2-terminal portion of heparin-binding epidermal growth factor and converts it into a heparin-independent growth factor.
Membrane type 1-matrix metalloproteinase induces epithelial-to-mesenchymal transition in esophageal squamous cell carcinoma: Observations from clinical and in vitro analyses.
Membrane type I matrix metalloproteinase usurps tumor growth control imposed by the three-dimensional extracellular matrix.
Membrane type-1 matrix metalloproteinase (MT1-MMP) exhibits an important intracellular cleavage function and causes chromosome instability.
Membrane type-1 matrix metalloproteinase and TIMP-2 in tumor angiogenesis.
Membrane type-1 matrix metalloproteinase confers aneuploidy and tumorigenicity on mammary epithelial cells.
Membrane Type-1 Matrix Metalloproteinase Expression in Acute Myeloid Leukemia and Its Upregulation by Tumor Necrosis Factor-?.
Membrane type-1 matrix metalloproteinase functions as a proprotein self-convertase. Expression of the latent zymogen in Pichia pastoris, autolytic activation, and the peptide sequence of the cleavage forms.
Membrane type-1 matrix metalloproteinase stimulates tumour cell-induced platelet aggregation: role of receptor glycoproteins.
Membrane-type 1 matrix metalloproteinase cleaves CD44 and promotes cell migration.
Membrane-type 1 matrix metalloproteinase cytoplasmic tail-binding protein-1 is a new member of the Cupin superfamily. A possible multifunctional protein acting as an invasion suppressor down-regulated in tumors.
Membrane-type 1 matrix metalloproteinase is regulated by sp1 through the differential activation of AKT, JNK, and ERK pathways in human prostate tumor cells.
Membrane-type 1 matrix metalloproteinase mRNA expression in colorectal cancer.
Membrane-type 1 matrix metalloproteinase regulates cell migration during zebrafish gastrulation: evidence for an interaction with non-canonical Wnt signaling.
Membrane-type 1 matrix metalloproteinase stimulates cell migration through epidermal growth factor receptor transactivation.
Membrane-type 1 matrix metalloproteinase: a key enzyme for tumor invasion.
Membrane-type matrix metalloproteinase-1 expression and activation of gelatinase A as prognostic markers in advanced pediatric neuroblastoma.
Membrane-type matrix metalloproteinases (MT-MMPs) in tumor metastasis.
Metalloproteinase binding proteins: WO2009097397.
Metastasis-suppressor NME1 controls the invasive switch of breast cancer by regulating MT1-MMP surface clearance.
Metastatic ability of MXT mouse mammary subpopulations correlates with clonal expression and/or membrane-association of gelatinase A.
MicroRNA-22 inhibits tumor growth and metastasis in gastric cancer by directly targeting MMP14 and Snail.
microRNA-26a Directly Targeting MMP14 and MMP16 Inhibits the Cancer Cell Proliferation, Migration and Invasion in Cutaneous Squamous Cell Carcinoma.
Miniaturized antibodies for imaging membrane type-1 matrix metalloproteinase in cancers.
Minocycline reduces glioma expansion and invasion by attenuating microglial MT1-MMP expression.
miR-150-5p and miR-133a suppress glioma cell proliferation and migration through targeting membrane-type-1 matrix metalloproteinase.
miR-181a-5p Inhibits Cancer Cell Migration and Angiogenesis via Downregulation of Matrix Metalloproteinase-14.
miR-34a inhibits migration and invasion of tongue squamous cell carcinoma via targeting MMP9 and MMP14.
miRNA-584-5p exerts tumor suppressive functions in human neuroblastoma through repressing transcription of matrix metalloproteinase 14.
miRNA-mRNA network detects hub mRNAs and cancer specific miRNAs in lung cancer.
MMP and TIMP gene expression in head and neck squamous cell carcinomas and adjacent tissues.
MMP-14 and TGF?-1 methylation in pituitary adenomas.
MMP-14 overexpression correlates with poor prognosis in non-small cell lung cancer.
MMP-14 Triggered Fluorescence Contrast Agent.
MMP14 as a novel downstream target of VEGFR2 in migratory glioma-tropic neural stem cells.
MMP14 empowers tumor-initiating breast cancer cells under hypoxic nutrient-depleted conditions.
MMP14 in Sarcoma: A Regulator of Tumor Microenvironment Communication in Connective Tissues.
MMP14 predicts a poor prognosis in patients with colorectal cancer.
MMP14 regulates cell migration and invasion through epithelial-mesenchymal transition in nasopharyngeal carcinoma.
Modulation of the membrane type 1 matrix metalloproteinase cytoplasmic tail enhances tumor cell invasion and proliferation in three-dimensional collagen matrices.
Molecular and functional extracellular vesicle analysis using nanopatterned microchips monitors tumor progression and metastasis.
Molecular recognition of proteolytic activity in metastatic cancer cells using fluorogenic gold nanoprobes.
Monocytic MDSC mobilization promotes tumor recurrence after liver transplantation via CXCL10/TLR4/MMP14 signaling.
MT-MMP, the cell surface activator of proMMP-2 (pro-gelatinase A), is expressed with its substrate in mouse tissue during embryogenesis.
