3.4.24.80: membrane-type matrix metalloproteinase-1

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For detailed information about membrane-type matrix metalloproteinase-1, go to the full flat file.

Word Map on EC 3.4.24.80

3.4.24.80

metalloproteinases

mmp-2

metastasis

endothelial

zymography

angiogenesis

gelatin

gelatinase

timps

prommp-2

mesenchymal

invasiveness

vessel

basement

integrins

angiogenic

fibrosarcoma

matrigel

transwell

furin

fibronectin

zymogen

gelatinolytic

progelatinase

ectodomain

invadopodia

hemopexin

alphavbeta3

proproteins

mt-mmps

collagen-rich

anti-invasive

matrix-degrading

collagenolytic

pro-matrix

emmprin

hemopexin-like

membrane-tethered

proenzyme

convertase

invasion-promoting

analysis

diagnostics

cona-induced

medicine

drug development

endoglin

reck

podosomes

mmp-dependent

cortactin

Reaction

endopeptidase activity. Activates progelatinase A by cleavage of the propeptide at Asn37-/-Leu. Other bonds hydrolysed include Gly35-/-Ile in the propeptide of collagenase 3, and Asn341-/-Phe, Asp441-/-Leu and Gln354-/-Thr in the aggrecan interglobular domain =

Synonyms

ectMMP-14, gelatinase A, interstitial MT1-MMP, matrix metalloprotease 14, matrix metalloproteinase 14, matrix metalloproteinase MT 1, matrix metalloproteinase MT-MMP-1, matrix metalloproteinase MT1-MMP, matrix metalloproteinase-14, membrane type 1 matrix, membrane type 1 matrix metalloproteinase, membrane type 1 MMP, membrane type 1-matrix metalloproteinase, membrane type 1-MMP, membrane type I MMP, membrane type matrix metalloproteinase, membrane type MMP-1, membrane type MT1-MMP, membrane type-1 matrix metalloprotease, membrane type-1 matrix metalloprotease 1, membrane type-1 matrix metalloproteinase, membrane type-1 MMP, membrane type-I matrix metalloproteinase, membrane type-I MMP, membrane-anchored matrix metalloproteinase 14, membrane-type 1 matrix metalloproteinase, membrane-type 1 matrix metalloproteinase 1, membrane-type 1 MMP, membrane-type 1-matrix metalloproteinase, membrane-type I matrix metalloproteinase, membrane-type matrix metalloproteinase MT1-MMP, membrane-type matrix metalloproteinase-1, membrane-type metalloproteinase MT1-MMP, membrane-type MMP, metalloproteinase, MMP-14, MMP-2, MMP-8, MMP14, mmp14a, mmp14b, More, MT-MMP-1, MT-MMP1, MT1-MMP, MT1-MMP/MMP-14, MT1-MPP, MTI-MMP, pericellular collagenase, proteinase, matrix metallo-, sMT1-MMP

ECTree

3 Hydrolases

3.4 Acting on peptide bonds (peptidases)

3.4.24 Metalloendopeptidases

3.4.24.80 membrane-type matrix metalloproteinase-1

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Results	in table
35	Activating Compound
325	AA Sequence
23	Application
1	CAS Registry Number
52	Cloned(Commentary)
3	Crystallization (Commentary)
3431	Disease/ Diagnostics
10	Expression
63	General Information
1	General Stability
20	IC50 Value
172	Inhibitors
24	kcat/KM [mM/s]
24	Ki Value [mM]
32	KM Value [mM]
87	Localization
24	Metals/Ions
54	Molecular Weight [Da]
81	Natural Substrates/ Products (Substrates)
136	Organism
12	PDB ID
5	pH Optimum
1	pH Range
21	Posttranslational Modification
63	Protein Variants
15	Purification (Commentary)
1	Reaction
2	Reaction Type
134	Reference
4	Renatured (Commentary)
207	Source Tissue
3	Specific Activity [micromol/min/mg]
299	Substrates and Products (Substrate)
24	Subunits
249	Synonyms
16	Temperature Optimum [°C]
1	Temperature Range [°C]
29	Turnover Number [1/s]

Purification

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Purification on EC 3.4.24.80 - membrane-type matrix metalloproteinase-1

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2 entries

18 kDa and 21 kDa fragment, homogeneity

Homo sapiens

P50281

638812

affinity purification from COS-7 cells

catalytic domain

inhibitor-tethered affinity purification with BB94

Homo sapiens

667498

nickel chelating column chromatography

Homo sapiens

P50281

733605

purified from exclusion bodies

Homo sapiens

668966

recombinant C-terminally His-tagged wild-type and mutant Co2+-MT1-MMPs and apoenzymes from Escherichia coli strain BL21(DE3) by nickel affinity chromatography and ultrafiltration

recombinant protein

solubilized recombinant wild-type and mutant enzymes from Escherichia coli strain Rosetta(DE3)pLysS

Homo sapiens

P50281

755435

truncated form, 90% pure

Homo sapiens

P50281

638806