3.4.24.80: membrane-type matrix metalloproteinase-1
This is an abbreviated version!
For detailed information about membrane-type matrix metalloproteinase-1, go to the full flat file.
Word Map on EC 3.4.24.80
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3.4.24.80
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metalloproteinases
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mmp-2
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metastasis
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endothelial
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zymography
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angiogenesis
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gelatin
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gelatinase
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timps
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prommp-2
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mesenchymal
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invasiveness
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vessel
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basement
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integrins
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angiogenic
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fibrosarcoma
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matrigel
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transwell
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furin
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fibronectin
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zymogen
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gelatinolytic
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progelatinase
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ectodomain
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invadopodia
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hemopexin
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alphavbeta3
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proproteins
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mt-mmps
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collagen-rich
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anti-invasive
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matrix-degrading
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collagenolytic
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pro-matrix
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emmprin
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hemopexin-like
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membrane-tethered
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proenzyme
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convertase
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invasion-promoting
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analysis
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diagnostics
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cona-induced
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medicine
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drug development
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endoglin
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reck
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podosomes
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mmp-dependent
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cortactin
- 3.4.24.80
- metalloproteinases
- mmp-2
- metastasis
- endothelial
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zymography
- angiogenesis
- gelatin
- gelatinase
- timps
- prommp-2
- mesenchymal
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invasiveness
- vessel
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basement
- integrins
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angiogenic
- fibrosarcoma
- matrigel
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transwell
- furin
- fibronectin
- zymogen
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gelatinolytic
- progelatinase
- ectodomain
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invadopodia
- hemopexin
- alphavbeta3
- proproteins
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mt-mmps
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collagen-rich
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anti-invasive
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matrix-degrading
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collagenolytic
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pro-matrix
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emmprin
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hemopexin-like
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membrane-tethered
- proenzyme
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convertase
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invasion-promoting
- analysis
- diagnostics
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cona-induced
- medicine
- drug development
- endoglin
- reck
- podosomes
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mmp-dependent
- cortactin
Reaction
endopeptidase activity. Activates progelatinase A by cleavage of the propeptide at Asn37-/-Leu. Other bonds hydrolysed include Gly35-/-Ile in the propeptide of collagenase 3, and Asn341-/-Phe, Asp441-/-Leu and Gln354-/-Thr in the aggrecan interglobular domain =
Synonyms
ectMMP-14, gelatinase A, interstitial MT1-MMP, matrix metalloprotease 14, matrix metalloproteinase 14, matrix metalloproteinase MT 1, matrix metalloproteinase MT-MMP-1, matrix metalloproteinase MT1-MMP, matrix metalloproteinase-14, membrane type 1 matrix, membrane type 1 matrix metalloproteinase, membrane type 1 MMP, membrane type 1-matrix metalloproteinase, membrane type 1-MMP, membrane type I MMP, membrane type matrix metalloproteinase, membrane type MMP-1, membrane type MT1-MMP, membrane type-1 matrix metalloprotease, membrane type-1 matrix metalloprotease 1, membrane type-1 matrix metalloproteinase, membrane type-1 MMP, membrane type-I matrix metalloproteinase, membrane type-I MMP, membrane-anchored matrix metalloproteinase 14, membrane-type 1 matrix metalloproteinase, membrane-type 1 matrix metalloproteinase 1, membrane-type 1 MMP, membrane-type 1-matrix metalloproteinase, membrane-type I matrix metalloproteinase, membrane-type matrix metalloproteinase MT1-MMP, membrane-type matrix metalloproteinase-1, membrane-type metalloproteinase MT1-MMP, membrane-type MMP, metalloproteinase, MMP-14, MMP-2, MMP-8, MMP14, mmp14a, mmp14b, More, MT-MMP-1, MT-MMP1, MT1-MMP, MT1-MMP/MMP-14, MT1-MPP, MTI-MMP, pericellular collagenase, proteinase, matrix metallo-, sMT1-MMP