MT1-MMP Activation of TGF-? Signaling Enables Intercellular Activation of an Epithelial-mesenchymal Transition Program in Cancer.
MT1-MMP Binds Membranes by Opposite Tips of Its ? Propeller to Position It for Pericellular Proteolysis.
MT1-MMP is required for efficient tumor dissemination in experimental metastatic disease.
MT1-MMP is the critical determinant of matrix degradation and invasion by ovarian cancer cells.
MT1-MMP promotes cell growth and ERK activation through c-Src and paxillin in three-dimensional collagen matrix.
MT1-MMP recognition by ERM proteins and its implication in CD44 shedding.
MT1-MMP regulates urothelial cell invasion via transcriptional regulation of Dickkopf-3.
MT1-MMP silencing by an shRNA-armed glioma-targeted conditionally replicative adenovirus (CRAd) improves its anti-glioma efficacy in vitro and in vivo.
MT1-MMP: Endosomal delivery drives breast cancer metastasis.
N-Acetylglucosaminyltransferase V triggers overexpression of MT1-MMP and reinforces the invasive/metastatic potential of cancer cells.
NEDD9 depletion leads to MMP14 inactivation by TIMP2 and prevents invasion and metastasis.
NEDD9/Arf6-dependent endocytic trafficking of matrix metalloproteinase 14: a novel mechanism for blocking mesenchymal cell invasion and metastasis of breast cancer.
Neoplastic Cells are the Major Source of MT-MMPs in IDH1-Mutant Glioma, Thus Enhancing Tumor-Cell Intrinsic Brain Infiltration.
NIK regulates MT1-MMP activity and promotes glioma cell invasion independently of the canonical NF-?B pathway.
Non-destructive and selective imaging of the functionally active, pro-invasive membrane type-1 matrix metalloproteinase (MT1-MMP) enzyme in cancer cells.
Noninvasive Bioluminescence Imaging of Matrix Metalloproteinase-14 Activity in Lung Cancer Using a Membrane-Bound Biosensor.
Novel MT1-MMP small molecule inhibitors based on insights into hemopexin domain function in tumor growth.
On the move: endocytic trafficking in cell migration.
Organelle Specific O-Glycosylation Drives MMP14 Activation, Tumor Growth, and Metastasis.
Orthotopic non-metastatic and metastatic oral cancer mouse models.
Osteopontin induces nuclear factor kappa B-mediated promatrix metalloproteinase-2 activation through I kappa B alpha /IKK signaling pathways, and curcumin (diferulolylmethane) down-regulates these pathways.
Osteopontin stimulates tumor growth and activation of promatrix metalloproteinase-2 through nuclear factor-kappa B-mediated induction of membrane type 1 matrix metalloproteinase in murine melanoma cells.
Overexpression of membrane-type matrix metalloproteinase-1 gene induces mammary gland abnormalities and adenocarcinoma in transgenic mice.
Overexpression of MMP14 predicts the poor prognosis in gastric cancer: Meta-analysis and database validation.
Overexpression of tissue inhibitor of matrix metalloproteinases-1 (TIMP-1) in metastatic MDCK cells transformed by v-src.
OXIDATIVE STRESS AND PROSTATE CANCER PROGRESSION ARE ELICITED BY MEMBRANE-TYPE 1 MATRIX METALLOPROTEINASE (MT1-MMP).
p63 drives invasion in keratinocytes expressing HPV16 E6/E7 genes through regulation of Src-FAK signalling.
Periprostatic Adipose Tissue Favors Prostate Cancer Cell Invasion in an Obesity-Dependent Manner: Role of Oxidative Stress.
Phosphorylation of membrane type 1-matrix metalloproteinase (MT1-MMP) and its vesicle-associated membrane protein 7 (VAMP7)-dependent trafficking facilitate cell invasion and migration.
Polarized MT1-MMP-CD44 interaction and CD44 cleavage during cell retraction reveal an essential role for MT1-MMP in CD44-mediated invasion.
Potent mechanism-based inhibitors for matrix metalloproteinases.
Potentially Novel Candidate Biomarkers for Head and Neck Squamous Cell Carcinoma Identified Using an Integrated Cell Line-based Discovery Strategy.
Predictive value of laminin-5 and membrane type 1-matrix metalloproteinase expression for cervical lymph node metastasis in T1 and T2 squamous cell carcinomas of the tongue and floor of the mouth.
Pressure and Temperature Effects on the Activity and Structure of the Catalytic Domain of Human MT1-MMP.
Prinomastat, a hydroxamate inhibitor of matrix metalloproteinases, has a complex effect on migration of breast carcinoma cells.
Prognostic Significance of Matrix Metalloproteinase 14 in Patients with Cancer: a Systematic Review and Meta-Analysis.
Prognostic targets recognition of rectal adenocarcinoma based on transcriptomics.
Prognostic value of tumor microinvasion and metalloproteinases expression in intracranial pediatric ependymomas.
Prointegrin maturation follows rapid trafficking and processing of MT1-MMP in Furin-Negative Colon Carcinoma LoVo Cells.
Prostate Cancer-Associated Membrane Type 1-Matrix Metalloproteinase. A Pivotal Role in Bone Response and Intraosseous Tumor Growth.
Prostate cancer-associated membrane type 1-matrix metalloproteinase: a pivotal role in bone response and intraosseous tumor growth.
Protein Tyrosine Phosphatase 4A3 (PTP4A3) Promotes Human Uveal Melanoma Aggressiveness Through Membrane Accumulation of Matrix Metalloproteinase 14 (MMP14).
Protein-tyrosine Pseudokinase 7 (PTK7) Directs Cancer Cell Motility and Metastasis.
Proteolysis of the membrane type-1 matrix metalloproteinase prodomain: implications for a two-step proteolytic processing and activation.
Proteolysis-driven oncogenesis.
Proteolytic activation of heparin-binding EGF-like growth factor by membrane-type matrix metalloproteinase-1 in ovarian carcinoma cells.
Proteolytic and non-proteolytic roles of membrane type-1 matrix metalloproteinase in malignancy.
PROX1 is a transcriptional regulator of MMP14.
Quantitative Analysis of Multiple Proteins of Different Invasive Tumor Cell Lines at the Same Single-Cell Level.
RABGTPases in MT1-MMP trafficking and cell invasion: Physiology versus pathology.
Radioimmunodetection of membrane type-1 matrix metalloproteinase relevant to tumor malignancy with a pre-targeting method.
Radioiodinated Peptidic Imaging Probes for in Vivo Detection of Membrane Type-1 Matrix Metalloproteinase in Cancers.
Rapid trafficking of membrane type 1-matrix metalloproteinase to the cell surface regulates progelatinase a activation.
Rapid Unperturbed-Tissue Analysis for Intraoperative Cancer Diagnosis Using an Enzyme-Activated NIR-II Nanoprobe.
Re-expression of miR-200 by novel approaches regulates the expression of PTEN and MT1-MMP in pancreatic cancer.
Recent advances in cytogenetics and molecular biology of adult hepatocellular tumors: implications for imaging and management.
Reducing proteolytic liability of a MMP-14 inhibitory antibody by site-saturation mutagenesis.
Reduction in tumour cell invasion by pigment epithelium-derived factor is mediated by membrane type-1 matrix metalloproteinase downregulation.
Regulation of MT1-MMP and MMP-2 by the serpin PEDF: a promising new target for metastatic cancer.
Relation of enhanced secretion of active matrix metalloproteinases with tumor spread in human hepatocellular carcinoma.
Relation of MT1-MMP gene expression to outcomes in colorectal cancer.
Remodeling of collagen matrix by human tumor cells requires activation and cell surface association of matrix metalloproteinase-2.
Rho-ROCK-myosin signaling mediates membrane type 1 matrix metalloproteinase-induced cellular aggregation of keratinocytes.
Role of COX-2 in epithelial-stromal cell interactions and progression of ductal carcinoma in situ of the breast.
Role of DHX33 in c-Myc-induced cancers.
Role of pericellular proteolysis by membrane-type 1 matrix metalloproteinase in cancer invasion and angiogenesis.
Role of PKC-? in NF-?B-MT1-MMP-mediated activation of proMMP-2 by TNF-? in pulmonary artery smooth muscle cells.
Role of the matrix metalloproteinase and tissue inhibitors of metalloproteinase families in noninvasive and invasive tumors transplanted in mice with severe combined immunodeficiency.
Role of tissue inhibitor of metalloproteinases-2 (TIMP-2) in regulation of pro-gelatinase A activation catalyzed by membrane-type matrix metalloproteinase-1 (MT1-MMP) in human cancer cells.
Roles of membrane type 1 matrix metalloproteinase and tissue inhibitor of metalloproteinases 2 in invasion and dissemination of human malignant glioma.
Roles of membrane-type matrix metalloproteinase-1 in tumor invasion and metastasis.
Roles of pericellular proteolysis by membrane type-1 matrix metalloproteinase in cancer invasion and angiogenesis.
Screening, Identification, and Characterization of an Affinity Peptide Specific to MT1-MMP and Its Application in Tumor Imaging.
Selective inhibition of matrix metalloproteinase-14 blocks tumor growth, invasion, and angiogenesis.
Selective Inhibition of Membrane Type 1 Matrix Metalloproteinase Abrogates Progression of Experimental Inflammatory Arthritis: Synergy With Tumor Necrosis Factor Blockade.
Sequence-specific silencing of MT1-MMP expression suppresses tumor cell migration and invasion: importance of MT1-MMP as a therapeutic target for invasive tumors.
Significance of caveolin-1 and matrix metalloproteinase 14 gene expression in canine mammary tumours.
Significant correlation of monocyte chemoattractant protein-1 expression with neovascularization and progression of breast carcinoma.
Simultaneous visualization of protumorigenic Src and MT1-MMP activities with fluorescence resonance energy transfer.
Single-nucleotide polymorphisms and haplotypes of membrane type 1-matrix metalloproteinase in susceptibility and clinical significance of squamous cell neoplasia of uterine cervix in taiwan women.