ECTree
3.4.24.80 membrane-type matrix metalloproteinase-1Advanced search results
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results (Turnover Number
Turnover Number on EC 3.4.24.80 - membrane-type matrix metalloproteinase-1
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TURNOVER NUMBER [1/s] 
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
IMAGE
0.14 - 0.84
(Gly-Pro-Hyp)5-Gly-Pro-Lys(Mca)-Gly-Pro-Gln-Gly-Cys(Mob)-Arg-Gly-Gln-Lys(Dnp)-Gly-Val-Arg-(Gly-Pro-Hyp)5-NH2
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0.33 - 6.8
methoxycoumarin-4-acetyl-Lys-Pro-Leu-Gly-Leu-Lys(2,4-dinitrophenyl)-Ala-Arg-NH2
additional information
additional information
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increase in substrate triple-helical thermal stability is detrimental to enzyme turnover of substrate
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0.14
(Gly-Pro-Hyp)5-Gly-Pro-Lys(Mca)-Gly-Pro-Gln-Gly-Cys(Mob)-Arg-Gly-Gln-Lys(Dnp)-Gly-Val-Arg-(Gly-Pro-Hyp)5-NH2
pH not specified in the publication, 37°C, recombinant wild-type membrane-bound enzyme
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0.2
(Gly-Pro-Hyp)5-Gly-Pro-Lys(Mca)-Gly-Pro-Gln-Gly-Cys(Mob)-Arg-Gly-Gln-Lys(Dnp)-Gly-Val-Arg-(Gly-Pro-Hyp)5-NH2
pH not specified in the publication, 37°C, recombinant enzyme mutant lacking the HPX domain
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0.21
(Gly-Pro-Hyp)5-Gly-Pro-Lys(Mca)-Gly-Pro-Gln-Gly-Cys(Mob)-Arg-Gly-Gln-Lys(Dnp)-Gly-Val-Arg-(Gly-Pro-Hyp)5-NH2
pH not specified in the publication, 37°C, recombinant enzyme mutant lacking the C-terminal domain
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0.84
(Gly-Pro-Hyp)5-Gly-Pro-Lys(Mca)-Gly-Pro-Gln-Gly-Cys(Mob)-Arg-Gly-Gln-Lys(Dnp)-Gly-Val-Arg-(Gly-Pro-Hyp)5-NH2
pH not specified in the publication, 37°C, recombinant soluble enzyme
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0.019
collagen I alpha-1 chain
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pH not specified in the publication, 37°C, MMP-1: 1-protonated
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0.47
collagen I alpha-1 chain
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pH not specified in the publication, 37°C, MMP-1: 0-protonated
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0.68
collagen I alpha-1 chain
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pH not specified in the publication, 37°C, MMP-1: 2-protonated
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1.1
collagen I alpha-1 chain
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pH not specified in the publication, 37°C, MMP-1: 3-protonated
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1.52
collagen I alpha-2 chain
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pH not specified in the publication, 37°C, MMP-1: 3-protonated
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5.79
collagen I alpha-2 chain
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pH not specified in the publication, 37°C, MMP-1: 1-protonated
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9.89
collagen I alpha-2 chain
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pH not specified in the publication, 37°C, MMP-1: 0-protonated
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255.6
collagen I alpha-2 chain
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pH not specified in the publication, 37°C, MMP-1: 2-protonated
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0.3
collagen type I alpha-1 chain
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1-protonated enzyme, 50 mM Tris-HCl, 0.1 M NaCl, 10 mM CaCl2 plus 0.05% Brij 35,at pH 7.3 and 37°C
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0.43
collagen type I alpha-1 chain
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2-protonated enzyme, 50 mM Tris-HCl, 0.1 M NaCl, 10 mM CaCl2 plus 0.05% Brij 35,at pH 7.3 and 37°C
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4.56
collagen type I alpha-1 chain
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0-protonated enzyme, 50 mM Tris-HCl, 0.1 M NaCl, 10 mM CaCl2 plus 0.05% Brij 35,at pH 7.3 and 37°C
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10.41
collagen type I alpha-1 chain
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4-protonated enzyme, 50 mM Tris-HCl, 0.1 M NaCl, 10 mM CaCl2 plus 0.05% Brij 35,at pH 7.3 and 37°C
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0.0089
collagen type I alpha-2 chain
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1-protonated enzyme, 50 mM Tris-HCl, 0.1 M NaCl, 10 mM CaCl2 plus 0.05% Brij 35,at pH 7.3 and 37°C
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0.014
collagen type I alpha-2 chain
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2-protonated enzyme, 50 mM Tris-HCl, 0.1 M NaCl, 10 mM CaCl2 plus 0.05% Brij 35,at pH 7.3 and 37°C
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4.09
collagen type I alpha-2 chain
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4-protonated enzyme, 50 mM Tris-HCl, 0.1 M NaCl, 10 mM CaCl2 plus 0.05% Brij 35,at pH 7.3 and 37°C
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58.61
collagen type I alpha-2 chain
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0-protonated enzyme, 50 mM Tris-HCl, 0.1 M NaCl, 10 mM CaCl2 plus 0.05% Brij 35,at pH 7.3 and 37°C
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0.33
methoxycoumarin-4-acetyl-Lys-Pro-Leu-Gly-Leu-Lys(2,4-dinitrophenyl)-Ala-Arg-NH2
pH 7.0, 10°C, recombinant enzyme
2.1
methoxycoumarin-4-acetyl-Lys-Pro-Leu-Gly-Leu-Lys(2,4-dinitrophenyl)-Ala-Arg-NH2
pH 7.0, 25°C, recombinant enzyme
3.4
methoxycoumarin-4-acetyl-Lys-Pro-Leu-Gly-Leu-Lys(2,4-dinitrophenyl)-Ala-Arg-NH2
pH 7.0, 30°C, recombinant enzyme
6.8
methoxycoumarin-4-acetyl-Lys-Pro-Leu-Gly-Leu-Lys(2,4-dinitrophenyl)-Ala-Arg-NH2
pH 7.0, 37°C, recombinant enzyme