SNAP23, Syntaxin4, and vesicle-associated membrane protein 7 (VAMP7) mediate trafficking of membrane type 1-matrix metalloproteinase (MT1-MMP) during invadopodium formation and tumor cell invasion.
Specific detection of soluble EphA2 fragments in blood as a new biomarker for pancreatic cancer.
Src-dependent phosphorylation of membrane type I matrix metalloproteinase on cytoplasmic tyrosine 573: role in endothelial and tumor cell migration.
Stroma-derived matrix metalloproteinase (MMP)-2 promotes membrane type 1-MMP-dependent tumor growth in mice.
Strong significant correlation between MMP-9 and systemic symptoms in patients with localized renal cell carcinoma.
Suppression of membrane-type 1 matrix metalloproteinase (MMP)-mediated MMP-2 activation and tumor invasion by testican 3 and its splicing variant gene product, N-Tes.
Targeting MT1-MMP as an ImmunoPET-Based Strategy for Imaging Gliomas.
Targeting the MMP-14/MMP-2/integrin ?v?3 axis with multispecific N-TIMP2-based antagonists for cancer therapy.
Tetra- and hexavalent mannosides inhibit the pro-apoptotic, antiproliferative and cell surface clustering effects of concanavalin-A: impact on MT1-MMP functions in marrow-derived mesenchymal stromal cells.
Tetraspanin proteins regulate membrane type-1 matrix metalloproteinase-dependent pericellular proteolysis.
TGF-?1 facilitates MT1-MMP-mediated proMMP-9 activation and invasion in oral squamous cell carcinoma cells.
The clinicopathological and prognostic significance of membrane type 1 matrix metalloproteinase (MT1-MMP) and MMP-9 according to their localization in invasive breast carcinoma.
The Effects of miR-195-5p/MMP14 on Proliferation and Invasion of Cervical Carcinoma Cells Through TNF Signaling Pathway Based on Bioinformatics Analysis of Microarray Profiling.
The emerging role of MMP14 in brain tumorigenesis and future therapeutics.
The Expanding Role of MT1-MMP in Cancer Progression.
The hemopexin domain of membrane-type matrix metalloproteinase-1 (MT1-MMP) Is not required for its activation of proMMP2 on cell surface but is essential for MT1-MMP-mediated invasion in three-dimensional type I collagen.
The hemopexin-like C-terminal domain of membrane type 1 matrix metalloproteinase regulates proteolysis of a multifunctional protein, gC1qR.
The hepatitis B virus X protein promotes tumor cell invasion by inducing membrane-type matrix metalloproteinase-1 and cyclooxygenase-2 expression.
The membrane type matrix metalloproteinase MMP14 mediates constitutive shedding of MHC class I chain-related molecule A independent of A disintegrin and metalloproteinases.
The overexpression membrane type 1 matrix metalloproteinase is associated with the progression and prognosis in breast cancer.
The Precise Diagnosis of Cancer Invasion/Metastasis via 2D Laser Ablation Mass Mapping of Metalloproteinase in Primary Cancer Tissue.
The role of matrix metalloproteinase in the intimal sarcoma-like cells derived from endarterectomized tissues from a chronic thromboembolic pulmonary hypertension patient.
The Wnt/planar cell polarity (PCP) protein tyrosine kinase-7 (PTK7) is a highly efficient proteolytic target of membrane type-1 matrix metalloproteinase (MT1-MMP): implications in cancer and embryogenesis.
Tip60 regulates MT1-MMP transcription and invasion of glioblastoma cells through NF-?B pathway.
Tissue inhibitor of metalloproteinase (TIMP)-2 acts synergistically with synthetic matrix metalloproteinase (MMP) inhibitors but not with TIMP-4 to enhance the (Membrane type 1)-MMP-dependent activation of pro-MMP-2.
Transcriptional cooperation between the transforming growth factor-beta and Wnt pathways in mammary and intestinal tumorigenesis.
Transforming growth factor-beta induces CD44 cleavage that promotes migration of MDA-MB-435s cells through the up-regulation of membrane type 1-matrix metalloproteinase.
Translocating a High-Affinity Designer TIMP-1 to the Cell Membrane for Total Renal Carcinoma Inhibition: Putting the Prion Protein to Good Use.
Transmembrane/cytoplasmic, rather than catalytic, domains of Mmp14 signal to MAPK activation and mammary branching morphogenesis via binding to integrin ?1.
Tumor cell invasion of von Hippel Lindau renal cell carcinoma cells is mediated by membrane type-1 matrix metalloproteinase.
Tumor cell invasion through matrigel is regulated by activated matrix metalloproteinase-2.
Tumor necrosis factor-alpha neutralization reduced cerebral edema through inhibition of matrix metalloproteinase production after transient focal cerebral ischemia.
Tumor necrosis factor-alpha-stimulated membrane type 1-matrix metalloproteinase production is modulated by epidermal growth factor receptor signaling in human gingival fibroblasts.
Tumor targeting of doxorubicin by anti-MT1-MMP antibody-modified PEG liposomes.
Tumor-Targeted Prodrug ICT2588 Demonstrates Therapeutic Activity against Solid Tumors and Reduced Potential for Cardiovascular Toxicity.
Two-step sandwich enzyme immunoassay using monoclonal antibodies for detection of soluble and membrane-associated human membrane type 1-matrix metalloproteinase.
Up-regulation of angiopoietin-2, matrix metalloprotease-2, membrane type 1 metalloprotease, and laminin 5 gamma 2 correlates with the invasiveness of human glioma.
Up-regulation of vascular endothelial growth factor-A by active membrane-type 1 matrix metalloproteinase through activation of Src-tyrosine kinases.
Upregulation of cyclin-dependent kinase 7 and matrix metalloproteinase-14 expression contribute to metastatic properties of gastric cancer.
Visualization of polarized membrane type 1 matrix metalloproteinase activity in live cells by fluorescence resonance energy transfer imaging.
Whole transcriptome analysis identifies differentially regulated networks between osteosarcoma and normal bone samples.
[Expression of membrane-type I matrix metalloproteinase and its correlation with gelatinase A activation in cancer cell lines]
[Expression of membrane-type matrix metalloproteinase (MT-MMP) and activation of MMP-2 in lung cancer]
[Gene expression of matrix mettallo-proteinase 14 in laryngeal squamous cell carcinoma]
[Inhibitory effect of MT1-MMP antisense nucleotide on invasion of human highly metastatic ovarian cancer cell line SW626.]
[Membrane type 1 matrix metalloproteinase (MT1-MMP) and the regulators of its activity as invasive factors in squamous cell cervical carcinomas.]
[Virtual screening and molecular simulations of antisense peptides targeting MT1-MMP].
Nephrosclerosis
Endothelial sirtuin 1 deficiency perpetrates nephrosclerosis through downregulation of matrix metalloproteinase-14: relevance to fibrosis of vascular senescence.
Neuralgia
Reciprocal relationship between membrane type 1 matrix metalloproteinase and the algesic peptides of myelin basic protein contributes to chronic neuropathic pain.
Neuroblastoma
Expression of the reversion-inducing cysteine-rich protein with Kazal motifs and matrix metalloproteinase-14 in neuroblastoma and the role in tumour metastasis.
Hepatocyte nuclear factor 4 alpha promotes the invasion, metastasis and angiogenesis of neuroblastoma cells via targeting matrix metalloproteinase 14.
Identification of membrane-type 1 matrix metalloproteinase tyrosine phosphorylation in association with neuroblastoma progression.
Matrix metalloproteinase 14 regulates HSV-1 infection in neuroblastoma cells.
Membrane-type matrix metalloproteinase-1 expression and activation of gelatinase A as prognostic markers in advanced pediatric neuroblastoma.
microRNA-9 targets matrix metalloproteinase 14 to inhibit invasion, metastasis, and angiogenesis of neuroblastoma cells.
miRNA-337-3p suppresses neuroblastoma progression by repressing the transcription of matrix metalloproteinase 14.
miRNA-584-5p exerts tumor suppressive functions in human neuroblastoma through repressing transcription of matrix metalloproteinase 14.
Primary renal neuroblastoma with metastasis and matrix metalloproteinase-14 expression.
Rapid Unperturbed-Tissue Analysis for Intraoperative Cancer Diagnosis Using an Enzyme-Activated NIR-II Nanoprobe.
Vandetanib-induced inhibition of neuroblastoma cell migration and invasion is associated with downregulation of the SDF-1/CXCR4 axis and matrix metalloproteinase 14.
Neuroinflammatory Diseases
Diverse roles of matrix metalloproteinases and tissue inhibitors of metalloproteinases in neuroinflammation and cerebral ischemia.
Nevus
Loss of dipeptidyl peptidase IV immunostaining discriminates malignant melanomas from deep penetrating nevi.
Newcastle Disease
Matrix metalloproteinase-14 regulates collagen degradation and migration of mononuclear cells during infection with genotype VII Newcastle disease virus.
Obesity
A case of 14q11.2 microdeletion with autistic features, severe obesity and facial dysmorphisms suggestive of Wolf-Hirschhorn syndrome.
Genetic link between obesity and MMP14-dependent adipogenic collagen turnover.
Obesity-induced remodeling of the adipose tissue elastin network is independent of the metalloelastase MMP-12.
The critical role of MMP14 in adipose tissue remodeling during obesity.
Obesity, Maternal
Matrix metalloproteinase 15 plays a pivotal role in human first trimester cytotrophoblast invasion and is not altered by maternal obesity.
Osteolysis
Characterization of Normal Murine Carpal Bone Development Prompts Re-Evaluation of Pathologic Osteolysis as the Cause of Human Carpal-Tarsal Osteolysis Disorders.
Peripheral osteolysis in adults linked to ASAH1 (acid ceramidase) mutations: A new presentation of Farber disease.
Osteoporosis
[Association of MMP14 gene polymorphisms and osteoporosis in Zhuang men from Baise region of Guangxi].
[Progranulin aggravates postmenopausal osteoporosis in ovariectomized mice].
Osteosarcoma
Co-localisation of intra-nuclear membrane type-1 matrix metalloproteinase and hypoxia inducible factor-2? in osteosarcoma and prostate carcinoma cells.
Increased expression of membrane-type matrix metalloproteinase-1 is correlated with poor prognosis in patients with osteosarcoma.
Inhibition of matrix metalloproteinase-14 in osteosarcoma cells by clodronate.
Ovarian Neoplasms
Aberrant activation of hedgehog signaling pathway in ovarian cancers: effect on prognosis, cell invasion and differentiation.
Expression of various matrix proteases and Ets family transcriptional factors in ovarian cancer cell lines: correlation to invasive potential.
Functional role of matrix metalloproteinases in ovarian tumor cell plasticity.
Lysophosphatidic acid promotes matrix metalloproteinase (MMP) activation and MMP-dependent invasion in ovarian cancer cells.
Membrane-type I matrix metalloproteinase-dependent ectodomain shedding of mucin16/ CA-125 on ovarian cancer cells modulates adhesion and invasion of peritoneal mesothelium.
New bifunctional metalloproteinase inhibitors: an integrated approach towards biological improvements and cancer therapy.
Ovarian cancer cell detachment and multicellular aggregate formation are regulated by membrane type 1 matrix metalloproteinase: a potential role in I.p. metastatic dissemination.
Overexpression of proto-oncogene FBI-1 activates membrane type 1-matrix metalloproteinase in association with adverse outcome in ovarian cancers.
Post-translational modification of the membrane type 1 matrix metalloproteinase (MT1-MMP) cytoplasmic tail impacts ovarian cancer multicellular aggregate dynamics.
Visual and automated assessment of matrix metalloproteinase-14 tissue expression for the evaluation of ovarian cancer prognosis.
Pancreatic Neoplasms
Bioinformatics Analysis of a Prognostic miRNA Signature and Potential Key Genes in Pancreatic Cancer.
Collagen regulation of let-7 in pancreatic cancer involves TGF-?1-mediated membrane type 1-matrix metalloproteinase expression.
High expression of MMP14 is associated with progression and poor short-term prognosis in muscle-invasive bladder cancer.
Identification of genomic alterations and associated transcriptomic profiling reveal the prognostic significance of MMP14 and PKM2 in patients with pancreatic cancer.
Interplay between ?1-Integrin and Rho Signaling Regulates Differential Scattering and Motility of Pancreatic Cancer Cells by Snail and Slug Proteins.
Pancreatic Cancer Cells Respond to Type I Collagen by Inducing Snail Expression to Promote Membrane Type 1 Matrix Metalloproteinase-dependent Collagen Invasion.
The non-receptor tyrosine kinase c-Src mediates the PDGF-induced association between Furin and pro-MT1-MMP in HPAC pancreatic cells.
Pancreatitis
Long-term overexpression of membrane type-1 matrix metalloproteinase and matrix metalloproteinase-2 in oleic acid-induced pancreatitis in rats.
Papilloma
Matrix-metalloproteinases in head and neck carcinoma-cancer genome atlas analysis and fluorescence imaging in mice.
Periodontal Diseases
Sequential IL-23 and IL-17 and increased Mmp8 and Mmp14 expression characterize the progression of an experimental model of periodontal disease in type 1 diabetes.
Periodontitis
A Systems Biology Approach to Reveal Putative Host-Derived Biomarkers of Periodontitis by Network Topology Characterization of MMP-REDOX/NO and Apoptosis Integrated Pathways.
Involvement of MT1-MMP and TIMP-2 in human periodontal disease.
[The significance of the expression of matrix metalloproteinases in the differential diagnosis of periodontal diseases].
Peripheral Arterial Disease
Number of endothelial progenitor cells in peripheral artery disease as a marker of severity and association with pentraxin-3, malondialdehyde-modified low-density lipoprotein and membrane type-1 matrix metalloproteinase.
Peripheral Nerve Injuries
Matrix Metalloproteinase-14 Both Sheds Cell Surface Neuronal Glial Antigen 2 (NG2) Proteoglycan on Macrophages and Governs the Response to Peripheral Nerve Injury.
Phyllodes Tumor
Stromal matrix metalloproteinase-14 expression correlates with the grade and biological behavior of mammary phyllodes tumors.
Pituitary Neoplasms
Expression of MMP14 in invasive pituitary adenomas: relationship to invasion and angiogenesis.
High levels of matrix metalloproteinases regulate proliferation and hormone secretion in pituitary cells.
Placenta Accreta
Extravillous trophoblast invasion in placenta accreta is associated with differential local expression of angiogenic and growth factors: a cross sectional study.
Pre-Eclampsia
Analyses of soluble endoglin and matrix metalloproteinase 14 using enzyme-linked immunosorbent assay in the diagnosis and assessment of severity of early- and late-onset pre-eclampsia
LIFR increases the release of soluble endoglin via the upregulation of MMP14 expression in preeclampsia.
Peptides do not prevent cleavage of endoglin to produce soluble endoglin.
Pregnancy, Ectopic
Co-ordinated expression of MMP-2 and its putative activator, MT1-MMP, in human placentation.
Prostatic Intraepithelial Neoplasia
Membrane type 1-matrix metalloproteinase (MT1-MMP) and MMP-2 immunolocalization in human prostate: change in cellular localization associated with high-grade prostatic intraepithelial neoplasia.
Prostatic Neoplasms
Expression of membrane-type 1 matrix metalloproteinase (MT1-MMP) on prostate cancer cell lines.
LIM kinase1 modulates function of membrane type matrix metalloproteinase 1: implication in invasion of prostate cancer cells.
Membrane type 1 matrix metalloprotease cleaves laminin-10 and promotes prostate cancer cell migration.
Membrane type 1 matrix metalloproteinase induces epithelial-to-mesenchymal transition in prostate cancer.
Membrane type 1-matrix metalloproteinase (MT1-MMP) and MMP-2 immunolocalization in human prostate: change in cellular localization associated with high-grade prostatic intraepithelial neoplasia.
Membrane type 1-matrix metalloproteinase promotes human prostate cancer invasion and metastasis.
Membrane-type 1 matrix metalloproteinase is regulated by sp1 through the differential activation of AKT, JNK, and ERK pathways in human prostate tumor cells.
Membrane-type-1 matrix metalloproteinase, matrix metalloproteinase 2, and tissue inhibitor of matrix proteinase 2 in prostate cancer: identification of patients with poor prognosis by immunohistochemistry.
OXIDATIVE STRESS AND PROSTATE CANCER PROGRESSION ARE ELICITED BY MEMBRANE-TYPE 1 MATRIX METALLOPROTEINASE (MT1-MMP).
Periprostatic Adipose Tissue Favors Prostate Cancer Cell Invasion in an Obesity-Dependent Manner: Role of Oxidative Stress.
Posttranslational regulation of membrane type 1-matrix metalloproteinase (MT1-MMP) in mouse PTEN null prostate cancer cells: Enhanced surface expression and differential O-glycosylation of MT1-MMP.
The new synthetic matrix metalloproteinase inhibitor (Roche 28-2653) reduces tumor growth and prolongs survival in a prostate cancer standard rat model.
protein acetyllysine n-acetyltransferase deficiency
Endothelial sirtuin 1 deficiency perpetrates nephrosclerosis through downregulation of matrix metalloproteinase-14: relevance to fibrosis of vascular senescence.
Pulmonary Disease, Chronic Obstructive
Matrix Metalloproteinase (MMP) 14 Mediates a Phenotypic Shift in the Airways to Increase Mucin Production.
MMP14 gene polymorphisms in chronic obstructive pulmonary disease.
Pulmonary Emphysema
Matrix metalloproteinase-mediated extracellular matrix protein degradation in human pulmonary emphysema.
Pulmonary Fibrosis
Role of MMP-2 in alveolar epithelial cell repair after bleomycin administration in rabbits.
[mRNA expression of matrix metalloproteinase-2 and membrane type matrix metalloproteinase in pulmonary fibroblasts and macrophages of rat pulmonary fibrosis model]
Retinoblastoma
Loss of dipeptidyl peptidase IV immunostaining discriminates malignant melanomas from deep penetrating nevi.
Rhabdomyosarcoma
Patched haploinsufficient mouse rhabdomyosarcoma overexpress secreted phosphoprotein 1 and matrix metalloproteinases.
Sarcoma
MMP14 in Sarcoma: A Regulator of Tumor Microenvironment Communication in Connective Tissues.
Sarcoma, Synovial
Matrix metalloproteinase-14 induces epithelial-to-mesenchymal transition in synovial sarcoma.
Sepsis
Identification of specific Tie2 cleavage sites and therapeutic modulation in experimental sepsis.
Severe Combined Immunodeficiency
Role of the matrix metalloproteinase and tissue inhibitors of metalloproteinase families in noninvasive and invasive tumors transplanted in mice with severe combined immunodeficiency.
Sleep Apnea, Obstructive
Increased Neuronal Depolarization Evoked by Autoantibodies in Diabetic Obstructive Sleep Apnea: Role for Inflammatory Protease(s) in Generation of Neurotoxic Immunoglobulin Fragment.
Squamous Cell Carcinoma of Head and Neck
Clinical significance of expression of membrane type 1 matrix metalloproteinase and matrix metalloproteinase-2 in human head and neck squamous cell carcinoma.
Discretionary Transduction of MMP-Sensitized Tousled in Head and Neck Cancer.
Enhanced production and activation of progelatinase A mediated by membrane-type 1 matrix metalloproteinase in human oral squamous cell carcinomas: implications for lymph node metastasis.
Granulocyte-macrophage colony-stimulating factor upregulates matrix metalloproteinase-2 (MMP-2) and membrane type-1 MMP (MT1-MMP) in human head and neck cancer cells.
Influence of TGF-?1 on tumor transition in oral cancer cell and BMSC co-cultures.
Influence of tumour necrosis factor alpha on epithelial-mesenchymal transition of oral cancer cells in co-culture with mesenchymal stromal cells.
Matrix metalloproteases in head and neck cancer.
MMP and TIMP gene expression in head and neck squamous cell carcinomas and adjacent tissues.
MMPs, TIMP-2, and TGF-beta1 in the cancerization of oral lichen planus.
Potentially Novel Candidate Biomarkers for Head and Neck Squamous Cell Carcinoma Identified Using an Integrated Cell Line-based Discovery Strategy.
Role of membrane type 1-matrix metalloproteinase and gelatinase A in head and neck squamous cell carcinoma invasion in vitro.
Stomach Neoplasms
Decreased MT1-MMP in gastric cancer suppressed cell migration and invasion via regulating MMPs and EMT.
Expression of tissue levels of matrix metalloproteinases and tissue inhibitors of metalloproteinases in gastric adenocarcinoma.
High serum MMP-14 predicts worse survival in gastric cancer.
High tissue MMP14 expression predicts worse survival in gastric cancer, particularly with a low PROX1.
IGFBP3, a transcriptional target of homeobox D10, is correlated with the prognosis of gastric cancer.
Increased expression of MMP14 correlates with the poor prognosis of Chinese patients with gastric cancer.
KIF1B promotes glioma migration and invasion via cell surface localization of MT1-MMP.
Matrix Metalloproteinase-14 Is a Negative Prognostic Marker for Patients with Gastric Cancer.
Membrane-type 1 matrix metalloproteinase enhances lymph node metastasis of gastric cancer.
Methyl jasmonate abolishes the migration, invasion and angiogenesis of gastric cancer cells through down-regulation of matrix metalloproteinase 14.
MicroRNA-22 inhibits tumor growth and metastasis in gastric cancer by directly targeting MMP14 and Snail.
miRNA-337-3p inhibits gastric cancer progression through repressing myeloid zinc finger 1-facilitated expression of matrix metalloproteinase 14.
miRNA-584-3p inhibits gastric cancer progression by repressing Yin Yang 1- facilitated MMP-14 expression.
Overexpression of MMP14 predicts the poor prognosis in gastric cancer: Meta-analysis and database validation.
Serum Membrane Type 1-Matrix Metalloproteinase (MT1-MMP) mRNA Protected by Exosomes as a Potential Biomarker for Gastric Cancer.
Upregulation of cyclin-dependent kinase 7 and matrix metalloproteinase-14 expression contribute to metastatic properties of gastric cancer.
Stroke
Selective MMP-inhibition with Ro 28-2653 in acute experimental stroke - a magnetic resonance imaging efficacy study.
Tumor necrosis factor-alpha neutralization reduced cerebral edema through inhibition of matrix metalloproteinase production after transient focal cerebral ischemia.
Tetanus
VAMP3, syntaxin-13 and SNAP23 are involved in secretion of matrix metalloproteinases, degradation of the extracellular matrix and cell invasion.
Thrombosis
Looking at the proteases from a simple perspective.
Thymoma
Effect of common B-RAF and N-RAS mutations on global gene expression in melanoma cell lines.
Thyroid Cancer, Papillary
Enhanced production and activation of progelatinase A mediated by membrane-type 1 matrix metalloproteinase in human papillary thyroid carcinomas.
Thyroid Carcinoma, Anaplastic
Membrane type 1 matrix metalloproteinase regulates anaplastic thyroid carcinoma cell growth and invasion into the collagen matrix.
Thyroid Neoplasms
Expression of membrane type 1 matrix metalloproteinase in medullary thyroid carcinoma: Prognostic implications.
mRNA levels of membrane-type 1 matrix metalloproteinase (MT1-MMP), MMP-2, and MMP-9 and of their inhibitors TIMP-2 and TIMP-3 in normal thyrocytes and thyroid carcinoma cell lines.
Triple Negative Breast Neoplasms
Receptor-type protein tyrosine phosphatase alpha (PTP?) mediates MMP14 localization and facilitates triple-negative breast cancer cell invasion.
Tuberculosis
Membrane Type 1 Matrix Metalloproteinase Regulates Monocyte Migration and Collagen Destruction in Tuberculosis.
Urinary Bladder Neoplasms
Clinical significance and prognostic value of S100A4 and matrix metalloproteinase-14 in patients with organ-confined bladder cancer.
High expression of MMP14 is associated with progression and poor short-term prognosis in muscle-invasive bladder cancer.
Uterine Cervical Neoplasms
DNMT1 recruited by EZH2-mediated silencing of miR-484 contributes to the malignancy of cervical cancer cells through MMP14 and HNF1A.
Membrane-associated MMP-2 in human cervical cancer.
Vascular Diseases
Matrix metalloproteinases and their inhibitors in vascular remodeling and vascular disease.
Vascular System Injuries
Transcription factor KLF6 upregulates expression of metalloprotease MMP14 and subsequent release of soluble endoglin during vascular injury.
Venous Thrombosis
Differential transcriptional activation of matrix metalloproteinase-2 and membrane type-1 matrix metalloproteinase by experimental deep venous thrombosis and thrombin.
Virus Diseases
Interaction between hepatic membrane type 1 matrix metalloproteinase and acireductone dioxygenase 1 regulates hepatitis C virus infection.
Whooping Cough
Heterotrimeric G Proteins Directly Regulate MMP14/Membrane Type-1 Matrix Metalloprotease: A Novel Mechanism for GPCR-EGFR Transactivation.
Wiskott-Aldrich Syndrome
The 'ins' and 'outs' of podosomes and invadopodia: characteristics, formation and function.